LIVIVO - Search results -

Search results

Result 1 - 10 of total 1066

Search options

Article ; Online: Tailoring the structure and self-activated photoluminescence of carbonated amorphous calcium phosphate nanoparticles for bioimaging applications.

Machado, Thales R / Zanardo, Carlos E / Vilela, Raquel R C / Miranda, Renata R / Moreno, Natália S / Leite, Celisnolia M / Longo, Elson / Zucolotto, Valtencir

Journal of materials chemistry. B

2024

Abstract: Self-activated luminescent calcium phosphate (CaP) nanoparticles, including hydroxyapatite (HA) and amorphous calcium phosphate (ACP), are promising for bioimaging and theragnostic applications in nanomedicine, eliminating the need for activator ions or ... ...

Abstract	Self-activated luminescent calcium phosphate (CaP) nanoparticles, including hydroxyapatite (HA) and amorphous calcium phosphate (ACP), are promising for bioimaging and theragnostic applications in nanomedicine, eliminating the need for activator ions or fluorophores. In this study, we developed luminescent and stable citrate-functionalized carbonated ACP nanoparticles for bioimaging purposes. Our findings revealed that both the CO
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb02915h
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Down-Regulation of Tinnitus Negative Valence via Concurrent HD-tDCS and PEI Technique: A Pilot Study.

Vaziri, Zahra / Salmon, Carlos E G / Ghodratitoostani, Iman / Santos, Antonio Carlos Dos / Hyppolito, Miguel A / Delbem, Alexandre C B / Leite, João P

Brain sciences

2023 Volume 13, Issue 5

Abstract: Around 30% of the general population experience subjective tinnitus, characterized by conscious attended awareness perception of sound without an external source. Clinical distress tinnitus is more than just experiencing a phantom sound, as it can be ... ...

Abstract	Around 30% of the general population experience subjective tinnitus, characterized by conscious attended awareness perception of sound without an external source. Clinical distress tinnitus is more than just experiencing a phantom sound, as it can be highly disruptive and debilitating, leading those affected to seek clinical help. Effective tinnitus treatments are crucial for psychological well-being, but our limited understanding of the underlying neural mechanisms and a lack of a universal cure necessitate further treatment development. In light of the neurofunctional tinnitus model predictions and transcranial electrical stimulation, we conducted an open-label, single-arm, pilot study that utilized high-definition transcranial direct current stimulation (HD-tDCS) concurrent with positive emotion induction (PEI) techniques for ten consecutive sessions to down-regulate tinnitus negative valence in patients with clinical distress tinnitus. We acquired resting-state functional magnetic resonance imaging scans of 12 tinnitus patients (7 females, mean age = 51.25 ± 12.90 years) before and after the intervention to examine resting-state functional connectivity (rsFC) alterations in specific seed regions. The results showed reduced rsFC at post-intervention between the attention and emotion processing regions as follows: (1) bilateral amygdala and left superior parietal lobule (SPL), (2) left amygdala and right SPL, (3) bilateral dorsolateral prefrontal cortex (dlPFC) and bilateral pregenual anterior cingulate cortex (pgACC), and (4) left dlPFC and bilateral pgACC (FWE corrected
Language	English
Publishing date	2023-05-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13050826
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Evidence of Validity and Normative Values of a New Auditory Backward Masking Test.

Filippini, Renata / Leite Filho, Carlos Alberto / Barros, Gabriela Melo Santos Bonassa / Musiek, Frank E / Schochat, Eliane

Journal of clinical medicine

2022 Volume 11, Issue 17

Abstract: There are still no valid, clinically feasible instruments to assess backward masking (BM), an auditory temporal processing (ATP) phenomenon. The aim of this study was to develop, standardize and present evidence of validity for a behavioral test for BM ... ...

Abstract	There are still no valid, clinically feasible instruments to assess backward masking (BM), an auditory temporal processing (ATP) phenomenon. The aim of this study was to develop, standardize and present evidence of validity for a behavioral test for BM assessment. Young adults were submitted to a BM test (BMT), where they were asked to identify a 1000 Hz pure tone followed by a narrowband noise with interstimulus intervals of 0 to 400 ms and signal-to-noise ratio (SNR) between -20 and -30 dB. The correct response rate and target sound detection threshold were calculated, and the results compared with those of young adults with abnormal ATP tests and older adults. Diagnostic accuracy analyses were carried out. Young adults with normal ATP obtained an average correct response rate of 89 and 87% for SNR -20 and -30 dB, respectively, with average thresholds between 10 and 15 ms and no difference between the left and right ears. Results were more consistent at SNR -20 dB, and the best diagnostic accuracy was obtained for SNR -20 dB, with good specificity, but low sensitivity. Normative values were obtained for the BMT, which proved to be clinically feasible, with preliminary evidence of validity.
Language	English
Publishing date	2022-08-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11174933
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Optimizing Antimicrobial Efficacy: Investigating the Impact of Zinc Oxide Nanoparticle Shape and Size.

Mendes, Ana Rita / Granadeiro, Carlos M / Leite, Andreia / Pereira, Eulália / Teixeira, Paula / Poças, Fátima

Nanomaterials (Basel, Switzerland)

2024 Volume 14, Issue 7

Abstract: Zinc oxide nanoparticles (ZnO NPs) have been investigated due to their distinct properties, variety of structures and sizes, and mainly for their antimicrobial activity. They have received a positive safety evaluation from the European Food Safety ... ...

Abstract	Zinc oxide nanoparticles (ZnO NPs) have been investigated due to their distinct properties, variety of structures and sizes, and mainly for their antimicrobial activity. They have received a positive safety evaluation from the European Food Safety Authority (EFSA) for packaging applications as transparent ultraviolet (UV) light absorbers based on the absence of significant migration of zinc oxide in particulate form. ZnO NPs with different morphologies (spherical, flower, and sheet) have been synthesized via different sol-gel methods and extensively characterized by several solid-state techniques, namely vibrational spectroscopy, powder X-ray diffraction (XRD), scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDS), Fourier Transform Infrared Spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-VIS), electron paramagnetic resonance (EPR), and nitrogen adsorption-desorption isotherms. The ZnO NPs were assessed for their antibacterial activity against
Language	English
Publishing date	2024-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano14070638
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A Triggering Mechanism for Cyber-Attacks in Naval Sensors and Systems.

Leite Junior, Walmor Cristino / de Moraes, Claudio Coreixas / de Albuquerque, Carlos E P / Machado, Raphael Carlos Santos / de Sá, Alan Oliveira

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 9

Abstract: ... threat hosted on a ship, even if the ship's systems are air gapped-i.e., are not connected ...

Abstract	In the maritime sector, the integration of radar systems, Automatic Identification System (AIS) and Electronic Chart Display and Information System (ECDIS) through digital technologies enables several benefits to maritime operations, but also make ships prone to cyberattacks. In this context, this work investigates the feasibility of an attacker using a radar system or AIS as open door to remotely send commands to a cyber threat hosted on a ship, even if the ship's systems are air gapped-i.e., are not connected to other networks. The received commands are intended to trigger a cyber threat located in the ship. Although the literature covers several analyzes on cyber risks and vulnerabilities in naval systems, it lacks exploiting mechanisms capable of acknowledging attack commands received through radar and AIS. To this end, this work proposes a triggering mechanism that uses a template matching technique to detect specific patterns transmitted by the attacker to the ship's radar or AIS. The results show the effectiveness of the proposed technique as a tool to acknowledge the received attack commands and activate a malicious code previously installed on the ship. In the case of attacks on a radar system, the accuracy achieved by the proposed method is 0.90. In the case of attacks on an AIS/ECDIS setup it presents an accuracy of 0.93. In both cases the proposed mechanism maintains the due safety against accidental attack activations.
Language	English
Publishing date	2021-05-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21093195
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Cytotoxic activity of Ru(II)/DPEPhos/N,S-mercapto complexes (DPEPhos = bis-[(2-diphenylphosphino)phenyl]ether).

Grawe, Gregory F / Oliveira, Katia M / Leite, Celisnolia M / de Oliveira, Tamires D / Costa, Analu R / Moraes, Carlos A F / Honorato, João / Cominetti, Marcia R / Castellano, Eduardo E / Correa, Rodrigo S / Machado, Sérgio P / Batista, Alzir A

Journal of inorganic biochemistry

2023 Volume 244, Page(s) 112204

Abstract: We report here on three new ruthenium(II) complexes, [Ru(DPEPhos)(mtz)(bipy)] ... ...

Abstract	We report here on three new ruthenium(II) complexes, [Ru(DPEPhos)(mtz)(bipy)]PF
MeSH term(s)	Humans ; Cell Line, Tumor ; Coordination Complexes/pharmacology ; Coordination Complexes/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Molecular Structure ; Ethers ; Ruthenium/chemistry
Chemical Substances	Coordination Complexes ; Antineoplastic Agents ; Ethers ; Ruthenium (7UI0TKC3U5)
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2023.112204
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1730: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Hooklets Are Important Clues in Echinococcosis Diagnosis.

Pena, Gil Patrus / Berenstein, Cynthia Koeppel / Oliveira, Sonia Boechat E / Leite, Rodrigo Fabiano Guedes / Ribeiro, Carlos Alberto

International journal of surgical pathology

2020 Volume 29, Issue 2, Page(s) 184–185

MeSH term(s)	Animals ; Echinococcosis, Hepatic/diagnosis ; Echinococcosis, Hepatic/parasitology ; Echinococcus/anatomy & histology ; Echinococcus/isolation & purification ; Humans ; Liver/parasitology ; Liver/pathology ; Staining and Labeling
Language	English
Publishing date	2020-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/1066896920918304
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4500: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Apolipoprotein E ε2 allele is associated with lower risk of carotid artery obstruction in a population-based autopsy study.

Paradela, Regina Silva / Farias-Itao, Daniela Souza / Leite, Renata E P / Pasqualucci, Carlos A / Grinberg, Lea T / Naslavsky, Michel Satya / Zatz, Mayana / Nitrini, Ricardo / Jacob-Filho, Wilson / Suemoto, Claudia Kimie

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2023 Volume 32, Issue 9, Page(s) 107229

Abstract: Introduction: Apolipoprotein E (APOE) ε4 allele has been associated with higher ...

Abstract	Introduction: Apolipoprotein E (APOE) ε4 allele has been associated with higher carotid atherosclerosis risk, while the APOE-ε2 seems to decrease this risk. Data from autopsy studies, where carotid arteries can be evaluated in their full extension, is scarce. Therefore, we investigated the association between APOE alleles and direct morphometric measurements of carotid atherosclerosis in an autopsy study with an admixed sample. Methods: We measured the intima-media thickness (IMT) and stenosis of the common (CCA) and internal carotid (ICA) arteries. The APOE polymorphisms were determined by real-time polymerase chain reaction. Participants were classified into three groups according to the APOE alleles (ε2, ε3, and ε4). We evaluated the association between APOE groups and carotid atherosclerosis using adjusted regression models and included interaction terms of APOE alleles with age, sex, and race. Results: We evaluated 1,850 carotid artery samples from 185 participants (mean age=75±12 years old, 55% female, and 71% White). The APOE-ε2 group (n=17) had a lower carotid obstruction and a lower number of severe stenoses (≥ 70%). Having at least one ε4 allele (n=51) was not associated with carotid atherosclerosis. APOE alleles were also not associated with carotid IMT. Age, sex, and race did not modify these relationships. Conclusion: APOE-ε2 carriers had a lower percentage of carotid obstruction and less severe stenosis. APOE-ε4 was not related to a higher risk of carotid atherosclerosis in this cross-sectional population-based autopsy study.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Alleles ; Apolipoprotein E2 ; Apolipoprotein E4/genetics ; Apolipoproteins E/genetics ; Autopsy ; Carotid Arteries/diagnostic imaging ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/genetics ; Carotid Intima-Media Thickness ; Constriction, Pathologic ; Cross-Sectional Studies ; Genetic Predisposition to Disease ; Genotype ; Risk Factors ; Thrombosis
Chemical Substances	Apolipoprotein E2 ; Apolipoprotein E4 ; Apolipoproteins E
Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2023.107229
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3519: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer's disease pathology: a population-based autopsy study in an admixed sample.

Paradela, Regina Silva / Justo, Alberto Fernando Oliveira / Paes, Vítor Ribeiro / Leite, Renata E P / Pasqualucci, Carlos A / Grinberg, Lea T / Naslavsky, Michel Satya / Zatz, Mayana / Nitrini, Ricardo / Jacob-Filho, Wilson / Suemoto, Claudia Kimie

Acta neuropathologica communications

2023 Volume 11, Issue 1, Page(s) 205

Abstract: Background: Apolipoprotein E ε4 allele (APOE-ε4) is the main genetic risk factor for late-onset ...

Abstract	Background: Apolipoprotein E ε4 allele (APOE-ε4) is the main genetic risk factor for late-onset Alzheimer's disease (AD) and may impact cognitive function also via other neuropathological lesions. However, there is limited evidence available from diverse populations, as APOE associations with dementia seem to differ by race. Therefore, we aimed to evaluate the pathways linking APOE-ε4 to cognitive abilities through AD and non-AD neuropathology in an autopsy study with an admixed sample. Methods: Neuropathological lesions were evaluated following international criteria using immunohistochemistry. Participants were classified into APOE-ε4 carriers (at least one ε4 allele) and non-carriers. Cognitive abilities were evaluated by the Clinical Dementia Rating Scale sum of boxes. Mediation analyses were conducted to assess the indirect association of APOE-ε4 with cognition through AD-pathology, lacunar infarcts, hyaline arteriosclerosis, cerebral amyloid angiopathy (CAA), Lewy body disease (LBD), and TAR DNA-binding protein 43 (TDP-43). Results: We included 648 participants (mean age 75 ± 12 years old, mean education 4.4 ± 3.7 years, 52% women, 69% White, and 28% APOE-ε4 carriers). The association between APOE-ε4 and cognitive abilities was mediated by neurofibrillary tangles (β = 0.88, 95% CI = 0.45; 1.38, p < 0.001) and neuritic plaques (β = 1.36, 95% CI = 0.86; 1.96, p < 0.001). Lacunar infarcts, hyaline arteriosclerosis, CAA, LBD, and TDP-43 were not mediators in the pathway from APOE-ε4 to cognition. Conclusion: The association between APOE-ε4 and cognitive abilities was partially mediated by AD-pathology. On the other hand, cerebrovascular lesions and other neurodegenerative diseases did not mediate the association between APOE-ε4 and cognition.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Alleles ; Alzheimer Disease/pathology ; Apolipoprotein E4/genetics ; Apolipoproteins E/metabolism ; Arteriosclerosis/genetics ; Autopsy ; Cerebral Amyloid Angiopathy/genetics ; Cognition ; DNA-Binding Proteins/genetics ; Genotype ; Lewy Body Disease/genetics ; Stroke, Lacunar/genetics
Chemical Substances	Apolipoprotein E4 ; Apolipoproteins E ; DNA-Binding Proteins ; ApoE protein, human
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-023-01681-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Recombinant BCG-LTAK63 Vaccine Candidate for Tuberculosis Induces an Inflammatory Profile in Human Macrophages.

Dos Santos, Carina C / Walburg, Kimberley V / van Veen, Suzanne / Wilson, Louis G / Trufen, Carlos E M / Nascimento, Ivan P / Ottenhoff, Tom H M / Leite, Luciana C C / Haks, Mariëlle C

Vaccines

2022 Volume 10, Issue 6

Abstract: Tuberculosis (TB) is one of the top 10 leading causes of death worldwide. The recombinant BCG strain expressing the genetically detoxified A subunit of the thermolabile toxin ... ...

Abstract	Tuberculosis (TB) is one of the top 10 leading causes of death worldwide. The recombinant BCG strain expressing the genetically detoxified A subunit of the thermolabile toxin from
Language	English
Publishing date	2022-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10060831
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito