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Article: [Docetaxel plus S-1 as a second-line chemotherapy for metastasis or recurrence of esophageal cancer].

Nakamura, Tsutomu / Ota, Masaho / Narumiya, Kosuke / Sato, Takuya / Shirai, Yuji / Yamamoto, Masakazu / Kuramochi, Hidetoshi / Hayashi, Kazuhiko

Gan to kagaku ryoho. Cancer & chemotherapy

2012 Volume 39, Issue 2, Page(s) 227–230

Abstract: ... of docetaxel plus S-1 used as a second line therapy. We reviewed 21 patients(postoperatively, 11; after ... mediastinum(n=1), and pleura(n=1). Docetaxel 30mg/m2 was infused every 2 weeks, and S-1 80mg/m2 was taken ... S-1 might be a feasible regimen as a second-line chemotherapy for metastasis or recurrence ...

Abstract	Although chemotherapy consisting of cisplatin and 5-fluorouracil(CF)has been a standard regimen for esophageal cancer, it might be difficult to use continuously. This study evaluated the response and safety of docetaxel plus S-1 used as a second line therapy. We reviewed 21 patients(postoperatively, 11; after definitive chemoradiotherapy, 8; after chemotherapy, 2) who received chemotherapy between 2006 and 2010. Metastatic or recurrent disease was detected in the organs(n=8), lymph nodes(n=8), main tumors(n=3), mediastinum(n=1), and pleura(n=1). Docetaxel 30mg/m2 was infused every 2 weeks, and S-1 80mg/m2 was taken for 2 weeks, then with 2 weeks rest until progression. Almost all of the patients received docetaxel in the outpatient chemotherapy room. The median number of treatment cycles was 3, ranging from 1-12. Among the 14 patients with a therapeutic response, three(21%)achieved PR, 8 showed SD, and 3 had PD. Toxicity which included grade 3/4 was neutropenia in 6 patients, and anemia in one patient. After a follow-up of over one year, the median overall survival was 10 months, and the one-year survival rate was 38%. Docetaxel plus S-1 might be a feasible regimen as a second-line chemotherapy for metastasis or recurrence of esophageal cancer.
MeSH term(s)	Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Drug Combinations ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/pathology ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Oxonic Acid/administration & dosage ; Oxonic Acid/adverse effects ; Recurrence ; Salvage Therapy ; Taxoids/administration & dosage ; Taxoids/adverse effects ; Tegafur/administration & dosage ; Tegafur/adverse effects
Chemical Substances	Drug Combinations ; Taxoids ; S 1 (combination) (150863-82-4) ; Tegafur (1548R74NSZ) ; docetaxel (15H5577CQD) ; Oxonic Acid (5VT6420TIG)
Language	Japanese
Publishing date	2012-02
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Opening the Door to Better Aspirin.

Thumkeo, Dean / Narumiya, Shuh

Structure (London, England : 1993)

2021 Volume 29, Issue 3, Page(s) 200–202

Abstract: In this issue of Structure, Nojima et al. (2021) report the structure of the ... ...

Abstract	In this issue of Structure, Nojima et al. (2021) report the structure of the PGE
MeSH term(s)	Aspirin ; Cryoelectron Microscopy ; Cyclic AMP ; GTP-Binding Proteins ; Receptors, Prostaglandin E, EP4 Subtype/metabolism
Chemical Substances	Receptors, Prostaglandin E, EP4 Subtype ; Cyclic AMP (E0399OZS9N) ; GTP-Binding Proteins (EC 3.6.1.-) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1213087-4
ISSN	1878-4186 ; 0969-2126
ISSN (online)	1878-4186
ISSN	0969-2126
DOI	10.1016/j.str.2021.02.003
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Article ; Online: Calcium transients trigger switch-like discharge of prostaglandin E

Watabe, Tetsuya / Yamahira, Shinya / Takakura, Kanako / Thumkeo, Dean / Narumiya, Shuh / Matsuda, Michiyuki / Terai, Kenta

eLife

2024 Volume 12

Abstract: Prostaglandin ... ...

Abstract	Prostaglandin E
MeSH term(s)	Mice ; Animals ; Dogs ; Extracellular Signal-Regulated MAP Kinases ; Calcium ; Dinoprostone ; Kidney ; Phosphorylation
Chemical Substances	Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Calcium (SY7Q814VUP) ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.86727
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Article ; Online: Kinetic Formation of Pt-Pt Dimers of Cationic and Neutral Platinum(II) Complexes under Rapid Freeze Conditions in Solution.

Hattori, Shingo / Kawajiri, Shusei / Sekine, Akiko / Sumi, Keisuke / Narumiya, Hitomi / Sato, Kyouhei / Shinozaki, Kazuteru

Inorganic chemistry

2023 Volume 62, Issue 24, Page(s) 9491–9500

Abstract: We report the formation of M-M dimers (M = Pt or Pd) of cationic [M(dpb)( ... ...

Abstract	We report the formation of M-M dimers (M = Pt or Pd) of cationic [M(dpb)(CH
Language	English
Publishing date	2023-06-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c00820
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Article ; Online: An optimized protocol to identify keratinocyte subpopulations in vitro by single-cell RNA sequencing analysis.

Siriwach, Ratklao / Ngo, Anh Quynh / Narumiya, Shuh / Thumkeo, Dean

STAR protocols

2022 Volume 3, Issue 4, Page(s) 101906

Abstract: Here, we describe a protocol for single-cell isolation from the primary culture of normal human epidermal keratinocytes derived from neonatal foreskin. The cell culture conditions have been optimized for inducing expression of keratinocyte ... ...

Abstract	Here, we describe a protocol for single-cell isolation from the primary culture of normal human epidermal keratinocytes derived from neonatal foreskin. The cell culture conditions have been optimized for inducing expression of keratinocyte differentiation markers. Cells are cultured in the absence or presence of a bioactive lipid lysophosphatidic acid (LPA). Single cells are isolated by Fluidigm C1 system. This is followed by cDNA library preparation using Takara SMART-Seq v4 Ultra and Illumina Nextera XT kit for RNA sequencing. For complete details on the use and execution of this protocol, please refer to Siriwach et al. (2022).
MeSH term(s)	Infant, Newborn ; Humans ; Keratinocytes ; Gene Library ; Sequence Analysis, RNA/methods ; Cell Culture Techniques ; Cell Separation
Language	English
Publishing date	2022-12-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2022.101906
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Article: Physiology and pathophysiology of prostanoid receptors.

Narumiya, Shuh

Proceedings of the Japan Academy. Series B, Physical and biological sciences

2013 Volume 83, Issue 9-10, Page(s) 296–319

Abstract: Prostanoids, consisting of prostaglandins (PGs) and thromboxanes (TXs), are oxygenated products of C20 unsaturated fatty acids. They include PGD2, PGE2, PGF2 α , PGI2, and TXA2. Given that aspirin-like nonsteroidal anti-inflammatory drugs exert their ... ...

Abstract	Prostanoids, consisting of prostaglandins (PGs) and thromboxanes (TXs), are oxygenated products of C20 unsaturated fatty acids. They include PGD2, PGE2, PGF2 α , PGI2, and TXA2. Given that aspirin-like nonsteroidal anti-inflammatory drugs exert their actions by suppressing prostanoid production, prostanoids have been implicated in processes inhibited by these drugs, including inflammation, fever, and pain. Prostanoids also contribute to vascular homeostasis, reproduction, and regulation of kidney and gastrointestinal functions. How prostanoids exert such a variety of actions had remained unclear, however. Prostanoids are released outside of cells immediately after their synthesis and exert their actions by binding to receptors on target cells. We have identified a family of eight types or subtypes of G protein-coupled receptors that mediate prostanoid actions. Another G protein-coupled receptor was also identified as an additional receptor for PGD2. Genes for these receptors have been individually disrupted in mice, and analyses of these knockout mice have not only elucidated the molecular and cellular mechanisms of known prostanoid actions but also revealed previously unknown actions. In this article, I review the physiological and pathophysiological roles of prostanoids and their receptors revealed by these studies.
Language	English
Publishing date	2013-12-18
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	161781-3
ISSN	1349-2896 ; 0386-2208
ISSN (online)	1349-2896
ISSN	0386-2208
DOI	10.2183/pjab/83.296
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Article ; Online: Association between eGFR and neurological outcomes among patients with out-of-hospital cardiac arrest: A nationwide prospective study in Japan.

Kandori, Kenji / Okada, Asami / Nakajima, Satoshi / Matsuyama, Tasuku / Kitamura, Tetsuhisa / Narumiya, Hiromichi / Iizuka, Ryoji / Hitosugi, Masahito / Okada, Yohei

Acute medicine & surgery

2024 Volume 11, Issue 1, Page(s) e952

Abstract: Aim: We aimed to investigate the association between estimated glomerular filtration rate and prognosis in out-of-hospital cardiac arrest patients and explore the heterogeneity of the association.: Methods: Patients experiencing out-of-hospital ... ...

Abstract	Aim: We aimed to investigate the association between estimated glomerular filtration rate and prognosis in out-of-hospital cardiac arrest patients and explore the heterogeneity of the association. Methods: Patients experiencing out-of-hospital cardiac arrest due to medical causes and registered in the JAAM-OHCA Registry between June 2014 and December 2019 were stratified into shockable rhythm, pulseless electrical activity, and asystole groups according to the cardiac rhythm at the scene. The primary outcome was a 1-month favorable neurological status. Adjusted odds ratios with 95% confidence intervals were calculated to investigate the association between estimated glomerular filtration rate and outcomes using a logistic model. Results: Of the 19,443 patients included, 2769 had initial shockable rhythm at the scene, 5339 had pulseless electrical activity, and 11,335 had asystole. As the estimated glomerular filtration rate decreased, the adjusted odds ratio for a 1-month favorable neurological status decreased among those with initial shockable rhythm (estimated glomerular filtration rate, adjusted odds ratio [95% CI]: 45-59 mL/min/1.73 m Conclusion: The estimated glomerular filtration rate is associated with neurological prognosis in out-of-hospital cardiac arrest patients with initial shockable rhythm at the scene but not in those with initial non-shockable rhythm.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2751184-4
ISSN	2052-8817 ; 2052-8817
ISSN (online)	2052-8817
ISSN	2052-8817
DOI	10.1002/ams2.952
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Article: Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells.

Hirai, A / Nakamura, S / Noguchi, Y / Yasuda, T / Kitagawa, M / Tatsuno, I / Oeda, T / Tahara, K / Terano, T / Narumiya, S / Kohn, L D / Saito, Y

The Journal of biological chemistry

1997 Volume 272, Issue 1, Page(s) 13–16

Abstract: Cyclin-dependent kinase (Cdk) enzymes are activated for entry into the S phase of the cell cycle ... Elimination of Cdk inhibitor protein p27Kip1 during the G1 to S phase is required for the activation process ... of geranylgeranyl pyrophosphate, Rho small GTPase(s) are geranylgeranylated and translocated to membranes during G1 ...

Abstract	Cyclin-dependent kinase (Cdk) enzymes are activated for entry into the S phase of the cell cycle. Elimination of Cdk inhibitor protein p27Kip1 during the G1 to S phase is required for the activation process. An inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase prevents its elimination and leads to G1 arrest. Mevalonate and its metabolite, geranylgeranyl pyrophosphate, but not farnesyl pyrophosphate, restore the inhibitory effect of pravastatin on the degradation of p27 and allow Cdk2 activation. By the addition of geranylgeranyl pyrophosphate, Rho small GTPase(s) are geranylgeranylated and translocated to membranes during G1/S progression. The restoring effect of geranylgeranyl pyrophosphate is abolished with botulinum C3 exoenzyme, which specifically inactivates Rho. These results indicate (i) among mevalonate metabolites, geranylgeranyl pyrophosphate is absolutely required for the elimination of p27 followed by Cdk2 activation; (ii) geranylgeranylated Rho small GTPase(s) promote the degradation of p27 during G1/S transition in FRTL-5 cells.
MeSH term(s)	Animals ; CDC2-CDC28 Kinases ; Cell Cycle/drug effects ; Cell Cycle Proteins ; Cell Line ; Cyclin-Dependent Kinase 2 ; Cyclin-Dependent Kinase Inhibitor p27 ; Cyclin-Dependent Kinases/metabolism ; GTP-Binding Proteins/physiology ; Insulin/pharmacology ; Mevalonic Acid/metabolism ; Microtubule-Associated Proteins/metabolism ; Pravastatin/pharmacology ; Protein Prenylation ; Protein-Serine-Threonine Kinases/metabolism ; Rats ; Thyrotropin/pharmacology ; Tumor Suppressor Proteins ; rho GTP-Binding Proteins
Chemical Substances	Cdkn1b protein, rat ; Cell Cycle Proteins ; Insulin ; Microtubule-Associated Proteins ; Tumor Suppressor Proteins ; Cyclin-Dependent Kinase Inhibitor p27 (147604-94-2) ; Thyrotropin (9002-71-5) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; CDC2-CDC28 Kinases (EC 2.7.11.22) ; Cdk2 protein, rat (EC 2.7.11.22) ; Cyclin-Dependent Kinase 2 (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; GTP-Binding Proteins (EC 3.6.1.-) ; rho GTP-Binding Proteins (EC 3.6.5.2) ; Pravastatin (KXO2KT9N0G) ; Mevalonic Acid (S5UOB36OCZ)
Language	English
Publishing date	1997-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
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Article ; Online: Prostaglandin-cytokine crosstalk in chronic inflammation.

Yao, Chengcan / Narumiya, Shuh

British journal of pharmacology

2018 Volume 176, Issue 3, Page(s) 337–354

Abstract: Chronic inflammation underlies various debilitating disorders including autoimmune, neurodegenerative, vascular and metabolic diseases as well as cancer, where aberrant activation of the innate and acquired immune systems is frequently seen. Since non- ... ...

Abstract	Chronic inflammation underlies various debilitating disorders including autoimmune, neurodegenerative, vascular and metabolic diseases as well as cancer, where aberrant activation of the innate and acquired immune systems is frequently seen. Since non-steroidal anti-inflammatory drugs exert their effects by inhibiting COX and suppressing PG biosynthesis, PGs have been traditionally thought to function mostly as mediators of acute inflammation. However, an inducible COX isoform, COX-2, is often highly expressed in tissues of the chronic disorders, suggesting an as yet unidentified role of PGs in chronic inflammation. Recent studies have shown that in addition to their short-lived actions in acute inflammation, PGs crosstalk with cytokines and amplify the cytokine actions on various types of inflammatory cells and drive pathogenic conversion of these cells by critically regulating their gene expression. One mode of such PG-mediated amplification is to induce the expression of relevant cytokine receptors, which is typically observed in Th1 cell differentiation and Th17 cell expansion, events leading to chronic immune inflammation. Another mode of amplification is cooperation of PGs with cytokines at the transcription level. Typically, PGs and cytokines synergistically activate NF-κB to induce the expression of inflammation-related genes, one being COX-2 itself, which makes PG-mediated positive feedback loops. This signalling consequently enhances the expression of various NF-κB-induced genes including chemokines to macrophages and neutrophils, which enables sustained infiltration of these cells and further amplifies chronic inflammation. In addition, PGs are also involved in tissue remodelling such as fibrosis and angiogenesis. In this article, we review these findings and discuss their relevance to human diseases.
MeSH term(s)	Animals ; Cytokines/metabolism ; Humans ; Inflammation/metabolism ; Inflammation Mediators/metabolism ; Prostaglandins/metabolism
Chemical Substances	Cytokines ; Inflammation Mediators ; Prostaglandins
Language	English
Publishing date	2018-12-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.14530
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Article ; Online: Rho signaling research: history, current status and future directions.

Narumiya, Shuh / Thumkeo, Dean

FEBS letters

2018 Volume 592, Issue 11, Page(s) 1763–1776

Abstract: One of the main research areas in biology from the mid-1980s through the 1990s was the elucidation of signaling pathways governing cell responses. These studies brought, among other molecules, the small GTPase Rho to the epicenter. Rho signaling research ...

Abstract	One of the main research areas in biology from the mid-1980s through the 1990s was the elucidation of signaling pathways governing cell responses. These studies brought, among other molecules, the small GTPase Rho to the epicenter. Rho signaling research has since expanded to all areas of biology and medicine. Here, we describe how Rho emerged as a key molecule governing cell morphogenesis and movement, how it was linked to actin reorganization, and how the study of Rho signaling has expanded from cultured cells to whole biological systems. We then give an overview of the current research status of Rho signaling in development, brain, cardiovascular system, immunity and cancer, and discuss the future directions of Rho signaling research, with emphasis on one Rho effector, ROCK. The Rho GTPase family. Rho family GTPases have now expanded to contain 20 members. Amino acid sequences of 20 Rho GTPases found in human were aligned and the phylogenetic tree was generated by ClustalW2 software (EMBL-EBI) based on NJ algorithm. The subfamilies of the Rho GTPases are highlighted by the circle and labeled on the right side. Rho cited in this review refers to the original members of Rho subfamily, RhoA, RhoB and RhoC, that are C3 substrates, and, unless specified, not to other members of the Rho subfamily such as Rac, Cdc42, and Rnd.
MeSH term(s)	Animals ; Brain/immunology ; Brain/pathology ; Cardiovascular System/immunology ; Cardiovascular System/pathology ; History, 20th Century ; History, 21st Century ; Humans ; Neoplasm Proteins/genetics ; Neoplasm Proteins/history ; Neoplasm Proteins/immunology ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/pathology ; Signal Transduction/immunology ; rho GTP-Binding Proteins/genetics ; rho GTP-Binding Proteins/history ; rho GTP-Binding Proteins/immunology ; rho-Associated Kinases/genetics ; rho-Associated Kinases/history ; rho-Associated Kinases/immunology
Chemical Substances	Neoplasm Proteins ; rho-Associated Kinases (EC 2.7.11.1) ; rho GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2018-05-24
Publishing country	England
Document type	Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.13087
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