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Article: Polyarthrite rhumatoïde difficile à traiter.

Alromaih, Fahad Jamal / Dumusc, Alexandre

2024 Volume 20, Issue 865, Page(s) 541–545

Abstract: Rheumatoid arthritis is the most common inflammatory arthritis and has benefited from significant advances in its management in the past years. However, specific challenges persist, including the management of difficult-to-treat rheumatoid (D2TRA), which ...

Title translation	Difficult-to-treat rheumatoid arthritis.
Abstract	Rheumatoid arthritis is the most common inflammatory arthritis and has benefited from significant advances in its management in the past years. However, specific challenges persist, including the management of difficult-to-treat rheumatoid (D2TRA), which is defined by the failure of at least two biological or targeted synthetic disease-modifying antirheumatic drugs with a different mechanism of action. D2TRA reported prevalence is from 5 to 20 %. EULAR (European Alliance of Associations for Rheumatology) proposed a step-by-step approach for managing D2TRA, starting with confirmation of diagnosis, assessment of inflammatory activity, immunosuppressive treatment choice and non-pharmacological treatment.
MeSH term(s)	Humans ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Antirheumatic Agents/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Rheumatology
Chemical Substances	Antirheumatic Agents ; Immunosuppressive Agents
Language	French
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2024.20.865.541
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Article: Utilité des scores pour le suivi de la polyarthrite rhumatoïde et autres arthropathies inflammatoires.

Schläpfer-Pessina, Aline / Dumusc, Alexandre

Revue medicale suisse

2022 Volume 18, Issue 773, Page(s) 462–466

Abstract: Many clinical scores have been developed in research to measure rheumatoid arthritis (RA), spondyloarthritis (SpA) and psoriatic arthritis (PsA) activity. In routine care, they may be used as part of a treat to target (T2T) strategy consisting of a ... ...

Title translation	Use of clinical scores for rheumatoid arthritis and inflammatory rheumatic diseases in routine care.
Abstract	Many clinical scores have been developed in research to measure rheumatoid arthritis (RA), spondyloarthritis (SpA) and psoriatic arthritis (PsA) activity. In routine care, they may be used as part of a treat to target (T2T) strategy consisting of a systematic evaluation of disease activity followed by an adaptation of the treatment in order to reach a predefined therapeutic target, generally remission. The benefits of this strategy have been showed in RA and its use is recommended for this condition. The added value of the T2T strategy for SpA and PsA remains debated, requiring further studies. Scores may be used for the follow-up of patients, but their limitations should be taken in consideration.
MeSH term(s)	Arthritis, Psoriatic/drug therapy ; Arthritis, Psoriatic/therapy ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/therapy ; Humans ; Spondylarthritis/drug therapy ; Spondylarthritis/therapy
Language	French
Publishing date	2022-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2022.18.773.462
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Article ; Online: Answer to Cipolletta et al. "Treatment of acute CPP crystal arthritis: What are we missing?". Joint Bone Spine 2021;88:105217.

Dumusc, Alexandre / So, Alexander

Joint bone spine

2021 Volume 88, Issue 5, Page(s) 105223

MeSH term(s)	Humans ; Arthritis ; Calcium Pyrophosphate ; Crystal Arthropathies
Chemical Substances	Calcium Pyrophosphate (X69NU20D19)
Language	English
Publishing date	2021-05-21
Publishing country	France
Document type	Letter ; Comment
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2021.105223
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Article: Syndrome de Sjögren : du diagnostic au traitement.

Dumusc, Alexandre / Ribi, Camillo

Revue medicale suisse

2021 Volume 17, Issue 729, Page(s) 477–480

Abstract: Sjögren's syndrome (SS) is an auto-immune condition involving salivary and lacrymal glands leading to dry mouth and dry eyes symptoms. Some patients also present with systemic manifestations. Diagnosis of SS is made after clinical, serological, and ... ...

Title translation	Sjögren's syndrome: from diagnosis to treatment.
Abstract	Sjögren's syndrome (SS) is an auto-immune condition involving salivary and lacrymal glands leading to dry mouth and dry eyes symptoms. Some patients also present with systemic manifestations. Diagnosis of SS is made after clinical, serological, and histological assessment according to the American College of Rheumatology and European League Against Rheumatism (EULAR) classification criteria. Recent clinical trials showed a significant decrease of systemic activity of SS in patients treated with iscalimab (anti-CD40) and ianalumab (anti-BAFF-R). These results need to be confirmed in larger studies. However, two phase 3 randomized trials did not show efficacy treating SS with abatacept. We also describe in this article the first EULAR recommendations on SS management.
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Humans ; Rheumatology ; Sjogren's Syndrome/diagnosis ; Sjogren's Syndrome/drug therapy ; United States
Chemical Substances	Antibodies, Monoclonal, Humanized ; ianalumab (ZN2GQ3II96)
Language	French
Publishing date	2021-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Article ; Online: Altered platelet functions during treatment with apremilast for psoriatic arthritis: A case report.

Tsilimidos, Gerasimos / Blum, Sabine / Aliotta, Alessandro / Dumusc, Alexandre / Alberio, Lorenzo

Current research in translational medicine

2022 Volume 70, Issue 4, Page(s) 103358

MeSH term(s)	Humans ; Arthritis, Psoriatic/drug therapy ; Thalidomide/adverse effects ; Treatment Outcome
Chemical Substances	apremilast (UP7QBP99PN) ; Thalidomide (4Z8R6ORS6L)
Language	English
Publishing date	2022-06-17
Publishing country	France
Document type	Case Reports ; Letter
ISSN	2452-3186
ISSN (online)	2452-3186
DOI	10.1016/j.retram.2022.103358
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Article: Rhumatologie et COVID-19.

Dumusc, Alexandre / Dan, Diana

Revue medicale suisse

2020 Volume 16, Issue N° 691-2, Page(s) 831–834

Abstract: Current pandemic implies changes in patient care in rheumatology to reduce the risk of coronavirus transmission to patients visiting health-care facilities, by organizing less frequent blood tests, using teleconsultations, and switching from intravenous ... ...

Title translation	Rheumatology and COVID-19.
Abstract	Current pandemic implies changes in patient care in rheumatology to reduce the risk of coronavirus transmission to patients visiting health-care facilities, by organizing less frequent blood tests, using teleconsultations, and switching from intravenous to subcutaneous drug administration. Patients under immunosuppressive treatment are considered at high risk of severe outcome and are protected accordingly by the Swiss authorities. However, current, scarce scientific evidence suggests that patients under immunosuppressive therapy do not necessarily develop severe COVID-19 presentations. Therefore, the current guidelines recommend pursuing the treatment throughout the pandemic. In case of SARS-CoV-2 infection, immunosuppressive drugs should be temporarily stopped, except for glucocorticoids, hydroxychloroquine and sulfasalazine.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Pandemics ; Pneumonia, Viral/epidemiology ; Rheumatology/trends ; SARS-CoV-2
Chemical Substances	Immunosuppressive Agents
Keywords	covid19
Language	French
Publishing date	2020-04-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Article: Arthrite 4.0 : le cycle numérique est en marche.

Hügle, Thomas / Dumusc, Alexandre

Revue medicale suisse

2019 Volume 15, Issue 641, Page(s) 549–553

Abstract: Current digital solutions in rheumatology support patients in terms of information and communication. E-diagnosis and symptom checker potentially reduce the delay of diagnosis. Patient reported outcome is increasingly used to monitor disease activity. In ...

Title translation	Arthritis 4.0 : The digital cycle has begun.
Abstract	Current digital solutions in rheumatology support patients in terms of information and communication. E-diagnosis and symptom checker potentially reduce the delay of diagnosis. Patient reported outcome is increasingly used to monitor disease activity. In future, motion tracker and other types of sensors e.g. in smartphones might provide further information in order to predict disease flares. Artificial intelligence will likely be used for disease stratification, prediction and treatment choice. Together a « digital cycle » including diagnosis, surveillance and treat-ment decision is going to be established. The role of the rheuma-tologists within this cycle needs to be defined.
MeSH term(s)	Arthritis/therapy ; Decision Making ; Forecasting ; Humans ; Patient Selection ; Rheumatology
Language	French
Publishing date	2019-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Article ; Online: Real-life drug retention rate and safety of rituximab when treating rheumatic diseases: a single-centre Swiss retrospective cohort study.

Dumusc, Alexandre / Alromaih, Fahad / Perreau, Matthieu / Hügle, Thomas / Zufferey, Pascal / Dan, Diana

Arthritis research & therapy

2023 Volume 25, Issue 1, Page(s) 91

Abstract: Background: In Switzerland, rituximab (RTX) is licenced for the treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitis (AAV) but is frequently used off-label to treat other auto-immune diseases (AID), especially connective tissue diseases ...

Abstract	Background: In Switzerland, rituximab (RTX) is licenced for the treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitis (AAV) but is frequently used off-label to treat other auto-immune diseases (AID), especially connective tissue diseases (CTD). We aimed to characterise the use of RTX in AID in a real-life Swiss setting and compare RTX retention rates and safety outcomes between patients treated for RA, CTD and AAV. Methods: A retrospective cohort study of patients who started RTX in the Rheumatology Department for RA or AID. The RTX retention rate was analysed using Kaplan-Meier survival curves. Occurrences of serious adverse events (SAE), low IgG levels and anti-drug antibodies (ADA) were reported. Results: Two hundred three patients were treated with RTX: 51.7% had RA, 29.6% CTD, 9.9% vasculitis and 8.9% other AIDs. The total observation time was 665 patient-years. RTX retention probability at 2 years (95%CI) was similar for RA and CTD 0.65 (0.55 to 0.73), 0.60 (0.47 to 0.72) and lower for vasculitis 0.25 (0.09 to 0.45). Survival curves for RTX retention matched closely (p = 0.97) between RA and CTD patients but were lower for patients with vasculitis due to a higher percentage of induced remission. Patients with vasculitis (95%) and CTD (75%) had a higher rate of concomitant glucocorticoid use than RA (60%). Moderate to severe hypogammaglobulinaemia was observed more frequently in patients with vasculitis (35%) than with RA (13%) or CTD (9%) and was associated with an increased risk of presenting a first infectious SAE (HR 2.01, 95% CI 1.04 to 3.91). The incidence rate of SAE was 23.3 SAE/100 patient-years (36% were infectious). When searched, ADAs were observed in 18% of the patients and were detected in 63% of infusions-related SAE. 10 patients died during RTX treatment and up to 12 months after the last RTX infusion, 50% from infection. Conclusion: RTX retention rates are similar for patients with RA and CTD but lower for those with vasculitis due to more frequent remission. Patients treated with RTX for vasculitis present more SAE and infectious SAE than patients with RA and CTD, potentially due to a higher use of concomitant glucocorticoids and the occurrence of hypogammaglobulinaemia.
MeSH term(s)	Humans ; Rituximab/adverse effects ; Retrospective Studies ; Switzerland/epidemiology ; Agammaglobulinemia/chemically induced ; Agammaglobulinemia/complications ; Agammaglobulinemia/drug therapy ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Connective Tissue Diseases/drug therapy ; Connective Tissue Diseases/complications ; Antibodies ; Glucocorticoids/therapeutic use ; Treatment Outcome
Chemical Substances	Rituximab (4F4X42SYQ6) ; Antibodies ; Glucocorticoids
Language	English
Publishing date	2023-06-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-023-03076-w
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Article ; Online: Idiopathic remitting seronegative symmetrical synovitis with pitting edema syndrome mimicking symptoms of polymyalgia rheumatica: a case report.

Tarasiuk-Stanislawek, Katarzyna / Dumusc, Alexandre / Favrat, Bernard / Kokkinakis, Ioannis

Journal of medical case reports

2022 Volume 16, Issue 1, Page(s) 334

Abstract: Background: Remitting seronegative symmetrical synovitis with pitting edema is a rare rheumatic condition of the elderly population that is well described but whose mechanisms remain little studied. This syndrome is characterized by symmetrical swelling ...

Abstract	Background: Remitting seronegative symmetrical synovitis with pitting edema is a rare rheumatic condition of the elderly population that is well described but whose mechanisms remain little studied. This syndrome is characterized by symmetrical swelling located mainly on the dorsal part of the hands and the feet. Because of possible heterogeneous clinical presentation, it can easily mimic the onset of other rheumatic diseases or appear associated with them. Here we report a case of a patient who developed remitting seronegative symmetrical synovitis with pitting edema with preexisting shoulder and hip girdle pain associated with progressive fatigue, indicating a possible differential diagnosis of polymyalgia rheumatica. We reviewed and compared classification for remitting seronegative symmetrical synovitis with pitting edema and polymyalgia rheumatica and discussed other differential diagnoses. Case presentation: An 84-year-old Caucasian woman presented to our General Medicine Unit with acute onset of symmetrical hands and feet edema, leading to functional limitation due to pain and stiffness. Additionally, she was complaining about neck, shoulder, and pelvic girdle pain present for about 2 months associated with worsening asthenia. Blood tests showed an elevated level of C-reactive protein and erythrocyte sedimentation rate, as well as absence of anti-cyclic citrullinated peptide antibodies and rheumatoid factor. As all criteria of remitting seronegative symmetrical synovitis with pitting edema syndrome were present, the patient was treated with low-dose prednisone, with a rapid and complete resolution of symptoms. She remains asymptomatic without treatment 2 years after the onset of symptoms, without any evident oncologic etiology. Conclusions: This case is an example of a classic representation of remitting seronegative symmetrical synovitis with pitting edema syndrome with clinical elements suggesting a concomitant existing early stage of polymyalgia rheumatica. These two entities, classified in the group of seronegative arthritis, can coexist (up to 10% of cases), with remitting seronegative symmetrical synovitis with pitting edema appearing as an initial or late manifestation of polymyalgia rheumatica. It is essential to remind that remitting seronegative symmetrical synovitis with pitting edema is associated with a higher risk of cancer (30%). A proper diagnosis allows the clinician to precisely define the appropriate therapy duration to limit its side effects in the elderly and remain aware of the potential risk of underlying malignancy.
MeSH term(s)	Aged ; Aged, 80 and over ; Edema ; Female ; Giant Cell Arteritis ; Humans ; Neoplasms ; Pain ; Polymyalgia Rheumatica ; Syndrome ; Synovitis
Language	English
Publishing date	2022-08-27
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-022-03535-z
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Article ; Online: Rhumatologie et COVID-19

Dan, Diana / Dumusc, Alexandre

Revue médicale suisse

2020

Keywords	covid19
Language	French
Publishing date	2020-04-06
Publishing country	ch
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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