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  1. Article ; Online: Rediscovering, reevaluating, and restoring Entiatqua: Identifying pre‐Anthropocene valleys in North Cascadia, USA

    Powers, Paul / Staab, Brian / Cluer, Brian / Thorne, Colin

    River Research and Applications. 2022 Nov., v. 38, no. 9 p.1527-1543

    2022  

    Abstract: A maturing body of evidence suggests that anthropogenic impacts on river‐wetland corridors (RWCs) are greater and more widespread than previously recognized. Partly, this stems from the difficulty of differentiating between legacy anthropogenic impacts ... ...

    Abstract A maturing body of evidence suggests that anthropogenic impacts on river‐wetland corridors (RWCs) are greater and more widespread than previously recognized. Partly, this stems from the difficulty of differentiating between legacy anthropogenic impacts and channel evolution resulting from natural disturbances. Here, we apply the geomorphic grade line (GGL) relative elevation model (REM) method to reveal pre‐Anthropocene fluvial features for a 42‐km reach of Entiatqua (English translation—the Entiat River) in the North Cascade Mountains, USA. We began by long profiling the entire length of the river valley and defining distinct valley segments based on breaks in profile. Next, we developed models of the valley profile for each segment, known as GGLs, and used them to develop high‐resolution REMs by detrending LiDAR‐derived digital elevation models. We then used the GGL‐REMs to map relict fluvial features in the valley floor. Validating the GGL‐REMs using surficial geologic maps, ¹⁴Cdated soil profiles, and the identifiable remnants of historic dams allows us to differentiate surfaces associated with the pre‐Anthropocene from those resulting from anthropogenic activities, including splash damming, channel straightening, large wood removal, and beaver extirpation. Our findings reveal 1–2.5 m of anthropogenically‐driven channel incision in unconfined and partially‐confined valley segments, wherein fluvial sediment balances transitioned from being net depositional to erosive, and later neutral, with river environments in these segments shifting from being complex, ecologically‐rich, RWCs to simpler, ecologically‐impoverished, single‐thread channels, like those found in confined valley segments. The adverse impacts of post‐Anthropocene fluvial responses on salmon habitats were likely profound and may help explain historical and ongoing declines in populations of listed species, including Chinook Salmon (Oncorhynchus tshawytscha) and Steelhead Trout (Oncorhynchus mykiss). Our study of Entiatqua, together with evidence from other western US rivers, demonstrates that the GGL‐REM approach can be used to re‐envisage pre‐Anthropocene fluvial process‐form domains including identifying valley segments wherein fluvial responses to human development have disconnected RWCs. Once the pre‐Anthropogenic conditions of rivers like Entiatqua have been recognized, the case for restoring lost RWCs to unlock their ecological potential becomes compelling.
    Keywords Oncorhynchus mykiss ; Oncorhynchus tshawytscha ; evolution ; human development ; models ; research ; river valleys ; rivers ; salmon ; sediments ; soil ; wood ; Western United States
    Language English
    Dates of publication 2022-11
    Size p. 1527-1543.
    Publishing place John Wiley & Sons, Ltd.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2072626-0
    ISSN 1535-1459
    ISSN 1535-1459
    DOI 10.1002/rra.4016
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Functional promiscuity of small multidrug resistance transporters from Staphylococcus aureus, Pseudomonas aeruginosa, and Francisella tularensis.

    Spreacker, Peyton J / Wegrzynowicz, Andrea K / Porter, Colin J / Beeninga, Will F / Demas, Sydnye / Powers, Emma N / Henzler-Wildman, Katherine A

    Molecular microbiology

    2024  Volume 121, Issue 4, Page(s) 798–813

    Abstract: Small multidrug resistance transporters efflux toxic compounds from bacteria and are a minimal system to understand multidrug transport. Most previous studies have focused on EmrE, the model SMR from Escherichia coli, finding that EmrE has a broader ... ...

    Abstract Small multidrug resistance transporters efflux toxic compounds from bacteria and are a minimal system to understand multidrug transport. Most previous studies have focused on EmrE, the model SMR from Escherichia coli, finding that EmrE has a broader substrate profile than previously thought and that EmrE may perform multiple types of transport, resulting in substrate-dependent resistance or susceptibility. Here, we performed a broad screen to identify potential substrates of three other SMRs: PAsmr from Pseudomonas aeruginosa; FTsmr from Francisella tularensis; and SAsmr from Staphylococcus aureus. This screen tested metabolic differences in E. coli expressing each transporter versus an inactive mutant, for a clean comparison of sequence and substrate-specific differences in transporter function, and identified many substrates for each transporter. In general, resistance compounds were charged, and susceptibility substrates were uncharged, but hydrophobicity was not correlated with phenotype. Two resistance hits and two susceptibility hits were validated via growth assays and IC50 calculations. Susceptibility is proposed to occur via substrate-gated proton leak, and the addition of bicarbonate antagonizes the susceptibility phenotype, consistent with this hypothesis.
    MeSH term(s) Escherichia coli/genetics ; Francisella tularensis/metabolism ; Pseudomonas aeruginosa/metabolism ; Staphylococcus aureus/metabolism ; Escherichia coli Proteins/metabolism ; Antiporters/genetics ; Membrane Transport Proteins/metabolism ; Drug Resistance, Multiple
    Chemical Substances Escherichia coli Proteins ; Antiporters ; Membrane Transport Proteins ; EmrE protein, E coli (147995-06-0)
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.15231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Donor-recipient race-ethnicity concordance and patient survival after liver transplantation.

    Laffey, Makenna / Ashwat, Eishan / Lui, Hao / Zhang, Xingyu / Kaltenmeier, Christof / Packiaraj, Godwin / Crane, Andrew / Alshamery, Sarmad / Gunabushanam, Vikraman / Ganoza, Armando / Dharmayan, Stalin / Powers, Colin A / Jonassaint, Naudia / Molinari, Michele

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2024  

    Abstract: Introduction: We assessed the association between patient survival after liver transplantation (LT) and donor-recipient race-ethnicity (R/E) concordance.: Methods: The Scientific Registry of Transplant Recipients (SRTR) was retrospectively analyzed ... ...

    Abstract Introduction: We assessed the association between patient survival after liver transplantation (LT) and donor-recipient race-ethnicity (R/E) concordance.
    Methods: The Scientific Registry of Transplant Recipients (SRTR) was retrospectively analyzed using data collected between 2002 and 2019. Only adults without history of prior organ transplant and recipients of LT alone were included. The primary outcome was patient survival. Donors and recipients were categorized into five R/E groups: White/Caucasian, African American/Black, Hispanic/Latino, Asian, and Others. Statistical analyses were performed using Kaplan-Meier survival curves and Cox Proportional Hazards models, adjusting for donor and recipient covariates.
    Results: 85,427 patients were included. Among all the R/E groups, Asian patients had the highest 5-year survival (81.3%; 95% CI = 79.9-82.7), while African American/Black patients had the lowest (71.4%; 95% CI = 70.3-72.6) (P < 0.001). Lower survival rates were observed in recipients who received discordant R/E grafts irrespective of their R/E group. The fully adjusted hazard ratio for death was statistically significant in African American/Black (aHR
    Conclusion: Disparities in post-LT outcomes might be influenced by biological factors in addition to well-known social determinants of health.
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2024.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A new first-principles model to predict mild and deep surge for a centrifugal compressor

    Powers, Katherine / Kennedy, Ian / Archer, Jamie / Eynon, Paul / Horsley, John / Brace, Chris / Copeland, Colin / Milewski, Paul

    Energy. 2022 Apr. 01, v. 244

    2022  

    Abstract: Centrifugal compressors are used in many applications, including automotive turbochargers. Surge is an instability that occurs at low mass flow rates that is often damaging. Even mild surge produces noise characteristics that cause problems with customer ...

    Abstract Centrifugal compressors are used in many applications, including automotive turbochargers. Surge is an instability that occurs at low mass flow rates that is often damaging. Even mild surge produces noise characteristics that cause problems with customer acceptance. It is therefore important to be able to predict both mild and deep surge onset. In existing literature, models resulting in cubic-shaped compressor characteristics have been developed from first principles. This paper extends these to include diffuser recirculation and show a new quintic-like shape for compressor characteristics which, for the first time, can differentiate between mild and deep surge. These characteristics are incorporated into a model for an experimental facility and resulting simulations show remarkable fit to experimental data. The model allows for variations in both space and time, so simulations can capture wave dynamics in the pipework. The model captures: stable operation, mild surge, transition from mild to deep surge, deep surge, and the potential for a stable quiet period beyond the surge limit. Furthermore, the model can provide physical explanations for the surge dynamics observed. This combined with the model's predictive ability will be of help to turbocharger manufacturers during early design stages, prior to experimental tests or detailed CFD studies.
    Keywords compressors ; energy ; mass flow ; models ; space and time
    Language English
    Dates of publication 2022-0401
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2019804-8
    ISSN 0360-5442 ; 0360-5442
    ISSN (online) 0360-5442
    ISSN 0360-5442
    DOI 10.1016/j.energy.2021.123050
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Maternal Choline Supplementation as a Potential Therapy for Down Syndrome: Assessment of Effects Throughout the Lifespan.

    Powers, Brian E / Velazquez, Ramon / Strawderman, Myla S / Ginsberg, Stephen D / Mufson, Elliott J / Strupp, Barbara J

    Frontiers in aging neuroscience

    2021  Volume 13, Page(s) 723046

    Abstract: Maternal choline supplementation (MCS) has emerged as a promising therapy to lessen the cognitive ... and affective dysfunction associated with Down syndrome (DS). Choline is an essential nutrient ... of DS, our group has demonstrated that supplementing the maternal diet with additional choline (4-5 ...

    Abstract Maternal choline supplementation (MCS) has emerged as a promising therapy to lessen the cognitive and affective dysfunction associated with Down syndrome (DS). Choline is an essential nutrient, especially important during pregnancy due to its wide-ranging ontogenetic roles. Using the Ts65Dn mouse model of DS, our group has demonstrated that supplementing the maternal diet with additional choline (4-5 × standard levels) during pregnancy and lactation improves spatial cognition, attention, and emotion regulation in the adult offspring. The behavioral benefits were associated with a rescue of septohippocampal circuit atrophy. These results have been replicated across a series of independent studies, although the magnitude of the cognitive benefit has varied. We hypothesized that this was due, at least in part, to differences in the age of the subjects at the time of testing. Here, we present new data that compares the effects of MCS on the attentional function of adult Ts65Dn offspring, which began testing at two different ages (6 vs. 12 months of age). These data replicate and extend the results of our previous reports, showing a clear pattern indicating that MCS has beneficial effects in Ts65Dn offspring throughout life, but that the magnitude of the benefit (relative to non-supplemented offspring) diminishes with aging, possibly because of the onset of Alzheimer's disease-like neuropathology. In light of growing evidence that increased maternal choline intake during pregnancy is beneficial to the cognitive and affective functioning of all offspring (e.g., neurotypical and DS), the addition of this nutrient to a prenatal vitamin regimen would be predicted to have population-wide benefits and provide early intervention for fetuses with DS, notably including babies born to mothers unaware that they are carrying a fetus with DS.
    Language English
    Publishing date 2021-10-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2021.723046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Dehydrated Human Amnion Chorion Membrane as Treatment for Pediatric Burns.

    Ahuja, Natasha / Jin, Richard / Powers, Colin / Billi, Alexandria / Bass, Kathryn

    Advances in wound care

    2019  Volume 9, Issue 11, Page(s) 602–611

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adolescent ; Amnion ; Body Surface Area ; Burns/surgery ; Child ; Child, Preschool ; Chorion ; Dehydration ; Female ; Hospitals, Pediatric ; Humans ; Infant ; Male ; New York ; Retrospective Studies ; Skin Transplantation ; Skin, Artificial ; Transplantation, Homologous ; Treatment Outcome ; Wound Healing
    Language English
    Publishing date 2019-12-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2650541-1
    ISSN 2162-1934 ; 2162-1918
    ISSN (online) 2162-1934
    ISSN 2162-1918
    DOI 10.1089/wound.2019.0983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: WHEN REPRODUCTION IS NO LONGER AUTONOMOUS: FEELING RESPECTED BY MATERNITY CARE PROVIDERS MODERATES THE ASSOCIATION BETWEEN AUTONOMY IN DECISION MAKING AND BIRTH-RELATED PTSD SYMPTOMS IN A COMMUNITY SAMPLE OF POSTPARTUM BLACK WOMEN.

    Lathan, Emma C / Britt, Abby / Ravi, Meghna / Ash, Marcia J / McAfee, Elizabeth / Wallace, Shimarith / Johnson, Colin B / Woods-Jaeger, Briana / Powers, Abigail / Michopoulos, Vasiliki

    Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD)

    2023  Volume 24, Issue 4, Page(s) 520–537

    Abstract: Black individuals are at particularly high risk for birth-related posttraumatic stress disorder (PTSD) symptoms, in part due to a lack of opportunity to lead maternity care decisions. Maternal care providers need evidence-based ways to reduce pregnant ... ...

    Abstract Black individuals are at particularly high risk for birth-related posttraumatic stress disorder (PTSD) symptoms, in part due to a lack of opportunity to lead maternity care decisions. Maternal care providers need evidence-based ways to reduce pregnant persons' risk for birth-related PTSD symptoms despite reduced autonomy in decision making resulting from heightened restrictions on reproductive rights. We investigated whether a potential relation between autonomy in decision making and birth-related PTSD symptoms would be moderated by being mistreated or feeling respected by maternity care providers in a community sample of Black women (N = 52; M
    MeSH term(s) Pregnancy ; Female ; Humans ; Adult ; Child, Preschool ; Stress Disorders, Post-Traumatic ; Maternal Health Services ; Parturition ; Postpartum Period ; Emotions ; Decision Making
    Language English
    Publishing date 2023-05-26
    Publishing country England
    Document type Journal Article
    ISSN 1529-9740
    ISSN (online) 1529-9740
    DOI 10.1080/15299732.2023.2212406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Rediscovering, Reevaluating, and Restoring Lost River-Wetland Corridors

    Ellen Wohl / Janine Castro / Brian Cluer / Dorothy Merritts / Paul Powers / Brian Staab / Colin Thorne

    Frontiers in Earth Science, Vol

    2021  Volume 9

    Abstract: River-wetland corridors form where a high degree of connectivity between the surface (rheic) and subsurface (hyporheic) components of streamflow creates an interconnected system of channels, wetlands, ponds, and lakes. River-wetland corridors occur where ...

    Abstract River-wetland corridors form where a high degree of connectivity between the surface (rheic) and subsurface (hyporheic) components of streamflow creates an interconnected system of channels, wetlands, ponds, and lakes. River-wetland corridors occur where the valley floor is sufficiently wide to accommodate a laterally unconfined river planform that may feature morphologically complex, multi-threaded channels with vegetated bars, islands, and floodplains. River-wetland corridors can develop anywhere there is valley expansion along a drainage network, from the headwaters to estuaries or deltas, and they are found across all latitudes and within all biomes and hydroclimates. River-wetland corridors may be longitudinally continuous but are commonly interspersed with single-thread reaches in narrower portions of the valley. The development and persistence of river-wetland corridors is driven by combinations of geologic, biotic, and geomorphic processes that create a river environment that is diverse, heterogeneous, patchy, and dynamically stable, and within which patterns of flow, sediment features, and habitats shift continually. Hence, we describe these polydimensional river corridors as “kaleidoscope rivers.” Historically, river-wetland corridors were pervasive in wide, alluvial valley reaches, but their presence has been so diminished worldwide (due to a diverse range of anthropogenic activities and impacts) that the general public and even most river managers are unaware of their former pervasiveness. Here, we define river-wetland corridors as a river type; review paleoenvironmental and historical records to establish their past ubiquity; describe the geologic, biotic, and geomorphic processes responsible for their formation and persistence; and provide examples of river-wetland corridor remnants that still survive. We close by highlighting the significance of the diverse river functions supported by river-wetland corridors, the consequences of diminution and neglect of this river type, and the implications for ...
    Keywords connectivity ; floodplain ; hyporheic ; kaleidoscope rivers ; perirheic ; river restoration ; Science ; Q
    Subject code 550
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Demographic consequences of heterogeneity in conspecific density dependence among mast-fruiting tropical trees.

    O'Brien, Michael J / Hector, Andy / Kellenberger, Roman T / Maycock, Colin R / Ong, Robert / Philipson, Christopher D / Powers, Jennifer S / Reynolds, Glen / Burslem, David F R P

    Proceedings. Biological sciences

    2022  Volume 289, Issue 1976, Page(s) 20220739

    Abstract: The role of conspecific density dependence (CDD) in the maintenance of species richness is a central focus of tropical forest ecology. However, tests of CDD often ignore the integrated effects of CDD over multiple life stages and their long-term impacts ... ...

    Abstract The role of conspecific density dependence (CDD) in the maintenance of species richness is a central focus of tropical forest ecology. However, tests of CDD often ignore the integrated effects of CDD over multiple life stages and their long-term impacts on population demography. We combined a 10-year time series of seed production, seedling recruitment and sapling and tree demography of three dominant Southeast Asian tree species that adopt a mast-fruiting phenology. We used these data to construct individual-based models that examine the effects of CDD on population growth rates (
    MeSH term(s) Demography ; Forests ; Seedlings ; Seeds ; Trees ; Tropical Climate
    Language English
    Publishing date 2022-06-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2022.0739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Below-ground traits mediate tree survival in a tropical dry forest restoration.

    Werden, Leland K / Averill, Colin / Crowther, Thomas W / Calderón-Morales, Erick / Toro, Laura / Alvarado, J Pedro / Gutiérrez, L Milena / Mallory, Danielle E / Powers, Jennifer S

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2022  Volume 378, Issue 1867, Page(s) 20210067

    Abstract: Reforestation is one of our most promising natural climate solutions, and one that addresses the looming biodiversity crisis. Tree planting can catalyse forest community reassembly in degraded landscapes where natural regeneration is slow, however, tree ... ...

    Abstract Reforestation is one of our most promising natural climate solutions, and one that addresses the looming biodiversity crisis. Tree planting can catalyse forest community reassembly in degraded landscapes where natural regeneration is slow, however, tree survival rates vary remarkably across projects. Building a trait-based framework for tree survival could streamline species selection in a way that generalizes across ecosystems, thereby increasing the effectiveness of the global restoration movement. We investigated how traits mediated seedling survival in a tropical dry forest restoration, and how traits were coordinated across plant structures. We examined growth and survival of 14 species for 2 years and measured six below-ground and 22 above-ground traits. Species-level survival ranged widely from 7.8% to 90.1%, and a model including growth rate, below-ground traits and their interaction explained more than 73% of this variation. A strong interaction between below-ground traits and growth rate indicated that selecting species with fast growth rates can promote establishment, but this effect was most apparent for species that invest in thick fine roots and deep root structures. Overall, results emphasize the prominent role of below-ground traits in determining early restoration outcomes, and highlight little above- and below-ground trait coordination, providing a path forward for tropical dry forest restoration efforts. This article is part of the theme issue 'Understanding forest landscape restoration: reinforcing scientific foundations for the UN Decade on Ecosystem Restoration'.
    MeSH term(s) Trees ; Ecosystem ; Forests ; Biodiversity ; Seedlings ; Tropical Climate
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2021.0067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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