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  1. Article ; Online: Targeting Syntaxin 17 to Improve Mitophagy in Heart Failure.

    Forte, Maurizio / Sarto, Gianmarco / Sciarretta, Sebastiano

    JACC. Basic to translational science

    2023  Volume 8, Issue 9, Page(s) 1240–1242

    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Editorial
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.06.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: miR-93 and synaptotagmin-7: two novel players in the regulation of autophagy during cardiac hypertrophy.

    Forte, Maurizio / Sarto, Gianmarco / Sciarretta, Sebastiano

    The FEBS journal

    2023  Volume 291, Issue 3, Page(s) 441–444

    Abstract: The molecular mechanisms involved in the transition of cardiac hypertrophy to heart failure (HF) are not fully characterized. Autophagy is a catabolic, self-renewal intracellular mechanism, which protects the heart during HF. In the heart of a mouse ... ...

    Abstract The molecular mechanisms involved in the transition of cardiac hypertrophy to heart failure (HF) are not fully characterized. Autophagy is a catabolic, self-renewal intracellular mechanism, which protects the heart during HF. In the heart of a mouse model of angiotensin-II-induced hypertrophy, Sun and colleagues demonstrated that reduced levels of miR-93 lead to synaptotagmin-7 (Syt-7) upregulation and consequent inhibition of autophagy. miR-93 overexpression or syt-7 inhibition rescues autophagy and maladaptive hypertrophy. This research identifies new players in the pathophysiology of cardiac hypertrophy, opening innovative therapeutic perspectives. miR-93 may also be considered in the future as a novel circulating biomarker for patients at high risk to develop HF.
    MeSH term(s) Animals ; Humans ; Mice ; Angiotensin II ; Autophagy/genetics ; Cardiomegaly/metabolism ; Heart Failure/genetics ; Heart Failure/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Myocytes, Cardiac/metabolism ; Synaptotagmins/genetics ; Synaptotagmins/metabolism
    Chemical Substances Angiotensin II (11128-99-7) ; MicroRNAs ; MIRN93 microRNA, human ; Synaptotagmins (134193-27-4) ; Syt7 protein, mouse ; Mirn93 microRNA, mouse
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.17008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 260: Show issues Location:
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  3. Article ; Online: Boosting circadian autophagy by means of intermittent time-restricted feeding: a novel anti-ageing strategy?

    Sciarretta, Sebastiano / Forte, Maurizio / Sadoshima, Junichi

    The journal of cardiovascular aging

    2022  Volume 2

    Language English
    Publishing date 2022-01-01
    Publishing country United States
    Document type Journal Article
    ISSN 2768-5993
    ISSN (online) 2768-5993
    DOI 10.20517/jca.2021.33
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  4. Article ; Online: New Insights Into the Role of GSK-3 in the Regulation of Human Cardiac Electrophysiology.

    Forte, Maurizio / Iacovone, Giuliano / Sciarretta, Sebastiano

    JACC. Basic to translational science

    2022  Volume 7, Issue 10, Page(s) 1018–1020

    Language English
    Publishing date 2022-10-24
    Publishing country United States
    Document type Editorial
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2022.06.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Regulation of calcium handling by autophagy: a novel mechanism limiting cardiac hypertrophy and dysfunction?

    Forte, Maurizio / Frati, Giacomo / Sciarretta, Sebastiano

    Cardiovascular research

    2022  Volume 118, Issue 6, Page(s) 1377–1379

    MeSH term(s) Animals ; Autophagy ; Autophagy-Related Protein 5 ; Calcium/metabolism ; Cardiomegaly/metabolism ; Heart/physiopathology ; Humans ; Mice
    Chemical Substances ATG5 protein, human ; Atg5 protein, mouse ; Autophagy-Related Protein 5 ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-04-14
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac035
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  6. Article: Editorial: Mitochondrial Dysfunction and Cardiovascular Diseases.

    Sadoshima, Junichi / Kitsis, Richard N / Sciarretta, Sebastiano

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 645986

    Language English
    Publishing date 2021-01-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.645986
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  7. Article ; Online: How much drug-induced blood pressure reduction is effective and safe in heart failure?

    Sciarretta, Sebastiano / Volpe, Massimo

    Journal of hypertension

    2019  Volume 37, Issue 9, Page(s) 1786–1787

    MeSH term(s) Antihypertensive Agents ; Blood Pressure/drug effects ; Heart Failure ; Humans ; Hypotension ; Randomized Controlled Trials as Topic
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2019-08-14
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000002142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 614: Show issues

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  8. Article ; Online: The complex network of mTOR signalling in the heart.

    Sciarretta, Sebastiano / Forte, Maurizio / Frati, Giacomo / Sadoshima, Junichi

    Cardiovascular research

    2021  Volume 118, Issue 2, Page(s) 424–439

    Abstract: The mechanistic target of rapamycin (mTOR) integrates several intracellular and extracellular signals involved in the regulation of anabolic and catabolic processes. mTOR assembles into two macromolecular complexes, named mTORC1 and mTORC2, which have ... ...

    Abstract The mechanistic target of rapamycin (mTOR) integrates several intracellular and extracellular signals involved in the regulation of anabolic and catabolic processes. mTOR assembles into two macromolecular complexes, named mTORC1 and mTORC2, which have different regulators, substrates and functions. Studies of gain- and loss-of-function animal models of mTOR signalling revealed that mTORC1/2 elicits both adaptive and maladaptive functions in the cardiovascular system. Both mTORC1 and mTORC2 are indispensable for driving cardiac development and cardiac adaption to stress, such as pressure overload. However, persistent and deregulated mTORC1 activation in the heart is detrimental during stress and contributes to the development and progression of cardiac remodelling and genetic and metabolic cardiomyopathies. In this review, we discuss the latest findings regarding the role of mTOR in the cardiovascular system, both under basal conditions and during stress, such as pressure overload, ischemia, and metabolic stress. Current data suggest that mTOR modulation may represent a potential therapeutic strategy for the treatment of cardiac diseases.
    MeSH term(s) Animals ; Heart Diseases/diagnosis ; Heart Diseases/drug therapy ; Heart Diseases/enzymology ; Heart Diseases/physiopathology ; Humans ; MTOR Inhibitors/therapeutic use ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/enzymology ; Myocytes, Cardiac/pathology ; Signal Transduction ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/metabolism ; Translational Research, Biomedical
    Chemical Substances MTOR Inhibitors ; MTOR protein, human (EC 2.7.1.1) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editorial commentary: How to implement research studies on extracellular vesicle administration in myocardial infarction.

    Sciarretta, Sebastiano / Schirone, Leonardo / Sadoshima, Junichi

    Trends in cardiovascular medicine

    2020  Volume 31, Issue 7, Page(s) 416–418

    MeSH term(s) Extracellular Vesicles ; Humans ; Myocardial Infarction/diagnosis ; Myocardial Infarction/therapy
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2020.09.003
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    Zs.A 3419: Show issues Location:
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  10. Article ; Online: A novel signalling mechanism regulating telomere length in cardiomyocytes.

    Frati, Giacomo / Versaci, Francesco / Sciarretta, Sebastiano

    Cardiovascular research

    2020  Volume 117, Issue 1, Page(s) 13–14

    MeSH term(s) Animals ; Cellular Senescence ; Mice ; Myocytes, Cardiac ; Signal Transduction ; Telomere/genetics ; Transforming Growth Factor beta
    Chemical Substances Transforming Growth Factor beta
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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