LIVIVO - Search results -

Search results

Result 1 - 10 of total 50

Search options

Article ; Online: Low-carbohydrate diets in type 1 diabetes: balancing benefits and risks.

Hancock, Michael / Burns, Kharis / Gan, Seng Khee / Chew, Gerard T

Current opinion in endocrinology, diabetes, and obesity

2023 Volume 30, Issue 2, Page(s) 113–122

Abstract: Purpose of review: Interest in the use of calorie restriction with low-carbohydrate diets for patients with type 1 diabetes appears to be increasing despite physicians' discomfort about its longer term outcomes. A divergence in opinion regarding the ... ...

Abstract	Purpose of review: Interest in the use of calorie restriction with low-carbohydrate diets for patients with type 1 diabetes appears to be increasing despite physicians' discomfort about its longer term outcomes. A divergence in opinion regarding the balance of benefits and safety may lead to patient disengagement from conventional medical supervision. This review describes the current evidence regarding the benefits and risks of these diets and suggests a way forward to addressing this potential misalignment between the aims of patients and their physicians. Recent findings: Benefits on glycaemia are observed in many studies, with improved HbA1c, time within target range and reduced glycaemic variability. A characteristic lipid profile with high LDL cholesterol is observed in many patients, but association with future cardiovascular events is undefined. A negative impact on growth has been identified in the paediatric population, and impact on mental health and disordered eating is of theoretical concern, without measurement in clinical studies. Summary: Patients will continue to trial and, with immediate glycaemic benefits, potentially remain on lower carbohydrate diets irrespective of concern by treating physicians about potential longer term risks. A supportive multidisciplinary approach with greater nutritional supervision and more research is required, to allow these patients to achieve their desired glycaemic outcomes without compromising longer term safety.
MeSH term(s)	Child ; Humans ; Diabetes Mellitus, Type 1 ; Blood Glucose ; Diet, Carbohydrate-Restricted ; Risk Assessment
Chemical Substances	Blood Glucose
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2272017-0
ISSN	1752-2978 ; 1752-296X
ISSN (online)	1752-2978
ISSN	1752-296X
DOI	10.1097/MED.0000000000000797
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 1363: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Clinicians' perceptions of medical student teaching in a tertiary hospital.

Lan, Nick S R / Nasim, Sana / Gan, Seng Khee / Chew, Gerard T

Education for health (Abingdon, England)

2022 Volume 35, Issue 1, Page(s) 16–19

Abstract: Background: Medical student placements in teaching hospitals are a cornerstone for gaining clinical experience. However, the ever-evolving nature of health care has also changed the delivery of student education. Few studies have examined clinicians' ... ...

Abstract	Background: Medical student placements in teaching hospitals are a cornerstone for gaining clinical experience. However, the ever-evolving nature of health care has also changed the delivery of student education. Few studies have examined clinicians' perspectives toward teaching students in this setting. We sought to explore the attitudes of clinicians involved in teaching medical students at an Australian tertiary hospital. Methods: Clinicians were invited by email to complete an anonymous online survey developed using a combination of questions from previously validated surveys. The questions utilized 5-point Likert scale statements and were based around the themes of "personal purpose and enjoyment of teaching" and "barriers and challenges to teaching." Results for each question are presented as frequency and percentage. Results: Of 490 invited, 67 (13.7%) consultant clinicians from various specialties responded. The majority (>92%) enjoy teaching and see it as part of their work. However, approximately half thought that medical student teaching was under-recognized and half did not have adequate time to teach due to workload. Approximately 60% responded that there was insufficient time to get to know students to provide feedback and approximately 40% indicated that the scope of student knowledge and desired outcomes are not clearly defined by medical schools. Discussion: Our contemporary survey identifies modifiable factors which should be targeted. If these factors are addressed successfully, it may allow the hospital and university medical school to harness the valuable resource of clinical teachers. This could enhance the medical student experience and promote a culture of teaching and learning in hospitals.
MeSH term(s)	Humans ; Students, Medical ; Tertiary Care Centers ; Australia ; Education, Medical/methods ; Schools, Medical ; Teaching ; Education, Medical, Undergraduate/methods
Language	English
Publishing date	2022-11-11
Publishing country	India
Document type	Journal Article
ZDB-ID	1318454-4
ISSN	1469-5804 ; 1357-6283
ISSN (online)	1469-5804
ISSN	1357-6283
DOI	10.4103/efh.efh_312_21
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 3294: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The rising tsunami of poor muscle health and sarcopenia in Asia-Pacific: Time for focused attention and targeted interventions.

Chew, Samuel T H / Nguyen, Hoai Thi Thu / Joshi, Shashank / Kamaruzzaman, Shahrul Bahyah / Landi, Francesco / Manuel, Maria Victoria / Moral, Patrick Gerard / Muangpaisan, Weerasak / Nangia, Vivek / Setiati, Siti / Yoshimura, Yoshihiro / Yu, Solomon / Maier, Andrea B

Archives of gerontology and geriatrics

2023 Volume 117, Page(s) 105275

MeSH term(s)	Humans ; Sarcopenia ; Asia/epidemiology ; Muscles ; Attention
Language	English
Publishing date	2023-11-12
Publishing country	Netherlands
Document type	Letter
ZDB-ID	603162-6
ISSN	1872-6976 ; 0167-4943
ISSN (online)	1872-6976
ISSN	0167-4943
DOI	10.1016/j.archger.2023.105275
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1729: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: HSV-2 and atherosclerosis: adding to the alphabet soup of coronary risk in HIV infection.

Chew, Gerard T / Watts, Gerald F

Atherosclerosis

2012 Volume 223, Issue 2, Page(s) 278–279

MeSH term(s)	Coinfection/epidemiology ; Coronary Artery Disease/epidemiology ; HIV Infections/epidemiology ; Herpes Simplex/epidemiology ; Herpesvirus 2, Human/isolation & purification ; Humans ; Male
Language	English
Publishing date	2012-08
Publishing country	Ireland
Document type	Comment ; Journal Article
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2012.04.027
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 226: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The effect of Vitamin-K

Bellinge, Jamie W / Francis, Roslyn J / Lee, Sing Ching / Vickery, Alistair / Macdonald, William / Gan, Seng Khee / Chew, Gerard T / Phillips, Michael / Lewis, Joshua R / Watts, Gerald F / Schultz, Carl J

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

2021 Volume 29, Issue 4, Page(s) 1855–1866

Abstract: Background: There is currently no treatment for attenuating progression of arterial calcification. : Methods: 154 patients with diabetes mellitus and coronary calcification, as detected using computed tomography (CT), were randomized to one of four ... ...

Abstract	Background: There is currently no treatment for attenuating progression of arterial calcification. Methods: 154 patients with diabetes mellitus and coronary calcification, as detected using computed tomography (CT), were randomized to one of four treatment groups (placebo/placebo, vitamin-K Results: 149 subjects completed follow-up (vitamin-K Conclusions: In patients with type 2 diabetes, neither vitamin-K Clinical trial registration: ACTRN12616000024448.
MeSH term(s)	Colchicine/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Double-Blind Method ; Humans ; Positron Emission Tomography Computed Tomography ; Sodium Fluoride ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/drug therapy ; Vitamin K 1 ; Vitamins
Chemical Substances	Vitamins ; Vitamin K 1 (84-80-0) ; Sodium Fluoride (8ZYQ1474W7) ; Colchicine (SML2Y3J35T)
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1212505-2
ISSN	1532-6551 ; 1071-3581
ISSN (online)	1532-6551
ISSN	1071-3581
DOI	10.1007/s12350-021-02589-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4121: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Recent advances in pharmacotherapy for hypertriglyceridemia.

Sahebkar, Amirhossein / Chew, Gerard T / Watts, Gerald F

Progress in lipid research

2014 Volume 56, Page(s) 47–66

Abstract: Elevated plasma triglyceride (TG) concentrations are associated with an increased risk of atherosclerotic cardiovascular disease (CVD), hepatic steatosis and pancreatitis. Existing pharmacotherapies, such as fibrates, n-3 polyunsaturated fatty acids ( ... ...

Abstract	Elevated plasma triglyceride (TG) concentrations are associated with an increased risk of atherosclerotic cardiovascular disease (CVD), hepatic steatosis and pancreatitis. Existing pharmacotherapies, such as fibrates, n-3 polyunsaturated fatty acids (PUFAs) and niacin, are partially efficacious in correcting elevated plasma TG. However, several new TG-lowering agents are in development that can regulate the transport of triglyceride-rich lipoproteins (TRLs) by modulating key enzymes, receptors or ligands involved in their metabolism. Balanced dual peroxisome proliferator-activated receptor (PPAR) α/γ agonists, inhibitors of microsomal triglyceride transfer protein (MTTP) and acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1), incretin mimetics, and apolipoprotein (apo) B-targeted antisense oligonucleotides (ASOs) can all decrease the production and secretion of TRLs; inhibitors of cholesteryl ester transfer protein (CETP) and angiopoietin-like proteins (ANGPTLs) 3 and 4, monoclonal antibodies (Mabs) against proprotein convertase subtilisin/kexin type 9 (PCSK9), apoC-III-targeted ASOs, selective peroxisome proliferator-activated receptor modulators (SPPARMs), and lipoprotein lipase (LPL) gene replacement therapy (alipogene tiparvovec) enhance the catabolism and clearance of TRLs; dual PPAR-α/δ agonists and n-3 polyunsaturated fatty acids can lower plasma TG by regulating both TRL secretion and catabolism. Varying degrees of TG reduction have been reported with the use of these therapies, and for some agents such as CETP inhibitors and PCSK9 Mabs findings have not been consistent. Whether they reduce CVD events has not been established. Trials investigating the effect of CETP inhibitors (anacetrapib and evacetrapib) and PCSK9 Mabs (AMG-145 and REGN727/SAR236553) on CVD outcomes are currently in progress, although these agents also regulate LDL metabolism and, in the case of CETP inhibitors, HDL metabolism. Further to CVD risk reduction, these new treatments might also have a potential role in the management of diabetes and non-alcoholic fatty liver disease owing to their insulin-sensitizing action (PPAR-α/γ agonists) and potential capacity to decrease hepatic TG accumulation (PPAR-α/δ agonists and DGAT-1 inhibitors), but this needs to be tested in future trials. We summarize the clinical trial findings regarding the efficacy and safety of these novel therapies for hypertriglyceridemia.
MeSH term(s)	Atherosclerosis/blood ; Atherosclerosis/complications ; Atherosclerosis/prevention & control ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/prevention & control ; Drug Therapy/methods ; Drug Therapy/trends ; Fatty Liver/blood ; Fatty Liver/complications ; Fatty Liver/prevention & control ; Humans ; Hypertriglyceridemia/complications ; Hypertriglyceridemia/drug therapy ; Molecular Targeted Therapy/methods ; Molecular Targeted Therapy/trends ; Pancreatitis/blood ; Pancreatitis/complications ; Pancreatitis/prevention & control ; Treatment Outcome
Language	English
Publishing date	2014-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	282560-0
ISSN	1873-2194 ; 0079-6832 ; 0163-7827
ISSN (online)	1873-2194
ISSN	0079-6832 ; 0163-7827
DOI	10.1016/j.plipres.2014.07.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 298: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease.

Sahebkar, Amirhossein / Chew, Gerard T / Watts, Gerald F

Expert opinion on pharmacotherapy

2014 Volume 15, Issue 4, Page(s) 493–503

Abstract: Introduction: Novel peroxisome proliferator-activated receptor (PPAR) modulators (selective PPAR modulators [SPPARMs]) and dual PPAR agonists may have an important role in the treatment of cardiometabolic disorders owing to lipid-modifying, insulin- ... ...

Abstract	Introduction: Novel peroxisome proliferator-activated receptor (PPAR) modulators (selective PPAR modulators [SPPARMs]) and dual PPAR agonists may have an important role in the treatment of cardiometabolic disorders owing to lipid-modifying, insulin-sensitizing and anti-inflammatory effects. Areas covered: This review summarizes the efficacy of new PPAR agonists and SPPARMs that are under development for the treatment of atherogenic dyslipidemia and non-alcoholic fatty liver disease (NAFLD). Expert opinion: ABT-335 is a new formulation of fenofibrate that has been approved for concomitant use with statins. K-877, a SPPARM-α with encouraging preliminary results in modulating atherogenic dyslipidemia, and INT131, a SPPARM-γ with predominantly insulin-sensitizing actions, may also have favorable lipid-modifying effects. Although the development of dual PPAR-α/γ agonists (glitazars) and the SPPARM-δ GW501516 has been abandoned because of safety issues, another SPPARM-δ (MBX-8025) and a dual PPAR-α/δ agonist (GFT-505) have shown promising efficacy in decreasing plasma triglyceride and increasing high-density lipoprotein cholesterol concentrations, as well as improving insulin sensitivity and liver function. The beneficial effects of GFT-505 are complemented by preclinical findings that indicate reduction of hepatic fat accumulation, inflammation and fibrosis, making it a promising candidate for the treatment of NAFLD/nonalcoholic steatohepatitis (NASH). Long-term trials are required to test the efficacy and safety of these new PPAR agonists in reducing cardiovascular outcomes and treating NAFLD/NASH.
MeSH term(s)	Acetates/therapeutic use ; Animals ; Atherosclerosis/prevention & control ; Chalcones/therapeutic use ; Cholesterol, HDL/blood ; Dyslipidemias/drug therapy ; Dyslipidemias/metabolism ; Fatty Liver/drug therapy ; Fatty Liver/metabolism ; Fenofibrate/analogs & derivatives ; Fenofibrate/therapeutic use ; Humans ; Insulin Resistance ; Lipoproteins, HDL/blood ; Non-alcoholic Fatty Liver Disease ; Peroxisome Proliferator-Activated Receptors/agonists ; Peroxisome Proliferator-Activated Receptors/metabolism ; Propionates/therapeutic use ; Quinolines/therapeutic use ; Sulfonamides/therapeutic use ; Thiazoles/therapeutic use ; Triazoles/therapeutic use ; Triglycerides/blood
Chemical Substances	(2-methyl-4-(5-methyl-2-(4-trifluoromethyl-phenyl)-2H-(1,2,3)triazol-4-ylmethylsulfanyl)phenoxy)acetic acid ; 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid ; 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid ; Acetates ; Chalcones ; Cholesterol, HDL ; GW 501516 ; INT 131 ; Lipoproteins, HDL ; Peroxisome Proliferator-Activated Receptors ; Propionates ; Quinolines ; Sulfonamides ; Thiazoles ; Triazoles ; Triglycerides ; Fenofibrate (U202363UOS)
Language	English
Publishing date	2014-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2001535-5
ISSN	1744-7666 ; 1465-6566
ISSN (online)	1744-7666
ISSN	1465-6566
DOI	10.1517/14656566.2014.876992
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5130: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Mortality and major postoperative complications within 1 year after vascular surgery: a prospective cohort study.

Polok, Kamil / Biccard, Bruce M / Chan, Matthew T V / Archbold, R Andrew / Wang, Chew Yin / Sigamani, Alben / Urrútia, Gerard / Cruz, Patricia / Srinathan, Sadeesh K / Szalay, David / Harlock, John / Tittley, Jacques G / Elias, Fadi / Jacka, Michael J / Malaga, German / Berwanger, Otavio / Studzińska, Dorota / Górka, Jacek / Montes, Félix R /

Chow, Clara K / Ackland, Gareth L / Dubois, Luc / Sapsford, Robert J / Williams, Colin / Cortés, Olga L / Devereaux, Philip J / Szczeklik, Wojciech

Polish archives of internal medicine

2024 Volume 134, Issue 2

Abstract: ... hospitalized for at least 1 night postoperatively. Plasma cardiac troponin T concentration was measured ...

Abstract	Introduction: Patients undergoing vascular procedures are prone to developing postoperative complications affecting their short‑term mortality. Prospective reports describing the incidence of long‑term complications after vascular surgery are lacking. Objectives: We aimed to describe the incidence of complications 1 year after vascular surgery and to evaluate an association between myocardial injury after noncardiac surgery (MINS) and 1‑year mortality. Patients and methods: This is a substudy of a large prospective cohort study Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION). Recruitment took place in 28 centers across 14 countries from August 2007 to November 2013. We enrolled patients aged 45 years or older undergoing vascular surgery, receiving general or regional anesthesia, and hospitalized for at least 1 night postoperatively. Plasma cardiac troponin T concentration was measured before the surgery and on the first, second, and third postoperative day. The patients or their relatives were contacted 1 year after the procedure to assess the incidence of major postoperative complications. Results: We enrolled 2641 patients who underwent vascular surgery, 2534 (95.9%) of whom completed 1‑year follow‑up. Their mean (SD) age was 68.2 (9.8) years, and the cohort was predominantly male (77.5%). The most frequent 1‑year complications were myocardial infarction (224/2534, 8.8%), amputation (187/2534, 7.4%), and congestive heart failure (67/2534, 2.6%). The 1‑year mortality rate was 8.8% (223/2534). MINS occurred in 633 patients (24%) and was associated with an increased 1‑year mortality (hazard ratio, 2.82; 95% CI, 2.14-3.72; P <0.001). Conclusions: The incidence of major postoperative complications after vascular surgery is high. The occurrence of MINS is associated with a nearly 3‑fold increase in 1‑year mortality.
MeSH term(s)	Humans ; Male ; Female ; Prospective Studies ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Myocardial Infarction/etiology ; Vascular Surgical Procedures/adverse effects ; Troponin T ; Heart Injuries
Chemical Substances	Troponin T
Language	English
Publishing date	2024-01-02
Publishing country	Poland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16645
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 360: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Is vitamin D testing at a tertiary referral hospital consistent with guideline recommendations?

Norton, Katherine / Vasikaran, Samuel D / Chew, Gerard T / Glendenning, Paul

Pathology

2015 Volume 47, Issue 4, Page(s) 335–340

Abstract: To determine if 25 hydroxyvitamin D (25OHD) testing at our tertiary referral hospital is consistent with guideline recommendations concerning the clinical indications for testing, the timing of repeat testing and utilisation of the test result, we ... ...

Abstract	To determine if 25 hydroxyvitamin D (25OHD) testing at our tertiary referral hospital is consistent with guideline recommendations concerning the clinical indications for testing, the timing of repeat testing and utilisation of the test result, we conducted a retrospective audit of electronic laboratory and patient case records. We included adult inpatients and outpatients who had serum 25OHD measured during a randomly selected one-week audit period and who had patient case records available for detailed review. The audit sample comprised 184 serum 25OHD measurements (134 initial and 50 repeat tests). There were 81 (60%) initial and 15 (30%) repeat tests [96 (52%) overall] that were consistent with guideline recommendations concerning clinical indication, timing of repeat testing and utilisation of result. Almost half the 25 hydroxyvitamin D tests audited were potentially unnecessary and/or not utilised clinically. Improved adherence to guideline recommendations for 25 hydroxyvitamin D testing, utilisation of test results and enforcement of new indications for testing due to be introduced by Medicare Australia could result in significant cost savings without adversely affecting patient outcomes.
MeSH term(s)	Adult ; Aged ; Female ; Guideline Adherence/statistics & numerical data ; Humans ; Male ; Medical Audit ; Middle Aged ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/statistics & numerical data ; Tertiary Care Centers/standards ; Tertiary Care Centers/statistics & numerical data ; Vitamin D/analogs & derivatives ; Vitamin D/blood
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2015-06
Publishing country	England
Document type	Journal Article
ZDB-ID	7085-3
ISSN	1465-3931 ; 0031-3025
ISSN (online)	1465-3931
ISSN	0031-3025
DOI	10.1097/PAT.0000000000000267
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 723: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients.

Hamilton, Sandra J / Chew, Gerard T / Watts, Gerald F

Diabetes care

2009 Volume 32, Issue 5, Page(s) 810–812

Abstract: Objective: The vascular benefits of statins might be attenuated by inhibition of coenzyme Q(10) (CoQ(10)) synthesis. We investigated whether oral CoQ(10) supplementation improves endothelial dysfunction in statin-treated type 2 diabetic patients.: ... ...

Abstract	Objective: The vascular benefits of statins might be attenuated by inhibition of coenzyme Q(10) (CoQ(10)) synthesis. We investigated whether oral CoQ(10) supplementation improves endothelial dysfunction in statin-treated type 2 diabetic patients. Research design and methods: In a double-blind crossover study, 23 statin-treated type 2 diabetic patients with LDL cholesterol <2.5 mmol/l and endothelial dysfunction (brachial artery flow-mediated dilatation [FMD] <5.5%) were randomized to oral CoQ(10) (200 mg/day) or placebo for 12 weeks. We measured brachial artery FMD and nitrate-mediated dilatation (NMD) by ultrasonography. Plasma F(2)-isoprostane and 24-h urinary 20-hydroxyeicosatetraenoic acid (HETE) levels were measured as systemic oxidative stress markers. Results: Compared with placebo, CoQ(10) supplementation increased brachial artery FMD by 1.0 +/- 0.5% (P = 0.04), but did not alter NMD (P = 0.66). CoQ(10) supplementation also did not alter plasma F(2)-isoprostane (P = 0.58) or urinary 20-HETE levels (P = 0.28). Conclusions: CoQ(10) supplementation improved endothelial dysfunction in statin-treated type 2 diabetic patients, possibly by altering local vascular oxidative stress.
MeSH term(s)	Adult ; Aged ; Blood Flow Velocity/drug effects ; Blood Flow Velocity/physiology ; Blood Pressure/drug effects ; Brachial Artery/drug effects ; Brachial Artery/physiopathology ; Cholesterol, LDL/blood ; Cross-Over Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/physiopathology ; Double-Blind Method ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiopathology ; Humans ; Hydroxyeicosatetraenoic Acids/urine ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Middle Aged ; Oxidative Stress/drug effects ; Placebos ; Ubiquinone/analogs & derivatives ; Ubiquinone/therapeutic use ; Vasodilation/drug effects
Chemical Substances	Cholesterol, LDL ; Hydroxyeicosatetraenoic Acids ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Placebos ; Ubiquinone (1339-63-5) ; 20-hydroxy-5,8,11,14-eicosatetraenoic acid (79551-86-3) ; coenzyme Q10 (EJ27X76M46)
Language	English
Publishing date	2009-02-19
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc08-1736
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 365: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito