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Artikel ; Online: Ecological and human health hazards of soil heavy metals after wildfire: A case study of Liangshan Yi autonomous prefecture, China.

Rao, Lin / Zheng, Chao / Chen, Jian-Bin / Cai, Jun-Zhuo / Yang, Zhan-Biao / Xu, Xiao-Xun / Lv, Guo-Chun / Xu, Chang-Lian / Wang, Gui-Yin / Man, Yu-Bon / Wong, Ming-Hung / Cheng, Zhang

Chemosphere

2024 Band 352, Seite(n) 141506

Abstract: Soil samples were collected in at different depths from the conflagration area in Liangshan Yi ...

Abstract	Soil samples were collected in at different depths from the conflagration area in Liangshan Yi Autonomous Region, China, to investigate the distribution characteristics and ecological and human health risks of heavy metals after a wildfire. The samples collected comprise wildfire ash (WA) above the soil surface, ash soil (AS) 0-5 cm, and plain soil (PS) 5-15 cm below the soil surface. Additionally, reference soil (RS) was collected from a nearby unburned area at the same latitude as the conflagration area. The results showed that the concentrations of zinc (Zn), copper (Cu), lead (Pb), and cadmium (Cd) in the WA and AS were significantly higher than in reference soil (RS) (p < 0.05). Concentrations of Pb in the PS were 2.52 times higher than that in RS (17.9 mg kg
Mesh-Begriff(e)	Humans ; Soil ; Environmental Monitoring ; Cadmium ; Lead ; Wildfires ; Risk Assessment ; Soil Pollutants/analysis ; Metals, Heavy/analysis ; China ; Neoplasms
Chemische Substanzen	Soil ; Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Soil Pollutants ; Metals, Heavy
Sprache	Englisch
Erscheinungsdatum	2024-02-21
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141506
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Reduction in gefitinib resistance mediated by Yi-Fei San-Jie pill in non-small cell lung cancer through regulation of tyrosine metabolism, cell cycle, and the MET/EGFR signaling pathway.

Yang, Cai-Zhi / Guo, Wei / Wang, Yi-Fan / Hu, Lei-Hao / Wang, Jing / Luo, Jia-Min / Yao, Xiao-Hui / Liu, Shan / Tao, Lan-Ting / Sun, Ling-Ling / Lin, Li-Zhu

Journal of ethnopharmacology

2023 Band 314, Seite(n) 116566

Abstract: Ethnopharmacological relevance: The Chinese herbal prescription Yi-Fei San-Jie pill (YFSJ) has ...

Abstract	Ethnopharmacological relevance: The Chinese herbal prescription Yi-Fei San-Jie pill (YFSJ) has been used for adjuvant treatment in patients with lung cancer for a long time. Aim of the study: Reports have indicated that the combination of gefitinib (Gef) with YFSJ inhibits the proliferation of EGFR-TKI-resistant cell lines by enhancing cellular apoptosis and autophagy in non-small cell lung cancer (NSCLC). However, the molecular mechanisms underlying the effect of YFSJ on EGFR-TKI resistance and related metabolic pathways remain to be explored. Materials and methods: In our report, ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), metabolomics, network pharmacology, bioinformatics, and biological analysis methods were used to investigate the mechanism. Results: The UPLC-MS/MS data identified 42 active compounds of YFSJ extracts. YFSJ extracts can enhance the antitumor efficacy of Gef without hepatic and renal toxicity in vivo. The analysis of the metabolomics pathway enrichment revealed that YFSJ mainly affected the tyrosine metabolism pathway in rat models. Moreover, YFSJ has been shown to reverse Gef resistance and improve the effects of Gef on the cellular viability, migration capacity, and cell cycle arrest of NSCLC cell lines with EGFR mutations. The results of network pharmacology and molecular docking analyses revealed that tyrosine metabolism-related active compounds of YFSJ affect EGFR-TKIs resistance in NSCLC by targeting cell cycle and the MET/EGFR signaling pathway; these findings were validated by western blotting and immunohistochemistry. Conclusions: YFSJ inhibits NSCLC by inducing cell cycle arrest in the G1/S phase to suppress tumor growth, cell viability, and cell migration through synergistic effects with Gef via the tyrosine metabolic pathway and the EGFR/MET signaling pathway. To summarize, the findings of the current study indicate that YFSJ is a prospective complementary treatment for Gef-resistant NSCLC.
Mesh-Begriff(e)	Rats ; Animals ; Carcinoma, Non-Small-Cell Lung/pathology ; Gefitinib/pharmacology ; Gefitinib/therapeutic use ; Lung Neoplasms/pathology ; Molecular Docking Simulation ; Chromatography, Liquid ; Prospective Studies ; ErbB Receptors/metabolism ; Drug Resistance, Neoplasm ; Tandem Mass Spectrometry ; Signal Transduction ; Cell Cycle ; Cell Line, Tumor ; Protein Kinase Inhibitors/pharmacology ; Cell Proliferation
Chemische Substanzen	Gefitinib (S65743JHBS) ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors
Sprache	Englisch
Erscheinungsdatum	2023-05-09
Erscheinungsland	Ireland
Dokumenttyp	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116566
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effect of Yi Jin Jing exercise plus Elastic Band Resistance exercise on overall bone mineral density in postmenopausal women.

Li, Jingyuan / Gu, Qing / Li, Ruixue / Wang, Ru / Cai, Yanwei / Huang, Yunda / Wang, Shasha / Wang, Suijun / Liu, Xiangyun

Journal of science and medicine in sport

2023 Band 26, Heft 2, Seite(n) 87–92

Abstract: Objectives: This work aimed to study the effects of Yi Jin Jing plus Elastic Band Resistance ... their lifestyle behaviors unaltered, whereas the exercise group received  Yi Jin Jing plus Elastic Band Resistance ... Conclusions: The results suggested that Yi Jin Jing plus Elastic Band Resistance exercise could delay ...

Abstract	Objectives: This work aimed to study the effects of Yi Jin Jing plus Elastic Band Resistance exercise on bone mineral density at all parts of the body and bone metabolism index levels in postmenopausal women. Design: Randomized controlled trial. Methods: Forty postmenopausal women were randomly assigned equally to the exercise or to the control group. The control group maintained their lifestyle behaviors unaltered, whereas the exercise group received  Yi Jin Jing plus Elastic Band Resistance exercise. The primary outcome was overall bone mineral density at each part, and the secondary one was bone metabolism indicator levels and bone mineral density on both sides. Results: The results after six months showed increased bone mineral density at all parts of the body in the exercise group (spine, P = 0.002; thighs, lumbar, and whole body, P < 0.05) and decreased bone mineral density in the control group (trunk, pelvis, and spine, P < 0.01). In particular, the decrease and increase were greater on the non-preferred (left) side than on the right side. As for bone metabolism indexes, β-Crosslaps levels reduced (P = 0.016) and a significant increase in 1,25-(OH)2-D3 (P < 0.001) can be observed in the exercise group. Conclusions: The results suggested that Yi Jin Jing plus Elastic Band Resistance exercise could delay the overall decrease of bone mineral density in postmenopausal women, especially on the non-preferred side. It also increased bone formation metabolite levels and inhibited bone resorption metabolite levels.
Mesh-Begriff(e)	Humans ; Female ; Bone Density ; Postmenopause ; Resistance Training ; Exercise ; Spine
Sprache	Englisch
Erscheinungsdatum	2023-01-14
Erscheinungsland	Australia
Dokumenttyp	Randomized Controlled Trial ; Journal Article
ZDB-ID	1437829-2
ISSN	1878-1861 ; 1440-2440
ISSN (online)	1878-1861
ISSN	1440-2440
DOI	10.1016/j.jsams.2023.01.006
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Network pharmacology study of Yi medicine Jinweitai Capsules in treating gastrointestinal diseases].

Li, Cai-Feng / Zhang, Feng-Rong / Zhu, Na / Cui, Jian-Zhi / Tang, Shi-Huan / Li, Zhi-Yong

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2021 Band 46, Heft 4, Seite(n) 865–876

Abstract: The network pharmacology and molecular docking methods were used to explore the mechanism of Jinweitai Capsules in the treatment of acute and chronic gastritis, gastric and duodenal ulcers, and chronic colitis. The chemical components of herbs in ... ...

Abstract	The network pharmacology and molecular docking methods were used to explore the mechanism of Jinweitai Capsules in the treatment of acute and chronic gastritis, gastric and duodenal ulcers, and chronic colitis. The chemical components of herbs in Jinweitai Capsules were collected through TCMSP, CNKI and PubMed. Target prediction was performed through PubChem and SwissTargetPrediction databases; genes relating to acute and chronic gastritis, gastric and duodenal ulcers, chronic colitis were collected from OMIM database; potential targets of Jinweitai Capsules for relevant gastrointestinal diseases were obtained by Venny analysis; DAVID database was used to perform GO and KEGG enrichment analysis; protein interactions were obtained by STRING database and visua-lized by Cytoscape; AutoDockVina was used for molecular docking of AKT1, EGFR, PTPN11 and its reverse-selected chemical components. Potential mechanisms of Jinweitai Capsules in treating relevant gastrointestinal diseases were clarified according to the results of the docking. The results showed 86 potential active ingredients of Jinweitai Capsules and 268 potential targets for treatment of acute and chronic gastritis, gastric and duodenal ulcers, and chronic colitis. KEGG pathway enrichment analysis showed that 20 pathways relating to acute and chronic gastritis, gastric and duodenal ulcers, and chronic colitis mainly involved calcium signaling pathway and chemokine signaling pathway. Molecular docking showed a good binding activity between AKT1, EGFR, PTPN11 and its reverse screening chemical components. Jinweitai Capsules may exert an effect in the treatment of acute and chronic gastritis, gastric and duodenal ulcers, and chronic colitis by acting on AKT1, EGFR, PTPN11 and other targets in 15 signal pathways relating to cell inflammation and immunity, cell proliferation and apoptosis, Helicobacter pylori infection, and gastrointestinal tract.
Mesh-Begriff(e)	Capsules ; Drugs, Chinese Herbal ; Gastrointestinal Diseases/drug therapy ; Helicobacter Infections ; Helicobacter pylori ; Humans ; Medicine ; Molecular Docking Simulation
Chemische Substanzen	Capsules ; Drugs, Chinese Herbal
Sprache	Chinesisch
Erscheinungsdatum	2021-03-01
Erscheinungsland	China
Dokumenttyp	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20200916.401
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach.

Lang, Wanying / Yang, Feng / Cai, Fanfan / Shi, Wengui / Dong, Min / An, Qi / Li, Yanping

Computational intelligence and neuroscience

2022 Band 2022, Seite(n) 1493137

Abstract: Objectives: The Traditional Chinese Medicine (TCM) formula Yi-Fei-Jian-Pi-Tang (YFJPT) has been ...

Abstract	Objectives: The Traditional Chinese Medicine (TCM) formula Yi-Fei-Jian-Pi-Tang (YFJPT) has been demonstrated effective against Corona Virus Disease 2019 (Covid-19). The aim of this article is to make a thorough inquiry about its active constituent as well as mechanisms against Covid-19 via TCM network pharmacology. Methods: All the ingredients of YFJPT are obtained from the pharmacology database of the TCM system. The genes which are associated with the targets are obtained by utilizing UniProt. The herb-target network is built up by utilizing Cytoscape. The target protein-protein interaction network is built by utilizing the STRING database and Cytoscape. The critical targets of YFJPT are explored by Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Results: The outcomes show that YFJPT might has 33 therapeutic targets on Covid-19, namely, interleukin 2 (IL2), heme oxygenase 1 (HMOX1), interleukin 4 (IL4), interferon gamma (FNG), Conclusions: That will lay a foundation for the clinical rational application and further experimental research of YFJPT.
Mesh-Begriff(e)	COVID-19 ; Chemokines ; Humans ; Ligands ; Metalloproteases ; Network Pharmacology
Chemische Substanzen	Chemokines ; Ligands ; Metalloproteases (EC 3.4.-)
Sprache	Englisch
Erscheinungsdatum	2022-07-16
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/1493137
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Jian-Pi-Yi-Shen drug-containing serum promotes proliferation and activity of mouse osteoblasts

Yuli Cai / Xiaochen Liu / Liang Ma / Wenxue Lv / Weiguo Wang / Xingcai Zhang

Bioscience Journal, Vol

2023 Band 39

Abstract: Jian-Pi-Yi-Shen (JPYS) decoction is a traditional Chinese herbal formula. The present study aimed ...

Abstract	Jian-Pi-Yi-Shen (JPYS) decoction is a traditional Chinese herbal formula. The present study aimed to investigate the effect of JPYS drug-containing serum on the proliferation and activity of mouse osteoblasts. Sprague‒Dawley rats were fed JPYS decoction, calcium supplement, or normal saline for 6 weeks, and the serum was collected. Mouse osteoblasts were treated with JPYS drug-containing serum, calcium supplement serum, or blank control serum. Cell proliferation was assayed using thiazolyl blue tetrazolium bromide. Levels of alkaline phosphatase, nitric oxide, and nitric oxide synthase in the culture medium were measured. The JPYS drug-containing serum significantly improved the proliferation of osteoblasts compared to the blank control serum and the calcium supplement serum. It also significantly increased the levels of alkaline phosphatase in the culture medium compared to the blank control serum and the calcium supplement serum. Treatment with JPYS drug-containing serum for 48 h and 72 h significantly increased the nitric oxide (NO) concentration in the culture medium compared to the blank control serum. The NOS activity of the osteoblasts was significantly increased by JPYS drug-containing serum compared to blank control serum and calcium supplement serum. All these results were enhanced that the JPYS decoction promotes the proliferation and activity of mouse osteoblasts. These effects may be the underlying mechanisms of JPYS decoction in treating osteoporosis.
Schlagwörter	Nitric Oxide ; Osteoporosis ; Agriculture ; S ; Biology (General) ; QH301-705.5
Thema/Rubrik (Code)	630
Sprache	Englisch
Erscheinungsdatum	2023-06-01T00:00:00Z
Verlag	Universidade Federal de Uberlândia
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Metallogeny of the Yi’nan Tongjing Au–Cu skarn deposit, Luxi district, North China Craton

Wen-Yan Cai / Zhao-Lu Zhang / Xiao Liu / Ji-Lei Gao / Ming Ma / Yadong Li / Ying-Xin Song / Zeng-Sheng Li

Frontiers in Earth Science, Vol

Perspective from in-suit trace elements, sulfur and lead isotopes of sulfides

2023 Band 10

Abstract: ... hydrothermal processes. The Yi’nan Tongjing Au–Cu deposit is located in the central part of the Luxi district ... of shallow crustal material. The Yi’nan Tongjing Au–Cu skarn deposit was formed in the ... ...

Abstract	Gold–Cu skarn deposits are characterized by a diverse mineral assemblage, whose in-situ major/trace elements and isotope compositions can provide key constraints to the migration and enrichment of Au during hydrothermal processes. The Yi’nan Tongjing Au–Cu deposit is located in the central part of the Luxi district, and both skarn and Au–Cu ore bodies occur at the contact between the Early Cretaceous diorite porphyry and the Neoproterozoic to Cambrian carbonate rocks. Five stages of mineralization were identified: 1) early skarn (garnet–diopside–wollastonite); 2) late skarn (magnetite–epidote–actinolite±tremolite); 3) oxide (specularite–hematite); 4) sulfide (pyrite–chalcopyrite–sphalerite–quartz–chlorite); and 5) late quartz–calcite. The mineralization process in the Tongjing Au-Cu deposit was revealed by detailed scanning electron microscope-backscattered electron imaging, electron probe microanalysis, in-situ trace element, sulfur and lead isotope analysis. Magnetite is enriched in chalcophile elements (Cu, Zn, Pb), Co and Ni, probably due to hydrothermal overprint. The substitution of As and other elements in the formation of pyrite is conducive to the entry of Au into pyrite. The increase of Se and As contents in pyrite from stage IVa to IVb indicates that the temperature, salinity and oxygen fugacity of the ore-forming fluid decrease while the pH rises, resulting in the unloading of Au. The temperature of Au mineralization based on the Se content in pyrite does not exceed 300°C. Furthermore, V positively correlated with Ti and Ni/Cr ratios ≥1 in magnetite and most Co/Ni ratios in pyrite >10 all confirm their hydrothermal origins. The restricted sulfur (δ34SV-CDT = −0.5–1.2‰; mean = 0.4‰) and lead (206Pb/204Pb = 17.323–17.383; 207Pb/204Pb = 15.424–15.452; 208Pb/204Pb = 37.367–37.454) isotopic compositions suggest that the deep magma provided the primary mineralized material, accompanied by a relatively small amount of shallow crustal material. The Yi’nan Tongjing Au–Cu skarn deposit was formed in the ...
Schlagwörter	in-situ trace elements analyses ; in-situ sulfur and lead isotopes ; Au precipitation mechanism ; Yi’nan Tongjing ; skarn deposit ; Luxi district ; Science ; Q
Thema/Rubrik (Code)	550
Sprache	Englisch
Erscheinungsdatum	2023-01-01T00:00:00Z
Verlag	Frontiers Media S.A.
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: [Estimation of newly HIV infection trend by using the back-calculation method in Honghe Hani and Yi autonomous prefecture].

Tang, L / Ling, Q / Chen, F F / Li, P L / Ge, L / Cai, C / Tang, H L / Lyu, P / Li, D M

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2020 Band 41, Heft 11, Seite(n) 1876–1881

Abstract: Objective: ...

Abstract	Objective:
Mesh-Begriff(e)	Adolescent ; Adult ; China/epidemiology ; Delayed Diagnosis/statistics & numerical data ; Epidemiologic Methods ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Testing/statistics & numerical data ; Humans
Sprache	Chinesisch
Erscheinungsdatum	2020-12-07
Erscheinungsland	China
Dokumenttyp	Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
DOI	10.3760/cma.j.cn112338-20200317-00369
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The investigation of anti-inflammatory activity of Yi Guanjian decoction by serum metabonomics approach.

Shui, Sufang / Cai, Xiaorong / Huang, Rongqing / Xiao, Bingkun / Yang, Jianyun

Journal of pharmaceutical and biomedical analysis

2017 Band 133, Seite(n) 41–48

Abstract: Yi Guanjian (YGJ), one of the Chinese herbal medicines most commonly used in western countries ...

Abstract	Yi Guanjian (YGJ), one of the Chinese herbal medicines most commonly used in western countries, reported to possess significant anti-inflammatary effects that inhibit the process of inflammation. However, the mechanisms underlying its anti-inflammation effects remain largely unresolved. This study was aimed to investigate the anti-inflammatory activity of YGJ and to explore its potential anti-inflammatory mechanisms by serum metabonomics approach. An xylene-induced mouse right-ear-edema model was used as an inflammatory response in vivo model. Ear edema, prostaglandin E2 (PGE
Mesh-Begriff(e)	Animals ; Anti-Inflammatory Agents/pharmacology ; Biomarkers/blood ; Dinoprostone/blood ; Drugs, Chinese Herbal/pharmacology ; Male ; Metabolomics ; Mice ; Signal Transduction/drug effects ; Tumor Necrosis Factor-alpha/blood
Chemische Substanzen	Anti-Inflammatory Agents ; Biomarkers ; Drugs, Chinese Herbal ; Tumor Necrosis Factor-alpha ; Yi Guan Jian Decoction ; Dinoprostone (K7Q1JQR04M)
Sprache	Englisch
Erscheinungsdatum	2017-01-30
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2016.11.017
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch: Yi bing yu she hui

Cai, Fuchang

Taiwan li jing SARS feng bao zhi yi xue yu ren wen fan xing

(Yi xue ren wen cong shu ; 17)

2012

Verfasserangabe	zhu bian Cai Fuchang, Jiang Yihua
Serientitel	Yi xue ren wen cong shu ; 17
Mesh-Begriff(e)	Severe Acute Respiratory Syndrome ; Communicable Disease Control ; Health Policy ; Risk Assessment
Schlagwörter	Taiwan
Sprache	Chinesisch
Umfang	xxiii, 383 pages :, illustrations.
Ausgabenhinweis	Chu ban.
Dokumenttyp	Buch
ISBN	9789860323672 ; 9860323674
Datenquelle	Katalog der US National Library of Medicine (NLM)

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