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  1. Book: Coagulation and hematology in neurological surgery

    Nimjee, Shahid M.

    (Neurosurgery clinics of North America ; volume 29, number 4 (October 2018))

    2018  

    Author's details editors Shahid M. Nimjee, Russell R. Lonser
    Series title Neurosurgery clinics of North America ; volume 29, number 4 (October 2018)
    Collection
    Language English
    Size xiv Seiten, Seite 476-613, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT019859710
    ISBN 978-0-323-64091-6 ; 0-323-64091-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1200 -29,4- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Stroke Thrombolysis: Can You Feel the Need for Speed?

    Nimjee, Shahid M / Hill, Michael D

    Neurology

    2024  Volume 102, Issue 7, Page(s) e209253

    MeSH term(s) Humans ; Stroke/drug therapy ; Tissue Plasminogen Activator/therapeutic use ; Thrombolytic Therapy ; Fibrinolytic Agents/therapeutic use
    Chemical Substances Tissue Plasminogen Activator (EC 3.4.21.68) ; Fibrinolytic Agents
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000209253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fibrinolysis without intracranial hemorrhage.

    Nimjee, Shahid M

    Blood

    2022  Volume 140, Issue 4, Page(s) 300–302

    MeSH term(s) Fibrinolysis ; Fibrinolytic Agents ; Hemorrhage ; Humans ; Intracranial Hemorrhages/etiology ; Ischemic Stroke ; Occludin ; Phosphorylation
    Chemical Substances Fibrinolytic Agents ; Occludin
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022016925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Venous Sinus Stenting in Patient With Medically Intractable Idiopathic Intracranial Hypertension.

    Zakeri, Jessica / Nimjee, Shahid M

    Radiologic technology

    2023  Volume 94, Issue 5, Page(s) 382–384

    MeSH term(s) Humans ; Pseudotumor Cerebri/complications ; Pseudotumor Cerebri/diagnostic imaging ; Pseudotumor Cerebri/surgery ; Stents ; Patients ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 414079-5
    ISSN 1943-5657 ; 0033-8397
    ISSN (online) 1943-5657
    ISSN 0033-8397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stroke and Neurogenesis: Bridging Clinical Observations to New Mechanistic Insights from Animal Models.

    Passarelli, Joshua P / Nimjee, Shahid M / Townsend, Kristy L

    Translational stroke research

    2022  Volume 15, Issue 1, Page(s) 53–68

    Abstract: Stroke was the 2nd leading cause of death and a major cause of morbidity. Unfortunately, there are limited means to promote neurological recovery post-stroke, but research has unearthed potential targets for therapies to encourage post-stroke ... ...

    Abstract Stroke was the 2nd leading cause of death and a major cause of morbidity. Unfortunately, there are limited means to promote neurological recovery post-stroke, but research has unearthed potential targets for therapies to encourage post-stroke neurogenesis and neuroplasticity. The occurrence of neurogenesis in adult mammalian brains, including humans, was not widely accepted until the 1990s. Now, adult neurogenesis has been extensively studied in human and mouse neurogenic brain niches, of which the subventricular zone of the lateral ventricles and subgranular zone of the dentate gyrus are best studied. Numerous other niches are under investigation for neurogenic potential. This review offers a basic overview to stroke in the clinical setting, a focused summary of recent and foundational research literature on cortical neurogenesis and post-stroke brain plasticity, and insights regarding how the meninges and choroid plexus have emerged as key players in neurogenesis and neuroplasticity in the context of focal cerebral ischemia disrupting the anterior circulation. The choroid plexus and meninges are vital as they are integral sites for neuroimmune interactions, glymphatic perfusion, and niche signaling pertinent to neural stem cells and neurogenesis. Modulating neuroimmune interactions with a focus on astrocyte activity, potentially through manipulation of the choroid plexus and meningeal niches, may reduce the exacerbation of stroke by inflammatory mediators and create an environment conducive to neurorecovery. Furthermore, addressing impaired glymphatic perfusion after ischemic stroke likely supports a neurogenic environment by clearing out inflammatory mediators, neurotoxic metabolites, and other accumulated waste. The meninges and choroid plexus also contribute more directly to promoting neurogenesis: the meninges are thought to harbor neural stem cells and are a niche amenable to neural stem/progenitor cell migration. Additionally, the choroid plexus has secretory functions that directly influences stem cells through signaling mechanisms and growth factor actions. More research to better understand the functions of the meninges and choroid plexus may lead to novel approaches for stimulating neuronal recovery after ischemic stroke.
    MeSH term(s) Adult ; Mice ; Animals ; Humans ; Neurogenesis/physiology ; Stroke ; Models, Animal ; Ischemic Stroke ; Inflammation Mediators ; Mammals
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2022-12-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2541897-X
    ISSN 1868-601X ; 1868-4483
    ISSN (online) 1868-601X
    ISSN 1868-4483
    DOI 10.1007/s12975-022-01109-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Sex differences in thrombosis as it affects acute ischemic stroke.

    Nimjee, Shahid M / Akhter, Asad S / Zakeri, Amanda / Herson, Paco S

    Neurobiology of disease

    2022  Volume 165, Page(s) 105647

    Abstract: Ischemic stroke is a devastating health problem, affecting approximately 800,000 patients in the US every year, making it the leading cause of combined death and disability in the country. Stroke has historically been thought of as predominantly ... ...

    Abstract Ischemic stroke is a devastating health problem, affecting approximately 800,000 patients in the US every year, making it the leading cause of combined death and disability in the country. Stroke has historically been thought of as predominantly impacting men, however it is becoming increasingly clear that stroke affects women to a greater degree than men. Indeed, women have worse outcomes compared to men following ischemic stroke. Recent clinical advances have shown great promise in acute stroke therapy, with the use of mechanical endovascular thrombectomy (with and without recombinant tissue plasminogen activator; rtPA) greatly improving outcomes. This observation makes it clear that removal of clots and reperfusion, either mechanically or pharmacologically, is critical for improving outcomes of patients following acute ischemic stroke. Despite these promising advances, long-term neurological sequelae persist in the post-stroke population. This review focuses on mechanisms of thrombosis (clot formation) as it pertains to stroke and important sex differences in thrombosis and responses to treatment. Finally, we describe recent data related to new therapeutic approaches to thrombolysis, with a particular focus on von Willebrand Factor (vWF).
    MeSH term(s) Brain Ischemia/drug therapy ; Brain Ischemia/therapy ; Female ; Fibrinolytic Agents/therapeutic use ; Humans ; Ischemic Stroke/complications ; Ischemic Stroke/therapy ; Male ; Sex Characteristics ; Thrombosis/drug therapy ; Tissue Plasminogen Activator/therapeutic use ; Treatment Outcome
    Chemical Substances Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2022.105647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Letter by Lee et al Regarding Article, "Acute Neurological Deterioration in Large Vessel Occlusions and Mild Symptoms Managed Medically".

    Lee, Vivien H / Heaton, Sharon / Nimjee, Shahid M

    Stroke

    2020  Volume 51, Issue 10, Page(s) e285–e286

    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.030370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Therapeutic Aptamers: Evolving to Find their Clinical Niche.

    Nimjee, Shahid M / Sullenger, Bruce A

    Current medicinal chemistry

    2019  Volume 27, Issue 25, Page(s) 4181–4193

    Abstract: Background: The discovery that short oligonucleotides, termed aptamers, can fold into three-dimensional structures that allow them to selectively bind and inhibit the activity of pathogenic proteins is now over 25 years old. The invention of the SELEX ... ...

    Abstract Background: The discovery that short oligonucleotides, termed aptamers, can fold into three-dimensional structures that allow them to selectively bind and inhibit the activity of pathogenic proteins is now over 25 years old. The invention of the SELEX methodology heralded in an era in which such nucleic acid-based ligands could be generated against a wide variety of therapeutic targets.
    Results: A large number of aptamers have now been identified by combinatorial chemistry methods in the laboratory and moreover, an increasing number have been discovered in nature. The affinities and activities of such aptamers have often been compared to that of antibodies, yet only a few of these agents have made it into clinical studies compared to a large and increasing number of therapeutic antibodies. One therapeutic aptamer targeting VEGF has made it to market, while 3 others have advanced as far as phase III clinical trials.
    Conclusion: In this manuscript, we hope the reader appreciates that the success of aptamers becoming a class of drugs is less about nucleic acid biochemistry and more about target validation and overall drug chemistry.
    MeSH term(s) Aptamers, Nucleotide/therapeutic use ; Ligands ; Nucleic Acids ; Proteins ; SELEX Aptamer Technique
    Chemical Substances Aptamers, Nucleotide ; Ligands ; Nucleic Acids ; Proteins
    Language English
    Publishing date 2019-10-01
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867326666191001125101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Coagulation and Hematology in Neurologic Surgery.

    Nimjee, Shahid M / Lonser, Russell R

    Neurosurgery clinics of North America

    2018  Volume 29, Issue 4, Page(s) xiii–xiv

    MeSH term(s) Blood Coagulation ; Blood Loss, Surgical/prevention & control ; Hematology ; Humans ; Neurosurgical Procedures/methods
    Language English
    Publishing date 2018-09-25
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1196855-2
    ISSN 1558-1349 ; 1042-3680
    ISSN (online) 1558-1349
    ISSN 1042-3680
    DOI 10.1016/j.nec.2018.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reversal of Systemic Anticoagulants and Antiplatelet Therapeutics.

    Dornbos, David / Nimjee, Shahid M

    Neurosurgery clinics of North America

    2018  Volume 29, Issue 4, Page(s) 537–545

    Abstract: Although antiplatelet medications and anticoagulants are necessary for numerous cardiac comorbidities, prevention of stroke, and treatment and prevention of venous thromboembolic events, they pose a significant treatment dilemma in neurosurgical patients, ...

    Abstract Although antiplatelet medications and anticoagulants are necessary for numerous cardiac comorbidities, prevention of stroke, and treatment and prevention of venous thromboembolic events, they pose a significant treatment dilemma in neurosurgical patients, particularly in the setting of intracranial hemorrhage or prior to emergent neurosurgical procedures. For the majority of current anticoagulation and antiplatelet therapies, no direct reversal agents exist; however, there are numerous strategies that can be used to reverse or mitigate their antithrombotic properties. This review provides a comprehensive summary of the latest antiplatelet and anticoagulant therapies and the role of emergency reversal prior to emergent neurosurgical procedures.
    MeSH term(s) Anticoagulants/adverse effects ; Humans ; Intracranial Hemorrhages/drug therapy ; Neurosurgical Procedures/methods ; Platelet Aggregation Inhibitors/adverse effects ; Treatment Outcome
    Chemical Substances Anticoagulants ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2018-07-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196855-2
    ISSN 1558-1349 ; 1042-3680
    ISSN (online) 1558-1349
    ISSN 1042-3680
    DOI 10.1016/j.nec.2018.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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