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Article: scRNAseq and High-Throughput Spatial Analysis of Tumor and Normal Microenvironment in Solid Tumors Reveal a Possible Origin of Circulating Tumor Hybrid Cells.

Ali, Abdullah Mahmood / Raza, Azra

2024 Volume 16, Issue 7

Abstract: Metastatic cancer is a leading cause of death in cancer patients worldwide. While circulating hybrid cells (CHCs) are implicated in metastatic spread, studies documenting their tissue origin remain sparse, with limited candidate approaches using one-two ... ...

Abstract	Metastatic cancer is a leading cause of death in cancer patients worldwide. While circulating hybrid cells (CHCs) are implicated in metastatic spread, studies documenting their tissue origin remain sparse, with limited candidate approaches using one-two markers. Utilizing high-throughput single-cell and spatial transcriptomics, we identified tumor hybrid cells (THCs) co-expressing epithelial and macrophage markers and expressing a distinct transcriptome. Rarely, normal tissue showed these cells (NHCs), but their transcriptome was easily distinguishable from THCs. THCs with unique transcriptomes were observed in breast and colon cancers, suggesting this to be a generalizable phenomenon across cancer types. This study establishes a framework for HC identification in large datasets, providing compelling evidence for their tissue residence and offering comprehensive transcriptomic characterization. Furthermore, it sheds light on their differential function and identifies pathways that could explain their newly acquired invasive capabilities. THCs should be considered as potential therapeutic targets.
Language	English
Publishing date	2024-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16071444
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Book: Myelodysplastic syndromes & secondary acute myelogenous leukemia

Raza, Azra

directions for the new millennium

(Cancer treatment and research ; 108)

2001

Author's details	ed. by: Azra Raza
Series title	Cancer treatment and research ; 108
Collection
Keywords	Myelodysplastic Syndromes ; Leukemia, Myelocytic, Acute ; Myelodysplastisches Syndrom
Subject	MDS ; Präleukämie ; Präleukose ; Präleukämisches Syndrom ; Hämatopoetische Dysplasie
Language	English
Size	XIV, 278 S. : Ill., graph. Darst.
Publisher	Kluwer
Publishing place	Boston u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT013181196
ISBN	0-7923-7396-0 ; 978-0-7923-7396-4
Database	Catalogue ZB MED Medicine, Health

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2001 A 6270	order for loan	Magazin

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Article ; Online: Novel multicancer early detection technology-potential value to employers and the workforce.

Ofman, Joshua J / Fendrick, A Mark / Raza, Azra

The American journal of managed care

2021 Volume 26, Issue 10 Spec No., Page(s) SP363

Abstract: Multicancer early detection technology could help reduce cancer mortality compared to the current strategy of single-cancer screening tests. ...

Abstract	Multicancer early detection technology could help reduce cancer mortality compared to the current strategy of single-cancer screening tests.
MeSH term(s)	Early Detection of Cancer ; Humans ; Neoplasms/diagnosis ; Technology ; Workforce
Language	English
Publishing date	2021-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2035781-3
ISSN	1936-2692 ; 1088-0224 ; 1096-1860
ISSN (online)	1936-2692
ISSN	1088-0224 ; 1096-1860
DOI	10.37765/ajmc.2020.88567
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Article ; Online: Mutation in SF3B1 gene promotes formation of polyploid giant cells in Leukemia cells.

Mukherjee, Sanjay / Ali, Abdullah Mahmood / Murty, Vundavalli V / Raza, Azra

Medical oncology (Northwood, London, England)

2022 Volume 39, Issue 5, Page(s) 65

Abstract: Giant cells with polyploidy, termed polyploid giant cells, have been observed during normal growth, development, and pathologic states, such as solid cancer progression and resistance to therapy. Functional studies of polyploidal giant cancer cells (PGCC) ...

Abstract	Giant cells with polyploidy, termed polyploid giant cells, have been observed during normal growth, development, and pathologic states, such as solid cancer progression and resistance to therapy. Functional studies of polyploidal giant cancer cells (PGCC) provided evidence that they arise when normal diploid cells are stressed, show stem cell-like properties, and give rise to tumors. In the present study, we report in K562 leukemia cell line that introduction of the hotspot K700E mutation in the gene SF3B1 using CRISPR/Cas9 method results in an increased frequency of multinucleated polyploid giant cells resistant to chemotherapeutic agent and serum starvation stress. These giant cells with higher ploidy are distinct from multinucleated megakaryocytes, are proliferative, and are characterized by increased accumulation of mitochondria. PGCC have been previously documented in solid tumors. This is the first report describing PGCCs in a cell line derived from a liquid cancer where increased frequency of PGCCs is linked to a specific genetic event. Since SF3B1 mutations are predominantly seen in MDS and other hematologic malignancies, our current findings will have significant clinical implications.
MeSH term(s)	Giant Cells/pathology ; Humans ; Leukemia/pathology ; Mutation ; Neoplasms/pathology ; Phosphoproteins/metabolism ; Polyploidy ; RNA Splicing Factors/genetics ; RNA Splicing Factors/metabolism
Chemical Substances	Phosphoproteins ; RNA Splicing Factors ; SF3B1 protein, human
Language	English
Publishing date	2022-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-022-01652-9
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Article: Two different "tales" of ATG7: Clinical relevance to myelodysplastic syndromes.

Ali, Abdullah M / Raza, Azra

Molecular & cellular oncology

2016 Volume 3, Issue 5, Page(s) e1212686

Abstract: Somatic mutations in U2 Small Nuclear RNA Auxiliary Factor 1 ( ...

Abstract	Somatic mutations in U2 Small Nuclear RNA Auxiliary Factor 1 (
Language	English
Publishing date	2016-07-26
Publishing country	United States
Document type	Journal Article
ISSN	2372-3556
ISSN	2372-3556
DOI	10.1080/23723556.2016.1212686
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Article ; Online: Rising Resistance In Uropathogens With An Indication Of Nitrofurantoin Mic Creep.

Hasan, Azra S / Garg, Richa / Nasimuddin, Sowmya / Dey, Sneha / Das, Ayan / Moosi Raza Ali, Syed Md / Rai, Sumit / Kakru, Dalip K

Journal of Ayub Medical College, Abbottabad : JAMC

2023 Volume 35, Issue 1, Page(s) 54–59

Abstract: Background: The irrational use of antibiotics has led to the emergence of multi drug resistant pathogens. The phenomenon of MIC creeps occurs when organisms start showing raised MIC but within susceptible range giving an indication of the prevalence of ... ...

Abstract	Background: The irrational use of antibiotics has led to the emergence of multi drug resistant pathogens. The phenomenon of MIC creeps occurs when organisms start showing raised MIC but within susceptible range giving an indication of the prevalence of rise in resistant pathogens in an area. Methods: A cross sectional study in a large tertiary care hospital in North India to observe the susceptibility pattern among uropathogens and the possibility of MIC creeps. The Antimicrobial Susceptibility Testing (AST) and Minimum Inhibitory Concentration (MIC) were conducted by Vitek Compact 2. The identification of Extended Spectrum Beta Lactamase (ESBL) producers and Carbapenem Resistant Enterobacteriaceae (CRE) among Escherichia coli were noted. The MIC 50 and MIC 90 for Nitrofurantoin, the most widely used antibiotic for lower UTI, was calculated to investigate the phenomenon of MIC creep. Results: In our study, a total of 2522 urine samples were analyzed: 1538 (61%) were positive with the commonest isolate being E. coli (n=736, 47.8%) followed by Klebsiella spp. (n=178, 11%). Less than 10% of resistance was observed for Fosfomycin, Amikacin, Nitrofurantoin, Imipenem, Meropenem and Colistin. ESBL producers and CRE E. coli were 528 (72% of 736) and 79 (11% of 736) respectively. Overall, 119/736 samples had an MIC ≥128. Amongst the ESBL producers, 96/528 had MIC ≥128 and amongst the CRE, 13/79 had MIC ≥128. Discussion: E. coli can be used to reflect the trends in development of resistance. In the current study, it was observed that E. coli showed a reduced susceptibility for Nitrofurantoin indicated by a creeping increase in MIC albeit within normal range. Conclusions: Trends in rising MIC should alert prescribers to use drugs such as Nitrofurantoin judiciously. Antimicrobial stewardship practices should be strongly implemented in hospitals to curb rising resistance and obtain better treatment outcomes for patients with infectious diseases.
MeSH term(s)	Humans ; Nitrofurantoin/pharmacology ; Nitrofurantoin/therapeutic use ; Cross-Sectional Studies ; Escherichia coli ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Microbial Sensitivity Tests
Chemical Substances	Nitrofurantoin (927AH8112L) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-02-27
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2192473-9
ISSN	1819-2718 ; 1025-9589
ISSN (online)	1819-2718
ISSN	1025-9589
DOI	10.55519/JAMC-01-11050
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Article ; Online: Untargeted metabolomics analysis of gentamicin-induced tolerant colonies of Klebsiella pneumoniae.

Raza, Ali / Zehra, Moatter / Ramzan, Muhammad / Siddiqui, Amna Jabbar / Akbar, Azra / Ahmed, Ayaz / Musharraf, Syed Ghulam

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2023 Volume 185, Page(s) 106436

Abstract: Purpose: Antibiotic resistance development in pathogenic bacteria like Klebsiella pneumoniae seriously threatens humankind. Therefore, it is important to understand the interaction of bacteria with antibiotic agents and how it acquires resistance at the ...

Abstract	Purpose: Antibiotic resistance development in pathogenic bacteria like Klebsiella pneumoniae seriously threatens humankind. Therefore, it is important to understand the interaction of bacteria with antibiotic agents and how it acquires resistance at the molecular level. The current study describes metabolomics analysis of K. pneumoniae sensitive strains and its gentamicin-tolerant (resistant) strains. Methods: K. pneumoniae strains were treated at five different concentrations of gentamicin, increasing from a low dose (16.2 µg/mL) to the highest dose (250 µg/mL) at three incubation time periods (24 h, 48 h, and 72 h). Colonies obtained at various concentrations and time intervals were subjected to metabolomic analysis using GC-MS. Results: A drastic change was observed in the morphology of K. pneumoniae colonies with the increasing gentamicin concentration. Moreover, K. pneumoniae strains grown at the highest concentration (250 µg/mL) were found tolerant to 1 mg/mL gentamicin (4-folds) and considered resistant strains. A total of 459 metabolites were identified. A sequential down/up-regulation in 4, 3, and 4 metabolites were observed in association with the increasing gentamicin concentration at 24 h, 48 h, and 72 h, respectively. While with the comparative analysis of resistant and sensitive strains, a total of seven down- and sixteen up-regulated metabolites were observed. The concentration of some fatty acids and sugars have been found to increase while, a few metabolites like inosine, tyrosine, 1-propionylproline, and 2-hydroxyacetic acid have been found down-regulated in resistant samples. Conclusion: These regulator metabolites might be associated with resistance development in K. pneumoniae against gentamicin and might be helpful in the rapid detection of gentamicin-resistant clinical strains.
MeSH term(s)	Gentamicins/pharmacology ; Klebsiella pneumoniae ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Microbial ; Microbial Sensitivity Tests
Chemical Substances	Gentamicins ; Anti-Bacterial Agents
Language	English
Publishing date	2023-03-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2023.106436
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Article: Rewriting the rules for care of MDS and AML patients in the time of COVID-19.

Raza, Azra / Assal, Amer / Ali, Abdullah M / Jurcic, Joseph G

Leukemia research reports

2020 Volume 13, Page(s) 100201

Abstract: The care of patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) has been radically altered by COVID-19, especially in New York City, the epicenter of the pandemic. Here we summarize how telemedicine, virtual visits, delayed ... ...

Abstract	The care of patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) has been radically altered by COVID-19, especially in New York City, the epicenter of the pandemic. Here we summarize how telemedicine, virtual visits, delayed transfusions, and chemotherapy, preferably selecting self-administered medications and visits by home healthcare workers, are employed to minimize exposure of our high-risk population of patients to the virus. The unique challenges of transplants during the pandemic and the consequences of an abrupt halt in all non-essential research activities are described. Not all the changes forced by COVID-19 are detrimental.
Keywords	covid19
Language	English
Publishing date	2020-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2706248-X
ISSN	2213-0489
ISSN	2213-0489
DOI	10.1016/j.lrr.2020.100201
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Article ; Online: A rapid colorimetric method for the detection of carminic acid in samples based on visible color change.

Akbar, Azra / Jabbar Siddiqui, Amna / Tarique Moin, Syed / Noman Khan, Muhammad / Raza, Ali / Khadim, Adeeba / Usman, Muhammad / Iqbal Choudhary, M / Ghulam Musharraf, Syed

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2023 Volume 302, Page(s) 122953

Abstract: Carminic Acid (CA), an insect-derived red color, is widely used as a colorant and additive in food and non-food items. The detection of CA is of great concern since it is unacceptable for vegetarians and vegans consumers. Therefore, it is important for ... ...

Abstract	Carminic Acid (CA), an insect-derived red color, is widely used as a colorant and additive in food and non-food items. The detection of CA is of great concern since it is unacceptable for vegetarians and vegans consumers. Therefore, it is important for food authorities to have a rapid detection method for CA. We describe here a simple and rapid method for the qualitative detection of CA, using Pb
MeSH term(s)	Carmine ; Colorimetry/methods ; Lead ; Spectrum Analysis ; Iron
Chemical Substances	Carmine (CID8Z8N95N) ; Lead (2P299V784P) ; Iron (E1UOL152H7)
Language	English
Publishing date	2023-06-06
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2023.122953
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Article: Evaluating Glycemic Control Efficacy and Safety of the Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron in Type 2 Diabetes Patients: A Systemic Review and Meta-Analysis.

Fatima, Hareer / Rangwala, Hussain Sohail / Mustafa, Muhammad Saqlain / Shafique, Muhammad Ashir / Abbas, Syed Raza / Rizwan, Azra / Fadlalla Ahmed, Tagwa Kalool / Arshad, Ainan

Diabetes, metabolic syndrome and obesity : targets and therapy

2023 Volume 16, Page(s) 3567–3578

Abstract: Introduction: Diabetes Mellitus (DM) is a significant global health concern, with Type 2 DM (T2DM) being highly prevalent. Glucagon-Like Peptide 1 receptor agonists (GLP-1RA), such as Danuglipron, offer potential benefits in T2DM management. This meta- ... ...

Abstract	Introduction: Diabetes Mellitus (DM) is a significant global health concern, with Type 2 DM (T2DM) being highly prevalent. Glucagon-Like Peptide 1 receptor agonists (GLP-1RA), such as Danuglipron, offer potential benefits in T2DM management. This meta-analysis examines the safety and efficacy of Danuglipron, focusing on adverse outcomes and glycemic parameters. Methods: A systematic search was conducted in PubMed, Scopus, and Cochrane Library for RCTs involving Danuglipron till August 2023, following PRISMA guidelines. The Cochrane risk-of-bias tool was used for quality assessment. Adverse outcomes (diarrhea, nausea, vomiting, headache, decreased appetite, dyspepsia, dizziness) and glycemic parameters like changes in HbA1C, fasting plasma glucose (FPG), and body weight were analyzed. Results: Four RCTs published from 2021 to 2023 were included. Both doses of Danuglipron were associated with diarrhea (RR=2.66, 90% CI: 1.32 to 5.35, p=0.02), nausea (RR=5.5, 90% CI: 3.4 to 8.88, p<0.00001), and vomiting (RR=5.98, 90% CI: 2.93 to 12.23, p=0.0001). The 120mg dose showed decreased appetite (RR=3.46, 90% CI: 1.57 to 7.62, p=0.01), dyspepsia (RR=4.04, 90% CI: 1.93 to 8.43, p=0.002), and dizziness (RR=5.08, 90% CI: 1.45 to 17.82, p=0.03). Reductions in HbA1C (SMD -1.09, 90% CI -1.39 to -0.8, p < 0.00001), FPG (SMD -1.10, 90% CI -1.46 to -0.75, p < 0.00001), and body weight (SMD -1.08, 90% CI -1.42 to -0.74, p < 0.00001) were observed for both doses. Conclusion: Danuglipron demonstrates potential for glycemic control and weight reduction in T2DM. Adverse outcomes include diarrhea, nausea, vomiting, and decreased appetite, with dose-related effects. Clinicians must weigh benefits against side effects when considering Danuglipron for T2DM management.
Language	English
Publishing date	2023-11-07
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S439587
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