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  1. Article ; Online: The "V" Sign: A Reliable Anatomic and Radiographic Landmark for Posterior Percutaneous S1 Screw Placement.

    Tannoury, Tony / Saade, Aziz / Thomas, Dylan Chevalier / Wisco, Jonathan / Ajmi, Qasim / Singh, Varun / AbdalKader, Mohamad / Tannoury, Chadi

    JB & JS open access

    2023  Volume 8, Issue 3

    Abstract: ... a reproducible anatomical landmark (the "V" sign) for the safe localization of the S1 pedicle entry point under ... fluoroscopy.: Methods: Human cadavers (n = 14) were dissected for the anatomical description of the "V ... landmark and its relationship with the entry point of the S1 pedicle screw. The "V" landmark was defined ...

    Abstract Background: Sacral (S1) pedicle screw misplacement in posterior percutaneous fixation (PPF) can be related to anatomical variability and a lack of reliable radiographic landmarks. This study highlights a reproducible anatomical landmark (the "V" sign) for the safe localization of the S1 pedicle entry point under fluoroscopy.
    Methods: Human cadavers (n = 14) were dissected for the anatomical description of the "V" landmark and its relationship with the entry point of the S1 pedicle screw. The "V" landmark was defined medially by the lateral border of the superior articulating process of S1 and laterally by the posterior projection of the sacral ala. The mean distance was measured between the bottom point of the "V" landmark and the anatomical entry point to the S1 pedicle (V-S1 entry point distance). A similar measurement was conducted on computed tomography (CT) scans of 135 patients who underwent PPF using the "V" sign as a landmark for S1 pedicle screw placement (270 screws). These were retrospectively evaluated for appropriateness of S1 screw entry points and for proper S1 screw alignment and breaches.
    Results: In the 14 cadavers, irrespective of the laterality and sex, the V-S1 entry point distance averaged 11.7 mm. On the medial-lateral axis, all entry points converged within 2 mm of a vertical line intersecting the base of the "V." Additionally, the CT scan analysis (135 patients, 270 screws) revealed an optimal entry point for 100% of the screws and a 3.3% (n = 9 screws) breach rate. Six of the 9 identified breaches were minor, and only 1 (0.4% of the 270 screws) warranted revision.
    Conclusions: The "V" sign serves as a reliable anatomical and radiographic landmark for identifying the S1 pedicle entry point under fluoroscopic guidance. This landmark can help surgeons overcome the radiographic ambiguity of the sacral anatomy and ultimately reduces the rate of S1 pedicle screw misplacement.
    Level of evidence: Diagnostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article
    ISSN 2472-7245
    ISSN (online) 2472-7245
    DOI 10.2106/JBJS.OA.22.00079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Two-year outcomes after deployment of XIENCE V everolimus-eluting stents in patients undergoing percutaneous coronary intervention of bifurcation lesions: a report from the SPIRIT V single arm study.

    Džavík, Vladimír / Kaul, Upendra / Guagliumi, Guilio / Chevalier, Bernard / Smits, Peter C / Stuteville, Marrianne / Li, Dong / Sudhir, Krishnankutty / Grube, Eberhard

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2013  Volume 82, Issue 3, Page(s) E163–72

    Abstract: The aim of this analysis was to analyze outcomes of patients undergoing Xience V EES treatment ... of bifurcation lesions, a subset in which treatment is particularly challenging. The SPIRIT V Study provided ... an evaluation of the Xience V everolimus eluting stent (EES) performance in complex patient and lesion ...

    Abstract The aim of this analysis was to analyze outcomes of patients undergoing Xience V EES treatment of bifurcation lesions, a subset in which treatment is particularly challenging. The SPIRIT V Study provided an evaluation of the Xience V everolimus eluting stent (EES) performance in complex patient and lesion population. The SPIRIT V Single Arm Study enrolled 2700 patients with de novo coronary artery lesions suitable to be optimally treated with a maximum of four planned Xience V EES. Lesion evaluation was by visual assessment. The outcomes of the 492 patients undergoing Xience V EES stenting of ≥1 bifurcation lesion were compared to those with no bifurcation lesion treated. Compared to those without bifurcation treatment, patients with bifurcation treatment were more likely to have multi-vessel disease (49% vs 40%), left main treatment (3.1% vs 0.9%), more lesions treated (1.5 vs 1.3), calcification (36.4% vs 27.5%), and ostial (17.1% vs 8.2%) and angulated lesions (29.3% vs 21.1%), all P < 0.001. The 30-day composite rate of death, myocardial infarction (MI), target vessel revascularization (TVR) was 4.3% in patients with bifurcation PCI and 2.2% in those with non-bifurcation PCI (P = 0.017). At 2 years, this composite event rate was 11.3% and 10.0% in these two groups, respectively (P = 0.403). Rates of cardiac death, MI, target lesion revascularization (TLR), TVR, and ARC defined definite or probable stent thrombosis (0.4% vs 0.9%, P = 0.402) were not significantly different between the two groups. Despite greater patient and lesion complexity, treatment of patients with bifurcation lesions using the Xience V EES in the SPIRIT V prospective Single Arm Study was safe and effective, with low overall event rates that were similar to those without bifurcation lesion treatment. © 2013 Wiley Periodicals, Inc.
    MeSH term(s) Asia ; Canada ; Cardiovascular Agents/administration & dosage ; Coronary Angiography ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/mortality ; Coronary Artery Disease/therapy ; Coronary Thrombosis/etiology ; Drug-Eluting Stents ; Europe ; Everolimus ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/etiology ; New Zealand ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/instrumentation ; Percutaneous Coronary Intervention/mortality ; Platelet Aggregation Inhibitors/therapeutic use ; Prospective Studies ; Prosthesis Design ; Risk Factors ; Sirolimus/administration & dosage ; Sirolimus/analogs & derivatives ; South Africa ; Time Factors ; Treatment Outcome
    Chemical Substances Cardiovascular Agents ; Platelet Aggregation Inhibitors ; Everolimus (9HW64Q8G6G) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2013-09-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.24775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The SPIRIT V study: a clinical evaluation of the XIENCE V everolimus-eluting coronary stent system in the treatment of patients with de novo coronary artery lesions.

    Grube, Eberhard / Chevalier, Bernard / Smits, Peter / Džavík, Vladimir / Patel, Tejas M / Mullasari, Ajit S / Wöhrle, Jochen / Stuteville, Marrianne / Dorange, Cécile / Kaul, Upendra

    JACC. Cardiovascular interventions

    2011  Volume 4, Issue 2, Page(s) 168–175

    Abstract: Objectives: The SPIRIT V (A Clinical Evaluation of the XIENCE V Everolimus-Eluting Coronary Stent ... surveillance experience of the XIENCE V (Abbott Vascular, Santa Clara, California) everolimus-eluting stent ... shown the safety and efficacy of EES in highly selected groups of patients.: Methods: The SPIRIT V ...

    Abstract Objectives: The SPIRIT V (A Clinical Evaluation of the XIENCE V Everolimus-Eluting Coronary Stent System in the Treatment of Patients With De Novo Coronary Artery Lesions) study is a post-market surveillance experience of the XIENCE V (Abbott Vascular, Santa Clara, California) everolimus-eluting stent (EES) in patients with higher-risk coronary anatomy.
    Background: Previous pre-approval studies have shown the safety and efficacy of EES in highly selected groups of patients.
    Methods: The SPIRIT V trial is a prospective, open label, single arm, multicenter study. Two thousand seven hundred patients with multiple de novo coronary artery lesions suitable for treatment with a planned maximum of 4 EES were enrolled at 93 centers in Europe, Asia Pacific, Canada, and South Africa. Lesions had a reference vessel diameter between 2.25 and 4.0 mm and a length of ≤ 28 mm by visual estimation. An independent clinical events committee adjudicated all end point-related events. The primary end point was the composite rate of all death, myocardial infarction (MI), and target vessel revascularization at 30 days. Secondary end points included stent thrombosis and acute success (clinical device and procedure success).
    Results: At 30 days, the primary composite end point of all death, MI, and target vessel revascularization was 2.7%. At 1 year, rates of cardiac death, overall MI, and target lesion revascularization were 1.1%, 3.5%, and 1.8%, respectively. The cumulative rate of definite and probable stent thrombosis was low at 0.66% at 1 year.
    Conclusions: Use of EES in patients with multiple, complex de novo lesions yielded 1-year major adverse cardiac events, stent thrombosis, and target lesion revascularization rates that are comparable to those of the more controlled SPIRIT II and SPIRIT III trials-which included patients with restricted inclusion/exclusion criteria-and other all-comer population, physician-initiated studies like the X-SEARCH (Xience Stent Evaluated At Rotterdam Cardiology Hospital) and COMPARE (A Randomized Controlled Trial of Everolimus-eluting Stents and Paclitaxel-eluting Stents for Coronary Revascularization in Daily Practice) trials.
    MeSH term(s) Aged ; Angioplasty, Balloon, Coronary/adverse effects ; Angioplasty, Balloon, Coronary/instrumentation ; Angioplasty, Balloon, Coronary/mortality ; Asia ; Canada ; Cardiovascular Agents/administration & dosage ; Coronary Artery Disease/mortality ; Coronary Artery Disease/therapy ; Disease-Free Survival ; Drug-Eluting Stents ; Europe ; Everolimus ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Myocardial Infarction/etiology ; Product Surveillance, Postmarketing ; Prospective Studies ; Prosthesis Design ; Registries ; Risk Assessment ; Risk Factors ; Sirolimus/administration & dosage ; Sirolimus/analogs & derivatives ; South Africa ; Thrombosis/etiology ; Time Factors ; Treatment Outcome
    Chemical Substances Cardiovascular Agents ; Everolimus (9HW64Q8G6G) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2011-02
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2010.11.006
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    Zs.A 6669: Show issues Location:
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  4. Article ; Online: The SPIRIT V diabetic study: a randomized clinical evaluation of the XIENCE V everolimus-eluting stent vs the TAXUS Liberté paclitaxel-eluting stent in diabetic patients with de novo coronary artery lesions.

    Grube, Eberhard / Chevalier, Bernard / Guagliumi, Giulio / Smits, Peter C / Stuteville, Marrianne / Dorange, Cécile / Papeleu, Peggy / Kaul, Upendra / Džavík, Vladimír

    American heart journal

    2012  Volume 163, Issue 5, Page(s) 867–875.e1

    Abstract: ... term outcomes. Our main aim was to evaluate the angiographic efficacy of XIENCE V (everolimus-eluting ... Methods: The SPIRIT V Diabetic Study was a prospective, single-blind, randomized study that enrolled 324 ...

    Abstract Background: Diabetic patients respond less favorably to revascularization and have poorer long-term outcomes. Our main aim was to evaluate the angiographic efficacy of XIENCE V (everolimus-eluting stent, or EES) in diabetic patients compared with TAXUS Liberté (paclitaxel-eluting stent, or PES).
    Methods: The SPIRIT V Diabetic Study was a prospective, single-blind, randomized study that enrolled 324 diabetic (insulin and non-insulin dependent) patients at 28 sites in Europe and Asia Pacific. Randomization was 2:1 between EES (n = 218) and PES (n = 106). The primary end point was sequential noninferiority and superiority of EES for in-stent late loss at 9 months. Secondary clinical end points included stent thrombosis, death, myocardial infarction, and revascularization rates up to 1 year.
    Results: Everolimus-eluting stent was superior to PES for in-stent late loss at 9 months (0.19 mm vs 0.39 mm, respectively; P(superiority) = .0001). The composite rate of death, myocardial infarction, and target vessel revascularization was the same in the 2 groups at 1 year (16.3% vs 16.4%). No stent thromboses (Academic Research Consortium definite and probable) were seen through 1 year with EES compared with 2 of 104 (2%) with PES (P = .11).
    Conclusion: In this prospective, randomized trial in a high-risk group of diabetic patients, implantation of EES compared with PES resulted in significantly better inhibition of intimal hyperplasia with a comparable safety outcome.
    MeSH term(s) Aged ; Angioplasty, Balloon, Coronary/methods ; Angioplasty, Balloon, Coronary/mortality ; Asia ; Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/therapy ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Diabetic Angiopathies/diagnosis ; Diabetic Angiopathies/epidemiology ; Diabetic Angiopathies/therapy ; Drug-Eluting Stents ; Europe ; Evaluation Studies as Topic ; Everolimus ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Risk Assessment ; Single-Blind Method ; Sirolimus/analogs & derivatives ; Sirolimus/pharmacology ; Statistics, Nonparametric ; Survival Analysis ; Taxus ; Treatment Outcome
    Chemical Substances Everolimus (9HW64Q8G6G) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2012-05
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2012.02.006
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  5. Article: Search for gluinos in events with an isolated lepton, jets and missing transverse momentum at [Formula: see text] = 13 Te V with the ATLAS detector.

    Aad, G / Abbott, B / Abdallah, J / Abdinov, O / Abeloos, B / Aben, R / Abolins, M / AbouZeid, O S / Abramowicz, H / Abreu, H / Abreu, R / Abulaiti, Y / Acharya, B S / Adamczyk, L / Adams, D L / Adelman, J / Adomeit, S / Adye, T / Affolder, A A /
    Agatonovic-Jovin, T / Agricola, J / Aguilar-Saavedra, J A / Ahlen, S P / Ahmadov, F / Aielli, G / Akerstedt, H / Åkesson, T P A / Akimov, A V / Alberghi, G L / Albert, J / Albrand, S / Verzini, M J Alconada / Aleksa, M / Aleksandrov, I N / Alexa, C / Alexander, G / Alexopoulos, T / Alhroob, M / Alimonti, G / Alison, J / Alkire, S P / Allbrooke, B M M / Allen, B W / Allport, P P / Aloisio, A / Alonso, A / Alonso, F / Alpigiani, C / Gonzalez, B Alvarez / Piqueras, D Álvarez / Alviggi, M G / Amadio, B T / Amako, K / Coutinho, Y Amaral / Amelung, C / Amidei, D / Santos, S P Amor Dos / Amorim, A / Amoroso, S / Amram, N / Amundsen, G / Anastopoulos, C / Ancu, L S / Andari, N / Andeen, T / Anders, C F / Anders, G / Anders, J K / Anderson, K J / Andreazza, A / Andrei, V / Angelidakis, S / Angelozzi, I / Anger, P / Angerami, A / Anghinolfi, F / Anisenkov, A V / Anjos, N / Annovi, A / Antonelli, M / Antonov, A / Antos, J / Anulli, F / Aoki, M / Bella, L Aperio / Arabidze, G / Arai, Y / Araque, J P / Arce, A T H / Arduh, F A / Arguin, J-F / Argyropoulos, S / Arik, M / Armbruster, A J / Armitage, L J / Arnaez, O / Arnold, H / Arratia, M / Arslan, O / Artamonov, A / Artoni, G / Artz, S / Asai, S / Asbah, N / Ashkenazi, A / Åsman, B / Asquith, L / Assamagan, K / Astalos, R / Atkinson, M / Atlay, N B / Augsten, K / Avolio, G / Axen, B / Ayoub, M K / Azuelos, G / Baak, M A / Baas, A E / Baca, M J / Bachacou, H / Bachas, K / Backes, M / Backhaus, M / Bagiacchi, P / Bagnaia, P / Bai, Y / Baines, J T / Baker, O K / Baldin, E M / Balek, P / Balestri, T / Balli, F / Balunas, W K / Banas, E / Banerjee, Sw / Bannoura, A A E / Barak, L / Barberio, E L / Barberis, D / Barbero, M / Barillari, T / Barklow, T / Barlow, N / Barnes, S L / Barnett, B M / Barnett, R M / Barnovska, Z / Baroncelli, A / Barone, G / Barr, A J / Navarro, L Barranco / Barreiro, F / da Costa, J Barreiro Guimarães / Bartoldus, R / Barton, A E / Bartos, P / Basalaev, A / Bassalat, A / Basye, A / Bates, R L / Batista, S J / Batley, J R / Battaglia, M / Bauce, M / Bauer, F / Bawa, H S / Beacham, J B / Beattie, M D / Beau, T / Beauchemin, P H / Bechtle, P / Beck, H P / Becker, K / Becker, M / Beckingham, M / Becot, C / Beddall, A J / Beddall, A / Bednyakov, V A / Bedognetti, M / Bee, C P / Beemster, L J / Beermann, T A / Begel, M / Behr, J K / Belanger-Champagne, C / Bell, A S / Bella, G / Bellagamba, L / Bellerive, A / Bellomo, M / Belotskiy, K / Beltramello, O / Belyaev, N L / Benary, O / Benchekroun, D / Bender, M / Bendtz, K / Benekos, N / Benhammou, Y / Noccioli, E Benhar / Benitez, J / Garcia, J A Benitez / Benjamin, D P / Bensinger, J R / Bentvelsen, S / Beresford, L / Beretta, M / Berge, D / Kuutmann, E Bergeaas / Berger, N / Berghaus, F / Beringer, J / Berlendis, S / Bernard, N R / Bernius, C / Bernlochner, F U / Berry, T / Berta, P / Bertella, C / Bertoli, G / Bertolucci, F / Bertram, I A / Bertsche, C / Bertsche, D / Besjes, G J / Bylund, O Bessidskaia / Bessner, M / Besson, N / Betancourt, C / Bethke, S / Bevan, A J / Bhimji, W / Bianchi, R M / Bianchini, L / Bianco, M / Biebel, O / Biedermann, D / Bielski, R / Biesuz, N V / Biglietti, M / De Mendizabal, J Bilbao / Bilokon, H / Bindi, M / Binet, S / Bingul, A / Bini, C / Biondi, S / Bjergaard, D M / Black, C W / Black, J E / Black, K M / Blackburn, D / Blair, R E / Blanchard, J-B / Blanco, J E / Blazek, T / Bloch, I / Blocker, C / Blum, W / Blumenschein, U / Blunier, S / Bobbink, G J / Bobrovnikov, V S / Bocchetta, S S / Bocci, A / Bock, C / Boehler, M / Boerner, D / Bogaerts, J A / Bogavac, D / Bogdanchikov, A G / Bohm, C / Boisvert, V / Bold, T / Boldea, V / Boldyrev, A S / Bomben, M / Bona, M / Boonekamp, M / Borisov, A / Borissov, G / Bortfeldt, J / Bortoletto, D / Bortolotto, V / Bos, K / Boscherini, D / Bosman, M / Sola, J D Bossio / Boudreau, J / Bouffard, J / Bouhova-Thacker, E V / Boumediene, D / Bourdarios, C / Bousson, N / Boutle, S K / Boveia, A / Boyd, J / Boyko, I R / Bracinik, J / Brandt, A / Brandt, G / Brandt, O / Bratzler, U / Brau, B / Brau, J E / Braun, H M / Madden, W D Breaden / Brendlinger, K / Brennan, A J / Brenner, L / Brenner, R / Bressler, S / Bristow, T M / Britton, D / Britzger, D / Brochu, F M / Brock, I / Brock, R / Brooijmans, G / Brooks, T / Brooks, W K / Brosamer, J / Brost, E / Broughton, J H / de Renstrom, P A Bruckman / Bruncko, D / Bruneliere, R / Bruni, A / Bruni, G / Brunt, B H / Bruschi, M / Bruscino, N / Bryant, P / Bryngemark, L / Buanes, T / Buat, Q / Buchholz, P / Buckley, A G / Budagov, I A / Buehrer, F / Bugge, M K / Bulekov, O / Bullock, D / Burckhart, H / Burdin, S / Burgard, C D / Burghgrave, B / Burka, K / Burke, S / Burmeister, I / Busato, E / Büscher, D / Büscher, V / Bussey, P / Butler, J M / Butt, A I / Buttar, C M / Butterworth, J M / Butti, P / Buttinger, W / Buzatu, A / Buzykaev, A R / Urbán, S Cabrera / Caforio, D / Cairo, V M / Cakir, O / Calace, N / Calafiura, P / Calandri, A / Calderini, G / Calfayan, P / Caloba, L P / Calvet, D / Calvet, S / Calvet, T P / Toro, R Camacho / Camarda, S / Camarri, P / Cameron, D / Armadans, R Caminal / Camincher, C / Campana, S / Campanelli, M / Campoverde, A / Canale, V / Canepa, A / Bret, M Cano / Cantero, J / Cantrill, R / Cao, T / Garrido, M D M Capeans / Caprini, I / Caprini, M / Capua, M / Caputo, R / Carbone, R M / Cardarelli, R / Cardillo, F / Carli, I / Carli, T / Carlino, G / Carminati, L / Caron, S / Carquin, E / Carrillo-Montoya, G D / Carter, J R / Carvalho, J / Casadei, D / Casado, M P / Casolino, M / Casper, D W / Castaneda-Miranda, E / Castelli, A / Gimenez, V Castillo / Castro, N F / Catinaccio, A / Catmore, J R / Cattai, A / Caudron, J / Cavaliere, V / Cavalli, D / Cavalli-Sforza, M / Cavasinni, V / Ceradini, F / Alberich, L Cerda / Cerio, B C / Cerqueira, A S / Cerri, A / Cerrito, L / Cerutti, F / Cerv, M / Cervelli, A / Cetin, S A / Chafaq, A / Chakraborty, D / Chan, S K / Chan, Y L / Chang, P / Chapman, J D / Charlton, D G / Chatterjee, A / Chau, C C / 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Conta, C / Conti, G / Conventi, F / Cooke, M / Cooper, B D / Cooper-Sarkar, A M / Cornelissen, T / Corradi, M / Corriveau, F / Corso-Radu, A / Cortes-Gonzalez, A / Cortiana, G / Costa, G / Costa, M J / Costanzo, D / Cottin, G / Cowan, G / Cox, B E / Cranmer, K / Crawley, S J / Cree, G / Crépé-Renaudin, S / Crescioli, F / Cribbs, W A / Ortuzar, M Crispin / Cristinziani, M / Croft, V / Crosetti, G / Donszelmann, T Cuhadar / Cummings, J / Curatolo, M / Cúth, J / Cuthbert, C / Czirr, H / Czodrowski, P / D'Auria, S / D'Onofrio, M / De Sousa, M J Da Cunha Sargedas / Via, C Da / Dabrowski, W / Dai, T / Dale, O / Dallaire, F / Dallapiccola, C / Dam, M / Dandoy, J R / Dang, N P / Daniells, A C / Dann, N S / Danninger, M / Hoffmann, M Dano / Dao, V / Darbo, G / Darmora, S / Dassoulas, J / Dattagupta, A / Davey, W / David, C / Davidek, T / Davies, M / Davison, P / Davygora, Y / Dawe, E / Dawson, I / Daya-Ishmukhametova, R K / De, K / de Asmundis, R / De Benedetti, A / De Castro, S / De Cecco, S / 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    The European physical journal. C, Particles and fields

    2016  Volume 76, Issue 10, Page(s) 565

    Abstract: ... to masses of approximately 1.6 Te V depending on the mass spectrum of the simplified model, thus surpassing ...

    Abstract The results of a search for gluinos in final states with an isolated electron or muon, multiple jets and large missing transverse momentum using proton-proton collision data at a centre-of-mass energy of [Formula: see text] are presented. The dataset used was recorded in 2015 by the ATLAS experiment at the Large Hadron Collider and corresponds to an integrated luminosity of 3.2 fb[Formula: see text]. Six signal selections are defined that best exploit the signal characteristics. The data agree with the Standard Model background expectation in all six signal selections, and the largest deviation is a 2.1 standard deviation excess. The results are interpreted in a simplified model where pair-produced gluinos decay via the lightest chargino to the lightest neutralino. In this model, gluinos are excluded up to masses of approximately 1.6 Te V depending on the mass spectrum of the simplified model, thus surpassing the limits of previous searches.
    Language English
    Publishing date 2016-10-21
    Publishing country France
    Document type Journal Article
    ZDB-ID 1459069-4
    ISSN 1434-6052 ; 1434-6044
    ISSN (online) 1434-6052
    ISSN 1434-6044
    DOI 10.1140/epjc/s10052-016-4397-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: V. NIH Toolbox Cognition Battery (CB): measuring working memory.

    Tulsky, David S / Carlozzi, Noelle E / Chevalier, Nicolas / Espy, Kimberly A / Beaumont, Jennifer L / Mungas, Dan

    Monographs of the Society for Research in Child Development

    2013  Volume 78, Issue 4, Page(s) 70–87

    Abstract: This chapter focuses on the NIH Toolbox List Sorting Working Memory Test, which was developed to assess processing speed within the NIH Toolbox Cognition Battery (CB). This test is a sequencing task requiring children and adults to process stimuli ( ... ...

    Abstract This chapter focuses on the NIH Toolbox List Sorting Working Memory Test, which was developed to assess processing speed within the NIH Toolbox Cognition Battery (CB). This test is a sequencing task requiring children and adults to process stimuli (presented both visually and auditorily) and sequence the stimuli according to size. We describe the development of the NIH Toolbox List Sorting Working Memory Test, highlighting its utility in children. We examine descriptive data, test-retest reliability, and convergent and discriminant validity. Results indicated that List Sorting performance was positively correlated with age indicating that performance on the task improved throughout childhood and early adolescence. Further, test-retest reliability coefficients were high and there was support for both convergent and discriminant validity. These data suggest that the NIH Toolbox List Sorting Working Memory Test is reliable and shows evidence of construct validity.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Humans ; Memory, Short-Term/physiology ; National Institutes of Health (U.S.) ; Neuropsychological Tests/standards ; Pilot Projects ; Reproducibility of Results ; United States
    Language English
    Publishing date 2013-09-30
    Publishing country United States
    Document type Journal Article ; Validation Study
    ZDB-ID 414392-9
    ISSN 1540-5834 ; 0037-976X
    ISSN (online) 1540-5834
    ISSN 0037-976X
    DOI 10.1111/mono.12035
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  7. Article ; Online: Sodium Channel Na v 1.5 Controls Epithelial-to-Mesenchymal Transition and Invasiveness in Breast Cancer Cells Through its Regulation by the Salt-Inducible Kinase-1

    Frédéric Gradek / Osbaldo Lopez-Charcas / Stéphanie Chadet / Lucile Poisson / Lobna Ouldamer / Caroline Goupille / Marie-Lise Jourdan / Stéphan Chevalier / Driffa Moussata / Pierre Besson / Sébastien Roger

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 14

    Abstract: Abstract Loss of epithelial polarity and gain in invasiveness by carcinoma cells are critical events in the aggressive progression of cancers and depend on phenotypic transition programs such as the epithelial-to-mesenchymal transition (EMT). Many ... ...

    Abstract Abstract Loss of epithelial polarity and gain in invasiveness by carcinoma cells are critical events in the aggressive progression of cancers and depend on phenotypic transition programs such as the epithelial-to-mesenchymal transition (EMT). Many studies have reported the aberrant expression of voltage-gated sodium channels (NaV) in carcinomas and specifically the NaV1.5 isoform, encoded by the SCN5A gene, in breast cancer. NaV1.5 activity, through an entry of sodium ions, in breast cancer cells is associated with increased invasiveness, but its participation to the EMT has to be clarified. In this study, we show that reducing the expression of NaV1.5 in highly aggressive human MDA-MB-231 breast cancer cells reverted the mesenchymal phenotype, reduced cancer cell invasiveness and the expression of the EMT-promoting transcription factor SNAI1. The heterologous expression of NaV1.5 in weakly invasive MCF-7 breast cancer cells induced their expression of both SNAI1 and ZEB1 and increased their invasive capacities. In MCF-7 cells the stimulation with the EMT-activator signal TGF-β1 increased the expression of SCN5A. Moreover, the reduction of the salt-inducible kinase 1 (SIK1) expression promoted NaV1.5-dependent invasiveness and expression of EMT-associated transcription factor SNAI1. Altogether, these results indicated a prominent role of SIK1 in regulating NaV1.5-dependent EMT and invasiveness.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Precision measurement of the ratio B(t→Wb)/B(t→Wq) and extraction of V(tb).

    Abazov, V M / Abbott, B / Acharya, B S / Adams, M / Adams, T / Alexeev, G D / Alkhazov, G / Alton, A / Alverson, G / Alves, G A / Aoki, M / Arov, M / Askew, A / Åsman, B / Atramentov, O / Avila, C / BackusMayes, J / Badaud, F / Bagby, L /
    Baldin, B / Bandurin, D V / Banerjee, S / Barberis, E / Baringer, P / Barreto, J / Bartlett, J F / Bassler, U / Bazterra, V / Beale, S / Bean, A / Begalli, M / Begel, M / Belanger-Champagne, C / Bellantoni, L / Beri, S B / Bernardi, G / Bernhard, R / Bertram, I / Besançon, M / Beuselinck, R / Bezzubov, V A / Bhat, P C / Bhatnagar, V / Blazey, G / Blessing, S / Bloom, K / Boehnlein, A / Boline, D / Boos, E E / Borissov, G / Bose, T / Brandt, A / Brandt, O / Brock, R / Brooijmans, G / Bross, A / Brown, D / Brown, J / Bu, X B / Buehler, M / Buescher, V / Bunichev, V / Burdin, S / Burnett, T H / Buszello, C P / Calpas, B / Camacho-Pérez, E / Carrasco-Lizarraga, M A / Casey, B C K / Castilla-Valdez, H / Chakrabarti, S / Chakraborty, D / Chan, K M / Chandra, A / Chen, G / Chevalier-Théry, S / Cho, D K / Cho, S W / Choi, S / Choudhary, B / Cihangir, S / Claes, D / Clutter, J / Cooke, M / Cooper, W E / Corcoran, M / Couderc, F / Cousinou, M-C / Croc, A / Cutts, D / Das, A / Davies, G / De, K / de Jong, S J / De La Cruz-Burelo, E / Déliot, F / Demarteau, M / Demina, R / Denisov, D / Denisov, S P / Desai, S / Deterre, C / DeVaughan, K / Diehl, H T / Diesburg, M / Ding, P F / Dominguez, A / Dorland, T / Dubey, A / Dudko, L V / Duggan, D / Duperrin, A / Dutt, S / Dyshkant, A / Eads, M / Edmunds, D / Ellison, J / Elvira, V D / Enari, Y / Evans, H / Evdokimov, A / Evdokimov, V N / Facini, G / Ferbel, T / Fiedler, F / Filthaut, F / Fisher, W / Fisk, H E / Fortner, M / Fox, H / Fuess, S / Garcia-Bellido, A / Gavrilov, V / Gay, P / Geng, W / Gerbaudo, D / Gerber, C E / Gershtein, Y / Ginther, G / Golovanov, G / Goussiou, A / Grannis, P D / Greder, S / Greenlee, H / Greenwood, Z D / Gregores, E M / Grenier, G / Gris, Ph / Grivaz, J-F / Grohsjean, A / Grünendahl, S / Grünewald, M W / Guillemin, T / Guo, F / Gutierrez, G / Gutierrez, P / Haas, A / Hagopian, S / Haley, J / Han, L / Harder, K / Harel, A / Hauptman, J M / Hays, J / Head, T / Hebbeker, T / Hedin, D / Hegab, H / Heinson, A P / Heintz, U / Hensel, C / Heredia-De La Cruz, I / Herner, K / Hesketh, G / Hildreth, M D / Hirosky, R / Hoang, T / Hobbs, J D / Hoeneisen, B / Hohlfeld, M / Hubacek, Z / Huske, N / Hynek, V / Iashvili, I / Ilchenko, Y / Illingworth, R / Ito, A S / Jabeen, S / Jaffré, M / Jamin, D / Jayasinghe, A / Jesik, R / Johns, K / Johnson, M / Johnston, D / Jonckheere, A / Jonsson, P / Joshi, J / Jung, A W / Juste, A / Kaadze, K / Kajfasz, E / Karmanov, D / Kasper, P A / Katsanos, I / Kehoe, R / Kermiche, S / Khalatyan, N / Khanov, A / Kharchilava, A / Kharzheev, Y N / Kirby, M H / Kohli, J M / Kozelov, A V / Kraus, J / Kulikov, S / Kumar, A / Kupco, A / Kurča, T / Kuzmin, V A / Kvita, J / Lammers, S / Landsberg, G / Lebrun, P / Lee, H S / Lee, S W / Lee, W M / Lellouch, J / Li, L / Li, Q Z / Lietti, S M / Lim, J K / Lincoln, D / Linnemann, J / Lipaev, V V / Lipton, R / Liu, Y / Liu, Z / Lobodenko, A / Lokajicek, M / Lopes de Sa, R / Lubatti, H J / Luna-Garcia, R / Lyon, A L / Maciel, A K A / Mackin, D / Madar, R / Magaña-Villalba, R / Malik, S / Malyshev, V L / Maravin, Y / Martínez-Ortega, J / McCarthy, R / McGivern, C L / Meijer, M M / Melnitchouk, A / Menezes, D / Mercadante, P G / Merkin, M / Meyer, A / Meyer, J / Miconi, F / Mondal, N K / Muanza, G S / Mulhearn, M / Nagy, E / Naimuddin, M / Narain, M / Nayyar, R / Neal, H A / Negret, J P / Neustroev, P / Novaes, S F / Nunnemann, T / Obrant, G / Orduna, J / Osman, N / Osta, J / Otero y Garzón, G J / Padilla, M / Pal, A / Parashar, N / Parihar, V / Park, S K / Parsons, J / Partridge, R / Parua, N / Patwa, A / Penning, B / Perfilov, M / Peters, K / Peters, Y / Petridis, K / Petrillo, G / Pétroff, P / Piegaia, R / Pleier, M-A / Podesta-Lerma, P L M / Podstavkov, V M / Polozov, P / Popov, A V / Prewitt, M / Price, D / Prokopenko, N / Protopopescu, S / Qian, J / Quadt, A / Quinn, B / Rangel, M S / Ranjan, K / Ratoff, P N / Razumov, I / Renkel, P / Rijssenbeek, M / Ripp-Baudot, I / Rizatdinova, F / Rominsky, M / Ross, A / Royon, C / Rubinov, P / Ruchti, R / Safronov, G / Sajot, G / Salcido, P / Sánchez-Hernández, A / Sanders, M P / Sanghi, B / Santos, A S / Savage, G / Sawyer, L / Scanlon, T / Schamberger, R D / Scheglov, Y / Schellman, H / Schliephake, T / Schlobohm, S / Schwanenberger, C / Schwienhorst, R / Sekaric, J / Severini, H / Shabalina, E / Shary, V / Shchukin, A A / Shivpuri, R K / Simak, V / Sirotenko, V / Skubic, P / Slattery, P / Smirnov, D / Smith, K J / Snow, G R / Snow, J / Snyder, S / Söldner-Rembold, S / Sonnenschein, L / Soustruznik, K / Stark, J / Stolin, V / Stoyanova, D A / Strauss, M / Strom, D / Stutte, L / Suter, L / Svoisky, P / Takahashi, M / Tanasijczuk, A / Taylor, W / Titov, M / Tokmenin, V V / Tsai, Y-T / Tsybychev, D / Tuchming, B / Tully, C / Uvarov, L / Uvarov, S / Uzunyan, S / Van Kooten, R / van Leeuwen, W M / Varelas, N / Varnes, E W / Vasilyev, I A / Verdier, P / Vertogradov, L S / Verzocchi, M / Vesterinen, M / Vilanova, D / Vokac, P / Wahl, H D / Wang, M H L S / Warchol, J / Watts, G / Wayne, M / Weber, M / Welty-Rieger, L / White, A / Wicke, D / Williams, M R J / Wilson, G W / Wobisch, M / Wood, D R / Wyatt, T R / Xie, Y / Xu, C / Yacoob, S / Yamada, R / Yang, W-C / Yasuda, T / Yatsunenko, Y A / Ye, Z / Yin, H / Yip, K / Youn, S W / Yu, J / Zelitch, S / Zhao, T / Zhou, B / Zhu, J / Zielinski, M / Zieminska, D / Zivkovic, L

    Physical review letters

    2011  Volume 107, Issue 12, Page(s) 121802

    Abstract: ... We measure R=0.90±0.04, and we extract the Cabibbo-Kobayashi-Maskawa (CKM) matrix element |V(tb)| as |V(tb ...

    Abstract We present a measurement of the ratio of top quark branching fractions R=B(t→Wb)/B(t→Wq), where q can be a d, s, or b quark, in the lepton+jets and dilepton tt final states. The measurement uses data from 5.4 fb(-1) of pp collisions collected with the D0 detector at the Fermilab Tevatron Collider. We measure R=0.90±0.04, and we extract the Cabibbo-Kobayashi-Maskawa (CKM) matrix element |V(tb)| as |V(tb)|=0.95±0.02, assuming unitarity of the 3×3 CKM matrix.
    Language English
    Publishing date 2011-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.107.121802
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  9. Article ; Online: Do heterozygous factor V Leiden and prothrombin G20210A mutations have different impact on the type and location of venous thromboembolism?

    Chevalier, Y / Mandrillon, G / Bestion, A / Lega, J C / Piquet, P / Ninet, J / Dargaud, Y

    International angiology : a journal of the International Union of Angiology

    2014  Volume 33, Issue 4, Page(s) 404–405

    MeSH term(s) Adult ; Factor V/genetics ; Female ; France/epidemiology ; Genetic Predisposition to Disease ; Heterozygote ; Humans ; Incidence ; Male ; Middle Aged ; Mutation ; Phenotype ; Predictive Value of Tests ; Prothrombin/genetics ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/genetics ; Retrospective Studies ; Risk Factors ; Tomography, Spiral Computed ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/genetics ; Venous Thrombosis/diagnosis ; Venous Thrombosis/epidemiology ; Venous Thrombosis/genetics
    Chemical Substances factor V Leiden ; Factor V (9001-24-5) ; Prothrombin (9001-26-7)
    Language English
    Publishing date 2014-08
    Publishing country Italy
    Document type Comparative Study ; Letter
    ZDB-ID 604910-2
    ISSN 1827-1839 ; 0392-9590
    ISSN (online) 1827-1839
    ISSN 0392-9590
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  10. Article ; Online: The edge vascular response following implantation of the Absorb everolimus-eluting bioresorbable vascular scaffold and the XIENCE V metallic everolimus-eluting stent. First serial follow-up assessment at six months and two years: insights from the first-in-man ABSORB Cohort B and SPIRIT II trials.

    Gogas, Bill D / Bourantas, Christos V / Garcia-Garcia, Hector M / Onuma, Yoshinobu / Muramatsu, Takashi / Farooq, Vasim / Diletti, Roberto / van Geuns, Robert-Jan M / De Bruyne, Bernard / Chevalier, Bernard / Thuesen, Leif / Smits, Pieter C / Dudek, Dariusz / Koolen, Jacques / Windecker, Stefan / Whitbourn, Robert / McClean, Dougal / Dorange, Cecile / Miquel-Hebert, Karine /
    Veldhof, Susan / Rapoza, Richard / Ormiston, John A / Serruys, Patrick W

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2013  Volume 9, Issue 6, Page(s) 709–720

    Abstract: ... with a XIENCE V EES from post procedure to two years did not show any signs of LL, only plaque area decrease ...

    Abstract Aims: To assess serially the edge vascular response (EVR) of a bioresorbable vascular scaffold (BVS) compared to a metallic everolimus-eluting stent (EES).
    Methods and results: Non-serial evaluations of the Absorb BVS at one year have previously demonstrated proximal edge constrictive remodelling and distal edge changes in plaque composition with increase of the percent fibro-fatty (FF) tissue component. The 5 mm proximal and distal segments adjacent to the implanted devices were investigated serially with intravascular ultrasound (IVUS), post procedure, at six months and at two years, from the ABSORB Cohort B1 (n=45) and the SPIRIT II (n=113) trials. Twenty-two proximal and twenty-four distal edge segments were available for analysis in the ABSORB Cohort B1 trial. In the SPIRIT II trial, thirty-three proximal and forty-six distal edge segments were analysed. At the 5-mm proximal edge, the vessels treated with an Absorb BVS from post procedure to two years demonstrated a lumen loss (LL) of 6.68% (-17.33; 2.08) (p=0.027) with a trend toward plaque area increase of 7.55% (-4.68; 27.11) (p=0.06). At the 5-mm distal edge no major changes were evident at either time point. At the 5-mm proximal edge the vessels treated with a XIENCE V EES from post procedure to two years did not show any signs of LL, only plaque area decrease of 6.90% (-17.86; 4.23) (p=0.035). At the distal edge no major changes were evident with regard to either lumen area or vessel remodelling at the same time point.
    Conclusions: The IVUS-based serial evaluation of the EVR up to two years following implantation of a bioresorbable everolimus-eluting scaffold shows a statistically significant proximal edge LL; however, this finding did not seem to have any clinical implications in the serial assessment. The upcoming imaging follow-up of the Absorb BVS at three years is anticipated to provide further information regarding the vessel wall behaviour at the edges.
    MeSH term(s) Absorbable Implants ; Drug-Eluting Stents ; Everolimus ; Follow-Up Studies ; Humans ; Male ; Sirolimus/administration & dosage ; Treatment Outcome
    Chemical Substances Everolimus (9HW64Q8G6G) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2013-10
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJV9I6A115
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