Article ; Online: Metabolic shift underlies tumor progression and immune evasion in S-nitrosoglutathione reductase-deficient cancer.
2023 Volume 260, Issue 3, Page(s) 261–275
Abstract: S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme that has been suggested to play ...
Abstract | S-nitrosoglutathione reductase (GSNOR) is a denitrosylase enzyme that has been suggested to play a tumor suppressor role, although the mechanisms responsible are still largely unclear. In this study, we show that GSNOR deficiency in tumors is associated with poor prognostic histopathological features and poor survival in patients with colorectal cancer (CRC). GSNOR-low tumors were characterized by an immunosuppressive microenvironment with exclusion of cytotoxic CD8 |
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MeSH term(s) | Mice ; Animals ; Humans ; Oxidoreductases ; CD8-Positive T-Lymphocytes ; Immune Evasion ; Proteomics ; Neoplasms ; Tumor Microenvironment |
Chemical Substances | Oxidoreductases (EC 1.-) ; formaldehyde dehydrogenase, glutathione-independent (EC 1.2.1.46) |
Language | English |
Publishing date | 2023-04-05 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 3119-7 |
ISSN | 1096-9896 ; 0022-3417 |
ISSN (online) | 1096-9896 |
ISSN | 0022-3417 |
DOI | 10.1002/path.6080 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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