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Article ; Online: José Rafael Arboleda s. J. (1916-1992)

Maguaré, Vol 0, Iss

el programa de los estudios afroamericanos y los inicios de la Reflexión antropológica sobre poblaciones negras en colombia

2009 Volume 21

Abstract: A pesar de su importancia para la historia de la ciencia social y la antropología colombianas, la obra intelectual del padre Arboleda ha sido relegada al olvido. El presente trabajo busca analizar la propuesta de investigación del padre Arboleda, ... ...

Abstract	A pesar de su importancia para la historia de la ciencia social y la antropología colombianas, la obra intelectual del padre Arboleda ha sido relegada al olvido. El presente trabajo busca analizar la propuesta de investigación del padre Arboleda, atendiendo a dos preguntas principales: ¿cómo constituye la antropología sus objetos de interés científico? ¿En qué términos ocurrió la aparición de los afrocolombianos en el horizonte discursivo de la antropología nacional? Esto, con el propósito de iluminar los debates actuales de los estudios afrocolombianos en conexión con la tradición académica existente sobre estas poblaciones. Palabras clave: antropología social, historia, estudios afroamericanos, afrocolombianos. ABSTRACT Despite its importance for the Colombian history of social sciences and anthropology, the intellectual work of Father Arboleda has been forgotten. This paper intends to analyze the research proposal of Father Arboleda, considering two major questions: How anthropology constitutes its objects of scientific interest? In which terms did the apparition of Afrocolombians occur in the discursive horizon of national anthropology? This, in order to enlighten the current debates in afrocolombian studies, related to the existing academic tradition about these populations. Keywords: social anthropology, history, Afro-American studies, Afro-Colombians.
Keywords	Anthropology ; GN1-890
Language	English
Publishing date	2009-06-01T00:00:00Z
Publisher	Universidad Nacional de Colombia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Random Allelic Expression in Inherited Retinal Disease Genes.

Richards, Collin J / Pulido, Jose S

Current issues in molecular biology

2023 Volume 45, Issue 12, Page(s) 10018–10025

Abstract: Inherited retinal diseases (IRDs) are a significant contributor to visual loss in children and young adults, falling second only to diabetic retinopathy. Understanding the pathogenic mechanisms of IRDs remains paramount. Some autosomal genes exhibit ... ...

Abstract	Inherited retinal diseases (IRDs) are a significant contributor to visual loss in children and young adults, falling second only to diabetic retinopathy. Understanding the pathogenic mechanisms of IRDs remains paramount. Some autosomal genes exhibit random allelic expression (RAE), similar to X-chromosome inactivation. This study identifies RAE genes in IRDs. Genes in the Retinal Information Network were cross-referenced with the recent literature to identify expression profiles, RAE, or biallelic expression (BAE). Loss-of-function intolerance (LOFI) was determined by cross-referencing the existing literature. Molecular and biological pathways that are significantly enriched were evaluated using gene ontology. A total of 184 IRD-causing genes were evaluated. Of these, 31 (16.8%) genes exhibited RAE. LOFI was exhibited in 6/31 (19.4%) of the RAE genes and 18/153 (11.8%) of the BAE genes. Brain tissue exhibited BAE in 107/128 (83.6%) genes for both sexes. The molecular pathways significantly enriched among BAE genes were photoreceptor activity, tubulin binding, and nucleotide/ribonucleotide binding. The biologic pathways significantly enriched for RAE genes were equilibrioception, parallel actin filament bundle assembly, photoreceptor cell outer segment organization, and protein depalmitoylation. Allele-specific expression may be a mechanism underlying IRD phenotypic variability, with clonal populations of embryologic precursor cells exhibiting RAE. Brain tissue preferentially exhibited BAE, possibly due to selective pressures against RAE. Pathways critical for cellular and visual function were enriched in BAE, which may offer a survival benefit.
Language	English
Publishing date	2023-12-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb45120625
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Article ; Online: José Rafael Arboleda s. J. (1916-1992)

Hernando Andrés Pulido Londoño

Maguaré, Iss

el programa de los estudios afroamericanos y los inicios de la Reflexión antropológica sobre poblaciones negras en colombia

2007 Volume 21

Abstract	A pesar de su importancia para la historia de la ciencia social y la antropología colombianas, la obra intelectual del padre Arboleda ha sido relegada al olvido. El presente trabajo busca analizar la propuesta de investigación del padre Arboleda, atendiendo a dos preguntas principales: ¿cómo constituye la antropología sus objetos de interés científico? ¿En qué términos ocurrió la aparición de los afrocolombianos en el horizonte discursivo de la antropología nacional? Esto, con el propósito de iluminar los debates actuales de los estudios afrocolombianos en conexión con la tradición académica existente sobre estas poblaciones. Palabras clave: antropología social, historia, estudios afroamericanos, afrocolombianos. ABSTRACT Despite its importance for the Colombian history of social sciences and anthropology, the intellectual work of Father Arboleda has been forgotten. This paper intends to analyze the research proposal of Father Arboleda, considering two major questions: How anthropology constitutes its objects of scientific interest? In which terms did the apparition of Afrocolombians occur in the discursive horizon of national anthropology? This, in order to enlighten the current debates in afrocolombian studies, related to the existing academic tradition about these populations. Keywords: social anthropology, history, Afro-American studies, Afro-Colombians.
Keywords	antropología social ; historia ; estudios afroamericanos ; afrocolombianos ; Anthropology ; GN1-890
Language	English
Publishing date	2007-01-01T00:00:00Z
Publisher	Universidad Nacional de Colombia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: José Rafael Arboleda s. J. (1916-1992)

Hernando Andrés Pulido Londoño

Maguaré, Iss

el programa de los estudios afroamericanos y los inicios de la Reflexión antropológica sobre poblaciones negras en colombia

2007 Volume 21

Abstract	A pesar de su importancia para la historia de la ciencia social y la antropología colombianas, la obra intelectual del padre Arboleda ha sido relegada al olvido. El presente trabajo busca analizar la propuesta de investigación del padre Arboleda, atendiendo a dos preguntas principales: ¿cómo constituye la antropología sus objetos de interés científico? ¿En qué términos ocurrió la aparición de los afrocolombianos en el horizonte discursivo de la antropología nacional? Esto, con el propósito de iluminar los debates actuales de los estudios afrocolombianos en conexión con la tradición académica existente sobre estas poblaciones. Palabras clave: antropología social, historia, estudios afroamericanos, afrocolombianos. ABSTRACT Despite its importance for the Colombian history of social sciences and anthropology, the intellectual work of Father Arboleda has been forgotten. This paper intends to analyze the research proposal of Father Arboleda, considering two major questions: How anthropology constitutes its objects of scientific interest? In which terms did the apparition of Afrocolombians occur in the discursive horizon of national anthropology? This, in order to enlighten the current debates in afrocolombian studies, related to the existing academic tradition about these populations. Keywords: social anthropology, history, Afro-American studies, Afro-Colombians.
Keywords	antropología social ; historia ; estudios afroamericanos ; afrocolombianos ; Anthropology ; GN1-890
Language	English
Publishing date	2007-01-01T00:00:00Z
Publisher	Universidad Nacional de Colombia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genetic analysis of ocular tumour-associated genes using large genomic datasets: insights into selection constraints and variant representation in the population.

Tanner, Alexander / Sagoo, Mandeep S / Mahroo, Omar A / Pulido, Jose S

BMJ open ophthalmology

2024 Volume 9, Issue 1

Abstract: Background: Large genomic databases enable genetic evaluation in terms of haploinsufficiency and prevalence of missense and synonymous variants. We explored these parameters in ocular tumour-associated genes.: Methods: A curated list of ocular tumour- ...

Abstract	Background: Large genomic databases enable genetic evaluation in terms of haploinsufficiency and prevalence of missense and synonymous variants. We explored these parameters in ocular tumour-associated genes. Methods: A curated list of ocular tumour-associated genes was assessed using the genomic databases Genome Aggregation Database (gnomAD) and DatabasE of genomiC varIation and Phenotype in Humans using Ensembl Resources (DECIPHER) and compared with breast and lung cancer-associated gene lists. Haploinsufficiency was determined based on specific criteria: probability of loss of function index ≥0.9 in gnomAD, upper CI O/E limit <0.35 for loss of function variants in gnomAD and/or a DECIPHER pHaplo ≥0.86. UniProt was used for further gene characterisation, and gene ontology Protein Analysis THrough Evolutionary Relationships was explored for common biological pathways. In addition, we identified genes with under-representation/over-representation of missense/synonymous variants. Results: Fifty-seven genes were identified in association with ocular and extraocular tumours.Regarding haploinsufficiency, 41% of genes met the criteria for negative selection, with 57% categorised as tumour-suppressing and 39% as oncogenic. Most genes were involved in regulatory processes. Regarding triplosensitivity, 33% of genes reached significance and 83% of these were haploinsufficient. Analysis of variants revealed under-representation of missense variants in 23% of genes and over-representation of synonymous variants in 5% of genes. Ocular tumour-associated genes exhibited higher scores for haploinsufficiency and triplosensitivity compared with breast and lung cancer-associated genes. Pathway analysis revealed significant enrichment in cellular proliferation, differentiation and division. Encoded proteins of ocular tumour-associated genes were generally longer than the median of the UniProt database. Conclusion: Our findings highlight the importance of negative selection in ocular tumour genes, supporting cranial gene conservation. This study provides insights into ocular tumourigenesis and future research avenues.
MeSH term(s)	Humans ; Proteins ; Haploinsufficiency/genetics ; Genomics ; Eye Neoplasms/genetics ; Lung Neoplasms
Chemical Substances	Proteins
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ISSN	2397-3269
ISSN (online)	2397-3269
DOI	10.1136/bmjophth-2023-001565
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Article ; Online: Histological Findings in the Eyes of Abcc6 Knockout Rat Model of Pseudoxanthoma Elasticum.

Sehgal, Anahita / Milman, Tatyana / Li, Qiaoli / Pulido, Jose S

Translational vision science & technology

2024 Volume 13, Issue 4, Page(s) 29

Abstract: Purpose: To describe the ocular findings of murine pseudoxanthoma elasticum (PXE) models with ATP-binding cassette subfamily C member 6 (Abcc6) gene knockout.: Methods: This experiment was conducted in four Abcc6-/- rats and compared with six wild- ... ...

Abstract	Purpose: To describe the ocular findings of murine pseudoxanthoma elasticum (PXE) models with ATP-binding cassette subfamily C member 6 (Abcc6) gene knockout. Methods: This experiment was conducted in four Abcc6-/- rats and compared with six wild-type Abcc6+/+ control rats. The animals underwent necropsy at 6 months of age. Histological examination of the eyes was performed. Results: Histological examination of eight eyes from four Abcc6-/- rats revealed multiple nodular foci of calcification in the uvea, sclera, and conjunctiva, focally in perivascular distribution, as well as linear and nodular calcification of Bruch's membrane. Calcific foci were not associated with inflammation in the knockout rats. There was no evidence of calcification in control eyes. Discussion: The Abcc6-/- rat model shows that PXE can affect multiple ocular tissues beyond the calcification in Bruch's membrane noted in human eyes. Nodular calcific foci probably correspond to comet lesions seen in patients with PXE. The presence of ectopic calcium without inflammation distinguishes it from inflammatory calcium deposition in atherosclerosis. Further studies are needed to determine why PXE does not cause inflammatory infiltration. Translational relevance: The Abcc6-/- murine model may be suitable for studying ocular PXE pathophysiology and ectopic calcification and developing effective therapies.
MeSH term(s)	Animals ; Pseudoxanthoma Elasticum/genetics ; Pseudoxanthoma Elasticum/pathology ; Pseudoxanthoma Elasticum/metabolism ; Disease Models, Animal ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/deficiency ; Multidrug Resistance-Associated Proteins/metabolism ; Rats ; Calcinosis/pathology ; Calcinosis/genetics ; Bruch Membrane/pathology ; Bruch Membrane/metabolism ; Gene Knockout Techniques ; Male
Chemical Substances	Multidrug Resistance-Associated Proteins
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.13.4.29
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Book: Retina, choroid, and vitreous

Pulido, José S.

2002

Author's details	Jose S. Pulido
Keywords	Retinal Diseases ; Choroid ; Retina ; Vitreous Body
Language	English
Size	VIII, 230 S. : zahlr. Ill.
Publisher	Mosby
Publishing place	St. Louis u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT013435224
ISBN	0-323-00237-4 ; 978-0-323-00237-0
Database	Catalogue ZB MED Medicine, Health

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2002 A 3979	order for loan	Magazin

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Article ; Online: Reliability and accuracy of artificial intelligence ChatGPT in providing information on ophthalmic diseases and management to patients.

Cappellani, Francesco / Card, Kevin R / Shields, Carol L / Pulido, Jose S / Haller, Julia A

Eye (London, England)

2024

Abstract: Purpose: To assess the accuracy of ophthalmic information provided by an artificial intelligence chatbot (ChatGPT).: Methods: Five diseases from 8 subspecialties of Ophthalmology were assessed by ChatGPT version 3.5. Three questions were asked to ... ...

Abstract	Purpose: To assess the accuracy of ophthalmic information provided by an artificial intelligence chatbot (ChatGPT). Methods: Five diseases from 8 subspecialties of Ophthalmology were assessed by ChatGPT version 3.5. Three questions were asked to ChatGPT for each disease: what is x?; how is x diagnosed?; how is x treated? (x = name of the disease). Responses were graded by comparing them to the American Academy of Ophthalmology (AAO) guidelines for patients, with scores ranging from -3 (unvalidated and potentially harmful to a patient's health or well-being if they pursue such a suggestion) to 2 (correct and complete). Main outcomes: Accuracy of responses from ChatGPT in response to prompts related to ophthalmic health information in the form of scores on a scale from -3 to 2. Results: Of the 120 questions, 93 (77.5%) scored ≥ 1. 27. (22.5%) scored ≤ -1; among these, 9 (7.5%) obtained a score of -3. The overall median score amongst all subspecialties was 2 for the question "What is x", 1.5 for "How is x diagnosed", and 1 for "How is x treated", though this did not achieve significance by Kruskal-Wallis testing. Conclusions: Despite the positive scores, ChatGPT on its own still provides incomplete, incorrect, and potentially harmful information about common ophthalmic conditions, defined as the recommendation of invasive procedures or other interventions with potential for adverse sequelae which are not supported by the AAO for the disease in question. ChatGPT may be a valuable adjunct to patient education, but currently, it is not sufficient without concomitant human medical supervision.
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-023-02906-0
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Article ; Online: The Concept of Minimal Residual Disease in the Treatment and Staging of Vitreoretinal Lymphoma.

Stacey, Andrew W / Pulido, Jose S

Retina (Philadelphia, Pa.)

2020 Volume 40, Issue 7, Page(s) 1213–1214

MeSH term(s)	Disease Management ; Humans ; Lymphoma/pathology ; Lymphoma/therapy ; Neoplasm Staging ; Neoplasm, Residual ; Retinal Neoplasms/pathology ; Retinal Neoplasms/therapy ; Vitreous Body/pathology
Language	English
Publishing date	2020-05-14
Publishing country	United States
Document type	Editorial
ZDB-ID	603192-4
ISSN	1539-2864 ; 0275-004X
ISSN (online)	1539-2864
ISSN	0275-004X
DOI	10.1097/IAE.0000000000002851
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Article ; Online: Random Allelic Expression in Inherited Retinal Disease Genes

Collin J. Richards / Jose S. Pulido

Current Issues in Molecular Biology, Vol 45, Iss 12, Pp 10018-

2023 Volume 10025

Abstract	Inherited retinal diseases (IRDs) are a significant contributor to visual loss in children and young adults, falling second only to diabetic retinopathy. Understanding the pathogenic mechanisms of IRDs remains paramount. Some autosomal genes exhibit random allelic expression (RAE), similar to X-chromosome inactivation. This study identifies RAE genes in IRDs. Genes in the Retinal Information Network were cross-referenced with the recent literature to identify expression profiles, RAE, or biallelic expression (BAE). Loss-of-function intolerance (LOFI) was determined by cross-referencing the existing literature. Molecular and biological pathways that are significantly enriched were evaluated using gene ontology. A total of 184 IRD-causing genes were evaluated. Of these, 31 (16.8%) genes exhibited RAE. LOFI was exhibited in 6/31 (19.4%) of the RAE genes and 18/153 (11.8%) of the BAE genes. Brain tissue exhibited BAE in 107/128 (83.6%) genes for both sexes. The molecular pathways significantly enriched among BAE genes were photoreceptor activity, tubulin binding, and nucleotide/ribonucleotide binding. The biologic pathways significantly enriched for RAE genes were equilibrioception, parallel actin filament bundle assembly, photoreceptor cell outer segment organization, and protein depalmitoylation. Allele-specific expression may be a mechanism underlying IRD phenotypic variability, with clonal populations of embryologic precursor cells exhibiting RAE. Brain tissue preferentially exhibited BAE, possibly due to selective pressures against RAE. Pathways critical for cellular and visual function were enriched in BAE, which may offer a survival benefit.
Keywords	inherited retinal disease ; genetics ; random allelic expression ; monoallelic expression ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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