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  1. Article: CARBOHYDRATE-INDUCED LIPEMIA. REPORT OF A FAMILIAL OCCURRENCE.

    Spritz, N

    The New England journal of medicine

    2007  Volume 271, Page(s) 291–293

    MeSH term(s) Carbohydrate Metabolism ; Cholesterol/blood ; Dietary Carbohydrates ; Dietary Fats ; Genetics, Medical ; Glycerides ; Humans ; Hyperlipidemias ; Lipid Metabolism ; Lipoprotein Lipase ; Phospholipids ; Povidone
    Chemical Substances Dietary Carbohydrates ; Dietary Fats ; Glycerides ; Phospholipids ; Cholesterol (97C5T2UQ7J) ; Lipoprotein Lipase (EC 3.1.1.34) ; Povidone (FZ989GH94E)
    Language English
    Publishing date 2007-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJM196408062710605
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  2. Article: Physician-assisted suicide: three crucial distinctions.

    Spritz, N

    The Fordham urban law journal

    1997  Volume 24, Issue 4, Page(s) 869–880

    MeSH term(s) Euthanasia, Active/ethics ; Euthanasia, Active/legislation & jurisprudence ; Euthanasia, Passive/ethics ; Euthanasia, Passive/legislation & jurisprudence ; Humans ; Mental Competency ; Right to Die/ethics ; Right to Die/legislation & jurisprudence ; Suicide, Assisted/ethics ; Suicide, Assisted/legislation & jurisprudence ; Supreme Court Decisions ; Terminally Ill ; United States ; Wedge Argument
    Language English
    Publishing date 1997
    Publishing country United States
    Document type Journal Article
    ISSN 0199-4646
    ISSN 0199-4646
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  3. Article: Gatekeeping.

    Spritz, N

    The New England journal of medicine

    1992  Volume 327, Issue 21, Page(s) 1533

    MeSH term(s) Health Services Misuse ; Hospitals/utilization ; Malpractice/statistics & numerical data ; New York ; United States
    Language English
    Publishing date 1992-11-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
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  4. Article ; Online: Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai.

    Powell, Christopher D / Wilson, Warren M / Olesaningo, Godwin / Manyama, Mange / Jamniczky, Heather / Spritz, Richard / Cross, James C / Lukowiak, Kenneth / Hallgrimsson, Benedikt / Gonzalez, Paula N

    PloS one

    2020  Volume 15, Issue 9, Page(s) e0237700

    Abstract: The reduction of food intake during pregnancy is part of many cultural and religious traditions around the world. The impact of such practices on fetal growth and development are poorly understood. Here, we examined the patterns of diet intake among ... ...

    Abstract The reduction of food intake during pregnancy is part of many cultural and religious traditions around the world. The impact of such practices on fetal growth and development are poorly understood. Here, we examined the patterns of diet intake among Maasai pregnant women and assessed their effect on newborn morphometrics. We recruited 141 mother-infant pairs from Ngorongoro Conservation Area (NCA) in Northern Tanzania and quantified dietary intake and changes in maternal diet during pregnancy. We obtained measurements of body weight (BW) and head circumference (HC) at birth. We found that Maasai women significantly reduced their dietary intake during the third trimester, going from an average of 1601 kcal/day during the first two trimesters to 799 kcal/day in the final trimester. The greatest proportion of nutrient reduction was in carbohydrates. Overall, 40% of HC Z-scores of the NCA sample were more than 2 standard deviations below the WHO standard. Nearly a third of neonates classify as low birth weight (< 2500g). HC was smaller relative to BW in this cohort than predicted using the WHO standard. This contrasts markedly to a Tanzanian birth cohort obtained at the same time in an urban context in which only 12% of infants exhibited low weight, only two individuals had HC Z-scores < 2 and HC's relative to birth weight were larger than predicted using the WHO standards. The surprising lack of head sparing in the NCA cohort suggests that the impact of third trimester malnutrition bears further investigation in both animal models and human populations, especially as low HC is negatively associated with long term health outcomes.
    MeSH term(s) Caloric Restriction/adverse effects ; Female ; Fetal Development ; Head/embryology ; Head/growth & development ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Male ; Mothers ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy Trimester, Third ; Tanzania
    Language English
    Publishing date 2020-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0237700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Oversight of physicians' conduct by state licensing agencies. Lessons from New York's Libby Zion case.

    Spritz, N

    Annals of internal medicine

    1991  Volume 115, Issue 3, Page(s) 219–222

    Abstract: The unexplained and highly publicized death of an 18-year-old woman in a New York Hospital in 1984 became the focus for debate throughout the country concerning working conditions and supervision of house officers. It also led to charges by the State of ... ...

    Abstract The unexplained and highly publicized death of an 18-year-old woman in a New York Hospital in 1984 became the focus for debate throughout the country concerning working conditions and supervision of house officers. It also led to charges by the State of New York of gross negligence against her resident physicians. The residents were exonerated of all charges by a review panel with lay and physician representation after testimony of expert witnesses. Although the Commissioner of Health concurred with this verdict, residents were charged with gross negligence by the Board of Regents, a lay panel. Fundamental contrasts in the way the two panels made their judgments supports the importance of peer review in disciplining physicians in matters of medical judgment. Analysis of the actions by New York State against the residents also underscores the importance of other principles in the oversight of physician behavior that are applicable to all jurisdictions: resolution of charges without undo delay, an equitable and consistent standard for the administration of sanctions, and adherence to a clearly defined standard for the level of culpability required for disciplinary action. Both the structure of the review process and its application in this instance led to violations of each of these principles.
    MeSH term(s) Internship and Residency/legislation & jurisprudence ; Licensure, Medical ; Malpractice/legislation & jurisprudence ; New York
    Language English
    Publishing date 1991-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-115-3-219
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  6. Article: Effects of coronary risk reduction on mortality.

    Spritz, N

    Lancet (London, England)

    1990  Volume 335, Issue 8694, Page(s) 923

    MeSH term(s) Cholesterol/blood ; Coronary Disease/blood ; Humans ; Male ; Middle Aged ; Mortality ; Risk Factors
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 1990-04-14
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/0140-6736(90)90527-c
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    Zs.MG 94: Show issues

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  7. Article: Streptokinase induced lysinemethylesterase activity of human euglobulin.

    SPRITZ, N / CAMERON, D J

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

    2003  Volume 109, Page(s) 848–852

    MeSH term(s) Deoxyribonuclease I ; Esterases/blood ; Globulins ; Humans ; Serum Globulins ; Streptodornase and Streptokinase/pharmacology ; Streptokinase
    Chemical Substances Globulins ; Serum Globulins ; Streptodornase and Streptokinase (EC 3.-) ; Esterases (EC 3.1.-) ; Deoxyribonuclease I (EC 3.1.21.1) ; Streptokinase (EC 3.4.-)
    Language English
    Publishing date 2003-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.3181/00379727-109-27355
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    Ua VI Zs.111: Show issues Location:
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  8. Article ; Online: (with research data) Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel.

    Gonzalez, P N / Pavlicev, M / Mitteroecker, P / Pardo-Manuel de Villena, F / Spritz, R A / Marcucio, R S / Hallgrímsson, B

    Journal of evolutionary biology

    2016  Volume 29, Issue 9, Page(s) 1737–1751

    Abstract: Developmental stability and canalization describe the ability of developmental systems to minimize phenotypic variation in the face of stochastic micro-environmental effects, genetic variation and environmental influences. Canalization is the ability to ... ...

    Abstract Developmental stability and canalization describe the ability of developmental systems to minimize phenotypic variation in the face of stochastic micro-environmental effects, genetic variation and environmental influences. Canalization is the ability to minimize the effects of genetic or environmental effects, whereas developmental stability is the ability to minimize the effects of micro-environmental effects within individuals. Despite much attention, the mechanisms that underlie these two components of phenotypic robustness remain unknown. We investigated the genetic structure of phenotypic robustness in the collaborative cross (CC) mouse reference population. We analysed the magnitude of fluctuating asymmetry (FA) and among-individual variation of cranial shape in reciprocal crosses among the eight parental strains, using geometric morphometrics and a diallel analysis based on a Bayesian approach. Significant differences among genotypes were found for both measures, although they were poorly correlated at the level of individuals. An overall positive effect of inbreeding was found for both components of variation. The strain CAST/EiJ exerted a positive additive effect on FA and, to a lesser extent, among-individual variance. Sex- and other strain-specific effects were not significant. Neither FA nor among-individual variation was associated with phenotypic extremeness. Our results support the existence of genetic variation for both developmental stability and canalization. This finding is important because robustness is a key feature of developmental systems. Our finding that robustness is not related to phenotypic extremeness is consistent with theoretical work that suggests that its relationship to stabilizing selection is not straightforward.
    MeSH term(s) Animals ; Bayes Theorem ; Genetic Structures ; Genetic Variation ; Genotype ; Inbreeding ; Mice ; Phenotype
    Language English
    Publishing date 2016-07-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1465318-7
    ISSN 1420-9101 ; 1010-061X
    ISSN (online) 1420-9101
    ISSN 1010-061X
    DOI 10.1111/jeb.12906
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  9. Article ; Online: Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression.

    Jin, Ying / Roberts, Genevieve H L / Ferrara, Tracey M / Ben, Songtao / van Geel, Nanja / Wolkerstorfer, Albert / Ezzedine, Khaled / Siebert, Janet / Neff, Charles P / Palmer, Brent E / Santorico, Stephanie A / Spritz, Richard A

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 391

    Abstract: Vitiligo is an autoimmune disease in which melanocyte destruction causes skin depigmentation, with 49 loci known from previous GWAS. Aiming to define vitiligo subtypes, we discovered that age-of-onset is bimodal; one-third of cases have early onset (mean ...

    Abstract Vitiligo is an autoimmune disease in which melanocyte destruction causes skin depigmentation, with 49 loci known from previous GWAS. Aiming to define vitiligo subtypes, we discovered that age-of-onset is bimodal; one-third of cases have early onset (mean 10.3 years) and two-thirds later onset (mean 34.0 years). In the early-onset subgroup we found novel association with MHC class II region indel rs145954018, and independent association with the principal MHC class II locus from previous GWAS, represented by rs9271597; greatest association was with rs145954018del-rs9271597A haplotype (P = 2.40 × 10
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Child ; Child, Preschool ; Dendritic Cells ; Female ; Gene Expression Regulation/genetics ; Genes, MHC Class II/genetics ; Genes, MHC Class II/immunology ; Genetic Loci ; Genetic Predisposition to Disease ; Genotype ; HLA-DQ Antigens/metabolism ; HLA-DQ beta-Chains/metabolism ; Haplotypes/immunology ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Monocytes ; Phenotype ; RNA, Messenger/metabolism ; Up-Regulation ; Vitiligo/genetics ; Vitiligo/immunology ; Young Adult
    Chemical Substances HLA-DQ Antigens ; HLA-DQ beta-Chains ; HLA-DQB1 antigen ; RNA, Messenger
    Language English
    Publishing date 2019-01-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-08337-4
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  10. Article ; Online: Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai.

    Christopher D Powell / Warren M Wilson / Godwin Olesaningo / Mange Manyama / Heather Jamniczky / Richard Spritz / James C Cross / Kenneth Lukowiak / Benedikt Hallgrimsson / Paula N Gonzalez

    PLoS ONE, Vol 15, Iss 9, p e

    2020  Volume 0237700

    Abstract: The reduction of food intake during pregnancy is part of many cultural and religious traditions around the world. The impact of such practices on fetal growth and development are poorly understood. Here, we examined the patterns of diet intake among ... ...

    Abstract The reduction of food intake during pregnancy is part of many cultural and religious traditions around the world. The impact of such practices on fetal growth and development are poorly understood. Here, we examined the patterns of diet intake among Maasai pregnant women and assessed their effect on newborn morphometrics. We recruited 141 mother-infant pairs from Ngorongoro Conservation Area (NCA) in Northern Tanzania and quantified dietary intake and changes in maternal diet during pregnancy. We obtained measurements of body weight (BW) and head circumference (HC) at birth. We found that Maasai women significantly reduced their dietary intake during the third trimester, going from an average of 1601 kcal/day during the first two trimesters to 799 kcal/day in the final trimester. The greatest proportion of nutrient reduction was in carbohydrates. Overall, 40% of HC Z-scores of the NCA sample were more than 2 standard deviations below the WHO standard. Nearly a third of neonates classify as low birth weight (< 2500g). HC was smaller relative to BW in this cohort than predicted using the WHO standard. This contrasts markedly to a Tanzanian birth cohort obtained at the same time in an urban context in which only 12% of infants exhibited low weight, only two individuals had HC Z-scores < 2 and HC's relative to birth weight were larger than predicted using the WHO standards. The surprising lack of head sparing in the NCA cohort suggests that the impact of third trimester malnutrition bears further investigation in both animal models and human populations, especially as low HC is negatively associated with long term health outcomes.
    Keywords Medicine ; R ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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