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  1. Article ; Online: Infection-Related Glomerulonephritis.

    Khalighi, Mazdak A / Chang, Anthony

    Glomerular diseases

    2021  Volume 1, Issue 2, Page(s) 82–91

    Abstract: Background: There has been a long, storied relationship between various bacterial infections and glomerular injury, which is now encompassed under the term of infection-related glomerulonephritis (GN). The clinical and pathologic manifestations vary ... ...

    Abstract Background: There has been a long, storied relationship between various bacterial infections and glomerular injury, which is now encompassed under the term of infection-related glomerulonephritis (GN). The clinical and pathologic manifestations vary depending on the duration, magnitude, and underlying pathogen associated with the inciting infectious process. A brief and acute episode may lead to a self-limiting glomerular manifestation while a chronic or repetitive infection can result in persistent and irreversible injury. In this review, we will discuss the clinical and pathologic findings associated with the infection-related glomerulonephritides.
    Summary: An acute exudative GN with an influx of neutrophils is the most characteristic morphologic alteration associated with infection-related glomerular injury. The immunofluorescence staining pattern often reveals prominent complement component C3 deposition in both capillary walls and mesangial regions with or without accompanying immunoglobulin. Large subepithelial electron-dense deposits known as "humps" are the hallmark ultrastructural finding; however, these features can also be present in C3 glomerulopathies, which are often triggered by infections and may have similar underlying abnormalities in alternative pathway complement activation. In addition, other glomerular injuries can simultaneously be present along with infection-related GN, such as diabetic nephropathy, lupus nephritis, or immunoglobulin A nephropathy, constituting a true diagnostic challenge for the pathologist.
    Key messages: Bacterial infection-related GN represents a spectrum of glomerular injury with variable clinical and pathologic presentations. The pathologic findings can show overlap with other glomerular diseases, and different forms of infection-related GN vary in terms of prognosis and treatment approach.
    Language English
    Publishing date 2021-04-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-3633
    ISSN (online) 2673-3633
    DOI 10.1159/000515461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A case of secondary syphilis presenting like pemphigus with positive direct immunofluorescence.

    Stone, Caroline J / Nicholson, Lowell / Florell, Scott R / Khalighi, Mazdak A / Lewis, Bethany K H

    JAAD case reports

    2023  Volume 42, Page(s) 38–41

    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2023.09.023
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  3. Article: Diagnostics for Dermatologic Diseases with Autoantibodies.

    Leiferman, Kristin M / Snook, Jeremy P / Khalighi, Mazdak A / Kuechle, Melanie K / Zone, John J

    The journal of applied laboratory medicine

    2022  Volume 7, Issue 1, Page(s) 165–196

    Abstract: Background: Dermatologic diseases with autoantibodies were recognized early as autoimmunity became accepted as a pathogenic immunologic concept. Laboratory testing to identify disease-defining autoantibodies and investigate their role in pathophysiology ...

    Abstract Background: Dermatologic diseases with autoantibodies were recognized early as autoimmunity became accepted as a pathogenic immunologic concept. Laboratory testing to identify disease-defining autoantibodies and investigate their role in pathophysiology has evolved since.
    Content: Blistering dermatologic diseases, profiled by autoantibody production, target epithelial components critical in cell-cell and cell-matrix adhesion, resulting in epithelial separation and other characteristic features of the disorders. This review covers the clinical indications for dermatologic disease-related autoantibody testing, the specifics of procuring specimens to test, the available diagnostic tests, and information provided by the testing. Atypical, uncharacteristic, and less well-known clinical and autoantibody profiles as well as several of the many future prospects for expansion of the testing applications are elaborated on in the online Data Supplement.
    Summary: Autoantibody-associated dermatologic diseases are acquired immunologic disorders that have considerable clinical implications affecting essential barrier functions of skin and mucous membranes and causing discomfort, including pain and pruritus. Certain of the diseases can have life-threatening manifestations, and treatments can have significant side-effects. The skin diseases may presage other clinical associations that are important to recognize and treat. Laboratory testing aids in the diagnosis of these diseases through identification of the autoantibodies and is essential for prompt and precise knowledge of the disease type for prognosis, further clinical evaluations, and treatment decisions.
    MeSH term(s) Autoantibodies ; Humans ; Pemphigoid, Bullous ; Skin
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2022-01-28
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1093/jalm/jfab147
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  4. Article ; Online: A new eruption of bullous pemphigoid following mRNA COVID-19 vaccination.

    Daines, Bryan / Madigan, Lauren M / Vitale, Patricia A / Khalighi, Mazdak / Innes, Matthew

    Dermatology online journal

    2022  Volume 28, Issue 4

    Abstract: The rapid development and implementation of COVID-19 vaccines throughout the global population has given rise to unique, rare, adverse skin reactions. This case report describes an elderly man with new-onset bullous pemphigoid following the second dose ... ...

    Abstract The rapid development and implementation of COVID-19 vaccines throughout the global population has given rise to unique, rare, adverse skin reactions. This case report describes an elderly man with new-onset bullous pemphigoid following the second dose of the Pfizer-BioNTech (mRNA) COVID-19 vaccine.
    MeSH term(s) Aged ; Humans ; Male ; COVID-19 ; COVID-19 Vaccines/adverse effects ; Exanthema ; Pemphigoid, Bullous/etiology ; RNA, Messenger ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2026239-5
    ISSN 1087-2108 ; 1087-2108
    ISSN (online) 1087-2108
    ISSN 1087-2108
    DOI 10.5070/D328458525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Lambda Light Chain Crystalline Cast Nephropathy and Proximal Tubulopathy.

    Gallan, Alexander J / Khalighi, Mazdak A

    Kidney international reports

    2016  Volume 1, Issue 4, Page(s) 316–320

    Language English
    Publishing date 2016-08-12
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN 2468-0249
    DOI 10.1016/j.ekir.2016.08.005
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  6. Article ; Online: Glomerulonephritis With Masked Monotypic Immunoglobulin Deposits and Concurrent Lymphomatous Infiltration.

    Lloyd, Isaac E / Khalighi, Mazdak A

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2016  Volume 68, Issue 4, Page(s) 640–644

    Abstract: Kidney injury can be a complication of hematopoietic neoplasia by both direct and indirect mechanisms. Virtually all lymphomas and plasma cell dyscrasias can show kidney involvement, including parenchymal infiltration and by secondary injury. Recently, a ...

    Abstract Kidney injury can be a complication of hematopoietic neoplasia by both direct and indirect mechanisms. Virtually all lymphomas and plasma cell dyscrasias can show kidney involvement, including parenchymal infiltration and by secondary injury. Recently, a unique form of glomerulonephritis with masked monotypic immunoglobulin deposits has been reported, which shows frequent association with hematopoietic neoplasia and a propensity for progressive kidney disease. In many instances, these cases are likely diagnosed as glomerulonephritis with dominant C3 due to the absence of immunoglobulin staining by routine immunofluorescence microscopy. The patient reported here showed lymphomatous infiltration on kidney biopsy and mesangial proliferative glomerulonephritis with dominant staining for C3 without immunoglobulins on initial immunofluorescence; however, monotypic immunoglobulin G κ light chain was revealed after additional immunofluorescence staining was performed on the paraffin-embedded tissue. This patient's case highlights the evolving state of kidney biopsy interpretation and the expanding spectrum of kidney disease in the setting of hematopoietic neoplasia.
    MeSH term(s) Aged ; Glomerulonephritis/immunology ; Glomerulonephritis/pathology ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin kappa-Chains/immunology ; Lymphocytes, Tumor-Infiltrating ; Lymphoma, Mantle-Cell/complications ; Lymphoma, Mantle-Cell/pathology ; Male
    Chemical Substances Immunoglobulin G ; Immunoglobulin kappa-Chains
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2016.05.012
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  7. Article ; Online: Neonatal pemphigoid gestationis: An atypical presentation of a rare disease.

    Jimenez, Amber / Blain, Kimberly / Khalighi, Mazdak / Clarke, Jennie T / Snook, Jeremy / Cipriano, Sarah D

    Pediatric dermatology

    2021  Volume 38, Issue 6, Page(s) 1575–1576

    Abstract: Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by urticarial plaques and/or vesicles and tense bullae. A unique presentation of BP can occur during pregnancy, the postpartum period after delivery, or with the initiation of ... ...

    Abstract Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by urticarial plaques and/or vesicles and tense bullae. A unique presentation of BP can occur during pregnancy, the postpartum period after delivery, or with the initiation of contraception, in which case it is referred to as pemphigoid gestationis (PG). In rare instances, newborns born to mothers with PG may also present with blisters due to transplacental passage of maternal anti-bullous pemphigoid 180 (BP180) or 230 (BP230) immunoglobulin G (IgG). In this report, we present an unusual case of neonatal PG in an infant born to an asymptomatic mother without a previous diagnosis of PG.
    MeSH term(s) Female ; Humans ; Infant, Newborn ; Mothers ; Pemphigoid Gestationis/diagnosis ; Pemphigoid Gestationis/drug therapy ; Pregnancy ; Rare Diseases
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.14849
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    Zs.A 1882: Show issues Location:
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  8. Article ; Online: Collapsing Glomerulopathy in Lambda Light Chain Amyloidosis: A Report of 2 Cases.

    Khalighi, Mazdak A / Gallan, Alexander J / Chang, Anthony / Meehan, Shane M

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2018  Volume 72, Issue 4, Page(s) 612–616

    Abstract: Amyloid nephropathy is an uncommon disease that frequently presents with reduced kidney function and proteinuria and, in developed nations, is most often associated with underlying paraproteinemia. The histologic appearance of glomerular amyloid ... ...

    Abstract Amyloid nephropathy is an uncommon disease that frequently presents with reduced kidney function and proteinuria and, in developed nations, is most often associated with underlying paraproteinemia. The histologic appearance of glomerular amyloid deposition includes mesangial and capillary wall infiltration by an amorphous eosinophilic material, and features of endo- or extracapillary proliferation are not typically seen. Rare cases of crescentic injury have been reported in a subset of patients with amyloid nephropathy, particularly those with amyloid derived from serum amyloid A protein. Collapsing glomerulopathy, which like crescentic injury is associated with an extracapillary proliferation, has not to our knowledge been reported in the setting of amyloid nephropathy. We report 2 patients presenting with acute kidney injury and nephrotic syndrome found to have amyloid nephropathy with prominent epithelial cell hyperplasia and glomerular collapse on biopsy. This injury is likely multifactorial and related to direct podocyte injury and vascular compromise and expands further the spectrum of paraprotein-associated renal injury.
    MeSH term(s) Acute Kidney Injury/etiology ; Acute Kidney Injury/pathology ; Acute Kidney Injury/therapy ; Aged ; Amyloidosis/complications ; Amyloidosis/pathology ; Amyloidosis/physiopathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biopsy, Needle ; Combined Modality Therapy ; Disease Progression ; Female ; Follow-Up Studies ; Glomerular Mesangium/pathology ; Glomerulonephritis/etiology ; Glomerulonephritis/pathology ; Glomerulonephritis/therapy ; Humans ; Immunohistochemistry ; Kidney Glomerulus/pathology ; Male ; Nephrotic Syndrome/etiology ; Nephrotic Syndrome/pathology ; Nephrotic Syndrome/therapy ; Renal Dialysis/methods ; Risk Assessment ; Serum Amyloid A Protein/metabolism ; Time Factors ; Treatment Outcome
    Chemical Substances Serum Amyloid A Protein
    Language English
    Publishing date 2018-06-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2018.04.009
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  9. Article ; Online: Hepatitis C-associated cryoglobulinemic glomerulonephritis with crystalline deposits.

    Khalighi, Mazdak A / Lassman, Charles R

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2013  Volume 62, Issue 2, Page(s) 384–389

    Abstract: Infection with hepatitis C virus has been associated with a number of extrahepatic manifestations, including kidney disease. Of the glomerular pathologic states described with hepatitis C virus infection, cryoglobulinemic glomerulonephritis is the most ... ...

    Abstract Infection with hepatitis C virus has been associated with a number of extrahepatic manifestations, including kidney disease. Of the glomerular pathologic states described with hepatitis C virus infection, cryoglobulinemic glomerulonephritis is the most prevalent. On kidney biopsy, cryoglobulinemic glomerulonephritis has a variable appearance, with a membranoproliferative pattern of injury as the most common light microscopic finding. Ultrastructurally, curved and paired microtubules are the most characteristic finding, but these also can be variable. We present a case of cryoglobulinemic glomerulonephritis with distinct and highly unusual ultrastructural findings.
    MeSH term(s) Aged ; Cryoglobulinemia/pathology ; Cryoglobulinemia/virology ; Crystallization ; Female ; Glomerulonephritis/pathology ; Glomerulonephritis/virology ; Hepatitis C/complications ; Hepatitis C/pathology ; Humans
    Language English
    Publishing date 2013-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2013.02.354
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  10. Article ; Online: De novo immune complex deposition in kidney allografts: a series of 32 patients.

    Lloyd, Isaac E / Ahmed, Faris / Revelo, Monica P / Khalighi, Mazdak A

    Human pathology

    2017  Volume 71, Page(s) 109–116

    Abstract: Immune complex deposition in kidney allografts can include both recurrent and de novo processes. Recurrent glomerulonephritis is a well-recognized phenomenon and has been shown to be a common cause of allograft failure. De novo immune complex-mediated ... ...

    Abstract Immune complex deposition in kidney allografts can include both recurrent and de novo processes. Recurrent glomerulonephritis is a well-recognized phenomenon and has been shown to be a common cause of allograft failure. De novo immune complex-mediated disease remains relatively poorly characterized, likely owing to the less frequent use of immunofluorescence and electron microscopy in the transplant setting. We performed a retrospective review of kidney allograft biopsies showing glomerular immune complex deposition. Cases with de novo deposits were identified and further organized into two groups depending on whether the immune complex deposition could be clinically and/or histologically classified. Thirty-two patients with de novo immune complex deposition were identified over a 7-year period. A broad range of immune complex-mediated injuries were observed, the majority (63%) of which could be readily classified either clinically or histologically. These included cases of membranous glomerulonephropathy, IgA nephropathy, infection-related glomerulonephritis and glomerulonephritis related to an underlying autoimmune process. A smaller subset of patients (37%) demonstrated immune complex deposition that was difficult to histologically or clinically classify. These patients typically showed mild mesangial immune complex deposition with co-dominant IgG and IgM staining by immunofluorescence microscopy. The presence of concurrent antibody-mediated rejection and donor-specific antibody positivity was significantly higher in the unclassifiable group. The significance of these deposits and their possible relationship to allograft rejection deserves further investigation.
    MeSH term(s) Adult ; Aged ; Allografts ; Antigen-Antibody Complex/immunology ; Female ; Glomerulonephritis/immunology ; Humans ; Immune Complex Diseases/immunology ; Immune Complex Diseases/pathology ; Kidney Transplantation ; Male ; Middle Aged ; Retrospective Studies
    Chemical Substances Antigen-Antibody Complex
    Language English
    Publishing date 2017-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207657-3
    ISSN 1532-8392 ; 0046-8177
    ISSN (online) 1532-8392
    ISSN 0046-8177
    DOI 10.1016/j.humpath.2017.10.012
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