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  1. Article ; Online: Signal Quality Analysis of Single-Arm Electrocardiography.

    Wang, Jia-Jung / Liu, Shing-Hong / Tsai, Cheng-Hsien / Manousakas, Ioannis / Zhu, Xin / Lee, Thung-Lip

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 13

    Abstract: The number of people experiencing mental stress or emotional dysfunction has increased since the onset of the COVID-19 pandemic, as many individuals have had to adapt their daily lives. Numerous studies have demonstrated that mental health disorders can ... ...

    Abstract The number of people experiencing mental stress or emotional dysfunction has increased since the onset of the COVID-19 pandemic, as many individuals have had to adapt their daily lives. Numerous studies have demonstrated that mental health disorders can pose a risk for certain diseases, and they are also closely associated with the problem of mental workload. Now, wearable devices and mobile health applications are being utilized to monitor and assess individuals' mental health conditions on a daily basis using heart rate variability (HRV), typically measured by the R-to-R wave interval (RRI) of an electrocardiogram (ECG). However, portable or wearable ECG devices generally require two electrodes to perform bipolar limb leads, such as the Einthoven triangle. This study aims to develop a single-arm ECG measurement method, with lead I ECG serving as the gold standard. We conducted static and dynamic experiments to analyze the morphological performance and signal-to-noise ratio (SNR) of the single-arm ECG. Three morphological features were defined, RRI, the duration of the QRS complex wave, and the amplitude of the R wave. Thirty subjects participated in this study. The results indicated that RRI exhibited the highest cross-correlation (R = 0.9942) between the single-arm ECG and lead I ECG, while the duration of the QRS complex wave showed the weakest cross-correlation (R = 0.2201). The best SNR obtained was 26.1 ± 5.9 dB during the resting experiment, whereas the worst SNR was 12.5 ± 5.1 dB during the raising and lowering of the arm along the z-axis. This single-arm ECG measurement method offers easier operation compared to traditional ECG measurement techniques, making it applicable for HRV measurement and the detection of an irregular RRI.
    MeSH term(s) Humans ; Pandemics ; COVID-19/diagnosis ; Wearable Electronic Devices ; Electrocardiography/methods ; Heart Rate
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23135818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Review of the present features and the infection control challenges of COVID-19 pandemic in dialysis facilities.

    Lee, Jia-Jung / Hwang, Shang-Jyh / Huang, Jee-Fu

    The Kaohsiung journal of medical sciences

    2020  Volume 36, Issue 6, Page(s) 393–398

    Abstract: The COVID-19 has swept the world causing suffering, death, loss, and massive economy damage. The dialysis population is vulnerable and the dialysis facility is critical in maintaining operations and avoiding disease transmission. The present information ... ...

    Abstract The COVID-19 has swept the world causing suffering, death, loss, and massive economy damage. The dialysis population is vulnerable and the dialysis facility is critical in maintaining operations and avoiding disease transmission. The present information regarding the clinical features of COVID-19 infection in the dialysis population was collected, and the useful measures of COVID-19 infection prevention and infection control in the dialysis facilities were summarized. Leadership, education, preparedness, management, and recovery phase were determined to be the critical procedures. It is hoped this updated interim review might provide information for medical professionals to take proactive action to best prepare and mitigate damage when facing the COVID-19 pandemic challenge.
    MeSH term(s) Ambulatory Care Facilities ; Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Health Education ; Humans ; Infection Control/methods ; Infection Control/organization & administration ; Pandemics/prevention & control ; Personal Protective Equipment ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Renal Dialysis ; Renal Insufficiency/epidemiology ; Renal Insufficiency/therapy ; SARS-CoV-2 ; Taiwan/epidemiology ; Triage
    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country China (Republic : 1949- )
    Document type Journal Article ; Review
    ZDB-ID 639302-0
    ISSN 2410-8650 ; 0257-5655
    ISSN (online) 2410-8650
    ISSN 0257-5655
    DOI 10.1002/kjm2.12239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Review of the present features and the infection control challenges of COVID‐19 pandemic in dialysis facilities

    Jia‐Jung Lee / Shang‐Jyh Hwang / Jee‐Fu Huang

    Kaohsiung Journal of Medical Sciences, Vol 36, Iss 6, Pp 393-

    2020  Volume 398

    Abstract: Abstract The COVID‐19 has swept the world causing suffering, death, loss, and massive economy damage. The dialysis population is vulnerable and the dialysis facility is critical in maintaining operations and avoiding disease transmission. The present ... ...

    Abstract Abstract The COVID‐19 has swept the world causing suffering, death, loss, and massive economy damage. The dialysis population is vulnerable and the dialysis facility is critical in maintaining operations and avoiding disease transmission. The present information regarding the clinical features of COVID‐19 infection in the dialysis population was collected, and the useful measures of COVID‐19 infection prevention and infection control in the dialysis facilities were summarized. Leadership, education, preparedness, management, and recovery phase were determined to be the critical procedures. It is hoped this updated interim review might provide information for medical professionals to take proactive action to best prepare and mitigate damage when facing the COVID‐19 pandemic challenge.
    Keywords COVID‐19 ; hemodialysis ; infection control ; Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Trends of treated hepatitis B, hepatitis C, and tuberculosis infection in long-term hemodialysis patients in Taiwan

    Jia-Jung Lee / Jer-Ming Chang / Lii-Jia Yang / Chih-Cheng Hsu / Ming-Huang Lin / Ming-Yen Lin

    Journal of the Formosan Medical Association, Vol 121, Iss , Pp S73-S

    A nationwide survey in 2010–2018

    2022  Volume 81

    Abstract: Background/Purpose: Hepatitis B virus (HBV), hepatitis C virus (HCV), and tuberculosis (TB) infections affect patient morbidity and mortality and challenge infection control procedures within dialysis facilities. Thus, updated information on the yearly ... ...

    Abstract Background/Purpose: Hepatitis B virus (HBV), hepatitis C virus (HCV), and tuberculosis (TB) infections affect patient morbidity and mortality and challenge infection control procedures within dialysis facilities. Thus, updated information on the yearly infection trends in the dialysis population is pivotal to preventing and improving the management of these infectious diseases. Methods: This study used reimbursement data from the Taiwan National Health Insurance Research Database. Long-term hemodialysis (HD) patients were defined as those receiving regular HD for more than 3 months. Treated HBV, HCV, and TB cases were defined according to the diagnosis codes, together with specified prescriptions. Liver malignancy and liver-related mortality were determined by the disease diagnosis. Results: The long-term HD population in Taiwan grew from 57,539 in 2010 to 74,203 in 2018. The mean number of treated HBV, HCV, and TB cases in the HD population was 254 (3.9 per thousand HD patients), 136 (2.0 per thousand), and 165 (2.6 per thousand), respectively. An increasing trend of treated viral hepatitis and a mildly decreasing trend in treated TB were observed. Liver outcome showed an increasing trend in liver malignancy prevalence and a stationary trend of liver-related mortality. Treated HBV and TB, liver malignancy, and liver-associated mortality were higher in men than women (all p < 0.001). The burden of liver complications was higher in southern Taiwan. Conclusion: The increasing yearly trend of treated HBV and HCV and a stable trend of treated TB provide evidence for further infection control management and risk population identification of the HD population.
    Keywords Hepatitis B virus infection ; Hepatitis C virus infection ; Tuberculosis ; Hemodialysis ; Trend analysis ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Take proactive measures for the pandemic COVID-19 infection in the dialysis facilities.

    Lee, Jia-Jung / Lin, Chun-Yu / Chiu, Yi-Wen / Hwang, Shang-Jyh

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2020  Volume 119, Issue 5, Page(s) 895–897

    MeSH term(s) Ambulatory Care Facilities/organization & administration ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/prevention & control ; Diagnostic Screening Programs ; Hand Disinfection ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Masks ; Pandemics/prevention & control ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/prevention & control ; Renal Dialysis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-11
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2020.03.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Take proactive measures for the pandemic COVID-19 infection in the dialysis facilities

    Jia-Jung Lee / Chun-Yu Lin / Yi-Wen Chiu / Shang-Jyh Hwang

    Journal of the Formosan Medical Association, Vol 119, Iss 5, Pp 895-

    2020  Volume 897

    Keywords Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Trends of treated hepatitis B, hepatitis C, and tuberculosis infection in long-term hemodialysis patients in Taiwan: A nationwide survey in 2010-2018.

    Lee, Jia-Jung / Chang, Jer-Ming / Yang, Lii-Jia / Hsu, Chih-Cheng / Lin, Ming-Huang / Lin, Ming-Yen

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2022  Volume 121 Suppl 1, Page(s) S73–S81

    Abstract: Background/purpose: Hepatitis B virus (HBV), hepatitis C virus (HCV), and tuberculosis (TB) infections affect patient morbidity and mortality and challenge infection control procedures within dialysis facilities. Thus, updated information on the yearly ... ...

    Abstract Background/purpose: Hepatitis B virus (HBV), hepatitis C virus (HCV), and tuberculosis (TB) infections affect patient morbidity and mortality and challenge infection control procedures within dialysis facilities. Thus, updated information on the yearly infection trends in the dialysis population is pivotal to preventing and improving the management of these infectious diseases.
    Methods: This study used reimbursement data from the Taiwan National Health Insurance Research Database. Long-term hemodialysis (HD) patients were defined as those receiving regular HD for more than 3 months. Treated HBV, HCV, and TB cases were defined according to the diagnosis codes, together with specified prescriptions. Liver malignancy and liver-related mortality were determined by the disease diagnosis.
    Results: The long-term HD population in Taiwan grew from 57,539 in 2010 to 74,203 in 2018. The mean number of treated HBV, HCV, and TB cases in the HD population was 254 (3.9 per thousand HD patients), 136 (2.0 per thousand), and 165 (2.6 per thousand), respectively. An increasing trend of treated viral hepatitis and a mildly decreasing trend in treated TB were observed. Liver outcome showed an increasing trend in liver malignancy prevalence and a stationary trend of liver-related mortality. Treated HBV and TB, liver malignancy, and liver-associated mortality were higher in men than women (all p < 0.001). The burden of liver complications was higher in southern Taiwan.
    Conclusion: The increasing yearly trend of treated HBV and HCV and a stable trend of treated TB provide evidence for further infection control management and risk population identification of the HD population.
    MeSH term(s) Female ; Hepacivirus ; Hepatitis B/diagnosis ; Hepatitis B/epidemiology ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Humans ; Male ; Prevalence ; Renal Dialysis ; Taiwan/epidemiology ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology
    Language English
    Publishing date 2022-01-05
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2021.12.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Opportunities and Challenges of Human IPSC Technology in Kidney Disease Research.

    Lee, Jia-Jung / Lin, Chuang-Yu / Chen, Hung-Chun / Hsieh, Patrick C H / Chiu, Yi-Wen / Chang, Jer-Ming

    Biomedicines

    2022  Volume 10, Issue 12

    Abstract: Human induced pluripotent stem cells (iPSCs), since their discovery in 2007, open a broad array of opportunities for research and potential therapeutic uses. The substantial progress in iPSC reprogramming, maintenance, differentiation, and ... ...

    Abstract Human induced pluripotent stem cells (iPSCs), since their discovery in 2007, open a broad array of opportunities for research and potential therapeutic uses. The substantial progress in iPSC reprogramming, maintenance, differentiation, and characterization technologies since then has supported their applications from disease modeling and preclinical experimental platforms to the initiation of cell therapies. In this review, we started with a background introduction about stem cells and the discovery of iPSCs, examined the developing technologies in reprogramming and characterization, and provided the updated list of stem cell biobanks. We highlighted several important iPSC-based research including that on autosomal dominant kidney disease and SARS-CoV-2 kidney involvement and discussed challenges and future perspectives.
    Language English
    Publishing date 2022-12-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10123232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Review of the present features and the infection control challenges of COVID ‐19 pandemic in dialysis facilities

    Lee, Jia‐Jung / Hwang, Shang‐Jyh / Huang, Jee‐Fu

    The Kaohsiung Journal of Medical Sciences

    2020  Volume 36, Issue 6, Page(s) 393–398

    Keywords General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2248033-X
    ISSN 1607-551X ; 0257-5655
    ISSN 1607-551X ; 0257-5655
    DOI 10.1002/kjm2.12239
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Association between Body Mass Index and Renal Outcomes Modified by Chronic Kidney Disease and Anemia: The Obesity Paradox for Renal Outcomes.

    Hung, Chi-Chih / Yu, Pei-Hua / Niu, Sheng-Wen / Kuo, I-Ching / Lee, Jia-Jung / Shen, Feng-Ching / Chang, Jer-Ming / Hwang, Shang-Jyh

    Journal of clinical medicine

    2022  Volume 11, Issue 10

    Abstract: Obesity-related nephropathy is associated with renal function progression. However, some studies have associated a high body mass index (BMI) with improved renal outcomes—this is referred to as the obesity paradox for renal outcomes, especially in ... ...

    Abstract Obesity-related nephropathy is associated with renal function progression. However, some studies have associated a high body mass index (BMI) with improved renal outcomes—this is referred to as the obesity paradox for renal outcomes, especially in relation to advanced chronic kidney disease (CKD). Central obesity can explain the obesity paradox in all-cause mortality. However, whether obesity or central obesity is associated with renal outcomes (renal replacement therapy or a 50% decline in the estimated glomerular filtration rate) in patients with advanced CKD remains unclear. Our study included 3605 Asian patients with CKD stages 1−5 divided into six groups according to their BMI (between 15 and 35 kg/m2). Through linear regression, BMI was positively associated with hemoglobin and albumin at CKD stages 4 and 5. In the competing risk Cox regression model, a high BMI (27.5−35 kg/m2) was associated with renal outcomes at CKD stages 1−3, but not stages 4 and 5. A high BMI was associated with renal outcomes in patients with hemoglobin ≥11 g/dL, but not <11 g/dL. A high waist-to-hip ratio was not associated with renal outcomes. We conclude that the CKD stage and anemia may explain the obesity paradox in renal outcomes in patients with CKD.
    Language English
    Publishing date 2022-05-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11102787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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