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Article ; Online: Introduction to the JPIC issue,

Zanjani, Faika / Gendron, Tracey

Journal of prevention & intervention in the community

2021 Volume 51, Issue 3, Page(s) 187–191

Abstract: Community-level health promotion programs offer opportunities to improve the lives of older adults and improve the cultural narrative about aging. However, age-discrimination, ageism, and negative attitudes about aging, across the systematic ecological ... ...

Abstract	Community-level health promotion programs offer opportunities to improve the lives of older adults and improve the cultural narrative about aging. However, age-discrimination, ageism, and negative attitudes about aging, across the systematic ecological community levels have undermined older adult health. While the longevity of a society is a marker for success worldwide, age-discrimination and ageism, seen through limited community-level health advancement opportunities, have thwarted progress toward societal elderhood, even in the most developed and advanced nations. As a society, we need to continue to push for community-level prevention and intervention across the older age spectrum, to continue human advancement through late life.
MeSH term(s)	Humans ; Aged ; Aging ; Ageism/prevention & control ; Health Promotion
Language	English
Publishing date	2021-05-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354884-0
ISSN	1540-7330 ; 1085-2352
ISSN (online)	1540-7330
ISSN	1085-2352
DOI	10.1080/10852352.2021.1930822
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Article ; Online: Specific olfactory deficit patterns observed in seniors and associated with cognitive decline.

Camara, Gemma / Alotaibi, Majed / Lessard-Beaudoin, Melissa / Busch, Kate / Gendron, Louis / Graham, Rona K

Progress in neuro-psychopharmacology & biological psychiatry

2023 Volume 126, Page(s) 110775

Abstract: ... performed to measure olfactory function and the telephone Mini Mental State Examination (t-MMSE) and ... the French version of the Telephone Interview for Cognitive Status Modified (F-TICS-m) for cognitive status ...

Abstract	Olfactory dysfunction is a common symptom in neurodegenerative disorders and is regarded as a potential early predictor of impending cognitive decline. This study was undertaken in order to determine if olfactory dysfunction observed in the elderly is due to a general loss of smell or the inability to detect specific odours, and if misidentification of odours correlates with cognitive scores. Seniors for the Olfactory Response and Cognition in Aging (ORCA) sub-study were recruited from the Quebec Nutrition and Successful Aging (NuAge) cohort. The University of Pennsylvania smell identification test (UPSIT) was performed to measure olfactory function and the telephone Mini Mental State Examination (t-MMSE) and the French version of the Telephone Interview for Cognitive Status Modified (F-TICS-m) for cognitive status. The results demonstrate that seniors exhibit specific olfactory loss and had severe difficulty in particular in identifying lemon, pizza, fruit punch, cheddar cheese and lime. Furthermore, there was a significant difference in the ability to detect certain odours between the sexes. Results also showed that misidentification of certain scents was associated with cognitive scores, and when the sexes were assessed separately sex-specific misidentification of cognitive-associated odours was observed. The relationship between the cognitive scores and scent misidentification suggests that impending cognitive decline may be highlighted by the inability to smell specific odours. Our study provides additional support for the testing of olfactory function in the elderly and suggests that loss of smell for particular scents may become a useful diagnostic tool.
MeSH term(s)	Male ; Female ; Humans ; Aged ; Smell ; Olfaction Disorders/diagnosis ; Anosmia ; Aging ; Cognitive Dysfunction/diagnosis
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2023.110775
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Article ; Online: Cryptic exon inclusion is a molecular signature of LATE-NC in aging brains.

Chung, Mingee / Carter, E Kathleen / Veire, Austin M / Dammer, Eric B / Chang, Jianjun / Duong, Duc M / Raj, Nisha / Bassell, Gary J / Glass, Jonathan D / Gendron, Tania F / Nelson, Peter T / Levey, Allan I / Seyfried, Nicholas T / McEachin, Zachary T

Acta neuropathologica

2024 Volume 147, Issue 1, Page(s) 29

Abstract: The aggregation, mislocalization, and phosphorylation of TDP-43 are pathologic hallmarks of several neurodegenerative diseases and provide a defining criterion for the neuropathologic diagnosis of Limbic-predominant Age-related TDP-43 Encephalopathy ( ... ...

Abstract	The aggregation, mislocalization, and phosphorylation of TDP-43 are pathologic hallmarks of several neurodegenerative diseases and provide a defining criterion for the neuropathologic diagnosis of Limbic-predominant Age-related TDP-43 Encephalopathy (LATE). LATE neuropathologic changes (LATE-NC) are often comorbid with other neurodegenerative pathologies including Alzheimer's disease neuropathologic changes (ADNC). We examined whether TDP-43 regulated cryptic exons accumulate in the hippocampus of neuropathologically confirmed LATE-NC cases. We found that several cryptic RNAs are robustly expressed in LATE-NC cases with or without comorbid ADNC and correlate with pTDP-43 abundance; however, the accumulation of cryptic RNAs is more robust in LATE-NC with comorbid ADNC. Additionally, cryptic RNAs can robustly distinguish LATE-NC from healthy controls and AD cases. These findings expand our current understanding and provide novel potential biomarkers for LATE pathogenesis.
MeSH term(s)	Humans ; Brain/pathology ; TDP-43 Proteinopathies/pathology ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Aging/genetics ; Aging/pathology ; DNA-Binding Proteins/metabolism ; Exons ; Dementia
Chemical Substances	DNA-Binding Proteins
Language	English
Publishing date	2024-02-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1079-0
ISSN	1432-0533 ; 0001-6322
ISSN (online)	1432-0533
ISSN	0001-6322
DOI	10.1007/s00401-023-02671-0
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Article: Single nucleus multiome analysis of the prefrontal cortex from

Wang, Hsiao-Lin V / Veire, Austin M / Gendron, Tania F / Gearing, Marla / Glass, Jonathan D / Jin, Peng / Corces, Victor G / McEachin, Zachary T

bioRxiv : the preprint server for biology

2023

Abstract: Repeat expansions in ... ...

Abstract	Repeat expansions in the
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.12.523820
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Article ; Online: Special Focus Facilities vs Special Focus Facility Candidates: What is the Difference?

Rhodes, Annie / Novak, Anna C / Caprio, Thomas V / Zanjani, Faika / Marrs, Sarah / Gendron, Tracey / Waters, Leland

Journal of the American Medical Directors Association

2023 Volume 25, Issue 3, Page(s) 390–395

Abstract: ... size, certification status, number of residents, and complaint citations: t tests, χ: Results ...

Abstract	Objectives: This study compares Special Focus Facilities (SFFs) and Special Focus Facility Candidate Facilities (SFFcs) on organizational traits and quality outcomes to evaluate the effectiveness of the SFF program as a quality improvement intervention and inform potential areas for program reform. Design: This is a retrospective analysis. Settings and participants: Using data from the Centers for Medicare and Medicaid Services archives for 2020, this retrospective study analyzed 247 nursing facilities (50 SFFs and 197 SFFcs). Methods: Variables of interest were staffing, profit status, facility size, certification status, number of residents, and complaint citations: t tests, χ Results: From an organizational perspective, SFFs and SFFcs are minimally different. Both groups had similar facility size, profit status, hospital affiliation, continuing care retirement community status, and Medicare/Medicaid certification. Large and for-profit facilities were overrepresented in both groups. SFFs and SFFcs exhibited statistical differences in the number of complaint deficiencies. The groups had no significant difference in staffing levels, category, severity of complaints, or incident reports. Conclusions and implication: The study's findings suggest that the SFF program, while resource-intensive, is minimally impactful. The similarities between SFFs and SFFcs raise questions about the program's effectiveness in improving nursing facility care. Previous adjustments to the program may not have successfully achieved the desired quality improvements. This research highlights the need to further evaluate the SFF program's effectiveness as a quality improvement intervention. It also underscores the importance of addressing biases and subjectivity in state survey agency processes, which affect the enrollment of nursing facilities. The study underscores the flaws within the nursing home monitoring system and the 5-star quality rating system, especially when comparing small samples between states.
MeSH term(s)	Aged ; Humans ; United States ; Retrospective Studies ; Medicare ; Nursing Homes ; Skilled Nursing Facilities ; Medicaid
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2023.10.005
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Article ; Online: Erratum: Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19.

iScience

2024 Volume 27, Issue 4, Page(s) 109501

Abstract: This corrects the article DOI: 10.1016/j.isci.2022.105272.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.isci.2022.105272.].
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Published Erratum
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109501
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Article ; Online: Monoallelic

Veiga, Diogo F T / Tremblay, Mathieu / Gerby, Bastien / Herblot, Sabine / Haman, André / Gendron, Patrick / Lemieux, Sébastien / Zúñiga-Pflücker, Juan Carlos / Hébert, Josée / Cohen, Joseph Paul / Hoang, Trang

Frontiers in immunology

2022 Volume 13, Page(s) 867443

Abstract: Early T-cell development is precisely controlled by E proteins, that indistinguishably include HEB ... TCF12 and E2A/TCF3 transcription factors, together with NOTCH1 and pre-T cell receptor (TCR) signalling ... Importantly, perturbations of early T-cell regulatory networks are implicated in leukemogenesis. NOTCH1 gain ...

Abstract	Early T-cell development is precisely controlled by E proteins, that indistinguishably include HEB/TCF12 and E2A/TCF3 transcription factors, together with NOTCH1 and pre-T cell receptor (TCR) signalling. Importantly, perturbations of early T-cell regulatory networks are implicated in leukemogenesis. NOTCH1 gain of function mutations invariably lead to T-cell acute lymphoblastic leukemia (T-ALL), whereas inhibition of E proteins accelerates leukemogenesis. Thus, NOTCH1, pre-TCR, E2A and HEB functions are intertwined, but how these pathways contribute individually or synergistically to leukemogenesis remain to be documented. To directly address these questions, we leveraged
MeSH term(s)	Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Humans ; Mice ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Proto-Oncogene Proteins/metabolism ; Receptor, Notch1/genetics ; Receptor, Notch1/metabolism ; Receptors, Antigen, T-Cell ; T-Cell Acute Lymphocytic Leukemia Protein 1 ; T-Lymphocytes/metabolism ; Transcription Factors/metabolism
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; NOTCH1 protein, human ; Proto-Oncogene Proteins ; Receptor, Notch1 ; Receptors, Antigen, T-Cell ; T-Cell Acute Lymphocytic Leukemia Protein 1 ; Tcf12 protein, mouse ; Transcription Factors ; TCF12 protein, human (142661-93-6)
Language	English
Publishing date	2022-03-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.867443
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Article ; Online: Cultivating Relationships as a Community-Based Recruitment Strategy in Transdisciplinary Aging Research: Lessons From an Academic-Community Partnership.

Diallo, Ana F / Mackiewicz, Marissa / Sargent, Lana / Roman, Youssef M / Slattum, Patricia W / Waters, Leland / Bennett, Johnathan / Battle, Kimberly / Zanjani, Faika / Gendron, Tracey / Winship, Jodi / Ford, Gregory / Falls, Katherine / Price, Elvin T / Parsons, Pamela / Chung, Jane

Family & community health

2023 Volume 47, Issue 1, Page(s) 32–40

Abstract: Participation of Black American older adults in community-engaged research remains challenging in health sciences. The objectives of this study were to describe the specific efforts, successes, and challenges in recruiting Black American older adults in ... ...

Abstract	Participation of Black American older adults in community-engaged research remains challenging in health sciences. The objectives of this study were to describe the specific efforts, successes, and challenges in recruiting Black American older adults in research led by the Health and Wellness in Aging Across the Lifespan core, part of the Virginia Commonwealth University Institute for Inclusion, Inquiry, and Innovation (iCubed). We conducted a cross-case analysis of 6 community-engaged research projects using the community-engaged research continuum model. Successful recruitment strategies comprised a multifaceted approach to community-based collaboration, including a wellness program with a long standing relationship with the community, engaging key stakeholders and a community advisory board, and building a community-based coalition of stakeholders. Posting flyers and modest monetary compensation remain standard recruitment strategies. The cross-case analysis offered critical lessons on the community's nature and level of engagement in research. Relationship building based on trust and respect is essential to solving complex aging issues in the community.
MeSH term(s)	Humans ; Aged ; Geroscience ; Community-Based Participatory Research/methods ; Health Promotion/methods ; Trust ; Aging
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	449879-3
ISSN	1550-5057 ; 0160-6379
ISSN (online)	1550-5057
ISSN	0160-6379
DOI	10.1097/FCH.0000000000000383
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Article: Socioeconomic Effects on Psychosocial Factors Among Low-Income Older Adults.

Sargent, Lana / Zanjani, Faika / Winship, Jodi / Gendron, Tracey / Mackiewicz, Marissa / Diallo, Ana / Waters, Leland / Battle, Kimberly / Ford, Gregory / Falls, Katherine / Chung, Jane / Price, Elvin T / Cisewski, Melissa / Parsons, Pamela / Health, Vcu iCubed

Gerontology & geriatric medicine

2022 Volume 8, Page(s) 23337214221084866

Abstract: ... for social activities/isolation (f = 3.69, : Discussion: Overall results highlight the social patterns for a diverse ...

Abstract	Objectives: Older adults have been disproportionately affected by COVID-19. The primary goal of this study is to determine the socioeconomic effects on psychosocial factors among low-income independent-living older adults, in an urban setting, during the COVID-pandemic. Methods: Participants were recruited through Virginia Commonwealth University's Richmond Health and Wellness Program. Telephone surveys ( Results: The sample population was between 51 and 87 years of age, 88% were Black, 57% reported incomes of $10,000/year or less, and 60% reported a high-school education or less. There were income effects for social activities/isolation (f = 3.69, Discussion: Overall results highlight the social patterns for a diverse sample of low-income urban older adults; education and income are identified as risk factors for social losses, COVID-infection experiences, racial/ethnic discrimination during the COVID-pandemic, and positive change behaviors.
Language	English
Publishing date	2022-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844974-5
ISSN	2333-7214 ; 2333-7214
ISSN (online)	2333-7214
ISSN	2333-7214
DOI	10.1177/23337214221084866
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Article ; Online: Development of the Relational Ageism Scale: Confirmatory Test on Survey Data.

Gendron, Tracey / Inker, Jennifer K / Andricosky, Rachel / Zanjani, Faika

International journal of aging & human development

2019 Volume 90, Issue 3, Page(s) 281–296

Abstract: The objective of the study is to test a refined measure of attitudes about aging as a multidimensional construct reflective of a relational process that includes personal identity (i.e., beliefs about oneself), social identity (i.e., self-conception ... ...

Abstract	The objective of the study is to test a refined measure of attitudes about aging as a multidimensional construct reflective of a relational process that includes personal identity (i.e., beliefs about oneself), social identity (i.e., self-conception based on group membership), and collective identity (i.e., self-conception based on comparison of groups) as well as capturing awareness of ageism and its impact. Researchers refined the Aging Anxiety Scale and recruited a convenience sample of 329 participants via a social media platform. A principal component factor analysis revealed the specification of three latent factors: personal, relational, and collective aging anxiety. Awareness of ageism as a problem in society was lower than awareness of other forms of discrimination, and awareness of the negative impacts of ageism was low. The findings support the incorporation of this new measure of relational aging anxiety as a by-product of social identity and construction in future ageism studies.
MeSH term(s)	Adult ; Aged ; Ageism/psychology ; Aging/psychology ; Anxiety/psychology ; Female ; Humans ; Male ; Middle Aged ; Psychometrics/instrumentation ; Social Discrimination/psychology ; Social Identification
Language	English
Publishing date	2019-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	187072-5
ISSN	1541-3535 ; 0091-4150
ISSN (online)	1541-3535
ISSN	0091-4150
DOI	10.1177/0091415019836956
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