LIVIVO - Search results -

Search results

Result 1 - 10 of total 49

Search options

Article ; Online: Comment on "Human dignity and gene editing".

Constam, Daniel B

2018 Volume 20, Issue 1

MeSH term(s)	Gene Editing ; Genome, Human ; Germ Cells ; Humans ; Personhood ; Respect
Language	English
Publishing date	2018-11-29
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.15252/embr.201847220
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5433: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 41: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING.

Pinjusic, Katarina / Ambrosini, Giovanna / Lourenco, Joao / Fournier, Nadine / Iseli, Christian / Guex, Nicolas / Egorova, Olga / Nassiri, Sina / Constam, Daniel B

Frontiers in immunology

2024 Volume 14, Page(s) 1335207

Abstract: The transforming growth factor-β (TGF-β) family member activin A (hereafter Activin-A) is overexpressed in many cancer types, often correlating with cancer-associated cachexia and poor prognosis. Activin-A secretion by melanoma cells indirectly impedes ... ...

Abstract	The transforming growth factor-β (TGF-β) family member activin A (hereafter Activin-A) is overexpressed in many cancer types, often correlating with cancer-associated cachexia and poor prognosis. Activin-A secretion by melanoma cells indirectly impedes CD8
MeSH term(s)	Animals ; Mice ; Activins/metabolism ; Melanoma/immunology ; Signal Transduction ; Transforming Growth Factor beta/metabolism ; Tumor Microenvironment ; Tumor Escape
Chemical Substances	activin A ; Activins (104625-48-1) ; Transforming Growth Factor beta
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1335207
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs.

Rothé, Benjamin / Fortier, Simon / Gagnieux, Céline / Schmuziger, Céline / Constam, Daniel B

iScience

2023 Volume 26, Issue 6, Page(s) 106855

Abstract: The growing number of diseases linked to aberrant phase transitioning of ribonucleoproteins highlights the need to uncover how the interplay between multivalent protein and RNA interactions is regulated. Cytoplasmic granules of the RNA binding protein ... ...

Abstract	The growing number of diseases linked to aberrant phase transitioning of ribonucleoproteins highlights the need to uncover how the interplay between multivalent protein and RNA interactions is regulated. Cytoplasmic granules of the RNA binding protein Bicaudal-C (Bicc1) are regulated by the ciliopathy proteins ankyrin (ANK) and sterile alpha motif (SAM) domain-containing ANKS3 and ANKS6, but whether and how target mRNAs are affected is unknown. Here, we show that head-to-tail polymers of Bicc1 nucleated by its SAM domain are interconnected by K homology (KH) domains in a protein meshwork that mediates liquid-to-gel transitioning of client transcripts. Moreover, while the dispersion of these granules by ANKS3 concomitantly released bound mRNAs, co-recruitment of ANKS6 by ANKS3 reinstated Bicc1 condensation and ribonucleoparticle assembly. RNA-independent Bicc1 polymerization and its dual regulation by ANKS3 and ANKS6 represent a new mechanism to couple the reversible immobilization of client mRNAs to controlled protein phase transitioning between distinct metastable states.
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.106855
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Regulation of TGFβ and related signals by precursor processing.

Constam, Daniel B

Seminars in cell & developmental biology

2014 Volume 32, Page(s) 85–97

Abstract: Secreted cytokines of the TGFβ family are found in all multicellular organisms and implicated in regulating fundamental cell behaviors such as proliferation, differentiation, migration and survival. Signal transduction involves complexes of specific type ...

Abstract	Secreted cytokines of the TGFβ family are found in all multicellular organisms and implicated in regulating fundamental cell behaviors such as proliferation, differentiation, migration and survival. Signal transduction involves complexes of specific type I and II receptor kinases that induce the nuclear translocation of Smad transcription factors to regulate target genes. Ligands of the BMP and Nodal subgroups act at a distance to specify distinct cell fates in a concentration-dependent manner. These signaling gradients are shaped by multiple factors, including proteases of the proprotein convertase (PC) family that hydrolyze one or several peptide bonds between an N-terminal prodomain and the C-terminal domain that forms the mature ligand. This review summarizes information on the proteolytic processing of TGFβ and related precursors, and its spatiotemporal regulation by PCs during development and various diseases, including cancer. Available evidence suggests that the unmasking of receptor binding epitopes of TGFβ is only one (and in some cases a non-essential) function of precursor processing. Future studies should consider the impact of proteolytic maturation on protein localization, trafficking and turnover in cells and in the extracellular space.
MeSH term(s)	Animals ; Humans ; Latent TGF-beta Binding Proteins/chemistry ; Latent TGF-beta Binding Proteins/metabolism ; Models, Molecular ; Proprotein Convertases/chemistry ; Proprotein Convertases/metabolism ; Protein Binding ; Protein Precursors/chemistry ; Protein Precursors/metabolism ; Protein Structure, Tertiary ; Signal Transduction ; Transforming Growth Factor beta/chemistry ; Transforming Growth Factor beta/metabolism
Chemical Substances	Latent TGF-beta Binding Proteins ; Protein Precursors ; Transforming Growth Factor beta ; Proprotein Convertases (EC 3.4.21.-)
Language	English
Publishing date	2014-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2014.01.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2918: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Role of the RNA-binding protein Bicaudal-C1 and interacting factors in cystic kidney diseases.

Rothé, Benjamin / Gagnieux, Céline / Leal-Esteban, Lucia Carolina / Constam, Daniel B

Cellular signalling

2019 Volume 68, Page(s) 109499

Abstract: Polycystic kidneys frequently associate with mutations in individual components of cilia, basal bodies or centriolar satellites that perturb complex protein networks. In this review, we focus on the RNA-binding protein Bicaudal-C1 (BICC1) which was found ...

Abstract	Polycystic kidneys frequently associate with mutations in individual components of cilia, basal bodies or centriolar satellites that perturb complex protein networks. In this review, we focus on the RNA-binding protein Bicaudal-C1 (BICC1) which was found mutated in renal cystic dysplasia, and on its interactions with the ankyrin repeat and sterile α motif (SAM)-containing proteins ANKS3 and ANKS6 and associated kinases and their partially overlapping ciliopathy phenotypes. After reviewing BICC1 homologs in model organisms and their functions in mRNA and cell metabolism during development and in renal tubules, we discuss recent insights from cell-based assays and from structure analysis of the SAM domains, and how SAM domain oligomerization might influence multivalent higher order complexes that are implicated in ciliary signal transduction.
MeSH term(s)	Amino Acid Sequence ; Animals ; Embryonic Development ; Gluconeogenesis ; Humans ; Kidney/metabolism ; Kidney/pathology ; Kidney/physiopathology ; Kidney Diseases, Cystic/metabolism ; Kidney Diseases, Cystic/physiopathology ; RNA/metabolism ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/metabolism
Chemical Substances	RNA-Binding Proteins ; RNA (63231-63-0)
Language	English
Publishing date	2019-12-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2019.109499
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2579: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3.

Rothé, Benjamin / Ikawa, Yayoi / Zhang, Zhidian / Katoh, Takanobu A / Kajikawa, Eriko / Minegishi, Katsura / Xiaorei, Sai / Fortier, Simon / Dal Peraro, Matteo / Hamada, Hiroshi / Constam, Daniel B

PLoS biology

2023 Volume 21, Issue 9, Page(s) e3002302

Abstract: Organ laterality of vertebrates is specified by accelerated asymmetric decay of Dand5 mRNA mediated by Bicaudal-C1 (Bicc1) on the left side, but whether binding of this or any other mRNA to Bicc1 can be regulated is unknown. Here, we found that a CRISPR- ... ...

Abstract	Organ laterality of vertebrates is specified by accelerated asymmetric decay of Dand5 mRNA mediated by Bicaudal-C1 (Bicc1) on the left side, but whether binding of this or any other mRNA to Bicc1 can be regulated is unknown. Here, we found that a CRISPR-engineered truncation in ankyrin and sterile alpha motif (SAM)-containing 3 (ANKS3) leads to symmetric mRNA decay mediated by the Bicc1-interacting Dand5 3' UTR. AlphaFold structure predictions of protein complexes and their biochemical validation by in vitro reconstitution reveal a novel interaction of the C-terminal coiled coil domain of ANKS3 with Bicc1 that inhibits binding of target mRNAs, depending on the conformation of ANKS3 and its regulation by ANKS6. The dual regulation of RNA binding by mutually opposing structured protein domains in this multivalent protein network emerges as a novel mechanism linking associated laterality defects and possibly other ciliopathies to perturbed dynamics in Bicc1 ribonucleoparticle (RNP) formation.
MeSH term(s)	Animals ; Functional Laterality ; Clustered Regularly Interspaced Short Palindromic Repeats ; Protein Domains ; RNA, Messenger/genetics ; Ribonucleoproteins/genetics
Chemical Substances	RNA, Messenger ; Ribonucleoproteins
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3002302
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6193: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Intracellular trafficking and signaling in development.

Constam, Daniel B

F1000 biology reports

2009 Volume 1, Page(s) 59

Abstract: Tissue patterning during development relies on cell communication by secreted proteins and receptors that engage in complex signaling crosstalk to induce distinct cell behaviors in a context-dependent fashion. Here I summarize recent insights into basic ... ...

Abstract	Tissue patterning during development relies on cell communication by secreted proteins and receptors that engage in complex signaling crosstalk to induce distinct cell behaviors in a context-dependent fashion. Here I summarize recent insights into basic mechanisms that control the distribution and activities of transforming growth factor beta, Wnt, Hedgehog, and Notch proteins, by regulating trafficking decisions during secretion and endocytosis.
Language	English
Publishing date	2009-08-17
Publishing country	England
Document type	Journal Article
ISSN	1757-594X
ISSN (online)	1757-594X
DOI	10.3410/B1-59
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen Nodal.

Constam, Daniel B

Current opinion in genetics & development

2009 Volume 19, Issue 4, Page(s) 302–307

Abstract: A fundamental challenge in biology is to explain how progenitor cells in developing tissues acquire distinct fates according to their position. In vertebrates, the positional information that specifies the germ layers and the primary body axes is ... ...

Abstract	A fundamental challenge in biology is to explain how progenitor cells in developing tissues acquire distinct fates according to their position. In vertebrates, the positional information that specifies the germ layers and the primary body axes is mediated by Nodal. Nodal meets the criteria of a morphogen since it can diffuse through tissues and signal far away from its source to directly specify multiple cell fates in a dosage-dependent manner. To consider the relationship between trafficking and graded Nodal signaling, this review summarizes recent findings how the spreading of Nodal activity is regulated by factors that promote long range signaling during left-right axis formation, and by structural features that affect Nodal protein stability and endosomal sorting.
MeSH term(s)	Animals ; Body Patterning/genetics ; Embryo, Nonmammalian/metabolism ; Gene Expression Regulation, Developmental ; Left-Right Determination Factors ; Nodal Protein/genetics ; Nodal Protein/metabolism ; Nodal Signaling Ligands ; Protein Transport ; Signal Transduction/genetics
Chemical Substances	Left-Right Determination Factors ; Nodal Protein ; Nodal Signaling Ligands
Language	English
Publishing date	2009-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1077312-5
ISSN	1879-0380 ; 0959-437X
ISSN (online)	1879-0380
ISSN	0959-437X
DOI	10.1016/j.gde.2009.06.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3240: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Riding shotgun: a dual role for the epidermal growth factor-Cripto/FRL-1/Cryptic protein Cripto in Nodal trafficking.

Constam, Daniel B

Traffic (Copenhagen, Denmark)

2009 Volume 10, Issue 7, Page(s) 783–791

Abstract: Nodal is a secreted protein of the transforming growth factor beta (TGFbeta) family that activates Smad2 and Smad3 transcription factors through complexes of type I and type II activin receptors and glycosyl-phosphatidylinositol-anchored coreceptors of ... ...

Abstract	Nodal is a secreted protein of the transforming growth factor beta (TGFbeta) family that activates Smad2 and Smad3 transcription factors through complexes of type I and type II activin receptors and glycosyl-phosphatidylinositol-anchored coreceptors of the epidermal growth factor-like Cripto/FRL-1/Cryptic family. During early embryogenesis, it stimulates the proliferation of pluripotent progenitor cells and specifies, in a dosage-dependent manner, their subsequent allocation to distinct germ layers. Available evidence indicates that the signaling strength of Nodal is controlled at the level of endocytic uptake and turnover of activated receptor complexes in early endosomes, but insights into the underlying molecular mechanisms are still limited. In this review, I briefly survey literature on the trafficking of the related TGFbeta receptors, and I discuss recent findings indicating that endocytosis of Nodal is coupled to proteolytic processing of its precursor at the cell surface and that the maturation and internalization of Nodal need to be guided by Cripto to stabilize endosomal signaling platforms.
MeSH term(s)	Animals ; Endocytosis/physiology ; Endosomes/metabolism ; Epidermal Growth Factor/metabolism ; Homeodomain Proteins/metabolism ; Humans ; Lysosomes/metabolism ; Membrane Proteins/metabolism ; Nodal Protein/metabolism ; Protein Precursors/metabolism ; Receptors, Transforming Growth Factor beta/metabolism ; Signal Transduction/physiology ; Smad Proteins/metabolism ; Transcription Factors/metabolism ; Xenopus Proteins/metabolism ; Zebrafish Proteins/metabolism
Chemical Substances	Homeodomain Proteins ; Membrane Proteins ; Nodal Protein ; Protein Precursors ; Receptors, Transforming Growth Factor beta ; Smad Proteins ; Transcription Factors ; Xenopus Proteins ; Zebrafish Proteins ; tdgf1 protein, zebrafish ; tdgf1.3 protein, Xenopus ; Epidermal Growth Factor (62229-50-9)
Language	English
Publishing date	2009-02-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1483852-7
ISSN	1600-0854 ; 1398-9219
ISSN (online)	1600-0854
ISSN	1398-9219
DOI	10.1111/j.1600-0854.2009.00874.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5634: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.

Bessonnard, Sylvain / Mesnard, Daniel / Constam, Daniel B

The Journal of cell biology

2015 Volume 210, Issue 7, Page(s) 1185–1197

Abstract: The first cell differentiation in mammalian embryos segregates polarized trophectoderm cells from an apolar inner cell mass (ICM). This lineage decision is specified in compacted morulae by cell polarization and adhesion acting on the Yes-associated ... ...

Abstract	The first cell differentiation in mammalian embryos segregates polarized trophectoderm cells from an apolar inner cell mass (ICM). This lineage decision is specified in compacted morulae by cell polarization and adhesion acting on the Yes-associated protein in the Hippo signaling pathway, but the regulatory mechanisms are unclear. We show that morula compaction and ICM formation depend on PC7 and the related proprotein convertases (PCs) Furin and Pace4 and that these proteases jointly regulate cell-cell adhesion mediated by E-cadherin processing. We also mapped the spatiotemporal activity profiles of these proteases by live imaging of a transgenic reporter substrate in wild-type and PC mutant embryos. Differential inhibition by a common inhibitor revealed that all three PCs are active in inner and outer cells, but in partially nonoverlapping compartments. E-cadherin processing by multiple PCs emerges as a novel mechanism to modulate cell-cell adhesion and fate allocation.
MeSH term(s)	Animals ; Blastocyst/cytology ; Blastocyst/metabolism ; Cadherins/genetics ; Cadherins/metabolism ; Cell Adhesion/physiology ; Furin/genetics ; Furin/metabolism ; Mice ; Mice, Knockout ; Mutation ; Proprotein Convertases/genetics ; Proprotein Convertases/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Subtilisins/genetics ; Subtilisins/metabolism
Chemical Substances	Cadherins ; Hippo protein, mouse (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Pcsk6 protein, mouse (EC 3.4.21.-) ; Pcsk7 protein, mouse (EC 3.4.21.-) ; Proprotein Convertases (EC 3.4.21.-) ; Subtilisins (EC 3.4.21.-) ; Furin (EC 3.4.21.75)
Language	English
Publishing date	2015-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.201503042
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Ub I Zs.190: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito