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  1. Article ; Online: Riesgo de reactivación de la hepatitis B asociado al tratamiento con corticoides frente a SARS-CoV-2 (COVID-19).

    Varona Pérez, J / Rodriguez Chinesta, J M

    Revista clinica espanola

    2020  Volume 220, Issue 8, Page(s) 534–536

    Title translation Risk of hepatitis B reactivation associated with treatment against SARS-CoV-2 (COVID-19) with corticosteroids.
    Keywords covid19
    Language Spanish
    Publishing date 2020-05-04
    Publishing country Spain
    Document type Journal Article
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rce.2020.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Micronuclei, Pesticides, and Element Mixtures in Mining Contexts: The Hormetic Effect of Selenium.

    Varona-Uribe, Marcela E / Díaz, Sonia M / Palma, Ruth-Marien / Briceño-Ayala, Leonardo / Trillos-Peña, Carlos / Téllez-Avila, Eliana M / Espitia-Pérez, Lyda / Pastor-Sierra, Karina / Espitia-Pérez, Pedro Juan / Idrovo, Alvaro J

    Toxics

    2023  Volume 11, Issue 10

    Abstract: The contexts where there are mining and agriculture activities are potential sources of risk to human health due to contamination by chemical mixtures. These contexts are frequent in several Colombian regions. This study explored the potential ... ...

    Abstract The contexts where there are mining and agriculture activities are potential sources of risk to human health due to contamination by chemical mixtures. These contexts are frequent in several Colombian regions. This study explored the potential association between the frequency of micronuclei and pesticides and elements in regions with ferronickel (Montelibano, Córdoba) and gold (Nechí, Antioquia) mining, and a closed native mercury mine (Aranzazu, Caldas), with an emphasis in the potential effect of selenium as a potential chelator. A cross-sectional study was carried out with 247 individuals. Sociodemographic, occupational, and toxicological variables were ascertained. Blood and urine samples were taken for pesticide analysis (5 organophosphates, 4 organochlorines, and 3 carbamates), 68 elements were quantified in hair, and micronuclei were quantified in lymphocytes. The mixtures of elements were grouped through principal component analysis. Prevalence ratios were estimated with robust variance Poisson regressions to explore associations. Interactions of selenium with toxic elements were explored. The highest concentrations of elements were in the active mines. The potentially most toxic chemical mixture was observed in the ferronickel mine. Pesticides were detected in a low proportion of participants (<2.5%), except paraoxon-methyl in blood (27.55%) in Montelibano and paraoxon-ethyl in blood (18.81%) in Aranzazu. The frequency of micronuclei was similar in the three mining contexts, with means between 4 to 7 (
    Language English
    Publishing date 2023-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11100821
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  3. Article ; Online: Effectiveness of topical insulin for the treatment of surface corneal pathologies.

    Castro Mora, M P / Palacio Varona, J / Perez Riaño, B / Laverde Cubides, C / Rey-Rodriguez, D V

    Archivos de la Sociedad Espanola de Oftalmologia

    2023  Volume 98, Issue 4, Page(s) 220–232

    Abstract: The Purpose is to identify, through a systematic literature review, the current evidence regarding the effectiveness of topical insulin treatment in ocular surface pathologies. A literature search was implemented in Medline (Pubmed), Embase and Web Of ... ...

    Abstract The Purpose is to identify, through a systematic literature review, the current evidence regarding the effectiveness of topical insulin treatment in ocular surface pathologies. A literature search was implemented in Medline (Pubmed), Embase and Web Of Science medical indexing databases by using keywords such as "insulin" AND "cornea" OR "corneal" OR "dry eye" in published papers in English or Spanish within the last eleven years (2011-2022). Nine papers were identified with 180 participants from the United States, Spain, Ireland, Canada, Portugal and Malaysia, with persistent refractory epithelial defects and secondary to vitrectomy, whose extension of the lesion was from 3,75mm
    MeSH term(s) Humans ; Insulin/therapeutic use ; Cornea ; Wound Healing ; Lubricant Eye Drops ; Administration, Topical
    Chemical Substances Insulin ; Lubricant Eye Drops
    Language English
    Publishing date 2023-03-05
    Publishing country Spain
    Document type Systematic Review ; Journal Article ; Review
    ISSN 2173-5794
    ISSN (online) 2173-5794
    DOI 10.1016/j.oftale.2023.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Retinal vein occlusion in patients under 50 years. Analysis of vascular risk factors, thrombophilia, carotid ultrasound findings and uncommon aetiologies.

    Sanlés González, I / Napal Lecumberri, J J / Pérez-Montes, R / Cerveró Varona, A / Casado Rojo, A / Hernández Hernández, J L

    Archivos de la Sociedad Espanola de Oftalmologia

    2022  Volume 97, Issue 8, Page(s) 443–449

    Abstract: Introdution: Retinal vein occlusion (RVO) has been related to vascular risk factors and thrombophilia.: Methods: This is a prospective cohort study of all patients diagnosed with RVO and referred to an Internal Medicine clinic of a tertiary teaching ... ...

    Abstract Introdution: Retinal vein occlusion (RVO) has been related to vascular risk factors and thrombophilia.
    Methods: This is a prospective cohort study of all patients diagnosed with RVO and referred to an Internal Medicine clinic of a tertiary teaching hospital during a 10-year period. Clinical, laboratory and supra-aortic trunks ultrasound variables were analysed and compared according to age.
    Results: Some 309 patients diagnosed with RVO were included, 25 of them younger than 50 years. The prevalence of high blood pressure, dyslipidaemia, diabetes mellitus, hyperhomocysteinemia, and carotid plaque was significantly higher in patients >50 years than in those below. However, the prevalence of inherited thrombophilia was higher in the younger group (32.0% vs 11.4%; p = 0.005). Uncommon diseases related to RVO such as hepatitis C, thalassemia minor, Lyme disease, vasculitis, and periphlebitis were observed in young patients without vascular risk factors.
    Conclusion: We suggest performing a genetic thrombophilia study in RVO patients younger than 50 years, while an exhaustive control of vascular risk factors is always recommended in all RVO patients. Moreover, we suggest bearing in mind uncommon diseases related to RVO, especially in young patients without vascular risk factors.
    MeSH term(s) Humans ; Hypertension/complications ; Prospective Studies ; Retinal Vein Occlusion/epidemiology ; Retinal Vein Occlusion/etiology ; Risk Factors ; Thrombophilia/complications ; Thrombophilia/epidemiology
    Language English
    Publishing date 2022-05-23
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5794
    ISSN (online) 2173-5794
    DOI 10.1016/j.oftale.2021.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Risk of hepatitis B reactivation associated with treatment against SARS-CoV-2 (COVID-19) with corticosteroids

    Varona Pérez, J. / Rodriguez Chinesta, J.M.

    Revista Clínica Española (English Edition)

    2020  Volume 220, Issue 8, Page(s) 535–536

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2254-8874
    DOI 10.1016/j.rceng.2020.04.006
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Riesgo de reactivación de la hepatitis B asociado al tratamiento con corticoides frente a SARS-CoV-2 (COVID-19)

    Varona Pérez, J. / Rodriguez Chinesta, J.M.

    Revista Clínica Española

    2020  Volume 220, Issue 8, Page(s) 534–536

    Keywords General Medicine ; covid19
    Language Spanish
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 123597-7
    ISSN 0014-2565 ; 0014-2565
    ISSN (online) 0014-2565
    ISSN 0014-2565
    DOI 10.1016/j.rce.2020.04.012
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 197: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Riesgo de reactivación de la hepatitis B asociado al tratamiento con corticoides frente a SARS-CoV-2 (COVID-19)./ [Risk of hepatitis B reactivation associated with treatment against SARS-CoV-2 (COVID-19) with corticosteroids]

    Varona Pérez, J / Rodriguez Chinesta, J M

    Rev. clin. esp. (Ed. impr.)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32372768
    Database COVID19

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  9. Article ; Online: Microdrilled tapers to enhance optical fiber lasers for sensing.

    Perez-Herrera, R A / Bravo, M / Roldan-Varona, P / Leandro, D / Rodriguez-Cobo, L / Lopez-Higuera, J M / Lopez-Amo, M

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 20408

    Abstract: In this work, an experimental analysis of the performance of different types of quasi-randomly distributed reflectors inscribed into a single-mode fiber as a sensing mirror is presented. These artificially-controlled backscattering fiber reflectors are ... ...

    Abstract In this work, an experimental analysis of the performance of different types of quasi-randomly distributed reflectors inscribed into a single-mode fiber as a sensing mirror is presented. These artificially-controlled backscattering fiber reflectors are used in short linear cavity fiber lasers. In particular, laser emission and sensor application features are analyzed when employing optical tapered fibers, micro-drilled optical fibers and 50 μm-waist or 100 μm-waist micro-drilled tapered fibers (MDTF). Single-wavelength laser with an output power level of about 8.2 dBm and an optical signal-to-noise ratio of 45 dB were measured when employing a 50 μm-waist micro-drilled tapered optical fiber. The achieved temperature sensitivities were similar to those of FBGs; however, the strain sensitivity improved more than one order of magnitude in comparison with FBG sensors, attaining slope sensitivities as good as 18.1 pm/με when using a 50 μm-waist MDTF as distributed reflector.
    Language English
    Publishing date 2021-10-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-00046-7
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  10. Article ; Online: Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations.

    Pastor-Sierra, Karina / Espitia-Pérez, Lyda / Espitia-Pérez, Pedro / Peñata-Taborda, Ana / Brango, Hugo / Galeano-Páez, Claudia / Bru-Cordero, Osnamir Elías / Palma-Parra, Marien / Díaz, Sonia M / Trillos, Carlos / Briceño, Leonardo / Idrovo, Álvaro J / Miranda-Pacheco, Juan / Téllez, Eliana / Jiménez-Vidal, Luisa / Coneo-Pretelt, Andrés / Álvarez, Alicia Humanez / Arteaga-Arroyo, Gean / Ricardo-Caldera, Dina /
    Salcedo-Arteaga, Shirley / Porras-Ramírez, Alexandra / Varona-Uribe, Marcela

    The Science of the total environment

    2023  Volume 901, Page(s) 165789

    Abstract: The Colombian mining industry has witnessed significant growth. Depending on the scale and mineral extracted, complex chemical mixtures are generated, impacting the health of occupationally exposed populations and communities near mining projects. ... ...

    Abstract The Colombian mining industry has witnessed significant growth. Depending on the scale and mineral extracted, complex chemical mixtures are generated, impacting the health of occupationally exposed populations and communities near mining projects. Increasing evidence suggests that chromosomal instability (CIN) is an important link between the development of certain diseases and exposure to complex mixtures. To better understand the effects of exposure to complex mixtures we performed a biomonitoring study on 407 healthy individuals from four areas: three located in municipalities exploiting different-scale mining systems and a reference area with no mining activity. Large, medium, and small-scale mining systems were analyzed in Montelibano (Córdoba), artisanal and small-scale mining (ASGM) in Nechí (Antioquia), and a closed mining system in Aranzazu (Caldas). The reference area with no mining activity was established in Montería (Córdoba). ICP-MS measured multi-elemental exposure in hair, and CIN was evaluated using the cytokinesis-block micronucleus technique (MNBN). Exposure to mixtures of chemical elements was comparable in workers and residents of the mining areas but significantly higher compared to reference individuals. In Montelibano, increased MNBN frequencies were associated with combined exposure to Se, Hg, Mn, Pb, and Mg. This distinct pattern significantly differed from other areas. Specifically, in Nechí, Cr, Ni, Hg, Se, and Mg emerged as the primary contributors to elevated frequencies of MNBN. In contrast, a combination of Hg and Ni played a role in increasing MNBN in Aranzazu. Interestingly, Se consistently correlated with increased MNBN frequencies across all active mining areas. Chemical elements in Montelibano exhibit a broader range compared to other mining zones, reflecting the characteristics of the high-impact and large-scale mining in the area. This research provides valuable insights into the effects of exposure to chemical mixtures, underscoring the importance of employing this approach in the risk assessment of communities, especially those from residential areas.
    Language English
    Publishing date 2023-07-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.165789
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    Zs.A 949: Show issues Location:
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