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  1. Article ; Online: What is your next step? In a case of hemolysis and pancytopenia.

    Perego, Martina / Muselli, Teresa / Schiavon, Riccardo

    Internal and emergency medicine

    2024  

    Language English
    Publishing date 2024-02-07
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03516-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Right Ventricular Longitudinal Strain: A New Prognostic Tool for COVID-19?

    Schiavon, Riccardo / Casazza, Giovanni / Cogliati, Chiara

    JACC. Cardiovascular imaging

    2020  Volume 13, Issue 8, Page(s) 1859

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Heart Ventricles ; Humans ; Pandemics ; Pneumonia, Viral ; Prognosis ; SARS-CoV-2 ; Ventricular Function, Right
    Keywords covid19
    Language English
    Publishing date 2020-07-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2020.06.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Drug-eluting stents vs. bare metal stents in elderly patients.

    Leidi, Federica / Schiavon, Riccardo

    Internal and emergency medicine

    2018  Volume 13, Issue 5, Page(s) 773–774

    MeSH term(s) Aged ; Coronary Artery Disease/drug therapy ; Drug-Eluting Stents ; Female ; Humans ; Incidence ; Male ; Metals ; Practice Guidelines as Topic ; Single-Blind Method ; Stents ; Treatment Outcome
    Chemical Substances Metals
    Language English
    Publishing date 2018-03-28
    Publishing country Italy
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-018-1839-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: I Will Be at Your (Bed)Side - The Role of Bedside Echocardiography for Non-Cardiologists.

    Casella, Francesco / Schiavon, Riccardo / Ceriani, Elisa / Cogliati, Chiara

    Ultraschall in der Medizin (Stuttgart, Germany : 1980)

    2020  Volume 41, Issue 4, Page(s) 362–386

    Abstract: As the availability of portable echocardiographic equipment is becoming more and more widespread, physicians can add a powerful tool to their bedside examination skills, thus helping them to more effectively face the growing complexity of patients ... ...

    Title translation Ich bin an Ihrer (Bett-) Seite. Die Rolle der bettseitigen Echokardiografie für Nicht-Kardiologen.
    Abstract As the availability of portable echocardiographic equipment is becoming more and more widespread, physicians can add a powerful tool to their bedside examination skills, thus helping them to more effectively face the growing complexity of patients admitted to internal medicine departments or the emergency room. Focused cardiac ultrasound (FoCUS) can be defined as a goal-directed, simplified, qualitative examination performed at the bedside using portable echocardiographic devices. FoCUS is not meant to be a substitute for a standard 2D color Doppler echocardiographic examination. Nevertheless, it can provide rapid and reliable information when limited to basic questions, even when performed by non-cardiologists with brief training. Furthermore, a focused cardiac ultrasound examination maximizes its diagnostic role when integrated with an ultrasonographic assessment of the lung, abdomen and deep veins, in a multisystem approach that is particularly dear to internists. In this article, we will focus on the specific targets of a focused cardiac ultrasound examination, as well as the most common pitfalls that can be encountered in ultrasonographic practice. We will also address the application of FoCUS in the management of two typical scenarios in clinical practice, such as dyspnea and non-post-traumatic hypotension.
    MeSH term(s) Echocardiography ; Emergency Service, Hospital ; Humans ; Physicians ; Point-of-Care Systems ; Ultrasonography
    Language English
    Publishing date 2020-08-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 801064-x
    ISSN 1438-8782 ; 1439-0914 ; 1431-4894 ; 0172-4614
    ISSN (online) 1438-8782
    ISSN 1439-0914 ; 1431-4894 ; 0172-4614
    DOI 10.1055/a-1198-4980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: HIV-Related Lymphoproliferative Diseases in the Era of Combination Antiretroviral Therapy.

    Castelli, Roberto / Schiavon, Riccardo / Preti, Carlo / Ferraris, Laurenzia

    Cardiovascular & hematological disorders drug targets

    2020  Volume 20, Issue 3, Page(s) 175–180

    Abstract: HIV-positive patients have a 60- to 200-fold increased incidence of Non-Hodgkin Lymphomas (NHL) because of their impaired cellular immunity. Some NHL are considered Acquired Immunodeficiency Syndrome (AIDS) defining conditions. Diffuse large B-cell ... ...

    Abstract HIV-positive patients have a 60- to 200-fold increased incidence of Non-Hodgkin Lymphomas (NHL) because of their impaired cellular immunity. Some NHL are considered Acquired Immunodeficiency Syndrome (AIDS) defining conditions. Diffuse large B-cell Lymphoma (DLBC) and Burkitt Lymphoma (BL) are the most commonly observed, whereas Primary Effusion Lymphoma (PEL), Central Nervous System Lymphomas (PCNSL), Plasmablastic Lymphoma (PBL) and classic Hodgkin Lymphoma (HL) are far less frequent. Multicentric Castleman disease (MCD) is an aggressive lymphoproliferative disorder highly prevalent in HIV-positive patients and strongly associated with HHV-8 virus infection. In the pre-Combination Antiretroviral Therapy (CART) era, patients with HIV-associated lymphoma had poor outcomes with median survival of 5 to 6 months. By improving the immunological status, CART extended the therapeutic options for HIV positive patients with lymphomas, allowing them to tolerate standard chemotherapies regimen with similar outcomes to those of the general population. The combination of CART and chemotherapy/ immuno-chemotherapy treatment has resulted in a remarkable prolongation of survival among HIVinfected patients with lymphomas. In this short communication, we briefly review the problems linked with the treatment of lymphoproliferative diseases in HIV patients. Combination Antiretroviral Therapy (CART) not only reduces HIV replication and restores the immunological status improving immune function of the HIV-related lymphomas patients but allows patients to deal with standard doses of chemotherapies. The association of CART and chemotherapy allowed to obtain better results in terms of overall survival and complete responses. In the setting of HIVassociated lymphomas, many issues remain open and their treatment is complicated by the patient's immunocompromised status and the need to treat HIV concurrently.
    MeSH term(s) Animals ; Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; HIV/drug effects ; HIV/immunology ; HIV/physiology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Lymphoma, AIDS-Related/drug therapy ; Lymphoma, AIDS-Related/etiology ; Lymphoma, AIDS-Related/immunology ; Lymphoma, AIDS-Related/virology ; Lymphoproliferative Disorders/drug therapy ; Lymphoproliferative Disorders/etiology ; Lymphoproliferative Disorders/immunology ; Lymphoproliferative Disorders/virology ; Virus Replication/drug effects
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2020-04-07
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2244164-5
    ISSN 2212-4063 ; 1871-529X
    ISSN (online) 2212-4063
    ISSN 1871-529X
    DOI 10.2174/1871529X20666200415121009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ibrutinib related bleeding complications in elderly patients with B cell malignancies.

    Castelli, Roberto / Schiavon, Riccardo / Preti, Carlo / Deliliers, Giorgio Lambertenghi

    Journal of thrombosis and thrombolysis

    2019  Volume 48, Issue 4, Page(s) 694–696

    MeSH term(s) Aged ; B-Lymphocytes/pathology ; Hemorrhage/chemically induced ; Humans ; Neoplasms/complications ; Neoplasms/drug therapy ; Neoplasms/pathology ; Pyrazoles/adverse effects ; Pyrazoles/therapeutic use ; Pyrimidines/adverse effects ; Pyrimidines/therapeutic use
    Chemical Substances Pyrazoles ; Pyrimidines ; ibrutinib (1X70OSD4VX)
    Language English
    Publishing date 2019-06-23
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-019-01907-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The impact of anaemia, transfusion dependency, comorbidities and polypharmacy in elderly patients with low-risk myelodysplastic syndromes.

    Castelli, Roberto / Schiavon, Riccardo / Deliliers, Giorgio Lambertenghi

    Medical oncology (Northwood, London, England)

    2018  Volume 35, Issue 3, Page(s) 33

    Abstract: Myelodysplastic syndromes (MDS) are heterogeneous clonal disorders ranging from indolent conditions with a near-normal life expectancy to forms approaching acute myeloid leukaemia. Comorbid conditions have rarely been systematically studied among ... ...

    Abstract Myelodysplastic syndromes (MDS) are heterogeneous clonal disorders ranging from indolent conditions with a near-normal life expectancy to forms approaching acute myeloid leukaemia. Comorbid conditions have rarely been systematically studied among patients with MDS. Older age per se has a negative impact on survival of MDS patients, in particular of those with lower risk. However, age indirectly affects also the survival of higher-risk patients by limiting their eligibility to intensive treatments. In addition, ageing is associated with an increasingly high risk of developing comorbidity, and a high prevalence of comorbid diseases has indeed been reported in MDS patients. The impact of multi-morbidities/comorbidities and polypharmacy in patients with low-risk MDS patients is a poorly explored topic. We focused on medications, multi-morbidities and comorbidities of 155 low-risk MDS patients followed in the haematological outpatients clinics or in medical/oncology wards of our University Hospital. One or more comorbidities were present at diagnosis in 24 younger patients with MDS syndromes (31%), whereas 56 older patients with MDS (75%) presented 1 or more comorbidities (P < 0.001).The most frequent comorbidity was cardiac comorbidity 18% in younger patients and 25% in older patients. With no statistical significance between older and younger patients, congestive heart failure was the most frequent observed disease. Our study has shown a statistical correlation between transfusion dependency and polypathology (P = 0.0014). These data were also confirmed in a subanalysis of the younger group of patients. Our study has shown that comorbidity is very common among patients with MDS, potentially affecting the clinical course and outcome of MDS patients.
    MeSH term(s) Aged ; Anemia/physiopathology ; Blood Transfusion/statistics & numerical data ; Comorbidity ; Female ; Follow-Up Studies ; Humans ; Italy/epidemiology ; Life Expectancy ; Male ; Myelodysplastic Syndromes/epidemiology ; Myelodysplastic Syndromes/etiology ; Myelodysplastic Syndromes/therapy ; Polypharmacy ; Prevalence ; Prognosis ; Risk Assessment ; Severity of Illness Index
    Language English
    Publishing date 2018-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-018-1094-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: I Will Be at Your (Bed)Side – The Role of Bedside Echocardiography for Non-Cardiologists

    Casella, Francesco / Schiavon, Riccardo / Ceriani, Elisa / Cogliati, Chiara

    Ultraschall in der Medizin - European Journal of Ultrasound

    2020  Volume 41, Issue 04, Page(s) 362–386

    Abstract: As the availability of portable echocardiographic equipment is becoming more and more widespread, physicians can add a powerful tool to their bedside examination skills, thus helping them to more effectively face the growing complexity of patients ... ...

    Abstract As the availability of portable echocardiographic equipment is becoming more and more widespread, physicians can add a powerful tool to their bedside examination skills, thus helping them to more effectively face the growing complexity of patients admitted to internal medicine departments or the emergency room. Focused cardiac ultrasound (FoCUS) can be defined as a goal-directed, simplified, qualitative examination performed at the bedside using portable echocardiographic devices. FoCUS is not meant to be a substitute for a standard 2D color Doppler echocardiographic examination. Nevertheless, it can provide rapid and reliable information when limited to basic questions, even when performed by non-cardiologists with brief training. Furthermore, a focused cardiac ultrasound examination maximizes its diagnostic role when integrated with an ultrasonographic assessment of the lung, abdomen and deep veins, in a multisystem approach that is particularly dear to internists. In this article, we will focus on the specific targets of a focused cardiac ultrasound examination, as well as the most common pitfalls that can be encountered in ultrasonographic practice. We will also address the application of FoCUS in the management of two typical scenarios in clinical practice, such as dyspnea and non-post-traumatic hypotension.

    Mit der zunehmenden breiten Verfügbarkeit tragbarer echokardiografischer Geräte können Ärzte eine leistungsstarke Methode hinzufügen, um ihre Fähigkeiten in der bettseitigen Untersuchung zu erweitern. So können sie der wachsenden Komplexität der Patienten, die in den Abteilungen für Innere Medizin oder in der Notaufnahme aufgenommen werden, wirksamer begegnen. Fokussierter kardialer Ultraschall (FoCUS) kann als zielgerichtete, vereinfachte, qualitative Untersuchung definiert werden, die am Krankenbett mittels tragbarer Echokardiografie-Geräte durchgeführt wird. FoCUS ist kein Ersatz für eine standardmäßige echokardiografische 2D-Farbdoppler-Untersuchung. Dennoch kann er bei Beschränkung auf grundlegende Fragestellungen schnelle und zuverlässige Informationen liefern, selbst wenn kurz ausgebildete Nicht-Kardiologen ihn durchführen. Darüber hinaus wird der diagnostische Wert des fokussierten kardialen Ultraschalls maximiert, wenn dieser in eine sonografische Beurteilung von Lunge, Abdomen und tiefen Venen integriert wird, und zwar in einem Multisystemansatz, der Internisten besonders am Herzen liegt. In diesem Artikel konzentrieren wir uns auf die spezifischen Ziele einer fokussierten kardialen Ultraschalluntersuchung sowie auf die häufigsten Fallstricke, die in der Ultraschallpraxis auftreten können. Wir werden uns auch mit der Anwendung von FoCUS bei der Behandlung von 2 typischen Szenarien in der klinischen Praxis befassen – Dyspnoe und nichtposttraumatische Hypotonie.
    Language English
    Publishing date 2020-08-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 801064-x
    ISSN 1438-8782 ; 0172-4614 ; 1439-0914 ; 1431-4894
    ISSN (online) 1438-8782
    ISSN 0172-4614 ; 1439-0914 ; 1431-4894
    DOI 10.1055/a-1198-4980
    Database Thieme publisher's database

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  9. Article ; Online: Management of anemia in low-risk myelodysplastic syndromes treated with erythropoiesis-stimulating agents newer and older agents.

    Castelli, Roberto / Schiavon, Riccardo / Rossi, Valentina / Deliliers, Giorgio Lambertenghi

    Medical oncology (Northwood, London, England)

    2018  Volume 35, Issue 5, Page(s) 76

    Abstract: The myelodysplastic syndromes (MDSs) are clonal hematopoietic stem cell disorders. The International Prognostic Score System (IPSS) groups MDS in lower-risk (IPSS low and intermediate-1) and higher-risk disease (IPSS intermediate-2 and high). AML ... ...

    Abstract The myelodysplastic syndromes (MDSs) are clonal hematopoietic stem cell disorders. The International Prognostic Score System (IPSS) groups MDS in lower-risk (IPSS low and intermediate-1) and higher-risk disease (IPSS intermediate-2 and high). AML transformation is the main concern in higher-risk MDS, while anemia and transfusion dependency represent the major issues for low-risk MDS patients. Improving erythropoiesis, and eliminating fatigue and symptoms, is the main therapeutic goal for low-risk MDS patients. Around 50% of MDS patients present with anemia with an Hb level < 100 g/L. Severe anemia increases the negative effects of comorbidities, such as heart and lung failure. Erythropoiesis-stimulating agents (ESAs), with or without granulocyte colony-stimulating factor, induce erythroid response rates in 40-50% of lower-risk anemic MDS patients. The median response duration of 24 months. Apoptosis of erythroid cells is inhibited by ESAs leading to erythrocyte production. Our paper considers the state of the art of treatment of anemia in low-risk MDS patients and the treatment options in MDS resistant or refractory to ESAs.
    MeSH term(s) Anemia/drug therapy ; Hematinics/therapeutic use ; Humans ; Myelodysplastic Syndromes/blood ; Randomized Controlled Trials as Topic ; Risk Factors
    Chemical Substances Hematinics
    Language English
    Publishing date 2018-04-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-018-1135-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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