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  1. Article: Kleine Chirurgie – Specials der Wundversorgung

    Hüfner, Andreas

    Notaufnahme up2date

    2022  Volume 04, Issue 01, Page(s) 33–55

    Keywords Weichteilinfektion ; Abszess ; Wunde ; Blutstillung ; Weichteilverletzung
    Language German
    Publishing date 2022-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2628-7609 ; 2628-7595
    ISSN (online) 2628-7609
    ISSN 2628-7595
    DOI 10.1055/a-1227-3731
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  2. Article: Handchirurgische Notfälle – Teil 2

    Hüfner, Andreas / Kemper, Robert

    Notaufnahme up2date

    2023  Volume 05, Issue 01, Page(s) 61–82

    Keywords Notfallmedizin ; Notaufnahme ; Hand ; Finger ; Weichteilinfektion
    Language German
    Publishing date 2023-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2628-7609 ; 2628-7595
    ISSN (online) 2628-7609
    ISSN 2628-7595
    DOI 10.1055/a-1848-0054
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  3. Article ; Online: Epidemiologie, Initialdiagnostik und -therapie des akuten und unklaren Bauchschmerzes in der Notaufnahme.

    Pemmerl, S / Hüfner, A

    Medizinische Klinik, Intensivmedizin und Notfallmedizin

    2020  Volume 116, Issue 7, Page(s) 578–585

    Abstract: Background: Abdominal pain is one of the most common symptoms of patients who present to the emergency department (ED). The aim of this study was to collect current epidemiological data, the frequency of these findings, and the measures that derived ... ...

    Title translation Epidemiology, initial diagnosis, and therapy of unexplained abdominal pain in the emergency department.
    Abstract Background: Abdominal pain is one of the most common symptoms of patients who present to the emergency department (ED). The aim of this study was to collect current epidemiological data, the frequency of these findings, and the measures that derived from them.
    Methods: We performed a retrospective analysis in the period between January 1 and June 30, 2016, including all patients who presented to the ED of the Caritas Hospital St. Josef in Regensburg (teaching hospital with an academic urology and gynecology department, about 32,000 patients in the ED per year) and were categorized as "abdominal pain in adults" using the Manchester Triage System (MTS).
    Results: The study population consisted of 1417 patients (9.8% of all ED patients). The admission rate was 48.2%. Vomiting and fever as concomitant symptoms made hospitalization more likely (p = 0.00). Almost half of the patients had nonspecific abdominal pain (28.2%), gynecological causes (13.2%), or suspected acute appendicitis (6.7%). In all, 10% of patients received an abdominal CT investigation; 73% of the patients presented in the time from 08:00-20:00 h, and more frequently on weekdays (74.2%). Of these patients, 6.4% returned after discharge because of persisting or worsening symptoms. Finally, 58.6% of outpatients and 77.5% of inpatients received further treatment recommendations for new pharmacologic therapy (e.g., analgesics, proton pump inhibitors, antibiotics).
    Conclusion: A variety of epidemiological data of our collective could be analyzed, which should be transferable to many other German EDs. The MTS shows a high reliability in terms of conversion rate in abdominal pain; despite comprehensive emergency diagnostics, a relevant proportion of complaints remain unclear.
    MeSH term(s) Abdominal Pain/epidemiology ; Abdominal Pain/therapy ; Emergency Service, Hospital ; Humans ; Reproducibility of Results ; Retrospective Studies
    Language German
    Publishing date 2020-06-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2636018-4
    ISSN 2193-6226 ; 1435-1420 ; 0723-5003 ; 2193-6218 ; 0175-3851
    ISSN (online) 2193-6226 ; 1435-1420
    ISSN 0723-5003 ; 2193-6218 ; 0175-3851
    DOI 10.1007/s00063-020-00696-x
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  4. Article: Handchirurgische Notfälle - Teil 1

    Hüfner, Andreas / Kemper, Robert

    Notaufnahme up2date

    2022  Volume 4, Issue 04, Page(s) 385–402

    Keywords Notfallmedizin ; Hand ; Finger ; Weichteilinfektion ; Notaufnahme
    Language German
    Publishing date 2022-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2628-7609 ; 2628-7595
    ISSN (online) 2628-7609
    ISSN 2628-7595
    DOI 10.1055/a-1483-3114
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  5. Article ; Online: Das akute Abdomen: Ätiologie und Klinik.

    Pemmerl, Sylvia / Hüfner, Andreas

    Deutsche medizinische Wochenschrift (1946)

    2020  Volume 145, Issue 21, Page(s) 1535–1543

    Abstract: Abdominal pain is one of the most common complaints that lead to an emergency department visit. Depending on the interpretation of the definition, 20-40 % of these patients present with an acute abdomen. This term summarizes a variety of diseases that ... ...

    Title translation The Acute Abdomen: Etiology and Clinical Presentation.
    Abstract Abdominal pain is one of the most common complaints that lead to an emergency department visit. Depending on the interpretation of the definition, 20-40 % of these patients present with an acute abdomen. This term summarizes a variety of diseases that often occur in the abdominal cavity, mostly acute, and can be accompanied by symptoms such as nausea and vomiting. The challenge for the physician is to differentiate a whole range of vital diseases from less urgent causes of complaints. Extra-abdominal differential diagnoses should also be considered. Initial diagnosis often requires a great deal of clinical experience.The targeted medical history and clinical assessment together with the selection of the appropriate technical investigation play a central role. The goal must be to move from symptom-based to causal therapy as quickly as possible and to clarify whether a patient needs to be referred to an emergency operation or whether there is time for further differential diagnostic measures. The prognosis of the acute abdomen often depends on the time latency until the definitive therapy is initiated. Rapid and determined action by the experienced initial examiner are important prerequisites for a favorable course of the disease process.
    MeSH term(s) Abdomen, Acute/diagnosis ; Abdomen, Acute/etiology ; Abdomen, Acute/therapy ; Diagnosis, Differential ; Humans ; Prognosis
    Language German
    Publishing date 2020-10-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1007-4174
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  6. Article ; Online: Ein Jahr Coronapandemiemanagement an einem 300-Betten-Krankenhaus : Report der Pandemiebeauftragten.

    Pemmerl, S / Treml, C / Hüfner, A

    Medizinische Klinik, Intensivmedizin und Notfallmedizin

    2021  Volume 117, Issue 7, Page(s) 549–557

    Abstract: Background: From the point of view of the pandemic officer of a 300-bed specialty care hospital, the first year of the SARS-CoV‑2 (Severe Acute Respiratory Syndrome Coronavirus Type 2) pandemic with all the challenges for daily clinical routine was ... ...

    Title translation One year corona pandemic management in a 300-bed hospital : Report of the pandemic officer.
    Abstract Background: From the point of view of the pandemic officer of a 300-bed specialty care hospital, the first year of the SARS-CoV‑2 (Severe Acute Respiratory Syndrome Coronavirus Type 2) pandemic with all the challenges for daily clinical routine was reviewed on the basis of the data collected with the aim of making future pandemic management easier to plan.
    Methods: The Caritas Hospital St. Josef in Regensburg employs around 1330 employees and treats almost 20,000 inpatients annually. All records of the pandemic officer between 1 March 2020 and 28 February 2021 were included in the present descriptive study.
    Results: In all, 280 SARS-CoV-2-positive patients (mean age 68 ± 19 years) were treated during the observation period; 81% (n = 227) of these were treated as inpatients between November 2020 and February 2021. In addition to the analysis of these patients, an analysis of the test concept was carried out, both for the patients (53% of the tests in the so-called 2nd wave) and for the employees; 1633 PCR tests were carried out, with 5.6% of all employees being infected with SARS-CoV‑2 in the course of the pandemic. In addition, other measures such as reducing the surgical program and other general measures were evaluated.
    Conclusion: Many established processes had to be changed in the hospital during the pandemic. Both staff shortages due to SARS-CoV-2-positive employees and the quarantine measures of contact persons led to further tension in the already tight staffing levels, especially in the nursing care sector, and made patient care more difficult. The test concept in the hospital was very complex and asymptomatic tests in particular showed a low hit rate, while being associated with high personnel costs.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19 ; Equipment and Supplies, Hospital ; Hospitals ; Humans ; Middle Aged ; Pandemics ; SARS-CoV-2
    Language German
    Publishing date 2021-10-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2636018-4
    ISSN 2193-6226 ; 1435-1420 ; 0723-5003 ; 2193-6218 ; 0175-3851
    ISSN (online) 2193-6226 ; 1435-1420
    ISSN 0723-5003 ; 2193-6218 ; 0175-3851
    DOI 10.1007/s00063-021-00867-4
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  7. Article ; Online: The Effect of Cold Exposure on Cognitive Performance in Healthy Adults: A Systematic Review.

    Falla, Marika / Micarelli, Alessandro / Hüfner, Katharina / Strapazzon, Giacomo

    International journal of environmental research and public health

    2021  Volume 18, Issue 18

    Abstract: Several aspects of cognition can be affected after cold exposure, but contradictory results have been reported regarding affected cognitive domains. The aim of the current systematic review was to evaluate the effects of specific cold exposure on ... ...

    Abstract Several aspects of cognition can be affected after cold exposure, but contradictory results have been reported regarding affected cognitive domains. The aim of the current systematic review was to evaluate the effects of specific cold exposure on cognitive performance in healthy subjects. A systematic search was performed using MEDLINE (through PubMed), EMBASE (Scopus) and PsycINFO databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria were healthy subjects exposed to a cold environment (either simulated or not) and cognitive performance related to cold exposure with an experimental design. The literature search identified 18 studies, eight studies investigated the effect of cold air exposure and ten the effect of cold water immersion on cognitive performance of healthy subjects. There were several differences among the studies (environmental temperature reached, time of exposure, timing, and type of cognitive test administration). Cold exposure induced in most of the experimental settings (15 of 18) an impairment of CP even before accidental hypothermia was established. The most investigated and affected cognitive domains were attention and processing speed, executive function, and memory. Gender differences and effects of repeated exposure and possible acclimation on cognitive performance need further studies to be confirmed.
    MeSH term(s) Acclimatization ; Adult ; Attention ; Cognition ; Cognitive Dysfunction ; Executive Function ; Humans
    Language English
    Publishing date 2021-09-15
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18189725
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  8. Article ; Online: Mutational Studies of Aldose Reductase to Trace a Transient Pocket Opening and to Explain Ligand Affinity Cliffs.

    Klee, Lea-Sophie / Gárdonyi, Marina / Hüfner, Tobias / Heine, Andreas / Klebe, Gerhard

    ChemMedChem

    2023  Volume 18, Issue 15, Page(s) e202300222

    Abstract: Human aldose reductase, a target for the development of inhibitors for preventing diabetic complications, displays a transient specificity pocket which opens upon binding with specific, potent inhibitors. We investigated the opening mechanism of this ... ...

    Abstract Human aldose reductase, a target for the development of inhibitors for preventing diabetic complications, displays a transient specificity pocket which opens upon binding with specific, potent inhibitors. We investigated the opening mechanism of this pocket by mutating leucine residues involved in the gate keeping mechanism to alanine. Two isostructural inhibitors distinguished only by a single nitro to carboxy group replacement, have a 1000-fold difference in their binding affinity to the wild type. This difference is reduced to 10-fold in the mutated variants as the nitro derivative loses in affinity but conserves binding to the open transient pocket. The affinity of the carboxylate analog is minimally altered but the analog binding preference changes from the closed to open state of the transient pocket. Differences in the solvation properties of ligands and the transient pocket as well as changes from induced fit to conformational selections provide an explanation for the altered behavior of the ligands with respect to their binding to the different variants.
    MeSH term(s) Humans ; Models, Molecular ; Binding Sites ; Enzyme Inhibitors/chemistry ; Aldehyde Reductase/genetics ; Ligands
    Chemical Substances Enzyme Inhibitors ; Aldehyde Reductase (EC 1.1.1.21) ; Ligands
    Language English
    Publishing date 2023-07-05
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218496-X
    ISSN 1860-7187 ; 1860-7179
    ISSN (online) 1860-7187
    ISSN 1860-7179
    DOI 10.1002/cmdc.202300222
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  9. Article ; Online: Trait emotional intelligence and resilience: gender differences among university students.

    Sojer, Patricia / Kainbacher, Susanne / Hüfner, Katharina / Kemmler, Georg / Deisenhammer, Eberhard A

    Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater

    2023  Volume 38, Issue 1, Page(s) 39–46

    Abstract: Background: Previous studies have reported strong correlations of emotional intelligence (EI) with mental health and wellbeing; it is also a powerful predictor of social functioning and personal adaption. Resilience is the ability to adapt to ... ...

    Title translation Emotionale Intelligenz als Eigenschaft und Resilienz: Geschlechtsunterschiede bei Universitätsstudierenden.
    Abstract Background: Previous studies have reported strong correlations of emotional intelligence (EI) with mental health and wellbeing; it is also a powerful predictor of social functioning and personal adaption. Resilience is the ability to adapt to significant life stressors and is also crucial for maintaining and restoring physical and mental health. The aim of this study was to investigate EI and resilience in healthy university students, with a focus on gender differences in EI and resilience components.
    Materials and methods: A total of 277 datasets collected via online questionnaire were analyzed. The questionnaire comprised the Self-Report Emotional Ability Scale (SEAS) developed by Freudenthaler and Neubauer for assessing trait EI facets and the Connor-Davidson Resilience Scale (CD-RISC).
    Results: Regarding trait EI, females scored significantly higher in the total score for interpersonal emotional skills and in the subscale "Perception of the emotions of others" than males. Men showed significantly higher total scores in intrapersonal emotion-related abilities than women, and in the subscales "Regulation of one's own emotions" and "Control over the expression of one's own emotions." Concerning resilience, female students had significantly higher scores in the CD-RISC subscales "Personal competence and tenacity," "Control," and "Spiritual influence." The intrapersonal trait EI (SEAS) sum score showed a significant positive correlation with the total scores of the CD-RISC (r
    Conclusion: The results indicate gender differences in specific facets of trait EI and resilience, and an interaction between the two psychological constructs was demonstrated regardless of gender. For prevention of mental disorders and to foster wellbeing, it might be helpful to focus on improvement of self-perception in girls and women, and on supporting emotional awareness towards other people's emotions in boys and men. Further studies in the field should address other populations.
    MeSH term(s) Male ; Humans ; Female ; Resilience, Psychological ; Sex Factors ; Universities ; Emotional Intelligence/physiology ; Students ; Psychological Tests
    Language English
    Publishing date 2023-11-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1027479-0
    ISSN 2194-1327 ; 0948-6259
    ISSN (online) 2194-1327
    ISSN 0948-6259
    DOI 10.1007/s40211-023-00484-x
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  10. Article ; Online: Gewalt und Aggression im Krankenhaus – Was, wenn das Personal Hilfe braucht?

    Hüfner, Andreas / Dudeck, Manuela / Zellner, Johannes / Mahr, Daniel

    Der Unfallchirurg

    2020  Volume 123, Issue 6, Page(s) 424–434

    Abstract: In view of the increasing violence and aggression against medical personnel in healthcare facilities, there are considerations by the legislature to punish violent offenders in hospitals more severely. Hospital and emergency room staff are increasingly ... ...

    Title translation Violence and aggression in hospitals-what if the personnel need help?
    Abstract In view of the increasing violence and aggression against medical personnel in healthcare facilities, there are considerations by the legislature to punish violent offenders in hospitals more severely. Hospital and emergency room staff are increasingly confronted by physically and psychologically violent patients or their relatives. Sometimes medical treatment in a hospital or emergency room is an exceptional physical or mental situation for many patients and their relatives. In addition, the consumption of alcohol and drugs, long waiting times, psychiatric illnesses and dissatisfaction with medical care or communication problems are considered to be the cause of violence against medical personnel in healthcare facilities. In addition to the physical consequences for the affected employees, the psychological consequences, such as job dissatisfaction, fear of work and posttraumatic stress disorder also pose major challenges for the employer. In order to fulfil the obligation of care towards employees, the latter should provide concepts for protection against violence as part of the company health management. Structural, organizational and personal measures as well as concepts for dealing with aggressive patients are the cornerstones of employee protection. Professional training courses on de-escalation, self-protection and self-defense can also contribute to the protection of employees and are gladly accepted by the staff. Even in the extreme case of a rampage situation, hospital deployment and alarm plans have to be developed and established.
    MeSH term(s) Aggression ; Epilepsy, Post-Traumatic/etiology ; Fear ; Health Personnel/psychology ; Hospitals ; Humans ; Workplace Violence/prevention & control ; Workplace Violence/psychology
    Language German
    Publishing date 2020-04-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 605965-x
    ISSN 1433-044X ; 0177-5537
    ISSN (online) 1433-044X
    ISSN 0177-5537
    DOI 10.1007/s00113-020-00806-6
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