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  1. Article: Rheumatological aspects of pathogenesis and treatment of COVID-19 infection.

    Kalinova, Desislava / Rashkov, Rasho

    Reumatologia

    2020  Volume 58, Issue 4, Page(s) 231–235

    Abstract: Contemporary rheumatology is a field dealing with the phenomena of autoimmune states and inflammation. Rheumatic diseases cover a wide spectrum of diseases of the musculoskeletal system, connective tissue and vessels. The occurrence of an immune, ... ...

    Abstract Contemporary rheumatology is a field dealing with the phenomena of autoimmune states and inflammation. Rheumatic diseases cover a wide spectrum of diseases of the musculoskeletal system, connective tissue and vessels. The occurrence of an immune, autoimmune and autoinflammatory response is often linked to different kinds of infections. Which aspects of the coronavirus infection relate to rheumatological therapy and practice? In order to answer this question one needs to look at the pathogenesis of the SARS-CoV-2 infection. Antimalarial drugs may block antigen presentation of the viral peptides from antigen presenting cells, as they may alter the lysosomal proteases that mediate the viral entry in the cells and have demonstrated efficacy in improving the infection. Anti-IL-6 may interfere with cytokine storm in severe cases and use of tocilizumab has had good results in a small cohort. Baricitinib not only plays a role in inhibiting the synthesis of cytokines but it also has a function in suppressing receptor-mediated endocytosis. The constantly new and tested concepts in the treatment of COVID testify to the growing knowledge about the virus, but also to the need for more targeted therapy. Treatment regimens have been developed for both patients with COVID-19 and those with symptomatic SARS-CoV infection and rheumatic disease. This article is an attempt to discuss the management of COVID-19 and coexisting rheumatic disease.
    Keywords covid19
    Language English
    Publishing date 2020-08-31
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 604151-6
    ISSN 0034-6233
    ISSN 0034-6233
    DOI 10.5114/reum.2020.98435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rheumatological aspects of pathogenesis and treatment of COVID-19 infection

    Desislava Kalinova / Rasho Rashkov

    Rheumatology, Vol 58, Iss 4, Pp 231-

    2020  Volume 235

    Abstract: Contemporary rheumatology is a field dealing with the phenomena of autoimmune states and inflammation. Rheumatic diseases cover a wide spectrum of diseases of the musculoskeletal system, connective tissue and vessels. The occurrence of an immune, ... ...

    Abstract Contemporary rheumatology is a field dealing with the phenomena of autoimmune states and inflammation. Rheumatic diseases cover a wide spectrum of diseases of the musculoskeletal system, connective tissue and vessels. The occurrence of an immune, autoimmune and autoinflammatory response is often linked to different kinds of infections. Which aspects of the coronavirus infection relate to rheumatological therapy and practice? In order to answer this question one needs to look at the pathogenesis of the SARS-CoV-2 infection. Antimalarial drugs may block antigen presentation of the viral peptides from antigen presenting cells, as they may alter the lysosomal proteases that mediate the viral entry in the cells and have demonstrated efficacy in improving the infection. Anti-IL-6 may interfere with cytokine storm in severe cases and use of tocilizumab has had good results in a small cohort. Baricitinib not only plays a role in inhibiting the synthesis of cytokines but it also has a function in suppressing receptor-mediated endocytosis. The constantly new and tested concepts in the treatment of COVID testify to the growing knowledge about the virus, but also to the need for more targeted therapy. Treatment regimens have been developed for both patients with COVID-19 and those with symptomatic SARS-CoV infection and rheumatic disease. This article is an attempt to discuss the management of COVID-19 and coexisting rheumatic disease.
    Keywords covid-19 infection ; anti-rheumatic drugs ; rheumatic disease ; pneumonitis ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Coincidence of Guillain-Barré syndrome presenting with Landry's acute flaccid paralysis and transverse myelitis.

    Kalinova, Desislava / Rashkov, Rasho

    Reumatologia

    2019  Volume 57, Issue 2, Page(s) 120–122

    Abstract: Transverse myelitis is one of the causes of acute transverse myelopathy; three main categories are described in the differential diagnosis of transverse myelitis: demyelination (multiple sclerosis, neuromyelitis optica), infections (herpes zoster and ... ...

    Abstract Transverse myelitis is one of the causes of acute transverse myelopathy; three main categories are described in the differential diagnosis of transverse myelitis: demyelination (multiple sclerosis, neuromyelitis optica), infections (herpes zoster and herpes simplex virus), and some autoimmune connective tissue disorders (systemic lupus erythematosus, vasculitis). The authors present a clinical case of a 33-year-old patient with transverse myelitis occurring in the course of acute inflammatory demyelinating polyradiculoneuropathy (Guillain-Barré syndrome). The patient's medical history was notable. The patient was diagnosed with thrombotic thrombocytopenic purpura (Moschcowitz syndrome) and leukocytoclastic vasculitis when he was 12 years old.
    Language English
    Publishing date 2019-04-29
    Publishing country Poland
    Document type Case Reports
    ZDB-ID 604151-6
    ISSN 0034-6233
    ISSN 0034-6233
    DOI 10.5114/reum.2019.84819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: Grancharov et al. Flexible Polymer-Organic Solar Cells Based on P3HT:PCBM Bulk Heterojunction Active Layer Constructed under Environmental Conditions.

    Grancharov, Georgy / Atanasova, Mariya-Desislava / Kalinova, Radostina / Gergova, Rositsa / Popkirov, Georgi / Dikov, Christosko / Sendova-Vassileva, Marushka

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 11

    Abstract: The authors would like to correct a mistake in Figure 3 as published in the original publication [ ... ]. ...

    Abstract The authors would like to correct a mistake in Figure 3 as published in the original publication [...].
    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28114556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Coincidence of Guillain-Barré syndrome presenting with Landry’s acute flaccid paralysis and transverse myelitis

    Desislava Kalinova / Rasho Rashkov

    Rheumatology, Vol 57, Iss 2, Pp 120-

    2019  Volume 122

    Abstract: Transverse myelitis is one of the causes of acute transverse myelopathy; three main categories are described in the differential diagnosis of transverse myelitis: demyelination (multiple sclerosis, neuromyelitis optica), infections (herpes zoster and ... ...

    Abstract Transverse myelitis is one of the causes of acute transverse myelopathy; three main categories are described in the differential diagnosis of transverse myelitis: demyelination (multiple sclerosis, neuromyelitis optica), infections (herpes zoster and herpes simplex virus), and some autoimmune connective tissue disorders (systemic lupus erythematosus, vasculitis). The authors present a clinical case of a 33-year-old patient with transverse myelitis occurring in the course of acute inflammatory demyelinating polyradiculoneuropathy (Guillain-Barré syndrome). The patient’s medical history was notable. The patient was diagnosed with thrombotic thrombocytopenic purpura (Moschcowitz syndrome) and leukocytoclastic vasculitis when he was 12 years old.
    Keywords guillain-barré syndrome ; transverse myelitis ; leukocytoclastic vasculitis ; moschcowitz syndrome ; polyradiculoneuropathy ; Medicine ; R
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Correction

    Georgy Grancharov / Mariya-Desislava Atanasova / Radostina Kalinova / Rositsa Gergova / Georgi Popkirov / Christosko Dikov / Marushka Sendova-Vassileva

    Molecules, Vol 28, Iss 4556, p

    Grancharov et al. Flexible Polymer–Organic Solar Cells Based on P3HT:PCBM Bulk Heterojunction Active Layer Constructed under Environmental Conditions. Molecules 2021, 26 , 6890

    2023  Volume 4556

    Abstract: The authors would like to correct a mistake in Figure 3 as published in the original publication [.] ...

    Abstract The authors would like to correct a mistake in Figure 3 as published in the original publication [.]
    Keywords n/a ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Spondylodiscitis developing in a young man - diagnostic and therapeutic difficulties.

    Kalinova, Desislava / Rashkov, Rasho

    Reumatologia

    2018  Volume 56, Issue 5, Page(s) 328–332

    Abstract: Infectious spondylodiscitis is characterized by vertebral osteomyelitis, spondylitis, and discitis. Patients present with persistent low back pain, fever, or neurological findings. Diagnosis is made with a combination of clinical, radiological, and ... ...

    Abstract Infectious spondylodiscitis is characterized by vertebral osteomyelitis, spondylitis, and discitis. Patients present with persistent low back pain, fever, or neurological findings. Diagnosis is made with a combination of clinical, radiological, and laboratory findings. Magnetic resonance tomography (MRI) has high sensitivity and specificity in diagnosis and differentiation of the type of spondylodiscitis and may reveal signs of spondylodiscitis even in very early stages. Infectious spondylodiscitis responds to antimicrobial therapy well if diagnosed early before development of neurological deficit and requirement of surgical intervention. We present a clinical case of spondylodiscitis developing in a young immunocompetent man without any predisposing factors.
    Language English
    Publishing date 2018-10-31
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 604151-6
    ISSN 0034-6233
    ISSN 0034-6233
    DOI 10.5114/reum.2018.79505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Spondylodiscitis developing in a young man – diagnostic and therapeutic difficulties

    Desislava Kalinova / Rasho Rashkov

    Rheumatology, Vol 56, Iss 5, Pp 328-

    2018  Volume 332

    Abstract: Infectious spondylodiscitis is characterized by vertebral osteomyelitis, spondylitis, and discitis. Patients present with persistent low back pain, fever, or neurological findings. Diagnosis is made with a combination of clinical, radiological, and ... ...

    Abstract Infectious spondylodiscitis is characterized by vertebral osteomyelitis, spondylitis, and discitis. Patients present with persistent low back pain, fever, or neurological findings. Diagnosis is made with a combination of clinical, radiological, and laboratory findings. Magnetic resonance tomography (MRI) has high sensitivity and specificity in diagnosis and differentiation of the type of spondylodiscitis and may reveal signs of spondylodiscitis even in very early stages. Infectious spondylodiscitis responds to antimicrobial therapy well if diagnosed early before development of neurological deficit and requirement of surgical intervention. We present a clinical case of spondylodiscitis developing in a young immunocompetent man without any predisposing factors.
    Keywords Staphylococcus aureus ; infectious spondylodiscitis ; magnetic resonance tomography ; Medicine ; R
    Language English
    Publishing date 2018-10-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Biorenewable Oxypropylated Pentane-1,2,5-triol as a Source for Incorporation in Rigid Polyurethane Foams.

    Grancharov, Georgy / Atanasova, Mariya-Desislava / Kalinova, Radostina / Tuleshkov, Pencho / Petrov, Petar D / Marinova, Maya K / Ravutsov, Martin A / Simeonov, Svilen P

    Polymers

    2023  Volume 15, Issue 20

    Abstract: In this study, as a product from the efficient Achmatowicz rearrangement and mild subsequent hydrogenation-reduction reactions of biorenewable C5 alcohols derived from lignocellulose, pentane-1,2,5-triol was successfully used after oxypropylation in the ... ...

    Abstract In this study, as a product from the efficient Achmatowicz rearrangement and mild subsequent hydrogenation-reduction reactions of biorenewable C5 alcohols derived from lignocellulose, pentane-1,2,5-triol was successfully used after oxypropylation in the preparation of rigid polyurethane foams-one of the most important classes of polymeric materials. Despite the broad range of applications, the production of polyurethanes is still highly dependent on petrochemical materials considering the need of renewable raw materials and new process technologies for the production of polyol or isocyanate components as a key point for the sustainable development of polyurethane foams. The synthesized oxypropylated pentane-1,2,5-triol was analyzed using proton NMR spectroscopy, hydroxyl number, and viscosity, whereas the newly obtained foams incorporated with up to 30% biorenewable polyol were characterized using compressive stress, thermogravimetry, dynamic mechanical analysis, and scanning electron microscopy. The modified rigid polyurethanes showed better compressive strength (>400.0 kPa), a comparable thermal degradation range at 325-450 °C, and similar morphological properties to those of commercial polyurethane formulations.
    Language English
    Publishing date 2023-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15204148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Severe mononeuritis multiplex in a patient with eosinophilic granulomatosis with polyangiitis.

    Kalinova, Desislava / Kukushev, Georgi / Kolarov, Zlatimir / Rashkov, Rasho

    Reumatologia

    2019  Volume 57, Issue 5, Page(s) 288–291

    Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis characterised by bronchial asthma, hypereosinophilia, and systemic vasculitis. History of asthma with blood eosinophilia and multiorgan involvement are the important clues to ... ...

    Abstract Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis characterised by bronchial asthma, hypereosinophilia, and systemic vasculitis. History of asthma with blood eosinophilia and multiorgan involvement are the important clues to suspect EGPA. In the original paper by Churg and Strauss cardiac, gastrointestinal tract, renal, and neurological involvement were noted more frequently. The pattern of neurological involvement may be mononeuritis multiplex, and symmetrical and asymmetrical polyneuropathy. Mononeuritis multiplex was present in 78.1% while cranial nerves were involved in only 4.1% of cases. Glucocorticosteroids and immunosuppressants, especially cyclophosphamide, have considerably improved the prognosis and overall survival rates in patients with systemic vasculitis, including eosinophilic granulomatosis with polyangiitis. The authors present a clinical case of eosinophilic granulomatosis with polyangiitis with severe mononeuritis multiplex. The case reflects the successful application of a cyclophosphamide regime as a remission inducer.
    Language English
    Publishing date 2019-10-31
    Publishing country Poland
    Document type Case Reports
    ZDB-ID 604151-6
    ISSN 0034-6233
    ISSN 0034-6233
    DOI 10.5114/reum.2019.89522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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