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  1. Article ; Online: Rheumatic heart disease.

    Steger, Christina Maria

    BMJ case reports

    2015  Volume 2015

    MeSH term(s) Aged ; Humans ; Male ; Rheumatic Heart Disease/pathology
    Language English
    Publishing date 2015-09-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2015-211943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Left ventricular non-compaction.

    Steger, Christina Maria

    BMJ case reports

    2014  Volume 2014

    MeSH term(s) Dyspnea/etiology ; Echocardiography ; Female ; Heart Transplantation ; Humans ; Infant ; Isolated Noncompaction of the Ventricular Myocardium/pathology ; Isolated Noncompaction of the Ventricular Myocardium/surgery ; Magnetic Resonance Angiography ; Tachycardia/etiology ; Weight Loss/physiology
    Language English
    Publishing date 2014-06-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2013-203430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Molecular differences between arterial and venous grafts in the first year after coronary artery bypass grafting.

    Steger, Christina Maria / Hartmann, Arndt / Rieker, Ralf Joachim

    Histochemistry and cell biology

    2020  Volume 154, Issue 4, Page(s) 405–419

    Abstract: Despite commonly used for coronary artery bypass surgery, saphenous vein (SV) grafts have significantly lower patency rates in comparison to internal thoracic artery (ITA) grafts, which might be due to the structural characteristics of the vessel wall ... ...

    Abstract Despite commonly used for coronary artery bypass surgery, saphenous vein (SV) grafts have significantly lower patency rates in comparison to internal thoracic artery (ITA) grafts, which might be due to the structural characteristics of the vessel wall but also due to differences in oxidative stress adaptation and molecular signaling and regulation. This human post mortem study included a total of 150 human bypass grafts (75 SV grafts and 75 ITA grafts) obtained from 60 patients divided into five groups due to the time period of implantation: group 1: baseline group without grafting; group 2: 1 day; group 3: > 1 day-1 week; group 4: > 1 week-1 month; group 5: > 1 month-1 year. Pieces of 3 mm length were fixed with formaldehyde, dehydrated, wax embedded, cut into sections of 3 µm thickness, and histologically and immunohistochemically examined. Over the whole time period, we observed a lower neointima formation and a better preserved media in ITA grafts with a higher percentage of TNF-α, PDGFR-α, and VEGF-A in nearly all vessel wall layers, a higher amount of MMP-7, MMP-9, EGFR, and bFGF positive cells in SV grafts and a timely different peak not only between ITA and SV grafts but also within the various vessel wall layers of both graft types. Since most of the examined growth factors, growth factor receptors and cytokines are regulated by MAPKs, our results suggest an activation of different pathways in both vessel graft types immediately after bypass grafting.
    MeSH term(s) Coronary Artery Bypass ; Cytokines/analysis ; Cytokines/metabolism ; Female ; Humans ; Intercellular Signaling Peptides and Proteins/analysis ; Intercellular Signaling Peptides and Proteins/metabolism ; Male ; Receptors, Growth Factor/analysis ; Receptors, Growth Factor/metabolism ; Saphenous Vein/metabolism ; Saphenous Vein/surgery ; Thoracic Arteries/metabolism ; Thoracic Arteries/surgery ; Time Factors
    Chemical Substances Cytokines ; Intercellular Signaling Peptides and Proteins ; Receptors, Growth Factor
    Language English
    Publishing date 2020-07-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1222930-1
    ISSN 1432-119X ; 0301-5564 ; 0948-6143
    ISSN (online) 1432-119X
    ISSN 0301-5564 ; 0948-6143
    DOI 10.1007/s00418-020-01896-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ub I Zs.94/a: Show issues Location:
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  4. Article ; Online: Staphylococcus aureus mitral valve endocarditis due to heel decubitus ulcer.

    Steger, Christina Maria

    BMJ case reports

    2012  Volume 2012

    MeSH term(s) Aged, 80 and over ; Diagnosis, Differential ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/etiology ; Endocarditis, Bacterial/microbiology ; Fatal Outcome ; Female ; Heel ; Humans ; Mitral Valve/microbiology ; Pressure Ulcer/complications ; Pressure Ulcer/diagnosis ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/etiology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/isolation & purification
    Language English
    Publishing date 2012-06-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr.02.2012.5852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Aortic valve ochronosis: a rare manifestation of alkaptonuria.

    Steger, Christina Maria

    BMJ case reports

    2011  Volume 2011

    Abstract: Alkaptonuric ochronosis is a heritable disorder of tyrosine metabolism, with various systemic abnormalities related to pigment deposition and degeneration of collagen and other tissues, including the heart and aorta. A 65-year-old woman with alkaptonuric ...

    Abstract Alkaptonuric ochronosis is a heritable disorder of tyrosine metabolism, with various systemic abnormalities related to pigment deposition and degeneration of collagen and other tissues, including the heart and aorta. A 65-year-old woman with alkaptonuric ochronosis and a history of four joint replacements required aortic valve replacement for severe aortic stenosis. Operative findings included ochronosis of a partly calcified aortic valve and the aortic intima. The aortic valve was removed at surgery and histologically investigated. Light microscopic examination of the aortic valve revealed intracellular and extracellular deposits of ochronotic pigment and a chronic inflammatory infiltrate. Beside the case representation, the disease history, aetiology, pathogenesis, clinical presentation and treatment of aortic valve ochronosis are reviewed.
    MeSH term(s) Aged ; Alkaptonuria/complications ; Alkaptonuria/diagnosis ; Alkaptonuria/surgery ; Aortic Valve ; Diagnosis, Differential ; Female ; Heart Valve Diseases/diagnosis ; Heart Valve Diseases/etiology ; Heart Valve Diseases/surgery ; Humans ; Ochronosis/diagnosis ; Ochronosis/etiology ; Ochronosis/surgery
    Language English
    Publishing date 2011-07-28
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr.04.2011.4119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Primary liposarcoma of the heart.

    Steger, Christina Maria

    BMJ case reports

    2011  Volume 2011

    Abstract: The author reports a case of a 64-year-old man, who presented with a 4-week history of dyspnoea and dizziness suffering from a large mass in the pericardium. CT of the chest showed a lobulated mass in the pericardial sac located between the pulmonary ... ...

    Abstract The author reports a case of a 64-year-old man, who presented with a 4-week history of dyspnoea and dizziness suffering from a large mass in the pericardium. CT of the chest showed a lobulated mass in the pericardial sac located between the pulmonary veins and the ascending aorta reaching the superior vena cava. The tumour was completely resected and histopathological analysis revealed the tumour to be a well-differentiated lipoma-like and focal sclerosing liposarcoma, which was composed predominantly of adipocytes with hyperchromatic nuclei and eosinophilic-to-vacuolated cytoplasm disrupted by fibrous septa. Two years after initial tumour diagnosis the patient is still alive without signs of tumour recurrence.
    MeSH term(s) Diagnosis, Differential ; Heart Neoplasms/diagnosis ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/pathology ; Heart Neoplasms/surgery ; Humans ; Liposarcoma/diagnosis ; Liposarcoma/diagnostic imaging ; Liposarcoma/pathology ; Liposarcoma/surgery ; Male ; Middle Aged ; Myocardium/pathology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2011-05-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr.03.2011.4013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Corrigendum to: Posttranslational Modification of the NADP-Malic Enzyme Involved in C4 Photosynthesis Modulates the Enzymatic Activity during the Day.

    Bovdilova, Anastasiia / Alexandre, Bruno M / Höppner, Astrid / Luís, Inês Matias / Alvarez, Clarisa E / Bickel, David / Gohlke, Holger / Decker, Christina / Nagel-Steger, Luitgard / Alseekh, Saleh / Fernie, Alisdair R / Drincovich, Maria F / Abreu, Isabel A / Maurino, Veronica G

    The Plant cell

    2021  Volume 34, Issue 1, Page(s) 698–699

    Language English
    Publishing date 2021-10-29
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 623171-8
    ISSN 1532-298X ; 1040-4651
    ISSN (online) 1532-298X
    ISSN 1040-4651
    DOI 10.1093/plcell/koab262
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    In stock of ZB MED Bonn / Germany

    Z 4952: Show issues

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  8. Article ; Online: Right ventricular hypertrabeculation due to right heart failure after left ventricular assist device implantation.

    Steger, Christina Maria / Reinold, Susanne

    BMJ case reports

    2012  Volume 2012

    MeSH term(s) Disease Progression ; Fatal Outcome ; Heart Failure/complications ; Heart Failure/physiopathology ; Heart Failure/surgery ; Heart-Assist Devices ; Humans ; Isolated Noncompaction of the Ventricular Myocardium/physiopathology ; Isolated Noncompaction of the Ventricular Myocardium/surgery ; Male ; Middle Aged ; Multiple Organ Failure/physiopathology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/surgery ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Dysfunction, Right/surgery
    Language English
    Publishing date 2012-08-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2012-006553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SARS-CoV-2 Test-to-Stay in Daycare.

    Dewald, Felix / Steger, Gertrud / Fish, Irina / Torre-Lage, Ivonne / Hellriegel, Christina / Milz, Esther / Kolb-Bastigkeit, Anja / Heger, Eva / Fries, Mira / Buess, Michael / Marizy, Niklas / Michaelis, Barbara / Suárez, Isabelle / Rubio Quintanares, Gibran Horemheb / Pirkl, Martin / Aigner, Annette / Oberste, Max / Hellmich, Martin / Wong, Anabelle /
    Orduz, Juan Camilo / Fätkenheuer, Gerd / Dötsch, Jörg / Kossow, Annelene / Moench, Eva-Maria / Quade, Gustav / Neumann, Udo / Kaiser, Rolf / Schranz, Madlen / Klein, Florian

    Pediatrics

    2024  Volume 153, Issue 5

    Abstract: Background and objectives: Test-to-stay concepts apply serial testing of children in daycare after exposure to SARS-CoV-2 without use of quarantine. This study aims to assess the safety of a test-to-stay screening in daycare facilities.: Methods: 714 ...

    Abstract Background and objectives: Test-to-stay concepts apply serial testing of children in daycare after exposure to SARS-CoV-2 without use of quarantine. This study aims to assess the safety of a test-to-stay screening in daycare facilities.
    Methods: 714 daycare facilities and approximately 50 000 children ≤6 years in Cologne, Germany participated in a SARS-CoV-2 Pool-polymerase chain reaction (PCR) screening from March 2021 to April 2022. The screening initially comprised post-exposure quarantine and was adapted to a test-to-stay approach during its course. To assess safety of the test-to-stay approach, we explored potential changes in frequencies of infections among children after the adaptation to the test-to-stay approach by applying regression discontinuity in time (RDiT) analyses. To this end, PCR-test data were linked with routinely collected data on reported infections in children and analyzed using ordinary least squares regressions.
    Results: 219 885 Pool-PCRs and 352 305 Single-PCRs were performed. 6440 (2.93%) Pool-PCRs tested positive, and 17 208 infections in children were reported. We estimated that during a period of 30 weeks, the test-to-stay concept avoided between 7 and 20 days of quarantine per eligible daycare child. RDiT revealed a 26% reduction (Exp. Coef: 0.74, confidence interval 0.52-1.06) in infection frequency among children and indicated no significant increase attributable to the test-to-stay approach. This result was not sensitive to adjustments for 7-day incidence, season, SARS-CoV-2 variant, and socioeconomic status.
    Conclusions: Our analyses provide evidence that suggest safety of the test-to-stay approach compared with quarantine measures. This approach offers a promising option to avoid use of quarantine after exposure to respiratory pathogens in daycare settings.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/diagnosis ; Child Day Care Centers ; Child, Preschool ; Germany/epidemiology ; Infant ; Quarantine ; Child ; SARS-CoV-2 ; Male ; COVID-19 Nucleic Acid Testing ; Female ; Mass Screening/methods
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2023-064668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.131: Show issues Location:
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    Zs.MO 357: Show issues

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  10. Article ; Online: Gene therapy with antisense oligonucleotides silencing c-myc reduces neointima formation and vessel wall thickness in a mouse model of vein graft disease.

    Steger, Christina Maria / Bonaros, Nikolaos / Rieker, Ralf Joachim / Bonatti, Johannes / Schachner, Thomas

    Experimental and molecular pathology

    2018  Volume 105, Issue 1, Page(s) 1–9

    Abstract: Gene therapy for avoiding intimal hyperplasia of vein grafts after coronary artery bypass grafting is still discussed controversially. A promising application of gene therapy in vein grafts is the use of antisense oligonucleotides to block the expression ...

    Abstract Gene therapy for avoiding intimal hyperplasia of vein grafts after coronary artery bypass grafting is still discussed controversially. A promising application of gene therapy in vein grafts is the use of antisense oligonucleotides to block the expression of genes encoding cell cycle regulatory proteins in vascular smooth muscle cells. C-myc, either directly or by regulating the expression of other proteins, controls cell proliferation, apoptosis and cell survival, tissue remodeling, angiogenesis, cell metabolism, production of inflammatory and anti-inflammatory cytokines, and also participates in cell transformation. Forty C57BL/6J mice underwent interposition of the inferior vena cava from isogenic donor mice into the common carotid artery using a previously described cuff technique. Twenty mice received periadventitial administration of antisense oligonucleotides directed against c-myc (treatment group), the other twenty mice received no treatment (control group). All vein grafts were harvested two weeks after surgery, dehydrated, wax embedded, cut into slides of 2 μm thickness, stained and histologically and immunohistochemically examined under light microscope. In our study, we could show the promising effects of antisense oligonucleotide treatment in a mouse model of vein graft disease including the significant reduction of neointimal, media and total vessel wall thickness with a significantly lower percentage of SMA positive cells, elastic fibres and acid mucopolysaccharides in the neointima and media, a decreased vascularization, and a lower expression of PDGFR ß, MMP-9 and VEGF-A positive cells throughout the whole vein graft wall.
    MeSH term(s) Animals ; Gene Silencing ; Graft Occlusion, Vascular/therapy ; Mice ; Mice, Inbred C57BL ; Neointima/drug therapy ; Oligonucleotides, Antisense ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; RNAi Therapeutics
    Chemical Substances Oligonucleotides, Antisense ; Proto-Oncogene Proteins c-myc
    Language English
    Publishing date 2018-05-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 207655-x
    ISSN 1096-0945 ; 0014-4800
    ISSN (online) 1096-0945
    ISSN 0014-4800
    DOI 10.1016/j.yexmp.2018.05.003
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