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  1. Article ; Online: Reconstruction of Cutaneous Nasal Defects.

    Dibelius, Gregory S / Toriumi, Dean M

    Facial plastic surgery clinics of North America

    2017  Volume 25, Issue 3, Page(s) 409–426

    Abstract: Mohs micrographic surgery has become the standard of care for the treatment of cutaneous malignancies. Reconstructing cutaneous defects of the nose can be challenging, as form and function must be respected to the greatest extent possible. A wide range ... ...

    Abstract Mohs micrographic surgery has become the standard of care for the treatment of cutaneous malignancies. Reconstructing cutaneous defects of the nose can be challenging, as form and function must be respected to the greatest extent possible. A wide range of reconstructive techniques are used. Secondary intent, primary closure, skin grafts, local flaps, and the interpolated workhorse flaps represent the spectrum of options, each with specific advantages and disadvantages. Vigilant postoperative care, including judicious use of adjunctive procedures, can improve outcomes. A subunit approach to reconstruction aids with surgical planning in order to achieve the best possible results.
    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1315178-2
    ISSN 1558-1926 ; 1064-7406
    ISSN (online) 1558-1926
    ISSN 1064-7406
    DOI 10.1016/j.fsc.2017.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Transpalpebral midface lift.

    Sclafani, Anthony P / Dibelius, Gregory

    Facial plastic surgery clinics of North America

    2015  Volume 23, Issue 2, Page(s) 209–219

    Abstract: Aging of the midface is a complex aesthetic problem requiring an individualized and multifaceted surgical approach. The objective of harmonious rejuvenation of the entire face as well as increasing patient interest in midface rejuvenation mandates ... ...

    Abstract Aging of the midface is a complex aesthetic problem requiring an individualized and multifaceted surgical approach. The objective of harmonious rejuvenation of the entire face as well as increasing patient interest in midface rejuvenation mandates surgical familiarity with these techniques. Midface rejuvenation procedures have evolved from traditional laterally based rhytidectomy techniques with superolateral elevation to modern centrofacial approaches designed to achieve more vertical vectors of elevation. These approaches are informed by an evolving understanding of the multiple processes that contribute to the aged appearance of the midface and are based on lower blepharoplasty surgical techniques.
    MeSH term(s) Blepharoplasty ; Face/anatomy & histology ; Face/physiopathology ; Humans ; Rejuvenation ; Rhytidoplasty/methods
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1315178-2
    ISSN 1558-1926 ; 1064-7406
    ISSN (online) 1558-1926
    ISSN 1064-7406
    DOI 10.1016/j.fsc.2015.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Esophageal perforation as a complication of the Heimlich maneuver in a pediatric patient: A case report.

    Koss, Shira L / Karle, William E / Dibelius, Gregory / Kamat, Ameet / Berzofsky, Craig

    Ear, nose, & throat journal

    2018  Volume 97, Issue 7, Page(s) E1–E3

    Abstract: We report a case of cervical esophageal perforation caused by the Heimlich maneuver in a healthy 16-year-old boy. The patient reported a short coughing episode while eating rice, and his mother performed the Heimlich maneuver on him. Five days later, he ... ...

    Abstract We report a case of cervical esophageal perforation caused by the Heimlich maneuver in a healthy 16-year-old boy. The patient reported a short coughing episode while eating rice, and his mother performed the Heimlich maneuver on him. Five days later, he presented to the emergency department with throat pain, odynophagia, secretion intolerance, muffled voice, and neck stiffness. He was admitted to the pediatric intensive care unit for conservative management. The next day he underwent transcervical incision and drainage of purulence, but the esophageal perforation could not be visualized at that time. The perforation was identified several days later and successfully repaired surgically. Esophageal perforation as a complication of the Heimlich maneuver is exceedingly rare, but the clinician should be aware of this entity in the differential diagnosis, as it is associated with a high mortality rate and warrants multidisciplinary care, including timely surgical intervention.
    MeSH term(s) Adolescent ; Esophageal Perforation/etiology ; Heimlich Maneuver/adverse effects ; Humans ; Male
    Language English
    Publishing date 2018-09-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/014556131809700701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Noninvasive anaplastic thyroid carcinoma: report of a case and literature review.

    Dibelius, Gregory / Mehra, Saral / Clain, Jason B / Urken, Mark L / Wenig, Bruce M

    Thyroid : official journal of the American Thyroid Association

    2014  Volume 24, Issue 8, Page(s) 1319–1324

    Abstract: Anaplastic thyroid carcinoma (ATC) is an uncommon thyroid malignancy. Noninvasive ATC is a rare, surgically resectable variant with only four reported cases. We report a case of an 81-year-old man who presented with a 3.1 cm right thyroid lobe mass that ... ...

    Abstract Anaplastic thyroid carcinoma (ATC) is an uncommon thyroid malignancy. Noninvasive ATC is a rare, surgically resectable variant with only four reported cases. We report a case of an 81-year-old man who presented with a 3.1 cm right thyroid lobe mass that on fine-needle aspiration biopsy was diagnosed as an ATC. Preoperative imaging revealed an encapsulated thyroid tumor without evidence of invasion of surrounding structures and no locoregional and distant metastases. A total thyroidectomy was performed that by histologic and immunohistochemical evaluation was diagnostic for a noninvasive ATC. Given the diagnosis of noninvasive ATC, adjuvant therapy was not administered. At 14 months following diagnosis, the patient remains disease free based on positron emission tomography/computed tomography imaging. A review of the outcomes of similar cases reported in the literature, as well as observations from our case, suggest a favorable prognosis for patients with noninvasive ATC. Noninvasive ATC may represent a distinct subset of resectable ATCs with an improved prognosis. The recently published American Thyroid Association (ATA) Guidelines for Management of Patients with ATC do not include this specific form of ATC. We encourage other authors to report similar cases in order to determine whether noninvasive ATC should be considered as a separate disease entity from the traditional highly lethal form of ATC.
    MeSH term(s) Aged ; Aged, 80 and over ; Biopsy, Fine-Needle ; Humans ; Immunohistochemistry ; Male ; Positron-Emission Tomography ; Prognosis ; Thyroid Carcinoma, Anaplastic/diagnosis ; Thyroid Carcinoma, Anaplastic/pathology ; Thyroid Gland/pathology ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/pathology ; Thyroidectomy ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2014-08
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1086044-7
    ISSN 1557-9077 ; 1050-7256
    ISSN (online) 1557-9077
    ISSN 1050-7256
    DOI 10.1089/thy.2013.0586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 106: Show issues

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  5. Article ; Online: Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras.

    Gidekel Friedlander, Sharon Y / Chu, Gerald C / Snyder, Eric L / Girnius, Nomeda / Dibelius, Gregory / Crowley, Denise / Vasile, Eliza / DePinho, Ronald A / Jacks, Tyler

    Cancer cell

    2009  Volume 16, Issue 5, Page(s) 379–389

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determined the effect of PDAC-relevant gene mutations in distinct cell types of the adult pancreas. We show ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determined the effect of PDAC-relevant gene mutations in distinct cell types of the adult pancreas. We show that a subpopulation of Pdx1-expressing cells is susceptible to oncogenic K-Ras-induced transformation without tissue injury, whereas insulin-expressing endocrine cells are completely refractory to transformation under these conditions. However, chronic pancreatic injury can alter their endocrine fate and allow them to serve as the cell of origin for exocrine neoplasia. These results suggest that one mechanism by which inflammation and/or tissue damage can promote neoplasia is by altering the fate of differentiated cells that are normally refractory to oncogenic stimulation.
    MeSH term(s) Adult ; Animals ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Disease Models, Animal ; Gene Expression ; Humans ; Mice ; Mice, Transgenic ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Proto-Oncogene Proteins p21(ras)/biosynthesis ; Proto-Oncogene Proteins p21(ras)/genetics ; Signal Transduction
    Chemical Substances Hras protein, mouse (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2009-10-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccr.2009.09.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 104: Show issues

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