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  1. Article ; Online: Severe preretinal fibrosis after Carlevale lens implant in a diabetic patient.

    de Vega-Garcia, R / Valor-Suarez, C / Martin-Rodrigo, J C

    Journal francais d'ophtalmologie

    2024  Volume 47, Issue 3, Page(s) 104027

    MeSH term(s) Humans ; Retina/diagnostic imaging ; Retina/pathology ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/diagnosis ; Fibrosis ; Diabetes Mellitus/pathology
    Language English
    Publishing date 2024-02-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 426662-6
    ISSN 1773-0597 ; 0181-5512
    ISSN (online) 1773-0597
    ISSN 0181-5512
    DOI 10.1016/j.jfo.2023.104027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1417: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Encapsulation of Olive (

    Montes, Antonio / Valor, Diego / García-Casas, Ignacio / Sánchez, Ana / Pereyra, Clara

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 6

    Abstract: Olive leaves ( ...

    Abstract Olive leaves (
    Language English
    Publishing date 2024-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13060905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Oropharyngeal dysphagia in head and neck cancer: how to reduce aspiration pneumonia.

    Martin-Gonzalez, C / Gonzalez-Gimeno, M J / De-Frutos-Hernan, B / Valor-Garcia, C

    The Journal of laryngology and otology

    2022  Volume 137, Issue 7, Page(s) 820–825

    Abstract: Objective: Oropharyngeal dysphagia is caused by difficulty in bolus preparation and transport from the mouth to the oesophagus; this may result in malnutrition and aspiration pneumonia. It has a high prevalence in head and neck cancer patients. The ... ...

    Abstract Objective: Oropharyngeal dysphagia is caused by difficulty in bolus preparation and transport from the mouth to the oesophagus; this may result in malnutrition and aspiration pneumonia. It has a high prevalence in head and neck cancer patients. The objective of this study is to reduce these complications using a new protocol of diagnosis and evaluation of oropharyngeal dysphagia.
    Method: This is a prospective study developed in a secondary hospital. All patients diagnosed with head and neck cancer in 2021 and 2022 are subjected to this protocol: an oropharyngeal dysphagia screening test, a swallowing-related quality of life questionnaire and a flexible endoscopic evaluation of swallow.
    Results: A total of 72 evaluations are reported using this protocol, before and after cancer treatment, and only 1 presents with aspiration pneumonia.
    Conclusion: Using this protocol, the incidence of aspiration pneumonia can be reduced, and diet recommendations can be given earlier in order to maintain a patient's nutritional requirements.
    MeSH term(s) Humans ; Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Deglutition Disorders/therapy ; Prospective Studies ; Quality of Life ; Head and Neck Neoplasms/complications ; Deglutition ; Pneumonia, Aspiration/etiology ; Pneumonia, Aspiration/prevention & control ; Pneumonia, Aspiration/epidemiology
    Language English
    Publishing date 2022-12-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215122002638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Supercritical Impregnation of

    Valor, Diego / García-Casas, Ignacio / Montes, Antonio / Danese, Ella / Pereyra, Clara / de la Ossa, Enrique Martínez

    Polymers

    2023  Volume 16, Issue 1

    Abstract: Plant leaves, such as those ... ...

    Abstract Plant leaves, such as those from
    Language English
    Publishing date 2023-12-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16010133
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  5. Article ; Online: Determining the Optimal Conditions for the Production by Supercritical CO

    Valor, Diego / Montes, Antonio / Monteiro, Marilia / García-Casas, Ignacio / Pereyra, Clara / Martínez de la Ossa, Enrique

    Polymers

    2021  Volume 13, Issue 10

    Abstract: Poly(D,L,-lactide- ...

    Abstract Poly(D,L,-lactide-
    Language English
    Publishing date 2021-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13101645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: PCSK9 inhibitors revisited: Effectiveness and safety of PCSK9 inhibitors in a real-life Spanish cohort.

    Vicente-Valor, Juan / García-González, Xandra / Ibáñez-García, Sara / Durán-García, María Esther / de Lorenzo-Pinto, Ana / Rodríguez-González, Carmen / Méndez-Fernández, Irene / Percovich-Hualpa, Juan Carlos / Herranz-Alonso, Ana / Sanjurjo-Sáez, María

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2021  Volume 146, Page(s) 112519

    Abstract: ... low-density lipoprotein cholesterol (LDL-C) goals and/or are intolerant to other lipid-lowering drugs. Our aim was to analyze ... followed up for a median of 20.4 months. The main outcomes were relative reduction in LDL-C, percentage ... cardiovascular events (MACEs) and drug-related adverse events (ADRs).: Results: The median LDL-C achieved was ...

    Abstract Introduction: Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have emerged as a therapeutic option for patients with hypercholesterolemia who do not attain low-density lipoprotein cholesterol (LDL-C) goals and/or are intolerant to other lipid-lowering drugs. Our aim was to analyze the effectiveness and safety of PCSK9i in routine clinical practice and factors related to poor outcomes.
    Materials and methods: We conducted an ambispective study in 115 patients who recieved alirocumab or evolocumab, in a tertiary level hospital. From February 2017 to April 2020, patients were recruited and followed up for a median of 20.4 months. The main outcomes were relative reduction in LDL-C, percentage of patients achieving the therapeutic goals established by 2016 ESC/EAS guidelines, incidence of major cardiovascular events (MACEs) and drug-related adverse events (ADRs).
    Results: The median LDL-C achieved was 57.0 mg/dL (relative reduction of 59.9% from baseline, p< 0.001). After adjusting for confounders, smaller LDL-C reductions were related to female sex, absence of concomitant lipid-lowering therapy and treatment with alirocumab. Overall, 84.6% of the patients achieved the therapeutic goals. During follow-up, 7 MACEs were detected. ADRs, generally considered mild, affected 38.1% of the participants (mainly mialgias and arthralgias) and triggered discontinuations in 8.7% of cases.
    Conclusions: PCSK9i are effective and safe, although certain factors may influence their effectiveness. Interestingly, our results suggest that alirocumab and evolocumab may not be therapeutic equivalents, as initially suggested.
    MeSH term(s) Age Factors ; Aged ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Anticholesteremic Agents/administration & dosage ; Anticholesteremic Agents/adverse effects ; Anticholesteremic Agents/therapeutic use ; Cardiovascular Diseases/epidemiology ; Comorbidity ; Dose-Response Relationship, Drug ; Female ; Humans ; Hypercholesterolemia/drug therapy ; Life Style ; Lipids/blood ; Male ; Middle Aged ; PCSK9 Inhibitors/administration & dosage ; PCSK9 Inhibitors/adverse effects ; PCSK9 Inhibitors/therapeutic use ; Sex Factors ; Spain
    Chemical Substances Antibodies, Monoclonal, Humanized ; Anticholesteremic Agents ; Lipids ; PCSK9 Inhibitors ; evolocumab (LKC0U3A8NJ) ; alirocumab (PP0SHH6V16)
    Language English
    Publishing date 2021-12-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2021.112519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Potential and real drug interactions in patients treated with abiraterone or enzalutamide in clinical practice.

    Vicente-Valor, Juan / Escudero-Vilaplana, Vicente / Collado-Borrell, Roberto / Pérez-Ramírez, Sara / Villanueva-Bueno, Cristina / Narrillos-Moraza, Álvaro / García-Sánchez, Sebastián / Beamud-Cortés, Manel / Herranz, Ana / Sanjurjo, María

    Expert opinion on drug metabolism & toxicology

    2022  Volume 17, Issue 12, Page(s) 1467–1473

    Abstract: Background: Abiraterone and enzalutamide, androgen receptor pathway inhibitors (ARPI) for the treatment of metastatic castration-resistant prostate cancer (mCRPC), are at high risk of potential drug interactions (PDIs). We aimed to describe PDIs and ... ...

    Abstract Background: Abiraterone and enzalutamide, androgen receptor pathway inhibitors (ARPI) for the treatment of metastatic castration-resistant prostate cancer (mCRPC), are at high risk of potential drug interactions (PDIs). We aimed to describe PDIs and their management, and triggered adverse events (AEs) in clinical practice.
    Methods: We conducted a cross-sectional study in mCRPC patients who started treatment with abiraterone or enzalutamide in a university hospital between August 1st, 2016 and July 31st, 2020. Lexicomp® was used to identify and analyze PDIs, and the clinical records to assess their management and the occurrence of AEs.
    Results: We included 173 patients: 36.8% and 93.0% treated with abiraterone and enzalutamide, respectively, had at least 1 PDI. Globally, 6.3% of PDIs had X-risk (contraindication due to high probability of AE). Treatment was modified in 9.2% of patients and 9.8% suffered AEs due to PDIs. Factors associated with a higher risk of PDIs were polypharmacy (OR= 41.0, p  0.003) and treatment with enzalutamide (OR= 128.26, p < 0.001).
    Conclusions: At least two-thirds of patients treated with ARPI suffered a PDI. Overall, abiraterone would have a more favorable PDI profile. Knowing these interaction profiles may be helpful to develop a more efficient therapeutic follow-up and to select the safest treatment.
    MeSH term(s) Abiraterone Acetate/therapeutic use ; Androstenes ; Benzamides ; Cross-Sectional Studies ; Drug Interactions ; Humans ; Male ; Nitriles/therapeutic use ; Phenylthiohydantoin ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/pathology ; Treatment Outcome
    Chemical Substances Androstenes ; Benzamides ; Nitriles ; Phenylthiohydantoin (2010-15-3) ; enzalutamide (93T0T9GKNU) ; Abiraterone Acetate (EM5OCB9YJ6) ; abiraterone (G819A456D0)
    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2021.2027908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6264: Show issues Location:
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  8. Article: Predicting Job Satisfaction in Military Organizations: Unpacking the Relationship Between Emotional Intelligence, Teamwork Communication, and Job Attitudes in Spanish Military Cadets.

    Valor-Segura, Inmaculada / Navarro-Carrillo, Ginés / Extremera, Natalio / Lozano, Luis M / García-Guiu, Carlos / Roldán-Bravo, María Isabel / Ruiz-Moreno, Antonia

    Frontiers in psychology

    2020  Volume 11, Page(s) 875

    Abstract: Although prior research has extensively examined the association of emotional intelligence (EI) with various job attitudes (e.g., job satisfaction), empirical and systematic investigation of this link within military institutions has captured ... ...

    Abstract Although prior research has extensively examined the association of emotional intelligence (EI) with various job attitudes (e.g., job satisfaction), empirical and systematic investigation of this link within military institutions has captured considerably less attention. The present research analyzed the relationship between EI, teamwork communication, and job satisfaction among Spanish military cadets. We tested the potential unique contribution of EI to job satisfaction over and above demographics (i.e., gender and age), proactive personality, and resilience. Moreover, we also examined whether EI was indirectly linked to job satisfaction via its relationship with teamwork communication. A sample of 363 cadet officers of the Spanish General Military Academy completed questionnaires assessing EI, teamwork communication, proactive personality, resilience, and job satisfaction. Hierarchical regression analysis revealed that EI exhibited incremental variance (Δ
    Language English
    Publishing date 2020-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2020.00875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Foaming of Polycaprolactone and Its Impregnation with Quercetin Using Supercritical CO

    García-Casas, Ignacio / Montes, Antonio / Valor, Diego / Pereyra, Clara / Martínez de la Ossa, Enrique J

    Polymers

    2019  Volume 11, Issue 9

    Abstract: Foamed polycaprolactone impregnated with quercetin was carried out with a batch foaming technique using supercritical ... ...

    Abstract Foamed polycaprolactone impregnated with quercetin was carried out with a batch foaming technique using supercritical CO
    Language English
    Publishing date 2019-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym11091390
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  10. Article: Potential Diagnostic Value of the Differential Expression of Histone H3 Variants between Low- and High-Grade Gliomas.

    Hervás-Corpión, Irati / Gallardo-Orihuela, Andrea / Catalina-Fernández, Inmaculada / Iglesias-Lozano, Irene / Soto-Torres, Olga / Geribaldi-Doldán, Noelia / Domínguez-García, Samuel / Luna-García, Nuria / Romero-García, Raquel / Mora-López, Francisco / Iriarte-Gahete, Marianela / Morales, Jorge C / Campos-Caro, Antonio / Castro, Carmen / Gil-Salú, José L / Valor, Luis M

    Cancers

    2021  Volume 13, Issue 21

    Abstract: Glioblastoma (GB) is the most aggressive form of glioma and is characterized by poor prognosis and high recurrence despite intensive clinical interventions. To retrieve the key factors underlying the high malignancy of GB with potential diagnosis utility, ...

    Abstract Glioblastoma (GB) is the most aggressive form of glioma and is characterized by poor prognosis and high recurrence despite intensive clinical interventions. To retrieve the key factors underlying the high malignancy of GB with potential diagnosis utility, we combined the analysis of The Cancer Gene Atlas and the REMBRANDT datasets plus a molecular examination of our own collection of surgical tumor resections. We determined a net reduction in the levels of the non-canonical histone H3 variant H3.3 in GB compared to lower-grade astrocytomas and oligodendrogliomas with a concomitant increase in the levels of the canonical histone H3 variants H3.1/H3.2. This increase can be potentially useful in the clinical diagnosis of high-grade gliomas, as evidenced by an immunohistochemistry screening of our cohort and can be at least partially explained by the induction of multiple histone genes encoding these canonical forms. Moreover, GBs showing low bulk levels of the H3.1/H3.2 proteins were more transcriptionally similar to low-grade gliomas than GBs showing high levels of H3.1/H3.2. In conclusion, this study identifies an imbalanced ratio between the H3 variants associated with glioma malignancy and molecular patterns relevant to the biology of gliomas, and proposes the examination of the H3.3 and H3.1/H3.2 levels to further refine diagnosis of low- and high-grade gliomas in future studies.
    Language English
    Publishing date 2021-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13215261
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