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  1. AU=Fadavi Pedram
  2. AU="Caravita, R."
  3. AU="Ruppert, David"
  4. AU="Ochoa, Ayako Miyashita"
  5. AU=Hemphill H E
  6. AU="Piton, Yasmin Vendruscolo"
  7. AU="Thadani, Nicole N"
  8. AU="Allison E. Norlander" AU="Allison E. Norlander"
  9. AU="Wei, Peifa"
  10. AU="Colak, Errol"
  11. AU="Hassan, Hosni M"
  12. AU="Becker, D T"
  13. AU="Lewis-Lloyd, Christopher A"
  14. AU=Doshi Rupali Kotwal AU=Doshi Rupali Kotwal
  15. AU="Kore Schlottau"
  16. AU="Jamjoom, Mona"
  17. AU="Bergmann, P."
  18. AU="Li, Congju"
  19. AU="Christenson, Robert"
  20. AU="O'Neill, Hugh M"
  21. AU="Vaccaro, Daniel H."
  22. AU=Panchin Yuri V
  23. AU=McIlvennan Colleen K
  24. AU="Khan, Mohammad Afsar"
  25. AU="Zhuang, Hua-Lu"
  26. AU="Lopez, Omar M"
  27. AU=Asfaw Abay
  28. AU="Santana, Ricardo Costa de"
  29. AU="Ortega, Johis"
  30. AU="Sogaolu, Moyosore"
  31. AU="Duchesne, Gabriela"
  32. AU="Sander, Klaus"
  33. AU="Wiegersma, Aline Marileen"
  34. AU=Mehta Yatin
  35. AU="Ki Hwan Kim"
  36. AU="Gulati, Rajiv"
  37. AU="Sullivan, Christopher"
  38. AU="Meier-Stephenson, Vanessa C"
  39. AU=Kim Joo Seop
  40. AU="Mortensen, Jennifer L"
  41. AU="Manthey, Helga D"
  42. AU="Baker, Susan"
  43. AU="Gunasegaram, James R"
  44. AU="Jung, Steffen"
  45. AU="Cairns, Anita"
  46. AU="Fox, Lindsay"

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  1. Artikel: Dramatic response to radiation of a sinus melanoma: A case report.

    Garousi, Maryam / Hariri, Ramyar / Fadavi, Pedram / Yousefi, Tahere / Bayani, Reyhaneh

    Clinical case reports

    2023  Band 11, Heft 3, Seite(n) e7037

    Abstract: In this report, we shared our experience in the treatment of a patient with unresectable sinonasal melanoma, in whom a complete radiographic response was seen after a course of conventional external beam radiotherapy. Given that local control has an ... ...

    Abstract In this report, we shared our experience in the treatment of a patient with unresectable sinonasal melanoma, in whom a complete radiographic response was seen after a course of conventional external beam radiotherapy. Given that local control has an important role in maintaining the quality of life of patients.
    Sprache Englisch
    Erscheinungsdatum 2023-03-02
    Erscheinungsland England
    Dokumenttyp Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7037
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  2. Artikel ; Online: Dramatic response to radiation of a sinus melanoma

    Maryam Garousi / Ramyar Hariri / Pedram Fadavi / Tahere Yousefi / Reyhaneh Bayani

    Clinical Case Reports, Vol 11, Iss 3, Pp n/a-n/a (2023)

    A case report

    2023  

    Abstract: Abstract In this report, we shared our experience in the treatment of a patient with unresectable sinonasal melanoma, in whom a complete radiographic response was seen after a course of conventional external beam radiotherapy. Given that local control ... ...

    Abstract Abstract In this report, we shared our experience in the treatment of a patient with unresectable sinonasal melanoma, in whom a complete radiographic response was seen after a course of conventional external beam radiotherapy. Given that local control has an important role in maintaining the quality of life of patients.
    Schlagwörter radiotherapy ; sinonasal melanoma ; Medicine ; R ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: The uterine adenosarcoma with postoperative residual in a woman treated by total abdominal hysterectomy/bilateral salpingo-oophorectomy: A case report and review of literature.

    Fadavi, Pedram / Garousi, Maryam / Soltani, Sepideh / Montazer, Fatemeh / Abolhasani, Maryam / Asgari, Salar / Mirzaee, Elahe

    Cancer reports (Hoboken, N.J.)

    2023  Band 6, Heft 10, Seite(n) e1891

    Abstract: Background: In patients with uterine adenosarcoma, a total abdominal hysterectomy (TAH) with bilateral salpingo-oophorectomy (BSO) is typically recommended as an initial treatment. There is no consensus on adjuvant therapies.: Case: We report the ... ...

    Abstract Background: In patients with uterine adenosarcoma, a total abdominal hysterectomy (TAH) with bilateral salpingo-oophorectomy (BSO) is typically recommended as an initial treatment. There is no consensus on adjuvant therapies.
    Case: We report the case of a patient with uterine adenosarcoma with postoperative residual disease. We performed four courses of adjuvant chemotherapy, including Ifosfamide, Mesna, and Adriamycin, and whole pelvic radiation with a dose of 50.4 Gy/28 Fr.
    Conclusion: A combination of chemotherapy and radiotherapy may be a promising treatment option for uterine adenosarcoma with postoperative residual disease.
    Mesh-Begriff(e) Female ; Humans ; Salpingo-oophorectomy ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/surgery ; Hysterectomy ; Adenosarcoma/diagnosis ; Adenosarcoma/surgery
    Sprache Englisch
    Erscheinungsdatum 2023-08-17
    Erscheinungsland United States
    Dokumenttyp Review ; Case Reports
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1891
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  4. Artikel ; Online: Outcomes of Induction Chemotherapy Followed by Chemoradiotherapy Versus Chemoradiotherapy Alone in Esophageal Squamous Cell Carcinoma Induction chemotherapy in Esophageal Squamous Cell Carcinoma.

    Hosseini Toudeshki, Saeed / Garousi, Maryam / Arefpour, Amir Mohammad / Fadavi, Pedram / Basi, Ali / Foroughi, Ahmad / Javadinia, Seyed Alireza

    Asian Pacific journal of cancer prevention : APJCP

    2024  Band 25, Heft 4, Seite(n) 1183–1188

    Abstract: Background: There is still no definite conclusion regarding the effect of Induction Chemotherapy (IC) combined with concurrent Chemoradiotherapy (CRT). Thus this study was aimed to assess outcomes of IC followed By CRT versus CRT alone in Esophageal ... ...

    Abstract Background: There is still no definite conclusion regarding the effect of Induction Chemotherapy (IC) combined with concurrent Chemoradiotherapy (CRT). Thus this study was aimed to assess outcomes of IC followed By CRT versus CRT alone in Esophageal Squamous Cell Carcinoma (ESCC).
    Methods: This multicenter retrospective study performed on 105 patients who underwent CRT and 73 patients who underwent IC+CRT, between January 2016 and December 2018. The primary endpoints were OS (from the date of treatment to the date of death or 3- years follow-Up). The toxicities of CRT were graded according to the National Cancer Institute Common Toxicity Criteria (version 3.0).
    Results: one-year (73.8% vs. 53.2%) and 2-year (53.4% vs. 38.5%) OS rate of the IC+CRT group was significantly higher than that of the CRT group (p < 0.05). No statistically significant differences were observed between the IC+CRT group and the CRT group (31.5% vs. 27.4%) in terms of the 3-year OS rate (p > 0.05). In multivariate logistic regression, age<60 (OR: 1.48; CI 95% 1.02-1.97), clinical staging II (OR: 1.36; CI 95% 1.11-1.88), and the addition of IC (OR: 1.66; CI 95% 1.07-2.19) were independent prognostic factors that affected survival positively.
    Conclusion: Our data demonstrated that a combination of IC and CRT might be a promising treatment strategy to further improve OS in ESCC patients.
    Mesh-Begriff(e) Humans ; Male ; Female ; Chemoradiotherapy ; Induction Chemotherapy ; Retrospective Studies ; Middle Aged ; Esophageal Neoplasms/therapy ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/mortality ; Esophageal Squamous Cell Carcinoma/therapy ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Squamous Cell Carcinoma/mortality ; Survival Rate ; Prognosis ; Follow-Up Studies ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Aged ; Adult
    Sprache Englisch
    Erscheinungsdatum 2024-04-01
    Erscheinungsland Thailand
    Dokumenttyp Journal Article ; Multicenter Study ; Comparative Study
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2024.25.4.1183
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  5. Artikel: Binary Logistic Regression Modeling of Voice Impairment and Voice Assessment in Iranian Patients with Nonlaryngeal Head-and-Neck Cancers after Chemoradiation Therapy: Objective and Subjective Voice Evaluation.

    Bagherzadeh, Sakineh / Shahbazi-Gahrouei, Daryoush / Torabinezhad, Farhad / Mahdavi, Seied Rabi Mehdi / Fadavi, Pedram / Salmanian, Soraya

    Journal of medical signals and sensors

    2023  Band 13, Heft 1, Seite(n) 40–48

    Abstract: Background: Laryngeal damages after chemoradiation therapy (RT) in nonlaryngeal head-and-neck cancers (HNCs) can cause voice disorders and finally reduce the patient's quality of life (QOL). The aim of this study was to evaluate voice and predict ... ...

    Abstract Background: Laryngeal damages after chemoradiation therapy (RT) in nonlaryngeal head-and-neck cancers (HNCs) can cause voice disorders and finally reduce the patient's quality of life (QOL). The aim of this study was to evaluate voice and predict laryngeal damages using statistical binary logistic regression (BLR) models in patients with nonlaryngeal HNCs.
    Methods: This cross-section experimental study was performed on seventy patients (46 males, 24 females) with an average age of 50.43 ± 16.54 years, with nonlaryngeal HNCs and eighty individuals with assumed normal voices. Subjective and objective voice assessment was carried out in three stages including before, at the end, and 6 months after treatment. Eventually, the Enter method of the BLR was used to measure the odds ratio of independent variables.
    Results: In objective evaluation, the acoustic parameters except for F0 increased significantly (
    Conclusions: Voice evaluation and the use of BLR models to determine important factors were the optimum methods to reduce laryngeal damages and maintain the patient's QOL.
    Sprache Englisch
    Erscheinungsdatum 2023-03-27
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2651622-6
    ISSN 2228-7477
    ISSN 2228-7477
    DOI 10.4103/jmss.jmss_143_21
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  6. Artikel ; Online: Ciliated, Mitochondria-Rich Postmitotic Cells are Immune-privileged, and Mimic Immunosuppressive Microenvironment of Tumor-Initiating Stem Cells: From Molecular Anatomy to Molecular Pathway.

    Behnam, Babak / Fazilaty, Hassan / Ghadyani, Mobina / Fadavi, Pedram / Taghizadeh-Hesary, Farzad

    Frontiers in bioscience (Landmark edition)

    2023  Band 28, Heft 10, Seite(n) 261

    Abstract: Cancer whose major problems are metastasis, treatment resistance, and recurrence is the leading cause of death worldwide. Tumor-initiating stem cells (TiSCs) are a subset of the tumor population responsible for tumor resistance and relapse. Understanding ...

    Abstract Cancer whose major problems are metastasis, treatment resistance, and recurrence is the leading cause of death worldwide. Tumor-initiating stem cells (TiSCs) are a subset of the tumor population responsible for tumor resistance and relapse. Understanding the characteristics and shared features between tumor-initiating stem cells (TiSCs) and long-lived postmitotic cells may hold a key to better understanding the biology of cancer. Postmitotic cells have exited the cell cycle and are transitioned into a non-dividing and terminally differentiated state with a specialized function within a tissue. Conversely, a cancer cell with TiSC feature can divide and produce a variety of progenies, and is responsible for disease progression, tumor resistance to therapy and immune system and disease relapse. Surprisingly, our comprehensive evaluation of TiSCs suggests common features with long-lived post-mitotic cells. They are similar in structure (primary cilia, high mitochondrial content, and being protected by a barrier), metabolism (autophagy and senescence), and function (immunoescape and/or immune-privileged by a blood barrier). In-depth exploration showed how mitochondrial metabolism contributes to these shared features, including high energy demands arising from ciliary and microtubular functionality, increased metabolic activity, and movement. These findings can assist in decoding the remaining properties which offer insights into the biology of TiSCs, with potential implications for enhancing cancer treatment strategies and patient prognosis.
    Mesh-Begriff(e) Humans ; Neoplasms/metabolism ; Mitochondria/metabolism ; Neoplastic Stem Cells/pathology ; Cell Differentiation ; Recurrence ; Tumor Microenvironment
    Sprache Englisch
    Erscheinungsdatum 2023-11-02
    Erscheinungsland Singapore
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2810261
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  7. Artikel: The Primary Brain Eosinophilic Angiocentric Fibrosis, A Rare Case Report.

    Daneshi, Seyed Abdolhadi / Taheri, Morteza / Fattahi, Arash / Fadavi, Pedram

    Prague medical report

    2022  Band 123, Heft 2, Seite(n) 113–119

    Abstract: Eosinophilic angiocentric fibrosis (EAF) is a rare progressive fibrosing lesion involving the nasal cavity, paranasal sinuses, and the upper respiratory tract. There are few reports that it rarely involves the orbit; however, there is no report of ... ...

    Abstract Eosinophilic angiocentric fibrosis (EAF) is a rare progressive fibrosing lesion involving the nasal cavity, paranasal sinuses, and the upper respiratory tract. There are few reports that it rarely involves the orbit; however, there is no report of intracranial involvement. Here, we report and share our experience with a rare case of primary intracranial EAF. A 33-year-old woman with a history of a suprasellar mass and unsuccessful surgical and medical treatment referred to us. Physical examination demonstrated right-sided blindness and ptosis, left-sided decreased visual acuity, and visual field defect. The brain imaging revealed an extra-axial intradural well-defined large suprasellar mass with parasellar (more on the right side) and retrosellar extension. Via pterional craniotomy and subfrontal approach, a very firm creamy-brownish well-defined fibrotic mass was encountered. The tumour texture was too firm to be totally resected. The microscope exited the surgical field off, and the tumour was incompletely resected using a rongeur. The histopathology finding favoured EAF. Further histopathology evaluation failed to show histologic features of IgG4-related disease. Although the preoperative diagnosis of EAF is impossible, in the setting of an indolent slow-growing lesion demonstrating hypointensity on the T2 image sequence of MRI (magnetic resonance imaging), EAF should be considered a differential diagnosis. In the setting of this diagnosis, the systemic and other organ involvement for a diagnosis of IgG4-RD should be evaluated. However, more cases are needed to illustrate the relation between these two entities.
    Mesh-Begriff(e) Adult ; Brain ; Eosinophilia/pathology ; Female ; Fibrosis ; Humans ; Magnetic Resonance Imaging/methods
    Sprache Englisch
    Erscheinungsdatum 2022-05-04
    Erscheinungsland Czech Republic
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2148569-0
    ISSN 1214-6994
    ISSN 1214-6994
    DOI 10.14712/23362936.2022.12
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    Zs.B 439: Hefte anzeigen Standort:
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  8. Artikel ; Online: Ciliated, Mitochondria-Rich Postmitotic Cells are Immune-privileged, and Mimic Immunosuppressive Microenvironment of Tumor-Initiating Stem Cells

    Babak Behnam / Hassan Fazilaty / Mobina Ghadyani / Pedram Fadavi / Farzad Taghizadeh-Hesary

    Frontiers in Bioscience-Landmark, Vol 28, Iss 10, p

    From Molecular Anatomy to Molecular Pathway

    2023  Band 261

    Abstract: Cancer whose major problems are metastasis, treatment resistance, and recurrence is the leading cause of death worldwide. Tumor-initiating stem cells (TiSCs) are a subset of the tumor population responsible for tumor resistance and relapse. Understanding ...

    Abstract Cancer whose major problems are metastasis, treatment resistance, and recurrence is the leading cause of death worldwide. Tumor-initiating stem cells (TiSCs) are a subset of the tumor population responsible for tumor resistance and relapse. Understanding the characteristics and shared features between tumor-initiating stem cells (TiSCs) and long-lived postmitotic cells may hold a key to better understanding the biology of cancer. Postmitotic cells have exited the cell cycle and are transitioned into a non-dividing and terminally differentiated state with a specialized function within a tissue. Conversely, a cancer cell with TiSC feature can divide and produce a variety of progenies, and is responsible for disease progression, tumor resistance to therapy and immune system and disease relapse. Surprisingly, our comprehensive evaluation of TiSCs suggests common features with long-lived post-mitotic cells. They are similar in structure (primary cilia, high mitochondrial content, and being protected by a barrier), metabolism (autophagy and senescence), and function (immunoescape and/or immune-privileged by a blood barrier). In-depth exploration showed how mitochondrial metabolism contributes to these shared features, including high energy demands arising from ciliary and microtubular functionality, increased metabolic activity, and movement. These findings can assist in decoding the remaining properties which offer insights into the biology of TiSCs, with potential implications for enhancing cancer treatment strategies and patient prognosis.
    Schlagwörter blood barrier ; cilium ; immunity ; postmitotic cells ; tumor-initiating stem cells ; tumor microenvironment ; Biochemistry ; QD415-436 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag IMR Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: The Primary Brain Eosinophilic Angiocentric Fibrosis, A Rare Case Report

    Seyed Abdolhadi Daneshi / Morteza Taheri / Arash Fattahi / Pedram Fadavi

    Prague Medical Report, Vol 123, Iss 2, Pp 113-

    2022  Band 119

    Abstract: Eosinophilic angiocentric fibrosis (EAF) is a rare progressive fibrosing lesion involving the nasal cavity, paranasal sinuses, and the upper respiratory tract. There are few reports that it rarely involves the orbit; however, there is no report of ... ...

    Abstract Eosinophilic angiocentric fibrosis (EAF) is a rare progressive fibrosing lesion involving the nasal cavity, paranasal sinuses, and the upper respiratory tract. There are few reports that it rarely involves the orbit; however, there is no report of intracranial involvement. Here, we report and share our experience with a rare case of primary intracranial EAF. A 33-year-old woman with a history of a suprasellar mass and unsuccessful surgical and medical treatment referred to us. Physical examination demonstrated right-sided blindness and ptosis, left-sided decreased visual acuity, and visual field defect. The brain imaging revealed an extra-axial intradural well-defined large suprasellar mass with parasellar (more on the right side) and retrosellar extension. Via pterional craniotomy and subfrontal approach, a very firm creamy-brownish well-defined fibrotic mass was encountered. The tumour texture was too firm to be totally resected. The microscope exited the surgical field off, and the tumour was incompletely resected using a rongeur. The histopathology finding favoured EAF. Further histopathology evaluation failed to show histologic features of IgG4-related disease. Although the preoperative diagnosis of EAF is impossible, in the setting of an indolent slow-growing lesion demonstrating hypointensity on the T2 image sequence of MRI (magnetic resonance imaging), EAF should be considered a differential diagnosis. In the setting of this diagnosis, the systemic and other organ involvement for a diagnosis of IgG4-RD should be evaluated. However, more cases are needed to illustrate the relation between these two entities.
    Schlagwörter Medicine ; R ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag Karolinum Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Comparison of the Pathological Response and Adverse Effects of Oxaliplatin and Capecitabine versus Paclitaxel and Carboplatin in the Neoadjuvant Chemoradiotherapy Treatment Approach for Esophageal and Gastroesophageal Junction Cancer: A Randomized Control Trial Study.

    Cheraghi, Aida / Barahman, Maedeh / Hariri, Ramyar / Nikoofar, Alireza / Fadavi, Pedram

    Medical journal of the Islamic Republic of Iran

    2021  Band 35, Seite(n) 140

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2021-10-25
    Erscheinungsland Iran
    Dokumenttyp Journal Article
    ZDB-ID 1095990-7
    ISSN 1016-1430
    ISSN 1016-1430
    DOI 10.47176/mjiri.35.140
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