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  1. Article ; Online: Treating hepatic encephalopathy in cirrhotic patients admitted to ICU with sodium phenylbutyrate: a preliminary study.

    Carrier, Paul / Loustaud-Ratti, Véronique

    Fundamental & clinical pharmacology

    2018  Volume 32, Issue 2, Page(s) 206–208

    MeSH term(s) Hepatic Encephalopathy/drug therapy ; Hepatic Encephalopathy/etiology ; Humans ; Intensive Care Units ; Liver Cirrhosis/complications ; Phenylbutyrates/therapeutic use
    Chemical Substances Phenylbutyrates ; 4-phenylbutyric acid (7WY7YBI87E)
    Language English
    Publishing date 2018-03-14
    Publishing country England
    Document type Editorial
    ZDB-ID 639134-5
    ISSN 1472-8206 ; 0767-3981
    ISSN (online) 1472-8206
    ISSN 0767-3981
    DOI 10.1111/fcp.12353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2247: Show issues Location:
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  2. Article ; Online: BDNF levels and liver stiffness in subjects with alcohol use disorder: Evaluation after alcohol withdrawal.

    Girard, Murielle / Carrier, Paul / Loustaud-Ratti, Véronique / Nubukpo, Philippe

    The American journal of drug and alcohol abuse

    2020  Volume 47, Issue 2, Page(s) 191–198

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Adult ; Alcoholism/complications ; Biomarkers/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Elasticity Imaging Techniques ; Female ; Fibrosis ; Humans ; Liver/pathology ; Male ; Middle Aged ; Substance Withdrawal Syndrome/metabolism
    Chemical Substances Biomarkers ; Brain-Derived Neurotrophic Factor ; BDNF protein, human (7171WSG8A2)
    Language English
    Publishing date 2020-11-11
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 193086-2
    ISSN 1097-9891 ; 0095-2990
    ISSN (online) 1097-9891
    ISSN 0095-2990
    DOI 10.1080/00952990.2020.1833211
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  3. Article: European Association for the Study of the Liver and French hepatitis C recent guidelines: The paradigm shift.

    Loustaud-Ratti, Véronique / Debette-Gratien, Marilyne / Carrier, Paul

    World journal of hepatology

    2018  Volume 10, Issue 10, Page(s) 639–644

    Abstract: The latest Association Française pour l'Etude du Foie - French Association for Study of the Liver (AFEF) and European Association for the Study of the Liver (EASL) recommendations announce a change of paradigm, for the management of patients infected ... ...

    Abstract The latest Association Française pour l'Etude du Foie - French Association for Study of the Liver (AFEF) and European Association for the Study of the Liver (EASL) recommendations announce a change of paradigm, for the management of patients infected with hepatitis C virus (HCV). The AFEF recommendations focus on the elimination of HCV infection on a national level by preventing reinfection, in less than ten years. This goal involves the facilitation of patients' management in a simplified pathway by increasing screening procedures and access to pangenotypic treatments mainly in the "reservoir" population of people who inject drugs and migrants. Even in the complex pathway of patients with previous comorbidities, AFEF takes the option of a therapeutic simplification. The EASL guidelines position themselves on the state of the art with a precise description of all therapeutic options available, without separating simplified and complex pathways even if they take into account the epidemiological evolution of difficult-to-treat populations.
    Language English
    Publishing date 2018-10-18
    Publishing country United States
    Document type Editorial
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v10.i10.639
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  4. Article: Iohexol plasma and urinary concentrations in cirrhotic patients: A pilot study.

    Carrier, Paul / Destere, Alexandre / Giguet, Baptiste / Debette-Gratien, Marilyne / Essig, Marie / Monchaud, Caroline / Woillard, Jean-Baptiste / Loustaud-Ratti, Véronique

    World journal of hepatology

    2022  Volume 14, Issue 8, Page(s) 1621–1632

    Abstract: Background: Renal failure is an independent prognostic factor for survival in patients with cirrhosis. Equations to calculate serum creatinine significantly overestimate the glomerular filtration rate (GFR). Plasma clearance of direct biomarkers has ... ...

    Abstract Background: Renal failure is an independent prognostic factor for survival in patients with cirrhosis. Equations to calculate serum creatinine significantly overestimate the glomerular filtration rate (GFR). Plasma clearance of direct biomarkers has been used to improve the accuracy of evaluations of GFR in this population, but no study has simultaneously measured plasma and urinary clearance, which is the gold standard.
    Aim: To study calculated plasma and urinary concentrations of iohexol, based on the kinetics of samples collected over 24 h from cirrhotic patients with three different grades of ascites.
    Methods: One dose of iohexol (5 mL) was injected intravenously and plasma concentrations were measured 11 times over 24 h in nine cirrhotic patients. The urinary concentration of iohexol was also measured, in urine collected at 4, 8, 12 and 24 h.
    Results: The plasma and urinary curves of iohexol were similar; however, incomplete urinary excretion was detected at 24 h. Within the estimated GFR limits of our population (> 30 and < 120 mL/min/1.73 m²), the median measured GFR (mGFR) was 63.7 mL/min/1.73 m² (range: 41.3-111.3 mL/min/1.73 m²), which was an accurate reflection of the actual GFR. Creatinine-based formulas for estimating GFR showed significant bias and imprecision, while the Brochner-Mortensen (BM) equation accurately estimated the mGFR (
    Conclusion: Plasma clearance of iohexol seems useful for determining GFR regardless of the ascites grade. We will secondly devise a pharmacokinetics model requiring fewer samples andvalidate the BM equation.
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Clinical Trial
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v14.i8.1621
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  5. Article ; Online: Early detection of liver injuries by the Serum enhanced binding test sensitive to albumin post-transcriptional modifications.

    El Balkhi, Souleiman / Rahali, Mohamad Ali / Lakis, Roy / Sauvage, François Ludovic / Martin, Marving / Janaszkiewicz, Angelika / Lawson, Roland / Goncalves, Ruben / Carrier, Paul / Loustaud-Ratti, Veronique / Guyot, Anne / Marquet, Pierre / Di Meo, Florent / Saint-Marcoux, Franck

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1434

    Abstract: Early and sensitive biomarkers of liver dysfunction and drug-induced liver injury (DILI) are still needed, both for patient care and drug development. We developed the Serum Enhanced Binding (SEB) test to reveal post-transcriptional modifications (PTMs) ... ...

    Abstract Early and sensitive biomarkers of liver dysfunction and drug-induced liver injury (DILI) are still needed, both for patient care and drug development. We developed the Serum Enhanced Binding (SEB) test to reveal post-transcriptional modifications (PTMs) of human serum albumin resulting from hepatocyte dysfunctions and further evaluated its performance in an animal model. The SEB test consists in spiking serum ex-vivo with ligands having specific binding sites related to the most relevant albumin PTMs and measuring their unbound fraction. To explore the hypothesis that albumin PTMs occur early during liver injury and can also be detected by the SEB test, we induced hepatotoxicity in male albino Wistar rats by administering high daily doses of ethanol and CCl
    MeSH term(s) Rats ; Male ; Humans ; Animals ; Liver/metabolism ; Rats, Wistar ; Chemical and Drug Induced Liver Injury/pathology ; Albumins/metabolism ; Ethanol/metabolism ; Biomarkers/metabolism ; Protein Isoforms/metabolism ; Carbon Tetrachloride/toxicity
    Chemical Substances Albumins ; Ethanol (3K9958V90M) ; Biomarkers ; Protein Isoforms ; Carbon Tetrachloride (CL2T97X0V0)
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-51412-0
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  6. Article ; Online: Sofosbuvir and the risk of kidney dysfunction.

    Carrier, Paul / Debette-Gratien, Marilyne / Bettayeb, Malika / Essig, Marie / Loustaud-Ratti, Véronique

    Journal of hepatology

    2020  Volume 74, Issue 1, Page(s) 256–257

    MeSH term(s) Antiviral Agents/adverse effects ; Kidney ; Sofosbuvir/adverse effects ; Sustained Virologic Response
    Chemical Substances Antiviral Agents ; Sofosbuvir (WJ6CA3ZU8B)
    Language English
    Publishing date 2020-10-16
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2020.08.019
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
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  7. Article: Cirrhotic patients and older people.

    Carrier, Paul / Debette-Gratien, Marilyne / Jacques, Jérémie / Loustaud-Ratti, Véronique

    World journal of hepatology

    2019  Volume 11, Issue 9, Page(s) 663–677

    Abstract: The global population is aging, and so the number of older cirrhotic patients is increasing. Older patients are characterised by a risk of frailty and comorbidities, and age is a risk factor for mortality in cirrhotic patients. The incidence of non- ... ...

    Abstract The global population is aging, and so the number of older cirrhotic patients is increasing. Older patients are characterised by a risk of frailty and comorbidities, and age is a risk factor for mortality in cirrhotic patients. The incidence of non-alcoholic fatty liver disease as an aetiology of cirrhosis is increasing, while that of chronic viral hepatitis is decreasing. Also, cirrhosis is frequently idiopathic. The management of portal hypertension in older cirrhotic patients is similar to that in younger patients, despite the greater risk of treatment-related adverse events of the former. The prevalence of hepatocellular carcinoma increases with age, but its treatment is unaffected. Liver transplantation is generally recommended for patients < 70 years of age. Despite the increasing prevalence of cirrhosis in older people, little data are available and few recommendations have been proposed. This review suggests that comorbidities have a considerable impact on older cirrhotic patients.
    Language English
    Publishing date 2019-09-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v11.i9.663
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  8. Article ; Online: Rooibos, a fake friend.

    Carrier, Paul / Debette-Gratien, Marilyne / Jacques, Jérémie / Grau, Muriel / Loustaud-Ratti, Véronique

    Clinics and research in hepatology and gastroenterology

    2020  Volume 45, Issue 2, Page(s) 101499

    Abstract: Rooibos is consumed worldwide and its use considered safe. It contains scavengers of free radicals and is so is deemed to be a liver protector. Nevertheless, hepatic toxicity exists even if rare. It is probably underdiagnosed and clinicians should think ... ...

    Abstract Rooibos is consumed worldwide and its use considered safe. It contains scavengers of free radicals and is so is deemed to be a liver protector. Nevertheless, hepatic toxicity exists even if rare. It is probably underdiagnosed and clinicians should think about it in case of acute hepatitis. We report a case of liver injury attributed to Rooibos.
    MeSH term(s) Aspalathus ; Humans ; Liver ; Plant Extracts
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2020-08-20
    Publishing country France
    Document type Case Reports
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2020.06.020
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  9. Article ; Online: Liver elastometry and alcohol withdrawal: Median-term follow-up in a psychiatric unit.

    Carrier, Paul / Girard, Murielle / Debette-Gratien, Marilyne / Ouedraogo, Natacha / Loustaud-Ratti, Véronique / Nubukpo, Philippe

    Alcohol (Fayetteville, N.Y.)

    2020  Volume 89, Page(s) 49–56

    Abstract: The measurement of liver stiffness (LS) shows promise as a follow-up tool after alcohol withdrawal, but it has mainly been studied in the early phase or in patients with severe liver disease. A 6-month ancillary study of a specific psychiatric cohort of ... ...

    Abstract The measurement of liver stiffness (LS) shows promise as a follow-up tool after alcohol withdrawal, but it has mainly been studied in the early phase or in patients with severe liver disease. A 6-month ancillary study of a specific psychiatric cohort of alcoholic patients without known liver disease followed after withdrawal was conducted (Clinical Trial NCT01491347). Clinical and biological data and LS values were collected every 2 months. A total of 129 patients were included in the study; 93 had an LS assessment within the first 7 days, and 37 had all four LS measurements. Only seven (7.5%) patients had an initial LS > 12.1 kPa, the threshold used to define severe fibrosis. Abstinence was not associated with changes in LS at the various median-term follow-up periods. However, LS of abstinent subjects decreased significantly relative to that of non-abstinent subjects between M0 and M2. CAP™ values were not associated with abstinence. The systematic median-term follow-up of withdrawn patients does not appear to be contributory. However, LS could help to detect relapse in the first 2 months after withdrawal for subjects treated in a psychiatric hospital for dependence. It thus could serve as a motivation tool. Prospective studies with various and higher baseline LS values are warranted for simultaneous longitudinal assessment, including for very short- and long-term LS after withdrawal.
    MeSH term(s) Alcoholism/physiopathology ; Elasticity Imaging Techniques ; Follow-Up Studies ; Humans ; Liver/physiopathology ; Prospective Studies ; Substance Withdrawal Syndrome/physiopathology
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 605912-0
    ISSN 1873-6823 ; 0741-8329
    ISSN (online) 1873-6823
    ISSN 0741-8329
    DOI 10.1016/j.alcohol.2020.07.007
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  10. Article ; Online: Double-pigtail plastic stent is effective as a rescue therapy after obstruction of choledochoduodenostomy using a lumen-apposing metal stent.

    Albouys, Jérémie / Geyl, Sophie / Redelsperger, Benjamin / Loustaud-Ratti, Véronique / Legros, Romain / Pioche, Mathieu / Jacques, Jérémie

    Endoscopy

    2021  Volume 54, Issue 5, Page(s) E184–E185

    MeSH term(s) Choledochostomy ; Drainage ; Endosonography ; Humans ; Plastics ; Stents
    Chemical Substances Plastics
    Language English
    Publishing date 2021-05-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1471-1444
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