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Book ; Online: John Macmurray's religious philosophy

McIntosh, Esther

what it means to be a person

2011

Abstract: A full-scale critical examination of Macmurray's religious philosophy has not been published and this work fills this gap, sharing his insistence that we define ourselves through action and through person-to-person relationships, while critiquing his ... ...

Institution	ebrary, Inc
Author's details	Esther McIntosh
Abstract	A full-scale critical examination of Macmurray's religious philosophy has not been published and this work fills this gap, sharing his insistence that we define ourselves through action and through person-to-person relationships, while critiquing his account of the ensuing political and religious issues. The key themes in this work are the concept of the person and the ethics of personal relations
Keywords	Act (Philosophy) ; Conduct of life ; Self (Philosophy)
Language	English
Size	Online-Ressource (276 p)
Publisher	Ashgate
Publishing place	Farnham, Surrey, England ;Burlington, Vt
Document type	Book ; Online
Note	Includes bibliographical references and index
ISBN	1283222876 ; 1283223724 ; 9780754651635 ; 9780754651635 ; 9781283223720 ; 9781283222877 ; 0754651630 ; 0754651630
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: John Daly's compound, epibatidine, facilitates identification of nicotinic receptor subtypes.

Marks, Michael J / Laverty, Duncan S / Whiteaker, Paul / Salminen, Outi / Grady, Sharon R / McIntosh, J Michael / Collins, Allan C

Journal of molecular neuroscience : MN

2009 Volume 40, Issue 1-2, Page(s) 96–104

Abstract: The diversity of nicotinic acetylcholine receptor (nAChR) subtypes was explored by measuring the effects of gene deletion and pharmacological diversity of epibatidine binding sites in mouse brain. All epibatidine binding sites require expression of ... ...

Abstract	The diversity of nicotinic acetylcholine receptor (nAChR) subtypes was explored by measuring the effects of gene deletion and pharmacological diversity of epibatidine binding sites in mouse brain. All epibatidine binding sites require expression of either the alpha7, beta2, or beta4 subunit. In agreement with general belief, the alpha4beta2-nAChR and alpha7-nAChR subtypes are major components of the epibatidine binding sites. alpha4beta2-nAChR sites account for approximately 70% of total high- and low-affinity epibatidine binding sites, while alpha7-nAChR accounts for 16% of the total sites all of which have lower affinity for epibatidine. The other subtypes are structurally diverse. Although these minor subtypes account for only 14% of total binding in whole brain, they are expressed at relatively high concentrations in specific brain areas indicating unique functional roles.
MeSH term(s)	Animals ; Binding Sites/drug effects ; Binding Sites/genetics ; Brain/drug effects ; Brain/metabolism ; Brain Chemistry/genetics ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Gene Deletion ; Mice ; Mice, Inbred C57BL ; Nicotinic Agonists/pharmacology ; Protein Subunits/analysis ; Protein Subunits/classification ; Protein Subunits/drug effects ; Pyridines/pharmacology ; Receptors, Nicotinic/analysis ; Receptors, Nicotinic/drug effects ; Receptors, Nicotinic/genetics ; Receptors, Nicotinic/metabolism ; Synaptic Transmission/drug effects ; Synaptic Transmission/genetics ; alpha7 Nicotinic Acetylcholine Receptor
Chemical Substances	Bridged Bicyclo Compounds, Heterocyclic ; Chrna7 protein, mouse ; Nicotinic Agonists ; Protein Subunits ; Pyridines ; Receptors, Nicotinic ; alpha7 Nicotinic Acetylcholine Receptor ; nicotinic receptor alpha4beta2 ; epibatidine (M6K314F1XX)
Language	English
Publishing date	2009-08-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1043392-2
ISSN	1559-1166 ; 0895-8696
ISSN (online)	1559-1166
ISSN	0895-8696
DOI	10.1007/s12031-009-9264-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: John T. Curtis : fifty years of Wisconsin plant ecology

Curtis, John T / Fralish, James S / McIntosh, Robert P / Loucks, Orie L

1993

Author's details	edited by James S. Fralish, Robert P. McIntosh and Orie L. Loucks
Keywords	Plant ecology/History. ; Botany/History.
Language	English
Size	vii, 339 p. :, ill., ports. ;, 25 cm.
Publisher	Wisconsin Academy of Sciences, Arts & Letters
Publishing place	Madison
Document type	Book
Database	NAL-Catalogue (AGRICOLA)

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Article: Memorial. John Bamber Hickam, M.D.

McIntosh, H D

Transactions of the American Clinical and Climatological Association

1971 Volume 82, Page(s) lx–lxii

MeSH term(s)	History of Medicine ; United States
Language	English
Publishing date	1971
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	603823-2
ISSN	0065-7778
ISSN	0065-7778
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Article ; Online: Undecanoic Acid and L-Phenylalanine in Vermiculite: Detection, Characterization, and UV Degradation Studies for Biosignature Identification on Mars.

McIntosh, Ophélie / García-Florentino, Cristina / Fornaro, Teresa / Marabello, Domenica / Alberini, Andrew / Silijeström, Sandra / Biczysko, Malgorzata / Szopa, Cyril / Brucato, John

Astrobiology

2024

Abstract: Solar radiation that arrives on the surface of Mars interacts with organic molecules present in the soil. The radiation can degrade or transform the organic matter and make the search for biosignatures on the planet's surface difficult. Therefore, ... ...

Abstract	Solar radiation that arrives on the surface of Mars interacts with organic molecules present in the soil. The radiation can degrade or transform the organic matter and make the search for biosignatures on the planet's surface difficult. Therefore, samples to be analyzed by instruments on board Mars probes for molecular content should be selectively chosen to have the highest organic preservation content. To support the identification of organic molecules on Mars, the behavior under UV irradiation of two organic compounds, undecanoic acid and L-phenylalanine, in the presence of vermiculite and two chloride salts, NaCl and MgCl, was studied. The degradation of the molecule's bands was monitored through IR spectroscopy. Our results show that, while vermiculite acts as a photoprotective mineral with L-phenylalanine, it catalyzes the photodegradation of undecanoic acid molecules. On the other hand, both chloride salts studied decreased the degradation of both organic species acting as photoprotectors. While these results do not allow us to conclude on the preservation capabilities of vermiculite, they show that places where chloride salts are present could be good candidates for
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2047736-3
ISSN	1557-8070 ; 1531-1074
ISSN (online)	1557-8070
ISSN	1531-1074
DOI	10.1089/ast.2023.0088
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ATM, KAP1 and the Epstein-Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication.

Xu, Huanzhou / Akinyemi, Ibukun A / Haley, John / McIntosh, Michael T / Bhaduri-McIntosh, Sumita

Nucleic acids research

2023 Volume 51, Issue 20, Page(s) 11104–11122

Abstract: The timing of transcription and replication must be carefully regulated for heavily-transcribed genomes of double-stranded DNA viruses: transcription of immediate early/early genes must decline as replication ramps up from the same genome-ensuring ... ...

Abstract	The timing of transcription and replication must be carefully regulated for heavily-transcribed genomes of double-stranded DNA viruses: transcription of immediate early/early genes must decline as replication ramps up from the same genome-ensuring efficient and timely replication of viral genomes followed by their packaging by structural proteins. To understand how the prototypic DNA virus Epstein-Barr virus tackles the logistical challenge of switching from transcription to DNA replication, we examined the proteome at viral replication forks. Specifically, to transition from transcription, the viral DNA polymerase-processivity factor EA-D is SUMOylated by the epigenetic regulator and E3 SUMO-ligase KAP1/TRIM28. KAP1's SUMO2-ligase function is triggered by phosphorylation via the PI3K-related kinase ATM and the RNA polymerase II-associated helicase RECQ5 at the transcription machinery. SUMO2-EA-D then recruits the histone loader CAF1 and the methyltransferase SETDB1 to silence the parental genome via H3K9 methylation, prioritizing replication. Thus, a key viral protein and host DNA repair, epigenetic and transcription-replication interference pathways orchestrate the handover from transcription-to-replication, a fundamental feature of DNA viruses.
MeSH term(s)	Humans ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; DNA Helicases/genetics ; DNA Replication/genetics ; Epstein-Barr Virus Infections ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/metabolism ; Histones/genetics ; Histones/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Virus Replication
Chemical Substances	Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; ATM protein, human (EC 2.7.11.1) ; DNA Helicases (EC 3.6.4.-) ; Histones ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; TRIM28 protein, human (EC 2.3.2.27) ; BALF5 protein, Epstein-barr virus (EC 2.7.7.7)
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad823
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Article ; Online: Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: A systematic review.

Chen, Pam / Vilorio, Nalini Campillo / Dhatariya, Ketan / Jeffcoate, William / Lobmann, Ralf / McIntosh, Caroline / Piaggesi, Alberto / Steinberg, John / Vas, Prash / Viswanathan, Vijay / Wu, Stephanie / Game, Fran

Diabetes/metabolism research and reviews

2024 Volume 40, Issue 3, Page(s) e3786

Abstract: Background: It is critical that interventions used to enhance the healing of chronic foot ulcers in diabetes are backed by high-quality evidence and cost-effectiveness. In previous years, the systematic review accompanying guidelines published by the ... ...

Abstract	Background: It is critical that interventions used to enhance the healing of chronic foot ulcers in diabetes are backed by high-quality evidence and cost-effectiveness. In previous years, the systematic review accompanying guidelines published by the International Working Group of the Diabetic Foot performed 4-yearly updates of previous searches, including trials of prospective, cross-sectional and case-control design. Aims: Due to a need to re-evaluate older studies against newer standards of reporting and assessment of risk of bias, we performed a whole new search from conception, but limiting studies to randomised control trials only. Materials and methods: For this systematic review, we searched PubMed, Scopus and Web of Science databases for published studies on randomised control trials of interventions to enhance healing of diabetes-related foot ulcers. We only included trials comparing interventions to standard of care. Two independent reviewers selected articles for inclusion and assessed relevant outcomes as well as methodological quality. Results: The literature search identified 22,250 articles, of which 262 were selected for full text review across 10 categories of interventions. Overall, the certainty of evidence for a majority of wound healing interventions was low or very low, with moderate evidence existing for two interventions (sucrose-octasulfate and leucocyte, platelet and fibrin patch) and low quality evidence for a further four (hyperbaric oxygen, topical oxygen, placental derived products and negative pressure wound therapy). The majority of interventions had insufficient evidence. Conclusion: Overall, the evidence to support any other intervention to enhance wound healing is lacking and further high-quality randomised control trials are encouraged.
MeSH term(s)	Pregnancy ; Female ; Humans ; Diabetic Foot/therapy ; Diabetic Foot/complications ; Cross-Sectional Studies ; Prospective Studies ; Placenta ; Foot Ulcer ; Wound Healing ; Diabetes Mellitus
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	1470192-3
ISSN	1520-7560 ; 1520-7552
ISSN (online)	1520-7560
ISSN	1520-7552
DOI	10.1002/dmrr.3786
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Book ; Online: Using Weak Supervision and Data Augmentation in Question Answering

Basu, Chumki / Garg, Himanshu / McIntosh, Allen / Sablak, Sezai / Wullert II, John R.

2023

Abstract: The onset of the COVID-19 pandemic accentuated the need for access to biomedical literature to answer timely and disease-specific questions. During the early days of the pandemic, one of the biggest challenges we faced was the lack of peer-reviewed ... ...

Abstract	The onset of the COVID-19 pandemic accentuated the need for access to biomedical literature to answer timely and disease-specific questions. During the early days of the pandemic, one of the biggest challenges we faced was the lack of peer-reviewed biomedical articles on COVID-19 that could be used to train machine learning models for question answering (QA). In this paper, we explore the roles weak supervision and data augmentation play in training deep neural network QA models. First, we investigate whether labels generated automatically from the structured abstracts of scholarly papers using an information retrieval algorithm, BM25, provide a weak supervision signal to train an extractive QA model. We also curate new QA pairs using information retrieval techniques, guided by the clinicaltrials.gov schema and the structured abstracts of articles, in the absence of annotated data from biomedical domain experts. Furthermore, we explore augmenting the training data of a deep neural network model with linguistic features from external sources such as lexical databases to account for variations in word morphology and meaning. To better utilize our training data, we apply curriculum learning to domain adaptation, fine-tuning our QA model in stages based on characteristics of the QA pairs. We evaluate our methods in the context of QA models at the core of a system to answer questions about COVID-19.
Keywords	Computer Science - Computation and Language ; Computer Science - Machine Learning
Subject code	006
Publishing date	2023-09-28
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sequential, low-temperature aqueous synthesis of Ag-In-S/Zn quantum dots

Ozdemir, Nur Koncuy / Cline, Joseph P / Sakizadeh, John / Collins, Shannon M / Brown, Angela C / McIntosh, Steven / Kiely, Christopher J / Snyder, Mark A

Journal of materials chemistry. B

2022 Volume 10, Issue 24, Page(s) 4529–4545

Abstract: The development of high quality, non-toxic ( ...

Abstract	The development of high quality, non-toxic (
MeSH term(s)	Biomineralization ; Cations ; Indium/chemistry ; Quantum Dots/chemistry ; Sulfides/chemistry ; Temperature ; Water/chemistry ; Zinc/chemistry
Chemical Substances	Cations ; Sulfides ; Indium (045A6V3VFX) ; Water (059QF0KO0R) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2022-06-22
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d2tb00682k
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway.

Xu, Huanzhou / Akinyemi, Ibukun A / Chitre, Siddhi A / Loeb, Julia C / Lednicky, John A / McIntosh, Michael T / Bhaduri-McIntosh, Sumita

Virology

2022 Volume 568, Page(s) 13–22

Abstract: Heightened inflammatory response is a prominent feature of severe COVID-19 disease. We report that the SARS-CoV-2 ORF3a viroporin activates the NLRP3 inflammasome, the most promiscuous of known inflammasomes. Ectopically expressed ORF3a triggers IL-1β ... ...

Abstract	Heightened inflammatory response is a prominent feature of severe COVID-19 disease. We report that the SARS-CoV-2 ORF3a viroporin activates the NLRP3 inflammasome, the most promiscuous of known inflammasomes. Ectopically expressed ORF3a triggers IL-1β expression via NFκB, thus priming the inflammasome. ORF3a also activates the NLRP3 inflammasome but not NLRP1 or NLRC4, resulting in maturation of IL-1β and cleavage/activation of Gasdermin. Notably, ORF3a activates the NLRP3 inflammasome via both ASC-dependent and -independent modes. This inflammasome activation requires efflux of potassium ions and oligomerization between the kinase NEK7 and NLRP3. Importantly, infection of epithelial cells with SARS-CoV-2 similarly activates the NLRP3 inflammasome. With the NLRP3 inhibitor MCC950 and select FDA-approved oral drugs able to block ORF3a-mediated inflammasome activation, as well as key ORF3a amino acid residues needed for virus release and inflammasome activation conserved in the new variants of SARS-CoV-2 isolates across continents, ORF3a and NLRP3 present prime targets for intervention.
MeSH term(s)	Amino Acid Sequence ; Antiviral Agents/pharmacology ; COVID-19/metabolism ; COVID-19/virology ; Cell Death ; Cell Line ; Host-Pathogen Interactions ; Humans ; Inflammasomes/metabolism ; Models, Biological ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Open Reading Frames ; Potassium/metabolism ; SARS-CoV-2/physiology ; Signal Transduction/drug effects ; Viroporin Proteins/chemistry ; Viroporin Proteins/genetics ; Viroporin Proteins/metabolism
Chemical Substances	Antiviral Agents ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Viroporin Proteins ; Potassium (RWP5GA015D)
Language	English
Publishing date	2022-01-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2022.01.003
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