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  1. Article ; Online: Improving the quality of image generation in art with top-k training and cyclic generative methods.

    Vela, Laura / Fuentes-Hurtado, Félix / Colomer, Adrián

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 17764

    Abstract: ... Impressionism and, specifically, that imitate the style of one of its greatest exponents, the painter Claude ...

    Abstract The creation of artistic images through the use of Artificial Intelligence is an area that has been gaining interest in recent years. In particular, the ability of Neural Networks to separate and subsequently recombine the style of different images, generating a new artistic image with the desired style, has been a source of study and attraction for the academic and industrial community. This work addresses the challenge of generating artistic images that are framed in the style of pictorial Impressionism and, specifically, that imitate the style of one of its greatest exponents, the painter Claude Monet. After having analysed several theoretical approaches, the Cycle Generative Adversarial Networks are chosen as base model. From this point, a new training methodology which has not been applied to cyclical systems so far, the top-k approach, is implemented. The proposed system is characterised by using in each iteration of the training those k images that, in the previous iteration, have been able to better imitate the artist's style. To evaluate the performance of the proposed methods, the results obtained with both methodologies, basic and top-k, have been analysed from both a quantitative and qualitative perspective. Both evaluation methods demonstrate that the proposed top-k approach recreates the author's style in a more successful manner and, at the same time, also demonstrate the ability of Artificial Intelligence to generate something as creative as impressionist paintings.
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44289-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Successional Stages in Infant Gut Microbiota Maturation.

    Beller, Leen / Deboutte, Ward / Falony, Gwen / Vieira-Silva, Sara / Tito, Raul Yhossef / Valles-Colomer, Mireia / Rymenans, Leen / Jansen, Daan / Van Espen, Lore / Papadaki, Maria Ioanna / Shi, Chenyan / Yinda, Claude Kwe / Zeller, Mark / Faust, Karoline / Van Ranst, Marc / Raes, Jeroen / Matthijnssens, Jelle

    mBio

    2021  Volume 12, Issue 6, Page(s) e0185721

    Abstract: Disturbances in the primary colonization of the infant gut can result in lifelong consequences and have been associated with a range of host conditions. Although early-life factors have been shown to affect infant gut microbiota development, our current ... ...

    Abstract Disturbances in the primary colonization of the infant gut can result in lifelong consequences and have been associated with a range of host conditions. Although early-life factors have been shown to affect infant gut microbiota development, our current understanding of human gut colonization in early life remains limited. To gain more insights into the unique dynamics of this rapidly evolving ecosystem, we investigated the microbiota over the first year of life in eight densely sampled infants (
    MeSH term(s) Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Cohort Studies ; Feces/microbiology ; Female ; Gastrointestinal Microbiome ; Gastrointestinal Tract/microbiology ; Humans ; Infant ; Infant, Newborn/growth & development ; Male
    Language English
    Publishing date 2021-12-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.01857-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Gap junction-mediated intercellular communication in the adrenal medulla: an additional ingredient of stimulus-secretion coupling regulation.

    Colomer, Claude / Martin, Agnès O / Desarménien, Michel G / Guérineau, Nathalie C

    Biochimica et biophysica acta

    2012  Volume 1818, Issue 8, Page(s) 1937–1951

    Abstract: The traditional understanding of stimulus-secretion coupling in adrenal neuroendocrine chromaffin cells states that catecholamines are released upon trans-synaptic sympathetic stimulation mediated by acetylcholine released from the splanchnic nerve ... ...

    Abstract The traditional understanding of stimulus-secretion coupling in adrenal neuroendocrine chromaffin cells states that catecholamines are released upon trans-synaptic sympathetic stimulation mediated by acetylcholine released from the splanchnic nerve terminals. Although this statement remains largely true, it deserves to be tempered. In addition to its neurogenic control, catecholamine secretion also depends on a local gap junction-mediated communication between chromaffin cells. We review here the insights gained since the first description of gap junctions in the adrenal medullary tissue. Adrenal stimulus-secretion coupling now appears far more intricate than was previously envisioned and its deciphering represents a challenge for neurobiologists engaged in the study of the regulation of neuroendocrine secretion. This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics.
    MeSH term(s) Adrenal Gland Neoplasms/metabolism ; Adrenal Medulla/metabolism ; Animals ; Biophysics/methods ; Catecholamines/metabolism ; Cell Communication/physiology ; Cell Line, Tumor ; Chromaffin Cells/cytology ; Connexins/metabolism ; Gap Junctions/physiology ; Gene Expression Regulation ; Humans ; Mice ; Models, Biological ; Neurosecretory Systems ; Rats
    Chemical Substances Catecholamines ; Connexins
    Language English
    Publishing date 2012-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamem.2011.07.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Revisiting the stimulus-secretion coupling in the adrenal medulla: role of gap junction-mediated intercellular communication.

    Colomer, Claude / Desarménien, Michel G / Guérineau, Nathalie C

    Molecular neurobiology

    2009  Volume 40, Issue 1, Page(s) 87–100

    Abstract: The current view of stimulation-secretion coupling in adrenal neuroendocrine chromaffin cells holds that catecholamines are released upon transsynaptic sympathetic stimulation mediated by acetylcholine released from the splanchnic nerve terminals. ... ...

    Abstract The current view of stimulation-secretion coupling in adrenal neuroendocrine chromaffin cells holds that catecholamines are released upon transsynaptic sympathetic stimulation mediated by acetylcholine released from the splanchnic nerve terminals. However, this traditional vertical scheme would merit to be revisited in the light of recent data. Although electrical discharges invading the splanchnic nerve endings are the major physiological stimulus to trigger catecholamine release in vivo, growing evidence indicates that intercellular chromaffin cell communication mediated by gap junctions represents an additional route by which biological signals (electrical activity, changes in intracellular Ca(2+) concentration,...) propagate between adjacent cells and trigger subsequent catecholamine exocytosis. Accordingly, it has been proposed that gap junctional communication efficiently helps synapses to lead chromaffin cell function and, in particular, hormone secretion. The experimental clues supporting this hypothesis are presented and discussed with regards to both interaction with the excitatory cholinergic synaptic transmission and physiopathology of the adrenal medulla.
    MeSH term(s) Adrenal Medulla/cytology ; Adrenal Medulla/metabolism ; Animals ; Catecholamines/metabolism ; Cell Communication ; Chromaffin Cells/metabolism ; Gap Junctions/physiology ; Humans ; Synaptic Transmission
    Chemical Substances Catecholamines
    Language English
    Publishing date 2009-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-009-8073-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Revisiting the Stimulus-Secretion Coupling in the Adrenal Medulla: Role of Gap Junction-Mediated Intercellular Communication

    Colomer, Claude / Desarménien, Michel G / Guérineau, Nathalie C

    Molecular neurobiology. 2009 Aug., v. 40, no. 1

    2009  

    Abstract: The current view of stimulation-secretion coupling in adrenal neuroendocrine chromaffin cells holds that catecholamines are released upon transsynaptic sympathetic stimulation mediated by acetylcholine released from the splanchnic nerve terminals. ... ...

    Abstract The current view of stimulation-secretion coupling in adrenal neuroendocrine chromaffin cells holds that catecholamines are released upon transsynaptic sympathetic stimulation mediated by acetylcholine released from the splanchnic nerve terminals. However, this traditional vertical scheme would merit to be revisited in the light of recent data. Although electrical discharges invading the splanchnic nerve endings are the major physiological stimulus to trigger catecholamine release in vivo, growing evidence indicates that intercellular chromaffin cell communication mediated by gap junctions represents an additional route by which biological signals (electrical activity, changes in intracellular Ca²⁺ concentration,[em leader]) propagate between adjacent cells and trigger subsequent catecholamine exocytosis. Accordingly, it has been proposed that gap junctional communication efficiently helps synapses to lead chromaffin cell function and, in particular, hormone secretion. The experimental clues supporting this hypothesis are presented and discussed with regards to both interaction with the excitatory cholinergic synaptic transmission and physiopathology of the adrenal medulla.
    Language English
    Dates of publication 2009-08
    Size p. 87-100.
    Publisher Humana Press Inc
    Publishing place New York
    Document type Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-009-8073-0
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Stress-induced intercellular communication remodeling in the rat adrenal medulla.

    Colomer, Claude / Lafont, Chrystel / Guérineau, Nathalie C

    Annals of the New York Academy of Sciences

    2008  Volume 1148, Page(s) 106–111

    Abstract: To understand the mechanisms by which a prolonged exposure to stress enhances catecholamine secretion, we examined the effects of 5-day cold exposure on cell-cell communication pathways in the rat adrenal medulla. Upon stress, the neurosecretory tissue ... ...

    Abstract To understand the mechanisms by which a prolonged exposure to stress enhances catecholamine secretion, we examined the effects of 5-day cold exposure on cell-cell communication pathways in the rat adrenal medulla. Upon stress, the neurosecretory tissue undergoes dramatic morphofunctional changes resulting in increased chromaffin cell excitability, upregulation of both chemical transmission at the splanchnic nerve terminal-chromaffin cell synapses and spreading of gap junction-permeant Lucifer yellow between cells. All these changes converge to improve the stimulus-secretion coupling efficiency within the adrenal medulla and subsequently to adapt catecholamine release to a sustained organism demand.
    MeSH term(s) Action Potentials/physiology ; Adrenal Medulla/cytology ; Adrenal Medulla/physiology ; Animals ; Catecholamines/metabolism ; Cell Communication/physiology ; Cold Temperature ; Electrophysiology ; Male ; Rats ; Rats, Wistar ; Stress, Physiological/physiology ; Synaptic Transmission/physiology
    Chemical Substances Catecholamines
    Language English
    Publishing date 2008-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1196/annals.1410.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Ernest Cabaner

    Colomer, Claude

    1833 - 1881; musicien catalan, grand animateur de la vie parisienne, ami intime de Rimbaud et des impressionnistes

    (Revista Terra nostra ; 82/83)

    1993  

    Author's details Claude Colomer
    Series title Revista Terra nostra ; 82/83
    Language French
    Size 248 S, Ill., zahlr. Noten
    Publisher Centre de Recerques i d'Estudis Catalans, Univ. de Perpinyà
    Publishing place Perpinyà
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book: Histoire des Catalans

    Colomer, Claude / Bouille, Michel

    1990  

    Author's details Claude Colomer [&] Michel Bouille
    Language French
    Size 407 S., 12 Bl. Abb, ill
    Publisher Milan
    Publishing place Toulouse
    Document type Book
    Note Includes bibliographical references (p. 401-403)
    ISBN 2867265312 ; 9782867265310
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Functional characterization of alpha9-containing cholinergic nicotinic receptors in the rat adrenal medulla: implication in stress-induced functional plasticity.

    Colomer, Claude / Olivos-Oré, Luis A / Vincent, Anne / McIntosh, J Michael / Artalejo, Antonio R / Guérineau, Nathalie C

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2010  Volume 30, Issue 19, Page(s) 6732–6742

    Abstract: An increase in circulating adrenal catecholamine levels constitutes one of the mechanisms whereby organisms cope with stress. Accordingly, stimulus-secretion coupling within the stressed adrenal medullary tissue undergoes persistent remodeling. In ... ...

    Abstract An increase in circulating adrenal catecholamine levels constitutes one of the mechanisms whereby organisms cope with stress. Accordingly, stimulus-secretion coupling within the stressed adrenal medullary tissue undergoes persistent remodeling. In particular, cholinergic synaptic neurotransmission between splanchnic nerve terminals and chromaffin cells is upregulated in stressed rats. Since synaptic transmission is mainly supported by activation of postsynaptic neuronal acetylcholine nicotinic receptors (nAChRs), we focused our study on the role of alpha9-containing nAChRs, which have been recently described in chromaffin cells. Taking advantage of their specific blockade by the alpha-conotoxin RgIA (alpha-RgIA), we unveil novel functional roles for these receptors in the stimulus-secretion coupling of the medulla. First, we show that in rat acute adrenal slices, alpha9-containing nAChRs codistribute with synaptophysin and significantly contribute to EPSCs. Second, we show that these receptors are involved in the tonic inhibitory control exerted by cholinergic activity on gap junctional coupling between chromaffin cells, as evidenced by an increased Lucifer yellow diffusion within the medulla in alpha-RgIA-treated slices. Third, we unexpectedly found that alpha9-containing nAChRs dominantly (>70%) contribute to acetylcholine-induced current in cold-stressed rats, whereas alpha3 nAChRs are the main contributing channels in unstressed animals. Consistently, expression levels of alpha9 nAChR transcript and protein are overexpressed in cold-stressed rats. As a functional relevance, we propose that upregulation of alpha9-containing nAChR channels and ensuing dominant contribution in cholinergic signaling may be one of the mechanisms whereby adrenal medullary tissue appropriately adapts to increased splanchnic nerve electrical discharges occurring in stressful situations.
    MeSH term(s) Acetylcholine/metabolism ; Animals ; Cold Temperature ; Diffusion ; Excitatory Postsynaptic Potentials/physiology ; Gap Junctions/physiology ; In Vitro Techniques ; Isoquinolines ; Medulla Oblongata/physiology ; Neural Inhibition/physiology ; Neuronal Plasticity/physiology ; Neurons/physiology ; Rats ; Rats, Wistar ; Receptors, Nicotinic/metabolism ; Stress, Physiological/physiology ; Synaptic Transmission/physiology ; Synaptophysin/metabolism ; Time Factors ; Up-Regulation
    Chemical Substances Isoquinolines ; Receptors, Nicotinic ; Synaptophysin ; nAChR alpha9 ; nicotinic receptor subunit alpha3 ; lucifer yellow (9654F8OVKE) ; Acetylcholine (N9YNS0M02X)
    Language English
    Publishing date 2010-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.4997-09.2010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Regulator of G protein signaling-4 controls fatty acid and glucose homeostasis.

    Iankova, Irena / Chavey, Carine / Clapé, Cyrielle / Colomer, Claude / Guérineau, Nathalie C / Grillet, Nicolas / Brunet, Jean-François / Annicotte, Jean-Sébastien / Fajas, Lluis

    Endocrinology

    2008  Volume 149, Issue 11, Page(s) 5706–5712

    Abstract: Circulating free fatty acids are a reflection of the balance between lipogenesis and lipolysis that takes place mainly in adipose tissue. We found that mice deficient for regulator of G protein signaling (RGS)-4 have increased circulating catecholamines, ...

    Abstract Circulating free fatty acids are a reflection of the balance between lipogenesis and lipolysis that takes place mainly in adipose tissue. We found that mice deficient for regulator of G protein signaling (RGS)-4 have increased circulating catecholamines, and increased free fatty acids. Consequently, RGS4-/- mice have increased concentration of circulating free fatty acids; abnormally accumulate fatty acids in liver, resulting in liver steatosis; and show a higher degree of glucose intolerance and decreased insulin secretion in pancreas. We show in this study that RGS4 controls adipose tissue lipolysis through regulation of the secretion of catecholamines by adrenal glands. RGS4 controls the balance between adipose tissue lipolysis and lipogenesis, secondary to its role in the regulation of catecholamine secretion by adrenal glands. RGS4 therefore could be a good target for the treatment of metabolic diseases.
    MeSH term(s) 3T3-L1 Cells ; Adipose Tissue/metabolism ; Animals ; Cells, Cultured ; Diet, Atherogenic ; Fasting/blood ; Fatty Acids/blood ; Fatty Acids/metabolism ; Fatty Liver/complications ; Fatty Liver/genetics ; Glucose/metabolism ; Homeostasis/genetics ; Hyperglycemia/complications ; Hyperglycemia/genetics ; Hyperinsulinism/complications ; Hyperinsulinism/genetics ; Insulin/metabolism ; Insulin Secretion ; Lipogenesis/genetics ; Lipolysis/genetics ; Mice ; Mice, Knockout ; RGS Proteins/genetics ; RGS Proteins/physiology
    Chemical Substances Fatty Acids ; Insulin ; RGS Proteins ; RGS4 protein (175335-35-0) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2008-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/en.2008-0717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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