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  1. Article ; Online: Dimensional distress and orbitofrontal thickness in anxiety patients.

    Sambuco, Nicola / Bradley, Margaret M / Lang, Peter J

    Psychiatry research. Neuroimaging

    2023  Volume 335, Page(s) 111708

    Abstract: Thickness of the medial orbitofrontal cortex (mOFC) was assessed as it varied with reported symptoms of anxiety and depression in a large sample of anxiety patients. A principal component analysis identified a primary factor of transdiagnostic ... ...

    Abstract Thickness of the medial orbitofrontal cortex (mOFC) was assessed as it varied with reported symptoms of anxiety and depression in a large sample of anxiety patients. A principal component analysis identified a primary factor of transdiagnostic dimensional distress that predicted 24% of the mOFC variance. Severity of distress symptomology was associated with thinning of the mOFC in both hemispheres for both men and women, regardless of the primary DSM diagnosis. Taken together, the data indicate that mOFC thickness might be useful as an objective measure of disorder severity as well as to assess pharmacological or psychological treatment outcome.
    MeSH term(s) Male ; Humans ; Female ; Prefrontal Cortex/diagnostic imaging ; Anxiety/diagnostic imaging ; Anxiety Disorders/diagnostic imaging ; Cerebral Cortex ; Frontal Lobe
    Language English
    Publishing date 2023-08-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 445361-x
    ISSN 1872-7506 ; 1872-7123 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7506 ; 1872-7123
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.pscychresns.2023.111708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Hippocampal and amygdala volumes vary with transdiagnostic psychopathological dimensions of distress, anxious arousal, and trauma.

    Sambuco, Nicola / Bradley, Margaret M / Lang, Peter J

    Biological psychology

    2023  Volume 177, Page(s) 108501

    Abstract: Reduced hippocampal and/or amygdala volumes have been reported in patients with a variety of different anxiety diagnoses, suggesting that structural alterations may vary transdiagnostically across the internalizing disorders. The current study measured ... ...

    Abstract Reduced hippocampal and/or amygdala volumes have been reported in patients with a variety of different anxiety diagnoses, suggesting that structural alterations may vary transdiagnostically across the internalizing disorders. The current study measured hippocampal and amygdala volumes in anxiety and mood disorder patients assessing differences that vary dimensionally with transdiagnostic factors of distress, anxious arousal, and trauma, based on a principal components analysis of questionnaires relating to symptomology. High-resolution structural images were collected in a sample of 165 patients, and volumes extracted from the hippocampal formation (including CA1, CA2/3, CA4/DG, subiculum, and molecular layer) and the amygdala. Transdiagnostically, increasing distress was associated with reduced hippocampal CA1 volume, increasing anxious arousal was associated with reduced hippocampal CA4/DG volume, and increasing trauma severity was associated with reduced amygdala volume in women. Taken together, the data indicate that subcortical brain volumes decrease as the severity of transdiagnostic psychopathological symptomology increases.
    MeSH term(s) Humans ; Female ; Magnetic Resonance Imaging/methods ; Hippocampus ; Amygdala ; Anxiety ; Anxiety Disorders ; Organ Size
    Language English
    Publishing date 2023-01-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 185105-6
    ISSN 1873-6246 ; 0301-0511
    ISSN (online) 1873-6246
    ISSN 0301-0511
    DOI 10.1016/j.biopsycho.2023.108501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1544: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Imagery, emotion, and bioinformational theory: From body to brain.

    Bradley, Margaret M / Sambuco, Nicola / Lang, Peter J

    Biological psychology

    2023  Volume 183, Page(s) 108669

    Abstract: The bioinformational theory of emotional imagery is a model of the hypothetical mental representations activated when people imagine emotionally engaging events, and was initially proposed to guide research and practice in the use of imaginal exposure as ...

    Abstract The bioinformational theory of emotional imagery is a model of the hypothetical mental representations activated when people imagine emotionally engaging events, and was initially proposed to guide research and practice in the use of imaginal exposure as a treatment for fear and anxiety (Lang, 1979). In this 50 year overview, we discuss the development of bioinformational theory and its impact on the study of psychophysiology and psychopathology, most importantly assessing its viability and predictions in light of more recent brain-based studies of neural functional activation. Bioinformational theory proposes that narrative imagery, typically cued by language scripts, activates an associative memory network in the brain that includes stimulus (e.g., agents, contexts), semantic (e.g., facts and beliefs) and, most critically for emotion, response information (e.g., autonomic and somatic) that represents relevant real-world coping actions and reactions. Psychophysiological studies in healthy and clinical samples reliably find measurable response output during aversive and appetitive narrative imagery. Neuroimaging studies confirm that emotional imagery is associated with significant activation in motor regions of the brain, as well as in regions implicated in episodic and semantic memory retrieval, supporting the bioinformational view that narrative imagery prompts mental simulation of events that critically includes the actions and reactions engaged in emotional contexts.
    Language English
    Publishing date 2023-08-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 185105-6
    ISSN 1873-6246 ; 0301-0511
    ISSN (online) 1873-6246
    ISSN 0301-0511
    DOI 10.1016/j.biopsycho.2023.108669
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1544: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Characterization and functional analysis of

    Pasquarelli, Rebecca R / Quan, Justin J / Yang, Vivian / Britton, Timmie A / Sha, Jihui / Wohlschlegel, James A / Bradley, Peter J

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Toxoplasma gondii: Importance: Apicomplexan parasites such ... ...

    Abstract Toxoplasma gondii
    Importance: Apicomplexan parasites such as
    Language English
    Publishing date 2024-02-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.02.578703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Toxoplasma gondii

    Quan, Justin J / Nikolov, Lachezar A / Sha, Jihui / Wohlschlegel, James A / Bradley, Peter J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Toxoplasma ... ...

    Abstract Toxoplasma gondii
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.28.542599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Identification of IMC43, a novel IMC protein that collaborates with IMC32 to form an essential daughter bud assembly complex in Toxoplasma gondii.

    Pasquarelli, Rebecca R / Back, Peter S / Sha, Jihui / Wohlschlegel, James A / Bradley, Peter J

    PLoS pathogens

    2023  Volume 19, Issue 10, Page(s) e1011707

    Abstract: The inner membrane complex (IMC) of Toxoplasma gondii is essential for all phases of the parasite's life cycle. One of its most critical roles is to act as a scaffold for the assembly of daughter buds during replication by endodyogeny. While many ... ...

    Abstract The inner membrane complex (IMC) of Toxoplasma gondii is essential for all phases of the parasite's life cycle. One of its most critical roles is to act as a scaffold for the assembly of daughter buds during replication by endodyogeny. While many daughter IMC proteins have been identified, most are recruited after bud initiation and are not essential for parasite fitness. Here, we report the identification of IMC43, a novel daughter IMC protein that is recruited at the earliest stages of daughter bud initiation. Using an auxin-inducible degron system we show that depletion of IMC43 results in aberrant morphology, dysregulation of endodyogeny, and an extreme defect in replication. Deletion analyses reveal a region of IMC43 that plays a role in localization and a C-terminal domain that is essential for the protein's function. TurboID proximity labelling and a yeast two-hybrid screen using IMC43 as bait identify 30 candidate IMC43 binding partners. We investigate two of these: the essential daughter protein IMC32 and a novel daughter IMC protein we named IMC44. We show that IMC43 is responsible for regulating the localization of both IMC32 and IMC44 at specific stages of endodyogeny and that this regulation is dependent on the essential C-terminal domain of IMC43. Using pairwise yeast two-hybrid assays, we determine that this region is also sufficient for binding to both IMC32 and IMC44. As IMC43 and IMC32 are both essential proteins, this work reveals the existence of a bud assembly complex that forms the foundation of the daughter IMC during endodyogeny.
    MeSH term(s) Toxoplasma/metabolism ; Nuclear Family ; Protozoan Proteins/metabolism ; Membrane Proteins/metabolism ; Two-Hybrid System Techniques
    Chemical Substances Protozoan Proteins ; Membrane Proteins
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011707
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  7. Article ; Online: Neural correlates of repeated retrieval of emotional autobiographical events.

    Bradley, Margaret M / Sambuco, Nicola / Lang, Peter J

    Neuropsychologia

    2022  Volume 169, Page(s) 108203

    Abstract: Understanding the neural correlates of repetitive retrieval of emotional events is critical in addressing pathological emotional processing, as repeated processing is central for a number of different therapeutic interventions. In the current study, ... ...

    Abstract Understanding the neural correlates of repetitive retrieval of emotional events is critical in addressing pathological emotional processing, as repeated processing is central for a number of different therapeutic interventions. In the current study, single-trial functional brain activity was assessed in key regions implicated in episodic retrieval, including the medial prefrontal cortex (mPFC), anterior hippocampus, posterior hippocampus, and the posteromedial parietal cortex (i.e., posterior cingulate cortex and the precuneus) following repeated retrieval of pleasant and unpleasant autobiographical events. Replicating previous studies, repetition prompted reduced blood-oxygen-level-dependent (BOLD) amplitude in the anterior hippocampus and the mPFC, but not in the posterior hippocampus, due to no functional activity during mental imagery, or in the posteromedial parietal cortex, due to enhanced activation that was sustained across repetitions. Neural activation during pleasant and unpleasant autobiographical retrieval did not differ as a function of repetition, indicating similar processing effects regardless of motivational relevance. Taken together, the hedonic valence of retrieved memories does not affect functional activity associated with repeated retrieval of episodic events, in which the pattern of BOLD amplitude change suggests a dissociation between the hippocampal-prefrontal circuit, which shows repetition suppression, and the posteromedial parietal cortex, which shows sustained activation.
    MeSH term(s) Brain/diagnostic imaging ; Brain/physiology ; Brain Mapping ; Emotions/physiology ; Hippocampus/diagnostic imaging ; Hippocampus/physiology ; Humans ; Magnetic Resonance Imaging ; Memory, Episodic ; Mental Recall/physiology ; Parietal Lobe
    Language English
    Publishing date 2022-03-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 207151-4
    ISSN 1873-3514 ; 0028-3932
    ISSN (online) 1873-3514
    ISSN 0028-3932
    DOI 10.1016/j.neuropsychologia.2022.108203
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 524: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Identification of IMC43, a novel IMC protein that collaborates with IMC32 to form an essential daughter bud assembly complex in Toxoplasma gondii.

    Rebecca R Pasquarelli / Peter S Back / Jihui Sha / James A Wohlschlegel / Peter J Bradley

    PLoS Pathogens, Vol 19, Iss 10, p e

    2023  Volume 1011707

    Abstract: The inner membrane complex (IMC) of Toxoplasma gondii is essential for all phases of the parasite's life cycle. One of its most critical roles is to act as a scaffold for the assembly of daughter buds during replication by endodyogeny. While many ... ...

    Abstract The inner membrane complex (IMC) of Toxoplasma gondii is essential for all phases of the parasite's life cycle. One of its most critical roles is to act as a scaffold for the assembly of daughter buds during replication by endodyogeny. While many daughter IMC proteins have been identified, most are recruited after bud initiation and are not essential for parasite fitness. Here, we report the identification of IMC43, a novel daughter IMC protein that is recruited at the earliest stages of daughter bud initiation. Using an auxin-inducible degron system we show that depletion of IMC43 results in aberrant morphology, dysregulation of endodyogeny, and an extreme defect in replication. Deletion analyses reveal a region of IMC43 that plays a role in localization and a C-terminal domain that is essential for the protein's function. TurboID proximity labelling and a yeast two-hybrid screen using IMC43 as bait identify 30 candidate IMC43 binding partners. We investigate two of these: the essential daughter protein IMC32 and a novel daughter IMC protein we named IMC44. We show that IMC43 is responsible for regulating the localization of both IMC32 and IMC44 at specific stages of endodyogeny and that this regulation is dependent on the essential C-terminal domain of IMC43. Using pairwise yeast two-hybrid assays, we determine that this region is also sufficient for binding to both IMC32 and IMC44. As IMC43 and IMC32 are both essential proteins, this work reveals the existence of a bud assembly complex that forms the foundation of the daughter IMC during endodyogeny.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Multivalent Interactions Drive the

    Back, Peter S / O'Shaughnessy, William J / Moon, Andy S / Dewangan, Pravin S / Reese, Michael L / Bradley, Peter J

    mBio

    2022  Volume 13, Issue 1, Page(s) e0286421

    Abstract: ... ...

    Abstract The
    MeSH term(s) Humans ; Toxoplasma/metabolism ; Protozoan Proteins/metabolism ; Toxoplasmosis/parasitology ; Cell Membrane/metabolism ; Cytoskeleton/metabolism
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02864-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The

    Thind, Amara C / Mota, Caroline M / Gonçalves, Ana Paula N / Sha, Jihui / Wohlschlegel, James A / Mineo, Tiago W P / Bradley, Peter J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Toxoplasma gondii: Importance: Toxoplasma ... ...

    Abstract Toxoplasma gondii
    Importance: Toxoplasma gondii
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.31.543158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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