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  1. Article ; Online: Air Aware: Improving Use of an Existing Air Quality and Health Tool.

    Damon, Scott A / Rupert, Douglas J / Pryzby, Rachel

    Journal of health communication

    2022  Volume 27, Issue 1, Page(s) 1–7

    Abstract: Exposure to air pollutants is a significant health risk for individuals with asthma, cardiovascular disease, and chronic obstructive pulmonary disease. Measures such as limiting time outdoors or performing less strenuous tasks when air quality levels are ...

    Abstract Exposure to air pollutants is a significant health risk for individuals with asthma, cardiovascular disease, and chronic obstructive pulmonary disease. Measures such as limiting time outdoors or performing less strenuous tasks when air quality levels are better can mitigate these risks, but only if people are aware of both these recommendations and how to know when air quality is best, and worst. Formative audience assessment determined that applications developed for mobile devices are the optimal way to provide this information, but knowledge of the existing United States Environmental Protection Agency (EPA) and partners' AirNow tool was minimal. We developed, field-tested, adapted, and implemented pilot efforts at both the national and local levels to address this knowledge gap, and present findings suggesting a concentrated local effort can heighten use of AirNow, leading to more pro-healthy behavior.
    MeSH term(s) Air Pollutants/adverse effects ; Air Pollution/adverse effects ; Air Pollution/prevention & control ; Cardiovascular Diseases ; Humans ; United States ; United States Environmental Protection Agency
    Chemical Substances Air Pollutants
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1427988-5
    ISSN 1087-0415 ; 1081-0730
    ISSN (online) 1087-0415
    ISSN 1081-0730
    DOI 10.1080/10810730.2021.2025173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction to: Understanding US Physician and Pharmacist Attitudes Toward Biosimilar Products: A Qualitative Study.

    Rupert, Douglas J / Jordan, Alyssa M / Ziemian, Marina A / Brown, Rachel M / Fleming, Neil S / Lefebvre, R Craig

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

    2023  Volume 37, Issue 3, Page(s) 441

    Language English
    Publishing date 2023-03-07
    Publishing country New Zealand
    Document type Published Erratum
    ZDB-ID 1364202-9
    ISSN 1179-190X ; 1173-8804
    ISSN (online) 1179-190X
    ISSN 1173-8804
    DOI 10.1007/s40259-023-00588-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Future Challenges and Opportunities in Online Prescription Drug Promotion Research Comment on "Trouble Spots in Online Direct-to-Consumer Prescription Drug Promotion: A Content Analysis of FDA Warning Letters".

    Southwell, Brian G / Rupert, Douglas J

    International journal of health policy and management

    2016  Volume 5, Issue 3, Page(s) 211–213

    Abstract: Despite increased availability of online promotional tools for prescription drug marketers, evidence on online prescription drug promotion is far from settled or conclusive. We highlight ways in which online prescription drug promotion is similar to ... ...

    Abstract Despite increased availability of online promotional tools for prescription drug marketers, evidence on online prescription drug promotion is far from settled or conclusive. We highlight ways in which online prescription drug promotion is similar to conventional broadcast and print advertising and ways in which it differs. We also highlight five key areas for future research: branded drug website influence on consumer knowledge and behavior, interactive features on branded drug websites, mobile viewing of branded websites and mobile advertisements, online promotion and non-US audiences, and social media and medication decisions.
    MeSH term(s) Humans ; Prescription Drugs ; Publications ; Research ; Social Media
    Chemical Substances Prescription Drugs
    Language English
    Publishing date 2016-01-16
    Publishing country Iran
    Document type Comment ; Journal Article
    ZDB-ID 2724317-5
    ISSN 2322-5939 ; 2322-5939
    ISSN (online) 2322-5939
    ISSN 2322-5939
    DOI 10.15171/ijhpm.2016.05
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Understanding US Physician and Pharmacist Attitudes Toward Biosimilar Products: A Qualitative Study.

    Rupert, Douglas J / Jordan, Alyssa M / Ziemian, Marina A / Brown, Rachel M / Fleming, Neil S / Lefebvre, R Craig

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

    2022  Volume 36, Issue 5, Page(s) 645–655

    Abstract: Background: Biosimilars account for 30-40% of biologic medications dispensed in the United States (US), yet healthcare providers in relevant medical specialties have limited awareness of biosimilars and their characteristics. Likewise, many providers ... ...

    Abstract Background: Biosimilars account for 30-40% of biologic medications dispensed in the United States (US), yet healthcare providers in relevant medical specialties have limited awareness of biosimilars and their characteristics. Likewise, many providers perceive biosimilars as less safe and effective than original biologics and are more comfortable prescribing original biologics to patients.
    Methods: We conducted in-person focus groups at three clinical sites in California and Texas (n = 49) to explore the reasons behind US healthcare providers' limited understanding of, cautious attitudes toward, and reluctance to prescribe biosimilars. We conducted thematic analysis by having three researchers independently analyze verbatim transcripts and identify patterns in provider responses.
    Results: Providers' limited knowledge of and cautious attitudes toward biosimilars are driven by uncertainty about how biosimilarity is defined and operationalized as well as negative past experiences with generic drugs that did not perform as well as branded counterparts. Additionally, healthcare providers are unfamiliar with the Food and Drug Administration's (FDA's) approval pathway for biosimilars and are skeptical that an abbreviated approval process is rigorous enough to ensure biosimilars deliver the same efficacy and have the same side effect profiles as original biologics. Physicians also expressed concerns about pharmacy substitution of biosimilars and interchangeables, explaining they would be unaware of which medication was ultimately given to their patients.
    Conclusions: Educating physicians and pharmacists about biosimilars-including how biosimilarity is defined and operationalized, the structure of the biosimilar approval process, and how analytical data can ensure biosimilar safety and efficacy-will be important for reducing healthcare providers' concerns and increasing biosimilar adoption in the US.
    MeSH term(s) Biosimilar Pharmaceuticals/therapeutic use ; Drug Approval ; Drugs, Generic ; Humans ; Pharmacists ; Physicians ; United States ; United States Food and Drug Administration
    Chemical Substances Biosimilar Pharmaceuticals ; Drugs, Generic
    Language English
    Publishing date 2022-08-13
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1364202-9
    ISSN 1179-190X ; 1173-8804
    ISSN (online) 1179-190X
    ISSN 1173-8804
    DOI 10.1007/s40259-022-00545-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Actors in whitespace: Communicating risk information on pharmaceutical websites.

    O'Donoghue, Amie C / Sullivan, Helen W / Rupert, Douglas J / Fitts Willoughby, Jessica / Aikin, Kathryn J

    Health marketing quarterly

    2019  Volume 36, Issue 2, Page(s) 152–167

    Abstract: This study examined the use of an actor to communicate prescription drug risks on pharmaceutical websites. Participants viewed risk information for a fictitious drug in one of several static visual formats or as a paragraph plus an animated actor; and ... ...

    Abstract This study examined the use of an actor to communicate prescription drug risks on pharmaceutical websites. Participants viewed risk information for a fictitious drug in one of several static visual formats or as a paragraph plus an animated actor; and with or without a signal directing them to the risk information text. The signal had little effect on outcomes. Format did not affect risk processing, but participants in the actor condition thought the website placed less emphasis on benefits. Actors communicating risk information on a pharmaceutical website do not appear to improve consumers' understanding of prescription drug information.
    MeSH term(s) Adult ; Aged ; Consumer Health Information ; Direct-to-Consumer Advertising/methods ; Drug Industry ; Female ; Humans ; Internet ; Male ; Middle Aged ; Prescription Drugs/adverse effects ; Risk Assessment ; Surveys and Questionnaires
    Chemical Substances Prescription Drugs
    Language English
    Publishing date 2019-03-23
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 639428-0
    ISSN 1545-0864 ; 0735-9683
    ISSN (online) 1545-0864
    ISSN 0735-9683
    DOI 10.1080/07359683.2019.1575063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Visual images of prescription drug benefits in direct-to-consumer television advertisements.

    Sullivan, Helen W / O'Donoghue, Amie C / Lynch, Molly / Johnson, Mihaela / Davis, Christine / Amoozegar, Jacqueline B / Rupert, Douglas J

    Patient education and counseling

    2021  Volume 104, Issue 9, Page(s) 2240–2249

    Abstract: Objective: Images demonstrating a prescription drug's efficacy are often included in direct-to-consumer television advertisements. The current research assessed whether exaggerated efficacy images can mislead individuals, and whether providing accurate ... ...

    Abstract Objective: Images demonstrating a prescription drug's efficacy are often included in direct-to-consumer television advertisements. The current research assessed whether exaggerated efficacy images can mislead individuals, and whether providing accurate quantitative information can reduce these misperceptions.
    Methods: We conducted two experimental studies with internet panelists 60 years and older testing drug efficacy images in television ads for wet age-related macular degeneration (N = 901) and plaque psoriasis (N = 902). In each study, participants viewed one of six ads that varied in the efficacy images included (no image, accurate image, exaggerated image) and the presentation of quantitative information (absent, present). Measures included recall, perceptions, and numeracy.
    Results: In both studies, participants who saw exaggerated images were more likely than those who saw no image or accurate images to overestimate efficacy. Presenting quantitative information increased participants' gist and verbatim recall of drug efficacy, and in some cases, led participants to have more accurate perceptions of the drug's efficacy even in the presence of exaggerated images. Higher numeracy was associated with better gist and verbatim recall.
    Conclusions: These results support visual persuasion theory. Moreover, they show that exaggerating benefits visually can mislead viewers.
    Practice implications: Stakeholders should ensure that images in direct-to-consumer promotion are accurate and non-misleading.
    MeSH term(s) Advertising ; Direct-to-Consumer Advertising ; Humans ; Mental Recall ; Persuasive Communication ; Prescription Drugs ; Television
    Chemical Substances Prescription Drugs
    Language English
    Publishing date 2021-02-13
    Publishing country Ireland
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 605590-4
    ISSN 1873-5134 ; 0738-3991
    ISSN (online) 1873-5134
    ISSN 0738-3991
    DOI 10.1016/j.pec.2021.02.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Examining Information Needs of Heart Failure Patients and Family Companions Using a Previsit Question Prompt List and Audiotaped Data: Findings From a Pilot Study.

    Jenkins, Hailey R / Rupert, Douglas J / Etta, Valerie / Peinado, Susana / Wolff, Jennifer L / Lewis, Megan A / Chang, Patricia / Cené, Crystal W

    Journal of cardiac failure

    2021  Volume 28, Issue 6, Page(s) 896–905

    Abstract: Background: Question prompt lists (QPLs) are an effective tool for improving communication during medical visits. However, no studies have attempted to correlate intentions related to question asking and actual questions asked during visits. Moreover, ... ...

    Abstract Background: Question prompt lists (QPLs) are an effective tool for improving communication during medical visits. However, no studies have attempted to correlate intentions related to question asking and actual questions asked during visits. Moreover, few studies have used QPLs with patients with heart failure (HF) or family companions who accompany them to visits. We examined the use of a previsit QPL for patients with HF and their family companions intended to enhance engagement in HF care. The aim of this research was to assess which questions from the QPL patients and companions selected most frequently to ask and compare this item with which questions were actually asked during the medical visit.
    Methods and results: This secondary analysis of QOLs and audiotaped visit data from a pilot study enrolled and consented patients with HF, family companions, and HF clinicians. A single group of 30 patients with HF and 23 family companions received the QPL to complete in the waiting room immediately before their cardiology visit. To meet our aims, we calculated the frequencies for each question selected and asked from the QPL, using data derived from completed prompt lists and audiotaped medical visits. A follow-up survey was administered 2 days after the appointment to assess differences in how participants filled out and used the prompt list. Patients and companions primarily selected and asked questions from the QPL regarding the management and treatment of the disease, general questions about HF, and questions about prognosis. Participants rarely asked questions about support for family and friends or health care team roles and responsibilities. Patients and companions did not ask many of the questions they reported wanting to ask.
    Conclusions: Prompt lists may empower patients and companions to communicate with their clinician by identifying important questions to help overcome patients' and companions' knowledge gaps. More research is needed to understand the true impact of prompt lists on patient-family-clinician communication and subsequent HF outcomes, and how best to implement them in clinical workflows to increase their potential usefulness.
    MeSH term(s) Friends ; Heart Failure/diagnosis ; Heart Failure/therapy ; Humans ; Patient Participation ; Physician-Patient Relations ; Pilot Projects ; Surveys and Questionnaires
    Language English
    Publishing date 2021-11-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2021.11.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Long-term mortality following complications after elective surgery: a secondary analysis of pooled data from two prospective cohort studies.

    Fowler, Alexander J / Wan, Yize I / Prowle, John R / Chew, Michelle / Campbell, Douglas / Cuthbertson, Brian / Wijeysundera, Duminda N / Pearse, Rupert / Abbott, Tom

    British journal of anaesthesia

    2022  Volume 129, Issue 4, Page(s) 588–597

    Abstract: Background: Complications after surgery affect survival and quality of life. We aimed to confirm the relationship between postoperative complications and death within 1 yr after surgery.: Methods: We conducted a secondary analysis of pooled data from ...

    Abstract Background: Complications after surgery affect survival and quality of life. We aimed to confirm the relationship between postoperative complications and death within 1 yr after surgery.
    Methods: We conducted a secondary analysis of pooled data from two prospective cohort studies of patients undergoing surgery in five high-income countries between 2012 and 2014. Exposure was any complication within 30 days after surgery. Primary outcome was death within 1 yr after surgery, ascertained by direct follow-up or linkage to national registers. We adjusted for clinically important covariates using a mixed-effect multivariable Cox proportional hazards regression model. We conducted a planned subgroup analysis by type of complication. Data are presented as mean with standard deviation (sd), n (%), and adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs).
    Results: The pooled cohort included 10 132 patients. After excluding 399 (3.9%) patients with missing data or incomplete follow-up, 9733 patients were analysed. The mean age was 59 [sd 16.8] yr, and 5362 (55.1%) were female. Of 9733 patients, 1841 (18.9%) had complications within 30 days after surgery, and 319 (3.3%) died within 1 yr after surgery. Of 1841 patients with complications, 138 (7.5%) died within 1 yr after surgery compared with 181 (2.3%) of 7892 patients without complications (aHR 1.94 [95% CI: 1.53-2.46]). Respiratory failure was associated with the highest risk of death, resulting in six deaths amongst 28 patients (21.4%).
    Conclusions: Postoperative complications are associated with increased mortality at 1 yr. Further research is needed to identify patients at risk of complications and to reduce mortality.
    MeSH term(s) Cohort Studies ; Elective Surgical Procedures/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications/etiology ; Prospective Studies ; Quality of Life
    Language English
    Publishing date 2022-08-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2022.06.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Future Challenges and Opportunities in Online Prescription Drug Promotion Research; Comment on “Trouble Spots in Online Direct-to-Consumer Prescription Drug Promotion

    Brian G. Southwell / Douglas J. Rupert

    International Journal of Health Policy and Management, Vol 5, Iss 3, Pp 211-

    A Content Analysis of FDA Warning Letters”

    2016  Volume 213

    Abstract: Despite increased availability of online promotional tools for prescription drug marketers, evidence on online prescription drug promotion is far from settled or conclusive. We highlight ways in which online prescription drug promotion is similar to ... ...

    Abstract Despite increased availability of online promotional tools for prescription drug marketers, evidence on online prescription drug promotion is far from settled or conclusive. We highlight ways in which online prescription drug promotion is similar to conventional broadcast and print advertising and ways in which it differs. We also highlight five key areas for future research: branded drug website influence on consumer knowledge and behavior, interactive features on branded drug websites, mobile viewing of branded websites and mobile advertisements, online promotion and non-US audiences, and social media and medication decisions.
    Keywords Direct-to-Consumer (DTC) Advertising ; Prescription Drug ; Social Media ; Health Communication ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2016-03-01T00:00:00Z
    Publisher Kerman University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The Effect of Including Quantitative Information on Multiple Endpoints in Direct-to-Consumer Prescription Drug Television Advertisements.

    Sullivan, Helen W / O'Donoghue, Amie C / Lynch, Molly / Johnson, Mihaela / Davis, Christine / Rupert, Douglas J

    Medical decision making : an international journal of the Society for Medical Decision Making

    2019  Volume 39, Issue 8, Page(s) 975–985

    Abstract: Background. ...

    Abstract Background.
    MeSH term(s) Aged ; Cataract/drug therapy ; Direct-to-Consumer Advertising/methods ; Drug Industry ; Female ; Humans ; Male ; Mental Recall ; Middle Aged ; Prescription Drugs/therapeutic use ; Risk Factors ; Surveys and Questionnaires ; Television ; Treatment Outcome
    Chemical Substances Prescription Drugs
    Language English
    Publishing date 2019-10-04
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 604497-9
    ISSN 1552-681X ; 0272-989X
    ISSN (online) 1552-681X
    ISSN 0272-989X
    DOI 10.1177/0272989X19875946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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