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  1. Article ; Online: Concerns Regarding Neuroimaging of Asymptomatic Infant Siblings of Children Who Experienced Abuse-Reply.

    Mankad, Kshitij / Sidpra, Jai / Offiah, Amaka C

    JAMA pediatrics

    2023  Volume 177, Issue 8, Page(s) 869–870

    MeSH term(s) Child ; Infant ; Humans ; Siblings ; Child Abuse/diagnosis ; Neuroimaging/methods
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2023.1715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Parenchymal brain injuries in abusive head trauma.

    Oates, Adam J / Sidpra, Jai / Mankad, Kshitij

    Pediatric radiology

    2021  Volume 51, Issue 6, Page(s) 898–910

    Abstract: The consequences of abusive head trauma (AHT) can be devastating for both the individual child and for wider society. Death is undoubtedly a very real possibility, but even for those children who survive, there is often very significant morbidity with ... ...

    Abstract The consequences of abusive head trauma (AHT) can be devastating for both the individual child and for wider society. Death is undoubtedly a very real possibility, but even for those children who survive, there is often very significant morbidity with the potential for gross motor and cognitive impairment, behavioural problems, blindness and epilepsy, which can greatly affect their quality of life. Caring for such children places a vast financial and infrastructural burden on society that frequently extends well into adulthood. While few struggle to have any sympathy for the perpetrator, frequently the infant's father, it should be noted that a single solitary and momentary loss of complete control can have horrific and unforeseen consequences. A number of papers within this edition describe features of AHT and include descriptions of skull fractures and extra-axial haemorrhage, along with mimics of such phenomena. However, in this review we concentrate our attention on the myriad of parenchymal findings that can occur. Such parenchymal injuries include hypoxic-ischaemic damage, clefts, contusion and focal haemorrhage. We offer our perspectives on current thinking on these entities and put them in the context of the immensely important question - how do we recognise abusive head trauma?
    MeSH term(s) Adult ; Brain Injuries/diagnostic imaging ; Child ; Child Abuse/diagnosis ; Craniocerebral Trauma/diagnostic imaging ; Humans ; Infant ; Quality of Life ; Skull Fractures/diagnostic imaging
    Language English
    Publishing date 2021-02-27
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-021-04981-5
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  3. Article: Diagnostic accuracy of qualitative MRI in 550 paediatric brain tumours: evaluating current practice in the computational era.

    Dixon, Luke / Jandu, Gurpreet Kaur / Sidpra, Jai / Mankad, Kshitij

    Quantitative imaging in medicine and surgery

    2021  Volume 12, Issue 1, Page(s) 131–143

    Abstract: Background: To investigate the accuracy of qualitative reporting of conventional magnetic resonance imaging (MRI) in the classification of paediatric brain tumours.: Methods: Preoperative MRI reports of 608 children prior to resection or biopsy of an ...

    Abstract Background: To investigate the accuracy of qualitative reporting of conventional magnetic resonance imaging (MRI) in the classification of paediatric brain tumours.
    Methods: Preoperative MRI reports of 608 children prior to resection or biopsy of an intracranial lesion were retrospectively reviewed. A total of 550 children had complete radiological and histopathological notes, thereby reaching our inclusion criteria. Concordance between MRI report and final histopathological diagnosis was assessed using an established lexicon derived from the WHO 2016 classification of CNS tumours. Levels of agreement based on cellular origin, tumour type, and tumour grade were evaluated. Diagnostic accuracy, sensitivity, specificity, confidence intervals, and positive and negative predictive values were calculated.
    Results: Diagnostic accuracy differed significantly between tumour types and tumour grades. Sensitivities were highest for ependymomas and sellar, pituitary, pineal, and cranial and/or paraspinal nerve tumours (range 80.65-100%). Sensitivity was slightly lower for astrocytic gliomas, oligodendrogliomas, and choroid plexus, neuronal, mixed neuronal-glial, embryonal, and histiocytic tumours (range 63.33-79.59%). Low sensitivities were noted for meningiomas and mesenchymal non-meningothelial, melanocytic, and germ cell tumours (range 0-56.25%). The most correct tumour type predictions were made in the posterior fossa whilst the most incorrect predictions were made in the lobar regions, pineal/tectal plate area, and the supratentorial ventricles.
    Conclusions: This is the largest published series investigating the predictive accuracy of MRI in paediatric brain tumours. We show that diagnostic accuracy varies greatly by tumour type and location. Looking forward, we should develop and leverage computational methods to improve accuracy in the tumour types and anatomical locations where qualitative diagnostic accuracy is lower.
    Language English
    Publishing date 2021-12-14
    Publishing country China
    Document type Journal Article
    ZDB-ID 2653586-5
    ISSN 2223-4306 ; 2223-4292
    ISSN (online) 2223-4306
    ISSN 2223-4292
    DOI 10.21037/qims-20-1388
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  4. Article ; Online: Rise in the incidence of abusive head trauma during the COVID-19 pandemic.

    Sidpra, Jai / Abomeli, Doris / Hameed, Biju / Baker, Janice / Mankad, Kshitij

    Archives of disease in childhood

    2020  Volume 106, Issue 3, Page(s) e14

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Child Abuse/prevention & control ; Child Abuse/statistics & numerical data ; Communicable Disease Control/methods ; Craniocerebral Trauma/diagnosis ; Craniocerebral Trauma/epidemiology ; Craniocerebral Trauma/etiology ; Female ; Humans ; Incidence ; Infant ; Male ; Needs Assessment ; Physical Distancing ; Risk Factors ; SARS-CoV-2 ; Socioeconomic Factors ; United Kingdom/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Letter
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2020-319872
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  5. Article ; Online: Sibling screening in suspected abusive head trauma: a proposed guideline.

    Mankad, Kshitij / Sidpra, Jai / Oates, Adam J / Calder, Alistair / Offiah, Amaka C / Choudhary, Arabinda

    Pediatric radiology

    2021  Volume 51, Issue 6, Page(s) 872–875

    Abstract: Abusive head trauma (AHT) is the leading cause of death from child abuse in children younger than 5 years. It is well documented that the infant contacts of children presenting with suspected AHT are at an increased risk of abuse when compared to the ... ...

    Abstract Abusive head trauma (AHT) is the leading cause of death from child abuse in children younger than 5 years. It is well documented that the infant contacts of children presenting with suspected AHT are at an increased risk of abuse when compared to the general infant population. Despite this association, a paucity of literature stratifies this risk and translates it to the clinic such that this high-risk group is stringently screened for abusive injuries. In this light, the authors propose a standardised screening method for all contact children of the index case and call for further consensus on the subject.
    MeSH term(s) Child ; Child Abuse/diagnosis ; Consensus ; Craniocerebral Trauma/diagnostic imaging ; Humans ; Infant ; Siblings
    Language English
    Publishing date 2021-05-17
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-020-04917-5
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  6. Article ; Online: Abusive head trauma: neuroimaging mimics and diagnostic complexities.

    Sidpra, Jai / Chhabda, Sahil / Oates, Adam J / Bhatia, Aashim / Blaser, Susan I / Mankad, Kshitij

    Pediatric radiology

    2021  Volume 51, Issue 6, Page(s) 947–965

    Abstract: Traumatic brain injury is responsible for approximately half of all childhood deaths from infancy to puberty, the majority of which are attributable to abusive head trauma (AHT). Due to the broad way patients present and the lack of a clear mechanism of ... ...

    Abstract Traumatic brain injury is responsible for approximately half of all childhood deaths from infancy to puberty, the majority of which are attributable to abusive head trauma (AHT). Due to the broad way patients present and the lack of a clear mechanism of injury in some cases, neuroimaging plays an integral role in the diagnostic pathway of these children. However, this nonspecific nature also presages the existence of numerous conditions that mimic both the clinical and neuroimaging findings seen in AHT. This propensity for misdiagnosis is compounded by the lack of pathognomonic patterns and clear diagnostic criteria. The repercussions of this are severe and have a profound stigmatic effect. The authors present an exhaustive review of the literature complemented by illustrative cases from their institutions with the aim of providing a framework with which to approach the neuroimaging and diagnosis of AHT.
    MeSH term(s) Child ; Child Abuse/diagnosis ; Craniocerebral Trauma/diagnostic imaging ; Humans ; Infant ; Neuroimaging
    Language English
    Publishing date 2021-05-17
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-020-04940-6
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  7. Article: Virtual multidisciplinary team meetings in the age of COVID-19: an effective and pragmatic alternative.

    Sidpra, Jai / Chhabda, Sahil / Gaier, Celia / Alwis, Anoushka / Kumar, Neetu / Mankad, Kshitij

    Quantitative imaging in medicine and surgery

    2020  Volume 10, Issue 6, Page(s) 1204–1207

    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country China
    Document type Editorial
    ZDB-ID 2653586-5
    ISSN 2223-4306 ; 2223-4292
    ISSN (online) 2223-4306
    ISSN 2223-4292
    DOI 10.21037/qims-20-638
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  8. Article: Sustaining education in the age of COVID-19: a survey of synchronous web-based platforms.

    Sidpra, Jai / Gaier, Celia / Reddy, Nihaal / Kumar, Neetu / Mirsky, David / Mankad, Kshitij

    Quantitative imaging in medicine and surgery

    2020  Volume 10, Issue 7, Page(s) 1422–1427

    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country China
    Document type Editorial
    ZDB-ID 2653586-5
    ISSN 2223-4306 ; 2223-4292
    ISSN (online) 2223-4306
    ISSN 2223-4292
    DOI 10.21037/qims-20-714
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  9. Article ; Online: International Consensus Statement on the Radiological Evaluation of Dysraphic Malformations of the Spine and Spinal Cord.

    Balani, Ankit / Sidpra, Jai / Sudhakar, Sniya / Biswas, Asthik / Öztekin, Özgür / Capra, Valeria / Catala, Martin / Copp, Andrew J / Kumar, Neetu / Johal, Navroop / Tahir, M Zubair / Thompson, Dominic / Pang, Dachling / Mirsky, David M / Ho, Mai-Lan / Huisman, Thierry A G M / Rossi, Andrea / Mankad, Kshitij

    AJNR. American journal of neuroradiology

    2024  

    Abstract: Dysraphic malformations of the spine and spinal cord (DMSSC) represent a spectrum of common congenital anomalies typically (though not exclusively) affecting the lower spinal segments. These may be responsible for varying degrees of neurologic, ... ...

    Abstract Dysraphic malformations of the spine and spinal cord (DMSSC) represent a spectrum of common congenital anomalies typically (though not exclusively) affecting the lower spinal segments. These may be responsible for varying degrees of neurologic, orthopedic, and urologic morbidity. With advances in neuroimaging, it is now possible to better diagnose and evaluate these disorders both prenatally and postnatally. Neuroimaging, performed at the right time and with technique optimization, is integral in guiding clinical management. However, the terminology used to describe these lesions has become increasingly confusing, and there is a lack of consensus regarding the essential radiologic features and their clinical weighting. This variability in radiologic practice risks unstructured decision making and increases the likelihood of suboptimal, less informed clinical management. In this manuscript, the first of a series of consensus statements, we outline a standardized international consensus statement for the radiologic evaluation of children with suspected DMSSC derived from a critical review of the literature, and the collective clinical experience of a multinational group of experts. We provide recommendations for plain radiography, sonography, CT, and MR imaging in the evaluation of DMSSC with an emphasis on technique of imaging and imaging protocols.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A8117
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