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  1. Book ; Thesis: The adaptive immunity in the context of natalizumab-associated progressive multifocal leukoencephalophaty

    Warnke, Clemens

    2015  

    Author's details vorgelegt von Dr. med. Clemens Warnke
    Language English
    Size 128 Blätter, Illustrationen, Diagramme
    Publishing place Düsseldorf
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Universität Düsseldorf und Universität zu Köln, 2017
    Note Zusammenfassung in deutscher Sprache
    HBZ-ID HT019505084
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2017 E 1750 order for loan Magazin

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  2. Book ; Online ; Thesis: Perinatale Programmierung - Der Effekt einer Stimulation mit Hyper-Interleukin-6 auf Mikroglia (BV-2 Zellen)

    Lanz, Isabel Marie [Verfasser] / Dötsch, Jörh [Gutachter] / Warnke, Clemens [Gutachter]

    2023  

    Author's details Isabel Marie Lanz ; Gutachter: Jörh Dötsch, Clemens Warnke
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Stadtbibliothek Köln
    Publishing place Köln
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article ; Online: Big data in MS-What can we learn from large international observational studies such as MSBase?

    Warnke, Clemens / Hartung, Hans-Peter

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2019  Volume 26, Issue 1, Page(s) 4–5

    MeSH term(s) Big Data ; Disease Progression ; Humans ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/therapy ; Observational Studies as Topic
    Language English
    Publishing date 2019-08-09
    Publishing country England
    Document type Editorial
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458519868982
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  4. Article ; Online: Challenging a concept: Pulsed treatment regimen-No risk of PML?

    Warnke, Clemens / Hartung, Hans-Peter

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2019  Volume 25, Issue 8, Page(s) 1076–1078

    MeSH term(s) Humans ; Immunologic Factors/adverse effects ; Leukoencephalopathy, Progressive Multifocal/chemically induced ; Multiple Sclerosis/drug therapy
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2019-04-09
    Publishing country England
    Document type Editorial
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458519843232
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  5. Article ; Online: Persons with multiple sclerosis older than 55 years: an analysis from the German MS registry.

    Goereci, Yasemin / Ellenberger, David / Rommer, Paulus / Dunkl, Veronika / Golla, Heidrun / Zettl, Uwe / Stahmann, Alexander / Warnke, Clemens

    Journal of neurology

    2024  

    Abstract: Background: Persons with MS (PwMS) ≥ 55 years are underrepresented in therapy studies leading to a lack of evidence.: Objective and methods: To study the subgroup of PwMS ≥ 55 years in the German MS registry in comparison with PwMS < 55 years. ... ...

    Abstract Background: Persons with MS (PwMS) ≥ 55 years are underrepresented in therapy studies leading to a lack of evidence.
    Objective and methods: To study the subgroup of PwMS ≥ 55 years in the German MS registry in comparison with PwMS < 55 years. Endpoints of interest were the grade of disability, leading symptoms, clinical and magnetic resonance imaging activity, and use of disease modifying therapy.
    Results: At the time of analysis, data from 40,428 PwMS were available for analysis. In PwMS aged ≥ 65 and PwMS aged ≥ 55 to 64 years, compared with PwMS aged < 55 years, the mean Expanded Disability Status Scale Scores were higher (5.3, 4.2 and 2.7, respectively), while the proportion of individuals with current use of disease modifying therapy was lower (42.6%, 60.9% and 76.7%, respectively). The older patient groups were more likely to be labeled with progressive MS and the frequency of occupational invalidity was high (38.8% in PwMS aged ≥ 55 to 64 years). Gait disorder, fatigue, bladder dysfunction, and spasticity were among the leading symptoms in PwMS aged ≥ 55 years.
    Conclusion: PwMS ≥ 55 years have a high degree of disability, but a large proportion do not receive disease modifying therapy, exposing an unmet need.
    Language English
    Publishing date 2024-03-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-024-12286-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [No title information]

    Eckardt, Carolin / Ulrike Vay, Sabine / Warnke, Clemens / Flossdorf, Pia / Weinert, Melanie

    neuroreha

    2024  Volume 16, Issue 01, Page(s) 34–46

    Abstract: In Deutschland sind schätzungsweise mehr als 280 000 Menschen an Multipler Sklerose (MS) erkrankt. Neben sensiblen, motorischen, vegetativen und neuropsychologischen Funktionsstörungen ist die Dysphagie ein ... ...

    Abstract In Deutschland sind schätzungsweise mehr als 280 000 Menschen an Multipler Sklerose (MS) erkrankt. Neben sensiblen, motorischen, vegetativen und neuropsychologischen Funktionsstörungen ist die Dysphagie ein hochrelevantes, stark beeinträchtigendes und zugleich bislang nicht gut untersuchtes Symptom der Erkrankung. Der Artikel bietet eine Übersicht über die aktuelle Studienlage zur Dysphagie bei MS und soll die Wahrnehmung für das Symptom Schluckstörung im Kontext der MS-Erkrankung schärfen. Techniken zur weiterführenden Diagnostik und Therapie werden vorgestellt mit dem langfristigen Ziel, betroffene Menschen mit MS künftig zuverlässiger zu diagnostizieren, ihnen optimierte Hilfe zu bieten und ihre Lebensqualität zu verbessern.:
    Language German
    Publishing date 2024-03-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2492087-3
    ISSN 1611-7654 ; 1611-6496
    ISSN (online) 1611-7654
    ISSN 1611-6496
    DOI 10.1055/a-2216-9704
    Database Thieme publisher's database

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  7. Article ; Online: Cultural adaptation of the Integrated Palliative care Outcome Scale for neurological symptoms - ERRATUM.

    Dillen, Kim / Goereci, Yasemin / Dunkl, Veronika / Müller, Anne / Fink, Gereon R / Voltz, Raymond / Hocaoglu, Mevhibe / Warnke, Clemens / Golla, Heidrun

    Palliative & supportive care

    2023  , Page(s) 1

    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2454009-2
    ISSN 1478-9523 ; 1478-9515
    ISSN (online) 1478-9523
    ISSN 1478-9515
    DOI 10.1017/S1478951523000561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6697: Show issues Location:
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  8. Article ; Online: "So at least now I know how to deal with things myself, what I can do if it gets really bad again"-experiences with a long-term cross-sectoral advocacy care and case management for severe multiple sclerosis: a qualitative study.

    Müller, Anne / Hebben, Fabian / Dillen, Kim / Dunkl, Veronika / Goereci, Yasemin / Voltz, Raymond / Löcherbach, Peter / Warnke, Clemens / Golla, Heidrun

    BMC health services research

    2024  Volume 24, Issue 1, Page(s) 453

    Abstract: Background: Persons with severe Multiple Sclerosis (PwsMS) face complex needs and daily limitations that make it challenging to receive optimal care. The implementation and coordination of health care, social services, and support in financial affairs ... ...

    Abstract Background: Persons with severe Multiple Sclerosis (PwsMS) face complex needs and daily limitations that make it challenging to receive optimal care. The implementation and coordination of health care, social services, and support in financial affairs can be particularly time consuming and burdensome for both PwsMS and caregivers. Care and case management (CCM) helps ensure optimal individual care as well as care at a higher-level. The goal of the current qualitative study was to determine the experiences of PwsMS, caregivers and health care specialists (HCSs) with the CCM.
    Methods: In the current qualitative sub study, as part of a larger trial, in-depth semi-structured interviews with PwsMS, caregivers and HCSs who had been in contact with the CCM were conducted between 02/2022 and 01/2023. Data was transcribed, pseudonymized, tested for saturation and analyzed using structuring content analysis according to Kuckartz. Sociodemographic and interview characteristics were analyzed descriptively.
    Results: Thirteen PwsMS, 12 caregivers and 10 HCSs completed interviews. Main categories of CCM functions were derived deductively: (1) gatekeeper function, (2) broker function, (3) advocacy function, (4) outlook on CCM in standard care. Subcategories were then derived inductively from the interview material. 852 segments were coded. Participants appreciated the CCM as a continuous and objective contact person, a person of trust (92 codes), a competent source of information and advice (on MS) (68 codes) and comprehensive cross-insurance support (128 codes), relieving and supporting PwsMS, their caregivers and HCSs (67 codes).
    Conclusions: Through the cross-sectoral continuous support in health-related, social, financial and everyday bureaucratic matters, the CCM provides comprehensive and overriding support and relief for PwsMS, caregivers and HCSs. This intervention bears the potential to be fine-tuned and applied to similar complex patient groups.
    Trial registration: The study was approved by the Ethics Committee of the University of Cologne (#20-1436), registered at the German Register for Clinical Studies (DRKS00022771) and in accordance with the Declaration of Helsinki.
    MeSH term(s) Humans ; Case Management ; Multiple Sclerosis/therapy ; Long-Term Care ; Caregivers ; Social Work ; Qualitative Research
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-024-10851-1
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  9. Article: Physical activity is related to disease severity and fatigue, but not to relapse rate in persons with relapsing remitting multiple sclerosis - a self-reported questionnaire based study.

    Schlagheck, Marit L / Hübner, Sven T / Joisten, Niklas / Walzik, David / Rademacher, Annette / Wolf, Florian / Bansi, Jens / Warnke, Clemens / Zimmer, Philipp

    Frontiers in neurology

    2023  Volume 14, Page(s) 1217000

    Abstract: Introduction: Based on theoretical models, physical activity has been introduced as a promoting method to mitigate the disease severity, fatigue and relapse rate in multiple sclerosis. The primary objective of the study was to investigate the relation ... ...

    Abstract Introduction: Based on theoretical models, physical activity has been introduced as a promoting method to mitigate the disease severity, fatigue and relapse rate in multiple sclerosis. The primary objective of the study was to investigate the relation between self-reported physical activity level and disease severity, fatigue and relapse rate in persons with relapsing remitting multiple sclerosis (RRMS).
    Methods: A survey was offered to persons with RRMS from March 2019 to August 2021 (
    Results: Bivariate correlations revealed an inverse relation between physical activity level and PDDS (
    Conclusion: Our findings confirm a relation between self-reported physical activity, disease severity and fatigue in persons with RRMS. However, self-reported physical activity level does not seem to affect the annualised relapse rate.
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1217000
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  10. Article ; Online: Natalizumab-associated progressive multifocal leukoencephalopathy is not preceded by elevated drug concentrations.

    Warnke, Clemens / Hartung, Hans-Peter

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2017  Volume 23, Issue 7, Page(s) 920–922

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Humans ; Leukoencephalopathy, Progressive Multifocal ; Multiple Sclerosis, Relapsing-Remitting ; Natalizumab
    Chemical Substances Antibodies, Monoclonal, Humanized ; Natalizumab
    Language English
    Publishing date 2017-05-08
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458517705480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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