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  1. Book: Pulmonal arterielle Hypertonie (PAH)

    Ghofrani, Hossein Ardeschir

    Optimierung der inhalativen Prostanoidtherapie

    (Case report ; 10. Jahrgang, Heft 8 (August 2018))

    2018  

    Author's details Herausgeber Prof. Dr. Ardeschir-Ghofrani
    Series title Case report ; 10. Jahrgang, Heft 8 (August 2018)
    Collection
    Language German
    Size 11 Seiten, Illustrationen
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT019811834
    Database Catalogue ZB MED Medicine, Health

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    Zs A 6843 -10,8- verfügbar in Königswinter Königswinter

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  2. Article: Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species.

    Goyal, Parag / Weissmann, Norbert / Grimminger, Friedrich / Hegel, Cornelia / Bader, Lucius / Rose, Frank / Fink, Ludger / Ghofrani, Hossein A / Schermuly, Ralph T / Schmidt, Harald H H W / Seeger, Werner / Hänze, Jörg

    Free radical biology & medicine

    2004  Volume 36, Issue 10, Page(s) 1279–1288

    Abstract: ... we investigated the role of NAD(P)H oxidase 1 (Nox1), suggested to be a subunit of a low-output NAD(P)H ...

    Abstract Hypoxia sensing and related signaling events, including activation of hypoxia-inducible factor 1 (HIF-1), represent key features in cell physiology and lung function. Using cultured A549 cells, we investigated the role of NAD(P)H oxidase 1 (Nox1), suggested to be a subunit of a low-output NAD(P)H oxidase complex, in hypoxia signaling. Nox1 expression was detected on both the mRNA and protein levels. Upregulation of Nox1 mRNA and protein occurred during hypoxia, accompanied by enhanced reactive oxygen species (ROS) generation. A549 cells, which were transfected with a Nox1 expression vector, revealed an increase in ROS generation accompanied by activation of HIF-1-dependent target gene expression (heme oxygenase 1 mRNA, hypoxia-responsive-element reporter gene activity). In A549 cells stably overexpressing Nox1, accumulation of HIF-1alpha in normoxia and an additional increase in hypoxia were noted. Interference with ROS metabolism by the flavoprotein inhibitor diphenylene iodonium (DPI) and catalase inhibited HIF-1 induction. This suggests that H2O2 links Nox1 and HIF-1 activation. We conclude that hypoxic upregulation of Nox1 and subsequently augmented ROS generation may activate HIF-1-dependent pathways.
    MeSH term(s) Catalase/pharmacology ; Cell Hypoxia ; Enzyme Inhibitors/pharmacology ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/enzymology ; Heme Oxygenase (Decyclizing)/genetics ; Heme Oxygenase (Decyclizing)/metabolism ; Heme Oxygenase-1 ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit ; Luciferases/metabolism ; Lung/cytology ; Lung/drug effects ; Lung/enzymology ; Membrane Proteins ; NADH, NADPH Oxidoreductases/metabolism ; NADPH Oxidase 1 ; Nitric Oxide Synthase/antagonists & inhibitors ; Onium Compounds/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reactive Oxygen Species/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Up-Regulation
    Chemical Substances Enzyme Inhibitors ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Membrane Proteins ; Onium Compounds ; RNA, Messenger ; Reactive Oxygen Species ; Transcription Factors ; diphenyleneiodonium (6HJ411TU98) ; Catalase (EC 1.11.1.6) ; Luciferases (EC 1.13.12.-) ; Nitric Oxide Synthase (EC 1.14.13.39) ; HMOX1 protein, human (EC 1.14.14.18) ; Heme Oxygenase (Decyclizing) (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18) ; NADH, NADPH Oxidoreductases (EC 1.6.-) ; NADPH Oxidase 1 (EC 1.6.3.-)
    Language English
    Publishing date 2004-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2004.02.071
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  3. Book: Pulmonale Hypertonie

    Ghofrani, Hossein Ardeschir / Grimminger, Friedrich

    neue Therapie mit Phosphodiesterase-5-Inhibitoren

    (UNI-MED Science)

    2007  

    Author's details [Hossein-Ardeschir Ghofrani ; Friedrich Grimminger]
    Series title UNI-MED Science
    Keywords Pulmonale Hypertonie ; Phosphodiesterasehemmer
    Subject Phosphodiesteraseinhibitor ; PDE-Hemmer ; Phosphodiesterase inhibitor ; Lungenhochdruck ; Pulmonale hypertension ; Pulmonal-arterielle Hypertonie ; PAH
    Subject code 616.24061
    Language German
    Size 69 S. : Ill., graph. Darst., 25 cm
    Edition 1. Aufl.
    Publisher UNI-MED-Verl
    Publishing place Bremen u.a.
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT016997571
    ISBN 978-3-89599-376-3 ; 3-89599-376-X
    Database Catalogue ZB MED Medicine, Health

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    2011 A 4171 order for loan Magazin

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  4. Article: Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)?

    Weissmann, N / Tadic, A / Hänze, J / Rose, F / Winterhalder, S / Nollen, M / Schermuly, R T / Ghofrani, H A / Seeger, W / Grimminger, F

    American journal of physiology. Lung cellular and molecular physiology

    2000  Volume 279, Issue 4, Page(s) L683–90

    Abstract: ... for a nonphagocytic NAD(P)H oxidase with superoxide and SOD-related hydrogen peroxide formation in HPV. Because HPV ...

    Abstract Hypoxic pulmonary vasoconstriction (HPV) matches lung perfusion with ventilation. Controversy exists whether decreased or increased reactive oxygen species may elicit HPV and from which source such oxygen metabolites are derived. In rabbit lungs, we detected transcripts of a nonphagocytic NADPH oxidase subunit homologous to mitogenic oxidase-1 (Mox1) or NADPH oxidase homolog 1 (NOH-1L). In perfused rabbit lungs, we employed 1) a new NADPH oxidase inhibitor [4-(2-aminoethyl)benzenesulfonyl fluoride (AEBSF; 100-600 microM)] and 2) the superoxide dismutase (SOD) inhibitors diethyldithiocarbamic acid (DETC; 100 microM to 10 mM) and triethylenetetramine (TETA; 1-25 mM). Specificity of these agents for HPV was investigated by comparison with U-46619-induced vasoconstrictions. AEBSF induced a transient increase in pulmonary arterial pressure with increased strength of HPV. Subsequent to this initial response, normoxic pulmonary arterial pressure was not affected and HPV was specifically suppressed. Whereas DETC turned out to act in a nonspecific fashion, TETA suppressed HPV specifically. These findings provide evidence of a role for a nonphagocytic NAD(P)H oxidase with superoxide and SOD-related hydrogen peroxide formation in HPV. Because HPV was inhibited but not mimicked by the inhibitors, increased rather than decreased superoxide and/or hydrogen peroxide formation is suggested as the hypoxia-provoked signaling event.
    MeSH term(s) 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology ; Animals ; Blood Pressure/drug effects ; Ditiocarb/pharmacology ; Female ; Hydrogen Peroxide/metabolism ; Hypoxia/physiopathology ; In Vitro Techniques ; Lung/blood supply ; Lung/physiology ; Lung/physiopathology ; Male ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Pulmonary Circulation/drug effects ; Pulmonary Circulation/physiology ; Rabbits ; Reactive Oxygen Species/physiology ; Sulfones/pharmacology ; Transcription, Genetic ; Trientine/pharmacology ; Vasoconstriction/drug effects ; Vasoconstriction/physiology
    Chemical Substances Reactive Oxygen Species ; Sulfones ; 4-(2-aminoethyl)benzenesulfonylfluoride (34284-75-8) ; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid (76898-47-0) ; Ditiocarb (99Z2744345) ; Hydrogen Peroxide (BBX060AN9V) ; NADPH Oxidases (EC 1.6.3.-) ; Trientine (SJ76Y07H5F)
    Language English
    Publishing date 2000-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.2000.279.4.L683
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  5. Article ; Online: Medical and interventional therapies for inoperable CTEPH: a necessary combination?

    Ghofrani, Hossein-Ardeschir / Kim, Nick H

    The Lancet. Respiratory medicine

    2022  Volume 10, Issue 10, Page(s) 926–927

    MeSH term(s) Angioplasty, Balloon ; Chronic Disease ; Endarterectomy ; Humans ; Hypertension, Pulmonary/therapy ; Pulmonary Embolism
    Language English
    Publishing date 2022-08-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(22)00227-2
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  6. Article ; Online: Reply to "Risk stratification in PH associated with interstitial lung disease: The Holy Grail?"

    Tello, Khodr / Yogeswaran, Athiththan / Ghofrani, Ardeschir / Gall, Henning

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2021  Volume 40, Issue 4, Page(s) 317

    MeSH term(s) Humans ; Lung Diseases, Interstitial/diagnosis ; Risk Assessment
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2021.01.003
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  7. Article ; Conference proceedings: Zunehmende Dyspnoe bei einer jungen Patientin mit chronisch myeloischer Leukämie (CML) – ein Fallbericht

    Schäfer, S / Kremer, N / Vitalii, K / Rako, Z / Yogeswaran, A / Yildiz, S / Ghofrani, H / Seeger, W / Tello, K / Richter, M

    Pneumologie

    2024  Volume 78, Issue S 01

    Event/congress 64. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V., Mannheim, 2024-03-20
    Language German
    Publishing date 2024-03-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/s-0044-1778843
    Database Thieme publisher's database

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  8. Article ; Online: Tachykardien bei pulmonalarterieller Hypertonie.

    Bandorski, D / Bogossian, H / Ghofrani, A / Schmitt, J / Höltgen, R

    Herzschrittmachertherapie & Elektrophysiologie

    2020  Volume 31, Issue 1, Page(s) 33–38

    Abstract: Pulmonary hypertension is newly defined as an elevation of the mean pulmonary arterial pressure >20 mmHg and a pulmonary vascular resistance ≥3 Wood units. Arrhythmias are an increasing problem in patients with pulmonary hypertension. Pathophysiological ... ...

    Title translation Tachycardia and pulmonary arterial hypertension.
    Abstract Pulmonary hypertension is newly defined as an elevation of the mean pulmonary arterial pressure >20 mmHg and a pulmonary vascular resistance ≥3 Wood units. Arrhythmias are an increasing problem in patients with pulmonary hypertension. Pathophysiological aspects leading to supraventricular arrhythmias are atrial fibrosis caused by increased right atrial pressure and dilation. An increased sympathetic tone leads to prolongation of action potential and delayed polarisations causing arrhythmias. Therapy of arrhythmias includes drugs (preferred amiodarone) and electrophysiological therapy like electric cardioversion and ablation, which is safe in patients with pulmonary hypertension.
    MeSH term(s) Amiodarone ; Atrial Fibrillation ; Electric Countershock ; Humans ; Pulmonary Arterial Hypertension ; Tachycardia, Supraventricular
    Chemical Substances Amiodarone (N3RQ532IUT)
    Language German
    Publishing date 2020-02-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1082953-2
    ISSN 1435-1544 ; 0938-7412
    ISSN (online) 1435-1544
    ISSN 0938-7412
    DOI 10.1007/s00399-020-00668-w
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  9. Article: Medikamentöse Therapie der pulmonal arteriellen Hypertonie und der chronisch thrombembolischen pulmonalen Hypertonie

    Yogeswaran, A. / Richter, M.J. / Tello, K. / Rako, Z.A. / Kremer, N.C. / Ghofrani, H.A. / Gall, H.

    Atemwegs- und Lungenkrankheiten

    2023  Volume 49, Issue 9, Page(s) 415

    Language German
    Document type Article
    ZDB-ID 534006-8
    ISSN 0341-3055
    Database Current Contents Medicine

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  10. Article ; Online: AI-enabled epidermal electronic system to automatically monitor a prognostic parameter for hypertension with a smartphone.

    Hesar, Milad Eyvazi / Seyedsadrkhani, Niloofar Sadat / Khan, Dibyendu / Naghashian, Adib / Piekarski, Mateusz / Gall, Henning / Schermuly, Ralph / Ghofrani, Hossein Ardeschir / Ingebrandt, Sven

    Biosensors & bioelectronics

    2023  Volume 241, Page(s) 115693

    Abstract: We present a wearable, flexible, wireless and smartphone-enabled epidermal electronic system (EES) for the continuous monitoring of a prognostic parameter for hypertension. The thin and lightweight EES can be tightly attached to the chest of a patient ... ...

    Abstract We present a wearable, flexible, wireless and smartphone-enabled epidermal electronic system (EES) for the continuous monitoring of a prognostic parameter for hypertension. The thin and lightweight EES can be tightly attached to the chest of a patient and synchronously monitor first lead electrocardiograms (ECG) and seismocardiograms (SCG). To demonstrate the concept, we developed the EES using state-of-the-art cleanroom technologies. Two types of sensors were integrated: A pair of metal electrodes to contact the skin and to record ECG and a vibration sensor based on a thin piezoelectric polymer to record SCG from the same location of the chest, simultaneously. The complete EES was powered by the near field communication functionality of the smartphone. We developed a machine-learning algorithm and trained it on public ECG data and recorded SCG signals to extract characteristic features of the recordings. Binary classifiers were used to automatically annotate peaks. After training, the algorithm was transferred to the smartphone to continuously analyze the timing between particular ECG and SCG peaks and to extract the Weissler's index as a prognostic parameter for hypertension. Tests with data of healthy control persons and clinical experiments with patients diagnosed with cardio-pulmonary hypertension showed a promising prognostic performance. The presented EES technology could be utilized for pre-screening of cardio-pulmonary hypertension, which is a strong burden in our today's healthcare system.
    MeSH term(s) Humans ; Smartphone ; Prognosis ; Hypertension, Pulmonary ; Biosensing Techniques ; Electrocardiography ; Electronics ; Artificial Intelligence
    Language English
    Publishing date 2023-09-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2023.115693
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