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Article ; Online: Patient-derived tumor spheroid-induced angiogenesis preclinical platform for exploring therapeutic vulnerabilities in cancer.

Ko, Jihoon / Hyung, Sujin / Heo, You Jeong / Jung, Sangmin / Kim, Seung Tae / Park, Se Hoon / Hong, Jung Yong / Lim, Sung Hee / Kim, Kyoung-Mee / Yoo, Sanghee / Jeon, Noo Li / Lee, Jeeyun

Biomaterials

2024 Volume 306, Page(s) 122504

Abstract: This study addresses the demand for research models that can support patient-treatment decisions and clarify the complexities of a tumor microenvironment by developing an advanced non-animal preclinical cancer model. Based on patient-derived tumor ... ...

Abstract	This study addresses the demand for research models that can support patient-treatment decisions and clarify the complexities of a tumor microenvironment by developing an advanced non-animal preclinical cancer model. Based on patient-derived tumor spheroids (PDTS), the proposed model reconstructs the tumor microenvironment with emphasis on tumor spheroid-driven angiogenesis. The resulting microfluidic chip system mirrors angiogenic responses elicited by PDTS, recapitulating patient-specific tumor conditions and providing robust, easily quantifiable outcomes. Vascularized PDTS exhibited marked angiogenesis and tumor proliferation on the microfluidic chip. Furthermore, a drug that targets the vascular endothelial growth factor receptor 2 (VEGFR2, ramucirumab) was deployed, which effectively inhibited angiogenesis and impeded tumor invasion. This innovative preclinical model was used for investigating distinct responses for various drug combinations, encompassing HER2 inhibitors and angiogenesis inhibitors, within the context of PDTS. This integrated platform could potentially advance precision medicine by harmonizing diverse data points within the tumor microenvironment with a focus on the interplay between cancer and the vascular system.
MeSH term(s)	Humans ; Vascular Endothelial Growth Factor A/metabolism ; Angiogenesis ; Neovascularization, Pathologic/metabolism ; Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Cell Line, Tumor ; Neoplasms/drug therapy
Chemical Substances	Vascular Endothelial Growth Factor A ; Angiogenesis Inhibitors
Language	English
Publishing date	2024-02-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2024.122504
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Article ; Online: Regulation of headache response and transcriptomic network by the trigeminal ganglion clock.

Han, Chorong / Lim, Ji Ye / Koike, Nobuya / Kim, Sun Young / Ono, Kaori / Tran, Celia K / Mangutov, Elizaveta / Kim, Eunju / Zhang, Yanping / Li, Lingyong / Pradhan, Amynah A / Yagita, Kazuhiro / Chen, Zheng / Yoo, Seung-Hee / Burish, Mark J

Headache

2024 Volume 64, Issue 2, Page(s) 195–210

Abstract: Objective: To characterize the circadian features of the trigeminal ganglion in a mouse model of headache.: Background: Several headache disorders, such as migraine and cluster headache, are known to exhibit distinct circadian rhythms of attacks. The ...

Abstract	Objective: To characterize the circadian features of the trigeminal ganglion in a mouse model of headache. Background: Several headache disorders, such as migraine and cluster headache, are known to exhibit distinct circadian rhythms of attacks. The circadian basis for these rhythmic pain responses, however, remains poorly understood. Methods: We examined trigeminal ganglion ex vivo and single-cell cultures from Per2::LucSV reporter mice and performed immunohistochemistry. Circadian behavior and transcriptomics were investigated using a novel combination of trigeminovascular and circadian models: a nitroglycerin mouse headache model with mechanical thresholds measured every 6 h, and trigeminal ganglion RNA sequencing measured every 4 h for 24 h. Finally, we performed pharmacogenomic analysis of gene targets for migraine, cluster headache, and trigeminal neuralgia treatments as well as trigeminal ganglion neuropeptides; this information was cross-referenced with our cycling genes from RNA sequencing data to identify potential targets for chronotherapy. Results: The trigeminal ganglion demonstrates strong circadian rhythms in both ex vivo and single-cell cultures, with core circadian proteins found in both neuronal and non-neuronal cells. Using our novel behavioral model, we showed that nitroglycerin-treated mice display circadian rhythms of pain sensitivity which were abolished in arrhythmic Per1/2 double knockout mice. Furthermore, RNA-sequencing analysis of the trigeminal ganglion revealed 466 genes that displayed circadian oscillations in the control group, including core clock genes and clock-regulated pain neurotransmitters. In the nitroglycerin group, we observed a profound circadian reprogramming of gene expression, as 331 of circadian genes in the control group lost rhythm and another 584 genes gained rhythm. Finally, pharmacogenetics analysis identified 10 genes in our trigeminal ganglion circadian transcriptome that encode target proteins of current medications used to treat migraine, cluster headache, or trigeminal neuralgia. Conclusion: Our study unveiled robust circadian rhythms in the trigeminal ganglion at the behavioral, transcriptomic, and pharmacogenetic levels. These results support a fundamental role of the clock in pain pathophysiology. Plain language summary: Several headache diseases, such as migraine and cluster headache, have headaches that occur at the same time each day. We learned that the trigeminal ganglion, an important pain structure in several headache diseases, has a 24-hour cycle that might be related to this daily cycle of headaches. Our genetic analysis suggests that some medications may be more effective in treating migraine and cluster headache when taken at specific times of the day.
MeSH term(s)	Mice ; Animals ; Trigeminal Ganglion ; Transcriptome ; Cluster Headache ; Trigeminal Neuralgia/genetics ; Nitroglycerin ; Headache ; Migraine Disorders ; Gene Expression Profiling ; Pain ; Circadian Rhythm/genetics ; Mice, Knockout
Chemical Substances	Nitroglycerin (G59M7S0WS3)
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	410130-3
ISSN	1526-4610 ; 0017-8748
ISSN (online)	1526-4610
ISSN	0017-8748
DOI	10.1111/head.14670
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Article: Diagnostic Yield of Transabdominal Ultrasonography for Evaluation of Pancreatic Cystic Lesions Compared with Endoscopic Ultrasonography.

Li, Yu Ji / Lee, Gil Ho / Yang, Min Jae / Hwang, Jae Chul / Yoo, Byung Moo / Kim, Soon Sun / Lim, Sun Gyo / Kim, Jin Hong

Journal of clinical medicine

2021 Volume 10, Issue 19

Abstract: Detection rates of pancreatic cystic lesions (PCLs) have increased, resulting in greater requirements for regular monitoring using imaging modalities. We aimed to evaluate the capability of ultrasonography (US) for morphological characterization of PCLs ... ...

Abstract	Detection rates of pancreatic cystic lesions (PCLs) have increased, resulting in greater requirements for regular monitoring using imaging modalities. We aimed to evaluate the capability of ultrasonography (US) for morphological characterization of PCLs as a reference standard using endoscopic ultrasonography (EUS). A retrospective analysis was conducted of 102 PCLs from 92 patients who underwent US immediately prior to EUS between January 2014 and May 2017. The intermodality reliability and agreement of the PCL morphologic findings of the two techniques were analyzed and compared using the intraclass correlation coefficient and κ values. The success rates of US for delineating PCLs in the head, body, and tail of the pancreas were 77.8%, 91.8%, and 70.6%, respectively. The intraclass correlation coefficient for US and the corresponding EUS lesion size showed very good reliability (0.978;
Language	English
Publishing date	2021-10-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10194616
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Article: Outcomes and Loop Pattern Analysis of a Road-Map Technique for ERCP with Side-Viewing Duodenoscope in Patients with Billroth II Gastrectomy (with Video).

Yang, Min Jae / Kim, Jin Hong / Hwang, Jae Chul / Yoo, Byung Moo / Li, Yu Ji / Kim, Soon Sun / Lim, Sun Gyo

Journal of personalized medicine

2021 Volume 11, Issue 5

Abstract: Endoscopic retrograde cholangiopancreatography (ERCP) in patients who have undergone a Billroth II gastrectomy is a major challenge. This study aimed to evaluate the outcomes of the road-map technique for duodenal intubation using a side-viewing ... ...

Abstract	Endoscopic retrograde cholangiopancreatography (ERCP) in patients who have undergone a Billroth II gastrectomy is a major challenge. This study aimed to evaluate the outcomes of the road-map technique for duodenal intubation using a side-viewing duodenoscope for ERCP in Billroth II gastrectomy patients with naïve papilla, and to analyze the formation and release patterns of common bowel loops that occur when the duodenoscope navigates the afferent limb. The duodenoscopy approach success rate was 85.8% (97/113). In successful duodenoscopy approach patients, there were five bowel looping patterns that occurred when the preceding catheter-connected duodenoscope was advanced into the duodenum: (1) reverse ɣ-loop (29.9%), (2) fixed reverse ɣ-loop (5.2%), (3) simple U-loop (22.7%), (4) N-loop (28.9%), and (5) reverse alpha loop (13.4%). The duodenoscopy cannulation and duodenoscopy therapeutic success rates were 81.4% (92/113) and 80.5% (91/113), respectively, while the overall cannulation and therapeutic success rates were 92.0% (104/113) and 87.6% (99/113), respectively. Bowel perforation occurred in three patients (2.7%). The road-map technique may benefit duodenoscope-based ERCP in Billroth II gastrectomy patients by minimizing the tangential axis alignment between the duodenoscopic tip and driving of the afferent limb, and by predicting and counteracting bowel loops that occur when the duodenoscope navigates the afferent limb.
Language	English
Publishing date	2021-05-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm11050404
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Article ; Online: 3D microprinting of inorganic porous materials by chemical linking-induced solidification of nanocrystals.

Song, Minju / Kim, Yoonkyum / Baek, Du San / Kim, Ho Young / Gu, Da Hwi / Li, Haiyang / Cunning, Benjamin V / Yang, Seong Eun / Heo, Seung Hwae / Lee, Seunghyun / Kim, Minhyuk / Lim, June Sung / Jeong, Hu Young / Yoo, Jung-Woo / Joo, Sang Hoon / Ruoff, Rodney S / Kim, Jin Young / Son, Jae Sung

Nature communications

2023 Volume 14, Issue 1, Page(s) 8460

Abstract: Three-dimensional (3D) microprinting is considered a next-generation manufacturing process for the production of microscale components; however, the narrow range of suitable materials, which include mainly polymers, is a critical issue that limits the ... ...

Abstract	Three-dimensional (3D) microprinting is considered a next-generation manufacturing process for the production of microscale components; however, the narrow range of suitable materials, which include mainly polymers, is a critical issue that limits the application of this process to functional inorganic materials. Herein, we develop a generalised microscale 3D printing method for the production of purely inorganic nanocrystal-based porous materials. Our process is designed to solidify all-inorganic nanocrystals via immediate dispersibility control and surface linking-induced interconnection in the nonsolvent linker bath and thereby creates multibranched gel networks. The process works with various inorganic materials, including metals, semiconductors, magnets, oxides, and multi-materials, not requiring organic binders or stereolithographic equipment. Filaments with a diameter of sub-10 μm are printed into designed complex 3D microarchitectures, which exhibit full nanocrystal functionality and high specific surface areas as well as hierarchical porous structures. This approach provides the platform technology for designing functional inorganics-based porous materials.
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-44145-7
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Article ; Online: Arazyme Suppresses Hepatic Steatosis and Steatohepatitis in Diet-Induced Non-Alcoholic Fatty Liver Disease-Like Mouse Model.

Li, Hua / Yoo, Wonbeak / Park, Hye-Mi / Lim, Soo-Youn / Shin, Dong-Ha / Kim, Seokho / Park, Ho-Yong / Jeong, Tae-Sook

International journal of molecular sciences

2019 Volume 20, Issue 9

Abstract: Arazyme, a metalloprotease from the ... ...

Abstract	Arazyme, a metalloprotease from the spider
MeSH term(s)	Animals ; Biomarkers/blood ; Body Weight ; Diet, High-Fat ; Disease Models, Animal ; Gene Expression Regulation ; Glucose Tolerance Test ; Hep G2 Cells ; Humans ; Inflammation/pathology ; Lipogenesis/genetics ; Macrophages/metabolism ; Male ; Metalloproteases/therapeutic use ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/drug therapy ; Organ Size ; Palmitic Acid ; RAW 264.7 Cells
Chemical Substances	Biomarkers ; Palmitic Acid (2V16EO95H1) ; Metalloproteases (EC 3.4.-)
Language	English
Publishing date	2019-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20092325
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Article ; Online: Ultra-low NA step-index large mode area Yb-doped fiber with a germanium doped cladding for high power pulse amplification.

Sidharthan, Raghuraman / Lin, Di / Jie Lim, Kang / Li, Huizi / Huiting Lim, Serene / Jian Chang, Chen / Men Seng, Yue / Liang Chua, Song / Jung, Yongmin / Richardson, David J / Yoo, Seongwoo

Optics letters

2020 Volume 45, Issue 14, Page(s) 3828–3831

Abstract: High concentration rare earth doped, large mode area (LMA) step-index fibers, which feature a very high cladding absorption per unit length at the pump wavelength, high efficiency, and excellent beam quality, are ideal for high power pulsed fiber lasers/ ... ...

Abstract	High concentration rare earth doped, large mode area (LMA) step-index fibers, which feature a very high cladding absorption per unit length at the pump wavelength, high efficiency, and excellent beam quality, are ideal for high power pulsed fiber lasers/amplifiers where large effective mode areas and short device lengths are crucial in order to reduce detrimental nonlinear effects associated with high peak power operation. In this Letter, we realize low numerical aperture (NA) high absorption fibers, simply by employing a germanium (Ge)-doped cladding rather than a pure silica cladding to offset the high refractive index associated with using a high concentration of ytterbium (Yb) in the core. This approach allows us to separate the two inter-linked fiber design parameters of pump absorption and NA in a step-index fiber. Using a conventional modified chemical vapor deposition process combined with solution doping, a low NA (0.04), LMA (475µ
Language	English
Publishing date	2020-07-15
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.396157
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Article: Bone Marrow-Derived Mesenchymal Stem Cells Isolated from Patients with Cirrhosis and Healthy Volunteers Show Comparable Characteristics.

Lim, Yoo Li / Eom, Young Woo / Park, Su Jung / Hong, Taeui / Kang, Seong Hee / Baik, Soon Koo / Park, Kyu-Sang / Kim, Moon Young

International journal of stem cells

2020 Volume 13, Issue 3, Page(s) 394–403

Abstract: Background and objectives: Autologous or allogeneic bone marrow-derived mesenchymal stem cells (BMSCs) have been applied in clinical trials to treat liver disease. However, only a few studies are comparing the characteristics of autologous MSCs from ... ...

Abstract	Background and objectives: Autologous or allogeneic bone marrow-derived mesenchymal stem cells (BMSCs) have been applied in clinical trials to treat liver disease. However, only a few studies are comparing the characteristics of autologous MSCs from patients and allogeneic MSCs from normal subjects. Methods and results: We compared the characteristics of BMSCs (BCs and BPs, respectively) isolated from six healthy volunteers and six patients with cirrhosis. In passage 3 (P3), senescent population and expression of p53 and p21 were slightly higher in BPs, but the average population doubling time for P3-P5 in BPs was approximately 65.3±11.1 h, which is 18.4 h shorter than that in BCs (83.7±9.2 h). No difference was observed in the expression of CD73, CD90, or CD105 between BCs and BPs. Adipogenic differentiation slightly increased in BCs, but the expression levels of leptin, peroxisome proliferator-activated receptor Conclusions: Taken together, there are marginal differences in the proliferation, differentiation, and mitochondrial activities of BCs and BPs, but both BMSCs from patients with cirrhosis and healthy volunteers show comparable characteristics.
Language	English
Publishing date	2020-08-20
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2914134-5
ISSN	2005-5447 ; 2005-3606
ISSN (online)	2005-5447
ISSN	2005-3606
DOI	10.15283/ijsc20072
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Book ; Online: Electrochemical Synthesis of Nanoengineered Materials and Their Applications

Vincent Myung, Nosang / Lim, Jae-Hong / Rohan, James / Mubeen Jawahar Hussaini, Syed / Yoo, Bongyoung

2019

Keywords	Science: general issues ; Electrodeposition ; Electroplating ; Nanomaterials ; Nanowires ; Nanoparticles
Size	1 electronic resource (116 pages)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021229903
ISBN	9782889631926 ; 2889631923
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Step-index high-absorption Yb-doped large-mode-area fiber with Ge-doped raised cladding.

Sidharthan, Raghuraman / Ji, Junhua / Lim, Kang Jie / Lim, Serene Huiting / Li, Huizi / Lua, Jian Wei / Zhou, Yanyan / Tse, Chun Ho / Ho, Daryl / Seng, Yue Men / Chua, Song Liang / Yoo, Seongwoo

Optics letters

2018 Volume 43, Issue 23, Page(s) 5897–5900

Abstract: We report an all-solid large-mode-area (LMA) step-index fiber offering high absorption and low core numerical aperture (NA) by introducing a highly ytterbium-doped P:Al core and germanium-doped cladding. The fiber provides core absorption of ∼1200 dB/m ... ...

Abstract	We report an all-solid large-mode-area (LMA) step-index fiber offering high absorption and low core numerical aperture (NA) by introducing a highly ytterbium-doped P:Al core and germanium-doped cladding. The fiber provides core absorption of ∼1200 dB/m at 976 nm with a low 0.07 core NA, due to the raised Ge cladding. Furthermore, matched profiles of P and Al across the core are successfully obtained with high concentration of Yb
Language	English
Publishing date	2018-12-20
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.43.005897
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