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  1. Article ; Online: Biomedical implications of nuclear transport.

    Arhel, Nathalie J / Field, Mark C

    FEBS letters

    2024  Volume 597, Issue 20, Page(s) 2499–2500

    MeSH term(s) Active Transport, Cell Nucleus ; Nuclear Pore/metabolism ; Cell Nucleus/metabolism ; Biological Transport
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Editorial
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 282: Show issues Location:
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  2. Article ; Online: La capside du virus de l’immunodéficience humaine au centre d’un engouement sans précédent.

    Arhel, Nathalie Jane

    Medecine sciences : M/S

    2021  Volume 37, Issue 5, Page(s) 549–552

    Title translation An unprecedented interest for the human immunodeficiency virus capsid.
    MeSH term(s) Capsid/metabolism ; Capsid Proteins/genetics ; HIV Infections ; HIV-1/genetics ; HIV-1/metabolism ; Humans ; Virus Replication
    Chemical Substances Capsid Proteins
    Language French
    Publishing date 2021-05-18
    Publishing country France
    Document type Journal Article
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2021050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Early HIV replication revisited.

    Arhel, Nathalie Jane

    Nature microbiology

    2020  Volume 5, Issue 9, Page(s) 1065–1066

    MeSH term(s) HIV Infections/drug therapy ; HIV-1/genetics ; Humans ; Nuclear Pore ; Reverse Transcription ; Virus Replication
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-020-0784-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: RANBP2 evolution and human disease.

    Desgraupes, Sophie / Etienne, Lucie / Arhel, Nathalie J

    FEBS letters

    2023  Volume 597, Issue 20, Page(s) 2519–2533

    Abstract: Ran-binding protein 2 (RANBP2)/Nup358 is a nucleoporin and a key component of the nuclear pore complex. Through its multiple functions (e.g., SUMOylation, regulation of nucleocytoplasmic transport) and subcellular localizations (e.g., at the nuclear ... ...

    Abstract Ran-binding protein 2 (RANBP2)/Nup358 is a nucleoporin and a key component of the nuclear pore complex. Through its multiple functions (e.g., SUMOylation, regulation of nucleocytoplasmic transport) and subcellular localizations (e.g., at the nuclear envelope, kinetochores, annulate lamellae), it is involved in many cellular processes. RANBP2 dysregulation or mutation leads to the development of human pathologies, such as acute necrotizing encephalopathy 1, cancer, neurodegenerative diseases, and it is also involved in viral infections. The chromosomal region containing the RANBP2 gene is highly dynamic, with high structural variation and recombination events that led to the appearance of a gene family called RANBP2 and GCC2 Protein Domains (RGPD), with multiple gene loss/duplication events during ape evolution. Although RGPD homoplasy and maintenance during evolution suggest they might confer an advantage to their hosts, their functions are still unknown and understudied. In this review, we discuss the appearance and importance of RANBP2 in metazoans and its function-related pathologies, caused by an alteration of its expression levels (through promotor activity, post-transcriptional, or post-translational modifications), its localization, or genetic mutations.
    MeSH term(s) Humans ; Nuclear Pore Complex Proteins/genetics ; Nuclear Pore Complex Proteins/metabolism ; Molecular Chaperones/metabolism ; Active Transport, Cell Nucleus ; Nuclear Envelope
    Chemical Substances ran-binding protein 2 ; Nuclear Pore Complex Proteins ; Molecular Chaperones
    Language English
    Publishing date 2023-10-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Coordination de la décapsidation et de l’import nucléaire de VIH-1 par la transportine-1.

    Fernandez, Juliette / Arhel, Nathalie J

    Medecine sciences : M/S

    2020  Volume 36, Issue 3, Page(s) 203–206

    Title translation Transportin-1 orchestrates HIV-1 uncoating and nuclear entry.
    MeSH term(s) Active Transport, Cell Nucleus/genetics ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Cell Nucleus/virology ; HIV Infections/pathology ; HIV Infections/virology ; HIV-1/physiology ; Host-Pathogen Interactions/genetics ; Humans ; Virus Internalization ; Virus Uncoating/genetics ; beta Karyopherins/genetics ; beta Karyopherins/physiology
    Chemical Substances TNPO1 protein, human ; beta Karyopherins
    Language French
    Publishing date 2020-03-31
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2020031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Capside du VIH et infection productive : comment arriver à bon pore ?

    Fernandez, Juliette / Arhel, Nathalie J

    Virologie (Montrouge, France)

    2020  Volume 24, Issue 2, Page(s) 88–98

    Abstract: The Human Immunodeficiency Virus Type-1, the causative agent of AIDS, reaches its site of replication by trafficking through the cytoplasm towards the nucleus, benefiting from an active nuclear import through the nuclear pore in order to integrate in the ...

    Title translation HIV capsid and productive infection: taking steps in the right direction.
    Abstract The Human Immunodeficiency Virus Type-1, the causative agent of AIDS, reaches its site of replication by trafficking through the cytoplasm towards the nucleus, benefiting from an active nuclear import through the nuclear pore in order to integrate in the genome of the host cell. Although it is generally accepted that the viral genome remains within the viral capsid for some time after cell entry, the mechanisms responsible for controlled uncoating, which is essential for productive infection, remain poorly understood. Numerous studies now show that the integrity of the viral capsid is essential for transport towards the nucleus, for reverse transcription and nuclear import, and to prevent sensing by innate immune receptors. This review aims to report recent developments in our understanding of the early stages of HIV infection, from entry into the cell to integration, highlighting the cellular partners of the HIV-1 capsid that promote or antagonize infection, as well as the different techniques that are developed for fundamental research and the identification of potential therapeutic targets.
    Language French
    Publishing date 2020-05-27
    Publishing country France
    Document type Journal Article
    ZDB-ID 2118387-9
    ISSN 1950-6961 ; 1267-8694
    ISSN (online) 1950-6961
    ISSN 1267-8694
    DOI 10.1684/vir.2020.0831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Faut-il vacciner contre la détection par PCR ou contre la maladie Covid-19 ?

    Sonigo, Pierre / Petit, Caroline / Arhel, Nathalie Jane

    Virologie (Montrouge, France)

    2021  Volume 25, Issue 5, Page(s) 241–244

    Title translation Vaccination endpoints: mucosal PCR or Covid-19 disease?
    MeSH term(s) COVID-19 ; Humans ; Mucous Membrane ; Polymerase Chain Reaction ; SARS-CoV-2 ; Vaccination
    Language French
    Publishing date 2021-11-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 2118387-9
    ISSN 1950-6961 ; 1267-8694
    ISSN (online) 1950-6961
    ISSN 1267-8694
    DOI 10.1684/vir.2021.0915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: RANBP2 evolution and human disease

    Desgraupes, Sophie / Etienne, Lucie / Arhel, Nathalie J.

    FEBS Letters. 2023 Oct., v. 597, no. 20 p.2519-2533

    2023  

    Abstract: Ran‐binding protein 2 (RANBP2)/Nup358 is a nucleoporin and a key component of the nuclear pore complex. Through its multiple functions (e.g., SUMOylation, regulation of nucleocytoplasmic transport) and subcellular localizations (e.g., at the nuclear ... ...

    Abstract Ran‐binding protein 2 (RANBP2)/Nup358 is a nucleoporin and a key component of the nuclear pore complex. Through its multiple functions (e.g., SUMOylation, regulation of nucleocytoplasmic transport) and subcellular localizations (e.g., at the nuclear envelope, kinetochores, annulate lamellae), it is involved in many cellular processes. RANBP2 dysregulation or mutation leads to the development of human pathologies, such as acute necrotizing encephalopathy 1, cancer, neurodegenerative diseases, and it is also involved in viral infections. The chromosomal region containing the RANBP2 gene is highly dynamic, with high structural variation and recombination events that led to the appearance of a gene family called RANBP2 and GCC2 Protein Domains (RGPD), with multiple gene loss/duplication events during ape evolution. Although RGPD homoplasy and maintenance during evolution suggest they might confer an advantage to their hosts, their functions are still unknown and understudied. In this review, we discuss the appearance and importance of RANBP2 in metazoans and its function‐related pathologies, caused by an alteration of its expression levels (through promotor activity, post‐transcriptional, or post‐translational modifications), its localization, or genetic mutations.
    Keywords Pongidae ; encephalopathy ; evolution ; gene deletion ; genes ; human diseases ; humans ; kinetochores ; nuclear pore ; nucleocytoplasmic transport ; sumoylation
    Language English
    Dates of publication 2023-10
    Size p. 2519-2533.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14749
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2005/702: Show issues
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  10. Article ; Online: Assessing the Impact of Persistent HIV Infection on Innate Lymphoid Cells Using In Vitro Models.

    Boulay, Aude / Trabanelli, Sara / Boireau, Stéphanie / Boyer-Clavel, Myriam / Nisole, Sébastien / Romero, Pedro / Jandus, Camilla / Beignon, Anne-Sophie / Arhel, Nathalie J

    ImmunoHorizons

    2023  Volume 7, Issue 3, Page(s) 243–255

    Abstract: Pathogens that persist in their host induce immune dysfunctions even in the absence of detectable replication. To better understand the phenotypic and functional changes that persistent infections induce in sentinel innate immune cells, we developed ... ...

    Abstract Pathogens that persist in their host induce immune dysfunctions even in the absence of detectable replication. To better understand the phenotypic and functional changes that persistent infections induce in sentinel innate immune cells, we developed human PBMC-based HIV models of persistent infection. Autologous nonactivated PBMCs were cocultured with chronically infected, acutely infected, or uninfected cells and were then analyzed by unsupervised high-dimensional flow cytometry. Using this approach, we identified prevalent patterns of innate immune dysfunctions associated with persistent HIV infections that at least in part mirror immune dysfunctions observed in patients. In one or more models of chronic infection, bystander CD16+ NK cells expressing markers of activation, such as CD94, CD45RO, CD62L, CD69, CD25, and immune checkpoints PD1, Tim3, TIGIT, NKG2A and Lag3, were significantly reduced. Conversely, helper ILC subsets expressing PDL1/PDL2 were significantly enriched in chronic infection compared with either uninfected or acute infection, suggesting that chronic HIV-1 infection was associated with an inhibitory environment for bystander ILC and NK subsets. The cell-based models of persistent infection that we describe here provide versatile tools to explore the molecular mechanisms of these immune dysfunctions and unveil the contribution of innate immunity in sustaining pathogen persistence.
    MeSH term(s) Humans ; HIV Infections ; Persistent Infection ; Immunity, Innate ; Leukocytes, Mononuclear ; Killer Cells, Natural
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2300007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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