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  1. Article: Bevacizumab in Oncology: Boon or Bane

    Sanghavi, Niyati / Shah, Krunal

    Indian Journal of Medical and Paediatric Oncology

    2022  Volume 43, Issue 04, Page(s) 390–391

    Language English
    Publishing date 2022-08-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2181724-8
    ISSN 0975-2129 ; 0971-5851 ; 0975-2129
    ISSN (online) 0975-2129
    ISSN 0971-5851 ; 0975-2129
    DOI 10.1055/s-0042-1746422
    Database Thieme publisher's database

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  2. Article: Correlation of Robinson's Cytological Grading with Elston and Ellis' Nottingham Modification of Bloom Richardson Score of Histopathology for Breast Carcinoma.

    Gandhi, Hardik / Maru, Alpeshkumar / Shah, Niyati / Mansuriya, Ravi Kumar / Rathod, Gunvanti / Parmar, Pragnesh

    Maedica

    2023  Volume 18, Issue 1, Page(s) 55–60

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-05-17
    Publishing country Romania
    Document type Editorial
    ZDB-ID 2399972-X
    ISSN 2069-6116 ; 1841-9038
    ISSN (online) 2069-6116
    ISSN 1841-9038
    DOI 10.26574/maedica.2023.18.1.55
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Role of Hematological Parameters in the Early Diagnosis of Neonatal Sepsis.

    Shah, Niyati / Gandhi, Hardik / Mansuriya, Ravikumar / Maru, Alpesh / Rathod, Gunvanti / Parmar, Pragnesh

    Journal of pharmacy & bioallied sciences

    2024  Volume 16, Issue Suppl 1, Page(s) S434–S436

    Abstract: The major cause of neonatal mortality and morbidity is bacterial sepsis. Blood culture is the most reliable method in neonatal sepsis. This study was conducted to study the usefulness of hematological parameters in the early diagnosis of neonatal sepsis ... ...

    Abstract The major cause of neonatal mortality and morbidity is bacterial sepsis. Blood culture is the most reliable method in neonatal sepsis. This study was conducted to study the usefulness of hematological parameters in the early diagnosis of neonatal sepsis and to assess the most sensitive and specific variables in diagnosing neonatal sepsis. This prospective study was conducted in a tertiary care hospital from January 2017 to January 2018. Peripheral blood smears were prepared from patients with clinical suspicion of sepsis or predisposing perinatal factors for sepsis and stained with Field's stain and examined. The hematological findings were analyzed according to the hematologic scoring system of Rodwell. It was found that immature PMN count, I: M ratio, and I: T ratio had the highest sensitivity (92.06%, 87.30%, and 74.60%, respectively) while I: M ratio, I: T ratio, and degenerative changes in PMN had the highest specificity (97.50%, 96.50%, and 94.0%, respectively) in the prediction of sepsis.
    Language English
    Publishing date 2024-02-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_657_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Influence of protein nativity on the stability of bovine serum albumin coated microbubbles.

    Dhara, Palash / Shah, Niyati / Sundaram, Vidya / Srivastava, Ashutosh / Solovev, Alexander A / Mei, Yongfeng / Gorin, Dmitry A / Dey, Krishna Kanti

    iScience

    2024  Volume 27, Issue 3, Page(s) 109286

    Abstract: Protein-coated microbubbles have become one of the emerging platforms in biomedical research as theranostic agents. In recent years, microbubbles have been extensively used as ultrasound contrast agents and carriers of molecular cargoes, pertaining to ... ...

    Abstract Protein-coated microbubbles have become one of the emerging platforms in biomedical research as theranostic agents. In recent years, microbubbles have been extensively used as ultrasound contrast agents and carriers of molecular cargoes, pertaining to which several studies have focused on tuning the properties of these bubbles to achieve a higher degree of biocompatibility and extended stability. Synthesis of microbubbles has so far been traditionally carried out with pre-heated proteins like bovine serum albumin (BSA) as shell coatings, owing to the ease in making BSA crosslinked structures through disulfide bridge formation. We, however, have performed experiments to demonstrate that air core microbubbles formed with native BSA are more stable compared with those formed using denatured BSA. The experimental observations have been supported with analytical modeling and computational studies, which offer insights into the effect of BSA conformation in stabilizing the microbubbles shells and prolonging their lifetimes.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Study of Sputum Bacteriology of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

    Shaila Jay Shah / Niyati Mehta / Shruti Shah

    Journal of Krishna Institute of Medical Sciences University, Vol 10, Iss 2, Pp 130-

    2021  Volume 138

    Abstract: Background: Chronic Obstructive Pulmonary Disease (COPD) would be the third leading cause of death by 2030 as per WHO. India has close to 30 million COPD patients at present. Acute exacerbations in these patients are associated with worse outcomes and ... ...

    Abstract Background: Chronic Obstructive Pulmonary Disease (COPD) would be the third leading cause of death by 2030 as per WHO. India has close to 30 million COPD patients at present. Acute exacerbations in these patients are associated with worse outcomes and are responsible for a decline in lung function. Bacterial infections cause exacerbations in 30-50% cases and new bacterial strains are often isolated; they are different in India than what Western studies report. Hence, it is useful to know the bacteriological profile of the prevalent strains as per geography so as to manage the exacerbations better. Aim and Objectives: The study aimed to determine the bacteriological profile and sensitivity to antibiotics in sputum of patients with Acute Exacerbation of COPD (AECOPD). Material and Methods: Ninety patients presenting with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) who met the inclusion criteria were included and their sputum was sent for Gram stain, Ziel-Neelson stain and bacterial culture and antibiotic sensitivity testing. Results: Culture was positive for pathogens in 34 (37.7%) patients. P. aeruginosa 14 (41.1%), K. pneumoniae 11 (32.35%) and E. coli 9 (26.47%) were the organisms isolated. The isolates were sensitive to Beta-Lactam/Beta-Lactamase Inhibitor (BL/BLI) combinations, carbapenems and colistin and polymyxin B. P. aeruginosa and E. coli were also sensitive to aminoglycosides and fluroquinolones while K. pneumoniae was variably resistant to them. Age, gender and leucocyte count were not significantly associated with the sputum positivity rate. Conclusion: Cefoperazone/sulbactam with an aminoglycoside and/or levofloxacin may be considered for initiation of therapy in AECOPD patients.
    Keywords acute exacerbation ; beta-lactam/beta-lactamase inhibitor ; chronic obstructive pulmonary disease ; exacerbations ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Krishna Institute of Medical Sciences University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Ampicillin-Ceftriaxone vs Ampicillin-Gentamicin for Definitive Therapy of

    Shah, Niyati H / Shutt, Kathleen A / Doi, Yohei

    Open forum infectious diseases

    2021  Volume 8, Issue 4, Page(s) ofab102

    Abstract: Background: Ampicillin-ceftriaxone (AC) has emerged as an alternative antibiotic regimen for enterococcal infective endocarditis (EIE) with reduced toxicity compared with ampicillin-gentamicin (AG), but evidence regarding its success in reducing EIE- ... ...

    Abstract Background: Ampicillin-ceftriaxone (AC) has emerged as an alternative antibiotic regimen for enterococcal infective endocarditis (EIE) with reduced toxicity compared with ampicillin-gentamicin (AG), but evidence regarding its success in reducing EIE-associated death in the United States is limited.
    Methods: We conducted a retrospective, propensity score-matched cohort analysis of EIE patients treated with AC or AG between 2010 and 2017 at 3 hospitals in Pittsburgh, Pennsylvania. We assessed all-cause 90-day mortality as the primary outcome and in-hospital mortality, length of hospital stay, hospital readmissions, adverse events, and relapse of bacteremia as the secondary outcomes.
    Results: A total of 190 patients with EIE (100 treated with AC and 90 with AG) were included. Ninety-day mortality was significantly higher with AC than AG (21% vs 8%;
    Conclusions: Patients treated with AC demonstrate no significant differences in mortality, treatment failure, or bacteremia relapse compared with AG in a propensity score-matched EIE cohort.
    Language English
    Publishing date 2021-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Thesis ; Online: Implementing Machine Learning Algorithms for Identifying Microstructure of Materials

    Shah, Niyati S.

    2018  

    Abstract: Alloys of different materials are extensively used in many fields of our day-to-day life. Several studies are performed at a microscopic level to analyze the properties of such alloys. Manually evaluating these microscopic structures (microstructures) ... ...

    Abstract Alloys of different materials are extensively used in many fields of our day-to-day life. Several studies are performed at a microscopic level to analyze the properties of such alloys. Manually evaluating these microscopic structures (microstructures) can be time-consuming. This thesis attempts to build different models that can automate the identification of an alloy from its microstructure. All the models were developed, with various supervised and unsupervised machine learning algorithms, and results of all the models were compared. The best accuracy of 92.01 ± 0.54% and 94.31 ± 0.59% was achieved, for identifying the type of an alloy from its microstructure (Task 1) and classifying the microstructure as belonging to either Ferrous, Non-Ferrous or Others class (Task 2), respectively. The model, which gave the best accuracy, was then used to build an Image Search Engine (ISE) that can predict the type of an alloy from its microstructure, search the microstructures by different keywords and search for visually similar microstructures.
    Keywords Computer science
    Subject code 006 ; 669
    Language ENG
    Publishing date 2018-01-01 00:00:01.0
    Publisher California State University, Long Beach
    Publishing country us
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Optic pathway tumor in an infant with KIAA1109 variants.

    Shah, Krunal / Sanghavi, Niyati / Viswanathan, Aarthi / Kumar, Arun / Kumar, Nuthan / Kaushik, Prakruthi / Kumari, B S Aruna / Appaji, L

    Pediatric blood & cancer

    2022  Volume 69, Issue 11, Page(s) e29701

    MeSH term(s) Eye/pathology ; Genetic Predisposition to Disease ; Humans ; Infant ; Magnetic Resonance Imaging ; Neoplasms ; Optic Nerve Glioma ; Polymorphism, Single Nucleotide ; Proteins/genetics
    Chemical Substances KIAA1109 protein, human ; Proteins
    Language English
    Publishing date 2022-04-04
    Publishing country United States
    Document type Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29701
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Computational Exploration of Naturally Occurring Flavonoids as TGF-β Inhibitors in Breast Cancer: Insights from Docking and Molecular Dynamics Simulations and In-vitro Cytotoxicity Study.

    Shah, Umang / Patel, Niyati / Patel, Mehul / Rohit, Shishir / Solanki, Nilay / Patel, Ashish / Patel, Swayamprakash / Patel, Vishwa / Patel, Rajvi / Jawarkar, Rahul D

    Chemistry & biodiversity

    2024  , Page(s) e202301903

    Abstract: Breast cancer is a global health concern, demanding innovative treatments. Targeting the Transforming Growth Factor-beta (TGF-β) signaling pathway, pivotal in breast cancer, is a promising approach. TGF-β inhibits proliferation via G1 phase cell cycle ... ...

    Abstract Breast cancer is a global health concern, demanding innovative treatments. Targeting the Transforming Growth Factor-beta (TGF-β) signaling pathway, pivotal in breast cancer, is a promising approach. TGF-β inhibits proliferation via G1 phase cell cycle arrest, acting as a suppressor initially, but in later stages, it promotes progression by enhancing motility, invasiveness, and metastasis formation. This study explores naturally occurring flavonoids' interactions with TGF-β. Using molecular docking against the protein's crystal structure (PDB Id: 1PY5), Gossypin showed the highest docking score and underwent molecular dynamics simulation, revealing complex flexibility and explaining how flavonoids impede TGF-β signaling in breast cancer. ADMET predictions adhered to Lipinski's rule of Five. Insights into flavonoid-TGF-β binding offer a novel angle for breast cancer treatment. Flavonoids having a good docking score like gossypin, morin, luteolin and taxifolin shown potent cytotoxic effect on breast cancer cell line, MCF-7. Understanding these interactions could inspire flavonoid-based therapies targeting TGF-β to halt breast cancer growth. These findings pave the way for personalized, targeted breast cancer therapies, offering hope against this formidable disease.
    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202301903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A meta-analysis on efficacy and tolerability of sildenafil for erectile dysfunction in patients with diabetes mellitus.

    Shah, P C / Trivedi, Niyati A

    Indian journal of sexually transmitted diseases and AIDS

    2018  Volume 39, Issue 1, Page(s) 1–6

    Abstract: Erectile dysfunction (ED) is a common complication in patients with diabetes mellitus (DM). Sildenafil, a phosphodiesterase-5 inhibitor, is commonly used in patients with ED. This meta-analysis was planned to determine the strength of evidence to assess ... ...

    Abstract Erectile dysfunction (ED) is a common complication in patients with diabetes mellitus (DM). Sildenafil, a phosphodiesterase-5 inhibitor, is commonly used in patients with ED. This meta-analysis was planned to determine the strength of evidence to assess the efficacy and tolerability of sildenafil in patients with DM-associated ED. Electronic searches were carried out to identify randomized controlled trials (RCTs) which reported clinical efficacy of sildenafil in patients with DM-associated ED. Data were extracted and methodological quality was assessed. Relative Risk (RR) with 95% confidence intervals (CIs) was estimated for the dichotomous outcomes, and the mean difference with 95% CI was estimated for continuous data. Eight randomized controlled trials (RCTs) involving 1172 patients met with our inclusion criteria. In comparison to placebo, sildenafil significantly improved the overall sexual performance in patients of ED associated with DM with relative risk (RR) of answering "yes" to global efficiency question being 3.99 (95% CI: 2.58-6.18) compared to placebo. The rate of discontinuation due to treatment-related adverse reactions was 2.4% in sildenafil arm with RR of 2.67 (95% CI: 0.74-9.62). Sildenafil is an effective and safe medication for the treatment of ED associated with DM.
    Language English
    Publishing date 2018-08-09
    Publishing country India
    Document type Journal Article ; Review
    ISSN 2589-0565
    ISSN (online) 2589-0565
    DOI 10.4103/ijstd.IJSTD_99_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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