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  1. Article ; Online: Response.

    Yung, Diana E / Koulaouzidis, Anastasios / Plevris, John N

    Gastrointestinal endoscopy

    2017  Volume 86, Issue 3, Page(s) 575

    Language English
    Publishing date 2017
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2017.05.020
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Angioectasias in the elderly: Interpreting the data.

    Pérez-Cuadrado-Robles, Enrique / Yung, Diana E / Koulaouzidis, Anastasios

    United European gastroenterology journal

    2018  Volume 6, Issue 5, Page(s) 791

    Language English
    Publishing date 2018-06
    Publishing country England
    Document type Journal Article
    ISSN 2050-6406
    ISSN 2050-6406
    DOI 10.1177/2050640618764166
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  3. Article ; Online: Earlier use of capsule endoscopy in clinical practice: don't hold back the scouts.

    Yung, Diana E / Koulaouzidis, Anastasios / Plevris, John N

    Gastrointestinal endoscopy

    2018  Volume 88, Issue 6, Page(s) 973

    MeSH term(s) Capsule Endoscopy ; Gastrointestinal Hemorrhage ; Humans ; Standard of Care ; Videotape Recording
    Language English
    Publishing date 2018-10-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2018.07.027
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  4. Article ; Online: Conventional cardiac risk factors associated with trastuzumab-induced cardiotoxicity in breast cancer: Systematic review and meta-analysis.

    Koulaouzidis, George / Yung, Amanda E / Yung, Diana E / Skonieczna-Żydecka, Karolina / Marlicz, Wojciech / Koulaouzidis, Anastasios / Charisopoulou, Dafni

    Current problems in cancer

    2021  Volume 45, Issue 5, Page(s) 100723

    Abstract: Background: Trastuzumab has had a major impact on the treatment of human epidermal growth factor receptor 2 (HER2) positive breast cancer patients. However, it is associated with cardiotoxicity, expressed as an asymptomatic decrease in left ventricular ... ...

    Abstract Background: Trastuzumab has had a major impact on the treatment of human epidermal growth factor receptor 2 (HER2) positive breast cancer patients. However, it is associated with cardiotoxicity, expressed as an asymptomatic decrease in left ventricular ejection fraction (LVEF) and less often as clinical HF. The aim of this meta-analysis is to identify the association of conventional cardiovascular risk factors with the development of trastuzumab-induced cardiotoxicity (TIC).
    Methods: A literature search of PubMed was conducted to identify studies examining the association between cardiovascular risk factors and TIC. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated examining the odds of developing TIC for each of the risk factors.
    Results: A total of 35 studies were included in the analysis. Age (OR:0.7; 95%CI 0.318-1.09; P= 0.0004), hypertension (OR:0.69; 95%CI 0.26-1.12; P = 0.001), smoking(OR:0.35; 95%CI 0.01- 0.69; P = 0.038), diabetes mellitus (OR:0.44; 95%CI 0.24- 0.68; P = 0.0001) and family history of CAD (OR:5.51, 95%CI 1.76-17.25; P< 0.00001)were significantly associated with the development of cardiotoxicity. Known history of CAD (OR: 3.72; 95%CI 2.11-6.57; P = 0.0005) was also associated with the development of TIC.
    Conclusion(s): Identifying women at risk for TIC have several important potential applications. Clinicians may decide to assess LVEF more frequently in patients at highest risk for TIC in order to detect LV systolic dysfunction earlier. Additionally, this could help identify patients who would benefit most from prophylactic therapy for preventing TIC.
    MeSH term(s) Antineoplastic Agents, Immunological/adverse effects ; Breast Neoplasms/drug therapy ; Female ; Heart Disease Risk Factors ; Heart Diseases/chemically induced ; Heart Diseases/epidemiology ; Humans ; Trastuzumab/adverse effects
    Chemical Substances Antineoplastic Agents, Immunological ; Trastuzumab (P188ANX8CK)
    Language English
    Publishing date 2021-03-06
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 441816-5
    ISSN 1535-6345 ; 0147-0272
    ISSN (online) 1535-6345
    ISSN 0147-0272
    DOI 10.1016/j.currproblcancer.2021.100723
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  5. Article: Earlier use of capsule endoscopy in inpatients with melena or severe iron deficiency anemia reduces need for colonoscopy and shortens hospital stay.

    Yung, Diana E / Koulaouzidis, Anastasios / Douglas, Sarah / Plevris, John N

    Endoscopy international open

    2018  Volume 6, Issue 9, Page(s) E1075–E1084

    Abstract: Background and study ... ...

    Abstract Background and study aims
    Language English
    Publishing date 2018-09-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-0640-2956
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  6. Article ; Online: Retention rate in small-bowel capsule endoscopy.

    Kopylov, Uri / Yung, Diana E / Koulaouzidis, Anastasios / Eliakim, Rami

    Gastrointestinal endoscopy

    2017  Volume 86, Issue 3, Page(s) 573

    MeSH term(s) Capsule Endoscopes ; Capsule Endoscopy ; Humans ; Intestine, Small
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2017.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Aortoenteric fistula: a rare but critical cause of small bowel bleeding discovered on capsule endoscopy.

    Davie, Matt / Yung, Diana E / Plevris, John N / Koulaouzidis, Anastasios

    BMJ case reports

    2019  Volume 12, Issue 5

    Abstract: A 78-year-old man attended for outpatient capsule endoscopy, to investigate a recent history of unexplained small bowel bleeding. His previous medical history included an abdominal aortic aneurysm repair 6 years ago. Soon after capsule ingestion, he ... ...

    Abstract A 78-year-old man attended for outpatient capsule endoscopy, to investigate a recent history of unexplained small bowel bleeding. His previous medical history included an abdominal aortic aneurysm repair 6 years ago. Soon after capsule ingestion, he experienced sudden onset abdominal pain and collapsed on hospital grounds. He was rapidly transferred to the emergency department as he was haemodynamically unstable, and a significant per rectum (PR) bleed was found on examination. The patient was quickly stabilised following fluid resuscitation. CT angiography was performed which did not show active bleeding. However, use of the real-time capsule viewer indicated a profuse active jejunal bleed originating from the aortic graft, suggestive of an aortoenteric fistula. The patient underwent emergency endovascular cuff placement, and subsequent endovascular abdominal aortic stent grafting, to good effect.
    MeSH term(s) Abdominal Pain/diagnostic imaging ; Aged ; Aorta, Abdominal/diagnostic imaging ; Aorta, Abdominal/pathology ; Capsule Endoscopy/adverse effects ; Computed Tomography Angiography ; Emergency Treatment ; Gastrointestinal Hemorrhage/diagnostic imaging ; Gastrointestinal Hemorrhage/pathology ; Gastrointestinal Hemorrhage/surgery ; Humans ; Intestinal Fistula/diagnostic imaging ; Intestinal Fistula/pathology ; Intestinal Fistula/surgery ; Male ; Stents ; Treatment Outcome ; Vascular Fistula/diagnostic imaging ; Vascular Fistula/pathology ; Vascular Fistula/surgery ; Vascular Surgical Procedures
    Language English
    Publishing date 2019-05-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-230083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Mapping the distribution of small bowel angioectasias.

    Davie, Matt / Yung, Diana E / Douglas, Sarah / Plevris, John N / Koulaouzidis, Anastasios

    Scandinavian journal of gastroenterology

    2019  Volume 54, Issue 5, Page(s) 597–602

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Aged ; Anemia, Iron-Deficiency/etiology ; Anemia, Iron-Deficiency/pathology ; Arteriovenous Malformations/pathology ; Capsule Endoscopy ; Double-Balloon Enteroscopy ; Endoscopy, Gastrointestinal ; Female ; Gastrointestinal Hemorrhage/pathology ; Humans ; Intestine, Small/blood supply ; Male ; Retrospective Studies ; Tertiary Care Centers
    Language English
    Publishing date 2019-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365521.2019.1608293
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    Zs.A 567: Show issues Location:
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  9. Article: Poor Quality of Small Bowel Capsule Endoscopy Images Has a Significant Negative Effect in the Diagnosis of Small Bowel Malignancy.

    Yung, Diana E / Plevris, John N / Leenhardt, Romain / Dray, Xavier / Koulaouzidis, Anastasios

    Clinical and experimental gastroenterology

    2020  Volume 13, Page(s) 475–484

    Abstract: Background and aims: Capsule endoscopy (CE) is a visual modality; hence, diagnosis relies on image quality. We studied the contribution of image parameters to visualization quality and their effect on diagnostic certainty of small bowel (SB) lesions.: ...

    Abstract Background and aims: Capsule endoscopy (CE) is a visual modality; hence, diagnosis relies on image quality. We studied the contribution of image parameters to visualization quality and their effect on diagnostic certainty of small bowel (SB) lesions.
    Methods: Five clear CE images of common SB pathology - two vascular lesions, two inflammatory, one polyp - were processed for three image parameters to simulate poor SB conditions: opacity (color-matched to luminal content; 10-90%, 10% increments); blurriness (radius 1-10 pixels; one pixel increments); and contrast (-50-50%; 10% increments). Nine expert readers evaluated whether images were adequate for diagnosis. Points where perception of image quality changed significantly were determined for each parameter. Three further sets of SBCE images (vascular, inflammatory, and neoplastic lesions; nine images/set) were processed for four points/parameters. Twenty experienced/expert CE readers reviewed these images.
    Results: The negative effects of opacity in diagnostic certainty were mostly evident in images of neoplasia; images of vascular and inflammatory lesions were less affected. Similar results were observed with increasing blur radius, simulating movement, and poor focus. The proportions of readers finding vascular and inflammatory images adequate for diagnosis did not drop significantly at wider blur radii, while images of neoplasia were quickly deemed inadequate. Low contrast had a greater negative effect than high, most consistently in neoplastic lesions.
    Conclusion: Poor visualization quality in all parameters affected mostly neoplastic lesions. Software to increase contrast and sharpen images can improve visualization quality; smart frame rate adaptation could improve the number of high-quality frames obtained. Thoroughness in SB cleansing is most important when there is a suspicion of neoplasia.
    Language English
    Publishing date 2020-10-21
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2520690-4
    ISSN 1178-7023
    ISSN 1178-7023
    DOI 10.2147/CEG.S260906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The validity of suspected blood indicator software in capsule endoscopy: a systematic review and meta-analysis.

    Yung, Diana E / Sykes, Catherine / Koulaouzidis, Anastasios

    Expert review of gastroenterology & hepatology

    2017  Volume 11, Issue 1, Page(s) 43–51

    Abstract: Introduction: Software tools have been developed as capsule endoscopy (CE) reading aids. The suspected blood indicator (SBI) tags possible areas of haemorrhage in the gastrointestinal (GI) tract. This meta-analysis aims to investigate the diagnostic ... ...

    Abstract Introduction: Software tools have been developed as capsule endoscopy (CE) reading aids. The suspected blood indicator (SBI) tags possible areas of haemorrhage in the gastrointestinal (GI) tract. This meta-analysis aims to investigate the diagnostic accuracy of SBI in CE. Areas covered: A systematic literature search was conducted for studies on the use of SBI in CE. Sensitivity, specificity and diagnostic odds ratio (DOR) of SBI in diagnosing GI bleeding was evaluated. 2040 patients from 16 studies underwent 2049 CE examinations. The overall sensitivity of SBI for bleeding or potentially bleeding lesions was 0.553, specificity 0.578, DOR 12.354. The sensitivity of SBI for active bleeding was 0.988, specificity 0.646, DOR 229.89. Expert commentary: Currently, SBI has limited validity in CE reading. However, in active GI bleeding, it has good sensitivity, supporting its use in the acute setting.
    MeSH term(s) Area Under Curve ; Capsule Endoscopy/methods ; Gastrointestinal Hemorrhage/diagnostic imaging ; Gastrointestinal Hemorrhage/etiology ; Humans ; Image Processing, Computer-Assisted ; Odds Ratio ; Predictive Value of Tests ; ROC Curve ; Reproducibility of Results ; Risk Factors ; Software
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2017.1257384
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