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Article ; Online: Manejo y presentaciÃ³n de las fracturas transtrocantÃ©ricas de cadera durante la pandemia de COVID-19 en un hospital de tercer nivel de atenciÃ³n

Gustavo Rivera-SaldÃvar / Chantal A. MartÃnez-GonzÃ¡lez

Gaceta Médica de México, Vol 91, Iss

2023 Volume 3

Abstract: Antecedentes. La prevalencia de las fracturas transtrocantéricas se sitúa alrededor del 30%. El tratamiento se realiza mediante sistema de tornillo deslizante (STD) o clavo centromedular (CCM). La pandemia de COVID-19 ha modificado las pautas de ... ...

Abstract	Antecedentes. La prevalencia de las fracturas transtrocantéricas se sitúa alrededor del 30%. El tratamiento se realiza mediante sistema de tornillo deslizante (STD) o clavo centromedular (CCM). La pandemia de COVID-19 ha modificado las pautas de tratamiento médico en todas las especialidades en todo el mundo. Objetivo. Reconocer la prevalencia y el manejo de las fracturas transtrocantéricas inestables durante la pandemia de COVID-19. Método. Se realizó un estudio observacional en un hospital de tercer nivel de atención en pacientes con fracturas de tipo AOOTA 31A2.1 y A2.2 manejados con CCM o STD, y se analizaron las tendencias de manejo por parte de los cirujanos ortopedistas. Resultados. La prevalencia durante el año 2019 fue del 38%, en 2020 fue del 21.3% y en 2021 fue del 32.6%. La proporción encontrada hombre-mujer fue de 1:1.7. La edad fue de 66.48 ± 21.6 años (rango: 17-92). De los cirujanos ortopedistas encuestados, el 80.4% prefieren el CCM. Conclusiones. La prevalencia disminuyó durante el año 2020. La tendencia de tratamiento durante la pandemia fue superior para el sistema STD y el uso de CCM disminuyó un 86%. El tratamiento de estas fracturas fue influenciado por la pandemia de COVID-19 hacia un método más económico.
Keywords	COVID-19. Fracturas de cadera. Prevalencia. Procedimientos quirÃºrgicos. Tratamiento ; Public aspects of medicine ; RA1-1270 ; Internal medicine ; RC31-1245
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Permanyer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: HLA peptide-binding pocket diversity modulates immunological complications after cord blood transplant in acute leukaemia.

Boukouaci, Wahid / Rivera-Franco, Monica M / Volt, Fernanda / Lajnef, Mohamed / Wu, Ching-Lien / Rafii, Hanadi / Cappelli, Barbara / Scigliuolo, Graziana Maria / Kenzey, Chantal / Ruggeri, Annalisa / Rocha, Vanderson / Gluckman, Eliane / Tamouza, Ryad

British journal of haematology

2024

Abstract: Pocket motifs and their amino acid positions of HLA molecules are known to govern antigen presentation to effector cells. Our objective was to analyse their influence on the risk of graft-versus-host disease (GVHD) and relapse after umbilical cord blood ... ...

Abstract	Pocket motifs and their amino acid positions of HLA molecules are known to govern antigen presentation to effector cells. Our objective was to analyse their influence on the risk of graft-versus-host disease (GVHD) and relapse after umbilical cord blood transplant (UCBT). The transplant characteristics of 849 patients with acute leukaemia were obtained from the Eurocord/EBMT database. Higher acute (a) GVHD was associated with homozygosity of UCB HLA-C amino acid positions 77 and 80 (NN/KK) (p = 0.008). Severe aGVHD was associated with HLA-A pocket B YSAVMENVHY motif (p = 0.002) and NN and RR genotypes of the HLA-C amino acid positions 77 and 156 (p = 0.006 and p = 0.002). Such risk was also increased in case of recipient and UCB mismatches in P4 (p < 0.0001) and P9 (p = 0.003) pockets of HLA-DQB1 alleles. For chronic GVHD, the pocket B YYAVMEISNY motif of the HLA-B15:01 allele and the absence of mismatch between recipient and UCB in the P6 pocket of HLA-DRB1 were associated with a lower risk (p = 0.0007 and p = 0.0004). In relapse, both UCB pocket B YFAVMENVHY belonging to HLA-A32:01 and recipient pocket B YDSVGENYQY motif of the HLA-C*07:01 allele were associated with higher risk (p = 0.0026 and p = 0.015). We provide clues on HLA-mediated cellular interactions and their role in the development of GVHD and relapse.
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.19339
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Article ; Online: Use of letermovir in umbilical cord blood transplantation based on risk scores.

Rivera Franco, Monica M / Rafii, Hanadi / Volt, Fernanda / Kenzey, Chantal / Cappelli, Barbara / Scigliuolo, Graziana Maria / Rocha, Vanderson / Raus, Nicole / Dalle, Jean-Hugues / Chevallier, Patrice / Robin, Marie / Rubio, Marie Thérèse / Ruggeri, Annalisa / Gluckman, Eliane

Blood advances

2023 Volume 7, Issue 16, Page(s) 4315–4318

MeSH term(s)	Cord Blood Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation ; Acetates ; Risk Factors
Chemical Substances	letermovir (1H09Y5WO1F) ; Acetates
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023010573
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Article: Risk factors and mechanisms of non-alcoholic steatohepatitis.

Rivera, Chantal A

Pathophysiology : the official journal of the International Society for Pathophysiology

2008 Volume 15, Issue 2, Page(s) 109–114

Abstract: The worldwide proportion of overweight and obese individuals has increased yearly for more than a decade. Along with rates of obesity, the incidence of co-morbid conditions such as type 2 diabetes, cardiovascular disease and liver disease has also ... ...

Abstract	The worldwide proportion of overweight and obese individuals has increased yearly for more than a decade. Along with rates of obesity, the incidence of co-morbid conditions such as type 2 diabetes, cardiovascular disease and liver disease has also increased. The form of liver disease associated with obesity is termed non-alcoholic steatohepatitis (NASH) due to the histological similarities to livers of chronic alcoholics. NASH has been observed in adult as well as pediatric populations; however, the etiology of this disease is still unknown. This review outlines some of the risk factors commonly associated with NASH and describes molecular mechanisms proposed to underlie disease pathogenesis.
Language	English
Publishing date	2008-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1212740-1
ISSN	0928-4680
ISSN	0928-4680
DOI	10.1016/j.pathophys.2008.04.003
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Article ; Online: Impact of allele-level HLA matching on outcomes after double cord blood transplantation in adults with malignancies.

Fatobene, Giancarlo / Mariano, Livia / Volt, Fernanda / Moreira, Frederico / Conelissen, Jan / Furst, Sabine / Daguindau, Etienne / Sirvent, Anne / Peffault de Latour, Régis / Rafii, Hanadi / Rivera-Franco, Monica M / Kenzey, Chantal / Scigliuolo, Graziana Maria / Cappelli, Barbara / Ruggeri, Annalisa / Gluckman, Eliane / Rocha, Vanderson

Blood advances

2023 Volume 7, Issue 13, Page(s) 3297–3306

Abstract: In single unrelated cord blood transplantation (UCBT), an increasing number of HLA allele mismatches (MM) has been associated with inferior overall survival (OS) and attributed to higher transplant-related mortality (TRM). Previous studies on the role of ...

Abstract	In single unrelated cord blood transplantation (UCBT), an increasing number of HLA allele mismatches (MM) has been associated with inferior overall survival (OS) and attributed to higher transplant-related mortality (TRM). Previous studies on the role of allele-level HLA matching after double UCBT (dUCBT) showed conflicting results. In this study, we report the impact of allele-level HLA matching on the outcomes of a large dUCBT cohort. We included 963 adults with hematologic malignancies, with available allele-level HLA matching at HLA-A, -B, -C, and -DRB1, receiving dUCBT between 2006 to 2019. Assignment of donor-recipient HLA match was performed considering the unit with the highest disparity with the recipient. Three hundred ninety-two patients received dUCBT with 0 to 3 MM and 571 with ≥4 allele MM. For recipients of dUCBT with 0 to 3 MM, day-100 and 4-year TRM were 10% and 23%, respectively, compared with 16% and 36% for those with ≥4 MM. A higher degree of allele MM was also associated with the worse neutrophil recovery and lower incidence of relapse; no significant effect on graft-versus-host disease was observed. Patients receiving units with 0 to 3 MM had a 4-year OS of 54% compared with 43% for those receiving units with ≥4 MM. The inferior OS associated with higher HLA disparity was only partially mitigated by increased total nucleated cell doses. Our results confirm that allele-level HLA typing is a significant factor for OS after dUCBT, and units with ≥4 MM (≤4/8 HLA-matched) should be avoided if possible.
MeSH term(s)	Humans ; Adult ; Alleles ; Cord Blood Stem Cell Transplantation/adverse effects ; Cord Blood Stem Cell Transplantation/methods ; Neoplasm Recurrence, Local ; Hematopoietic Stem Cell Transplantation ; Hematologic Neoplasms/genetics ; Hematologic Neoplasms/therapy
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2022009251
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Article ; Online: HLA haplotype frequencies and diversity in patients with hemoglobinopathies.

Scigliuolo, Graziana M / Boukouaci, Wahid / Cappelli, Barbara / Volt, Fernanda / Rivera Franco, Monica M / Dhédin, Nathalie / de Latour, Regis Peffault / Devalck, Christine / Dalle, Jean-Hugues / Castelle, Martin / Hermine, Olivier / Chardin, Marie Ouachée / Poiré, Xavier / Brichard, Bénédicte / Paillard, Catherine / Rafii, Hanadi / Kenzey, Chantal / Wu, Ching-Lien / Bouassida, Jihène /

Robin, Marie / Raus, Nicole / Rocha, Vanderson / Ruggeri, Annalisa / Gluckman, Eliane / Tamouza, Ryad

EJHaem

2023 Volume 4, Issue 4, Page(s) 963–969

Abstract: The genetic diversity of the human leukocyte antigen (HLA) system was shaped by evolutionary constraints exerted by environmental factors. Analyzing HLA diversity may allow understanding of the underlying pathways and offer useful tools in transplant ... ...

Abstract	The genetic diversity of the human leukocyte antigen (HLA) system was shaped by evolutionary constraints exerted by environmental factors. Analyzing HLA diversity may allow understanding of the underlying pathways and offer useful tools in transplant setting. The aim of this study was to investigate the HLA haplotype diversity in patients with sickle cell disease (SCD,
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article
ISSN	2688-6146
ISSN (online)	2688-6146
DOI	10.1002/jha2.763
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Article ; Online: Comparative analysis of the variability of the human leukocyte antigen peptide-binding pockets in patients with acute leukaemia.

Boukouaci, Wahid / Rivera-Franco, Monica M / Volt, Fernanda / Wu, Ching-Lien / Rafii, Hanadi / Cappelli, Barbara / Scigliuolo, Graziana Maria / Kenzey, Chantal / Ruggeri, Annalisa / Rocha, Vanderson / Gluckman, Eliane / Tamouza, Ryad

British journal of haematology

2022 Volume 200, Issue 2, Page(s) 197–209

Abstract: The association between acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) and the human leukocyte antigens (HLA) has rarely been studied in terms of diversity of peptide-binding pockets. The objective of this study was to analyse ... ...

Abstract	The association between acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) and the human leukocyte antigens (HLA) has rarely been studied in terms of diversity of peptide-binding pockets. The objective of this study was to analyse whether motifs of HLA class I and class II peptide-binding pockets and/or their amino acid positions were differentially associated with ALL and AML. We included 849 patients from the Eurocord/European Blood and Marrow Transplant registry. The HLA peptide-binding pockets whose amino acid variability was analysed were B and F for HLA class I, P4, P6, and P9 for HLA-DRB1, and P4 and P9 for HLA-DQB1. The motif RFDRAY in P4 of HLA-DRB116:01/02/03/05 alleles and the motif YYVSY in P9 of HLA-DQB105:02/04/05 alleles, were statistically associated with ALL (corrected p value [p
MeSH term(s)	Humans ; HLA-DRB1 Chains/genetics ; Protein Binding ; Peptides ; Histocompatibility Antigens Class I ; Leukemia, Myeloid, Acute/genetics ; Amino Acids ; Alleles ; Gene Frequency
Chemical Substances	HLA-DRB1 Chains ; Peptides ; Histocompatibility Antigens Class I ; Amino Acids
Language	English
Publishing date	2022-10-20
Publishing country	England
Document type	Journal Article
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18517
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Article ; Online: Umbilical Cord Blood Transplantation for Fanconi Anemia With a Special Focus on Late Complications: a Study on Behalf of Eurocord and SAAWP-EBMT.

Rafii, Hanadi / Volt, Fernanda / Bierings, Marc / Dalle, Jean-Hugues / Ayas, Mouhab / Rihani, Rawad / Faraci, Maura / de Simone, Giuseppina / Sengeloev, Henrik / Passweg, Jakob / Cavazzana, Marina / Costello, Regis / Maertens, Johan / Biffi, Alessandra / Johansson, Jan-Erik / Montoro, Juan / Guepin, Gabrielle Roth / Diaz, Miguel Angel / Sirvent, Anne /

Kenzey, Chantal / Rivera Franco, Monica M / Cappelli, Barbara / Scigliuolo, Graziana Maria / Rocha, Vanderson / Ruggeri, Annalisa / Risitano, Antonio / De Latour, Regis Peffault / Gluckman, Eliane

Transplantation and cellular therapy

2024 Volume 30, Issue 5, Page(s) 532.e1–532.e16

Abstract: Hematopoietic cell transplantation (HCT) remains the sole available curative treatment for Fanconi anemia (FA), with particularly favorable outcomes reported after matched sibling donor (MSD) HCT. This study aimed to describe outcomes, with a special ... ...

Abstract	Hematopoietic cell transplantation (HCT) remains the sole available curative treatment for Fanconi anemia (FA), with particularly favorable outcomes reported after matched sibling donor (MSD) HCT. This study aimed to describe outcomes, with a special focus on late complications, of FA patients who underwent umbilical cord blood transplantation (UCBT). In this retrospective analysis of allogeneic UCBT for FA performed between 1988 and 2021 in European Society for Blood and Marrow Transplantation (EBMT)-affiliated centers, a total of 205 FA patients underwent UCBT (55 related and 150 unrelated) across 77 transplant centers. Indications for UCBT were bone marrow failure in 190 patients and acute leukemia/myelodysplasia in 15 patients. The median age at transplantation was 9 years (range, 1.2 to 43 years), with only 20 patients aged >18 years. Among the donor-recipient pairs, 56% (n = 116) had a 0 to 1/6 HLA mismatch. Limited-field radiotherapy was administered to 28% (n = 58) and 78% (n = 160) received a fludarabine (Flu)-based conditioning regimen. Serotherapy consisted of antithymocyte globulin (n = 159; 78%) or alemtuzumab (n = 12; 6%). The median follow-up was 10 years for related UCBT and 7 years for unrelated UCBT. Excellent outcomes were observed in the setting of related UCBT, including a 60-day cumulative incidence (CuI) of neutrophil recovery of 98.1% (95% confidence interval [CI], 93.9% to 100%), a 100-day CuI of grade II-IV acute graft-versus-host disease (GVHD) of 17.3% (95% CI, 9.5% to 31.6%), and a 5-year CuI of chronic GVHD (cGVHD) of 22.7% (95% CI, 13.3% to 38.7%; 13% extensive). Five-year overall survival (OS) was 88%. In multivariate analysis, none of the factors included in the model predicted a better OS. In unrelated UCBT, the 60-day CuI of neutrophil recovery was 78.7% (95% CI, 71.9% to 86.3%), the 100-day CuI of grade II-IV aGVHD was 31.4% (95% CI, 24.6% to 40.2%), and the 5-year CuI of cGVHD was 24.3% (95% CI, 17.8% to 32.2%; 12% extensive). Five-year OS was 44%. In multivariate analysis, negative recipient cytomegalovirus serology, Flu-based conditioning, age <9 years at UCBT, and 0 to 1/6 HLA mismatch were associated with improved OS. A total of 106 patients, including 5 with acute leukemia/myelodysplasia, survived for >2 years after UCBT. Nine of these patients developed subsequent neoplasms (SNs), including 1 donor-derived acute myelogenous leukemia and 8 solid tumors, at a median of 9.7 years (range, 2.3 to 21.8 years) post-UCBT (1 related and 8 unrelated UCBT). In a subset of 49 patients with available data, late nonmalignant complications affecting various organ systems were observed at a median of 8.7 years (range, 2.7 to 28.8 years) post-UCBT. UCB is a valid source of stem cells for transplantation in patients with FA, with the best results observed after related UCBT. After unrelated UCBT, improved survival was observed in patients who underwent transplantation at a younger age, with Flu-based conditioning, and with better HLA parity. The incidence of organ-specific complications and SNs was relatively low. The incidence of SNs, mostly squamous cell carcinoma, increases with time. Rigorous follow-up and lifelong screening are crucial in survivors of UCBT for FA.
MeSH term(s)	Humans ; Fanconi Anemia/therapy ; Fanconi Anemia/complications ; Cord Blood Stem Cell Transplantation ; Female ; Male ; Adult ; Child ; Child, Preschool ; Adolescent ; Retrospective Studies ; Infant ; Transplantation Conditioning/methods ; Graft vs Host Disease/epidemiology ; Young Adult
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2024.02.024
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Article ; Online: Outcomes of subsequent neoplasms after umbilical cord blood transplantation in Europe.

Rafii, Hanadi / Ruggeri, Annalisa / Kenzey, Chantal / Sanz, Jaime / Peffault De La Tour, Régis / Esquirol, Albert / Michel, Gérard / Chevallier, Patrice / Rubio, Marie-Thérèse / Cornelissen, Jan J / Michallet, Mauricette / Volt, Fernanda / Rivera-Franco, Monica M / Scigliuolo, Graziana Maria / Cappelli, Barbara / Rocha, Vanderson / Gluckman, Eliane

Blood advances

2022 Volume 7, Issue 10, Page(s) 1976–1986

Abstract: Subsequent neoplasms (SNs) compromise long-term survivors after hematopoietic cell transplantation. We performed a retrospective analysis of SNs in 10 358 recipients of umbilical cord blood transplantation (UCBT) from 1988 to 2018. SNs developed in 233 ... ...

Abstract	Subsequent neoplasms (SNs) compromise long-term survivors after hematopoietic cell transplantation. We performed a retrospective analysis of SNs in 10 358 recipients of umbilical cord blood transplantation (UCBT) from 1988 to 2018. SNs developed in 233 patients and 84 were of pediatric age. Indications for UCBT were malignant hematological diseases in 199 patients (85%). Three groups of SNs were observed. Posttransplant lymphoproliferative disorders (PTLD) were reported in 145 patients in a median of 4 months after UCBT. Of these, 9 patients died from relapse, 83 from PTLD, and 24 from transplant-related causes. At last follow-up, 29 were alive; 5-year overall survival (OS) after PTLD diagnosis was 21%. Acute leukemia/myelodysplasia (AL/MDS) was diagnosed in 23 patients in a median of 28 months after UCBT and included 3 donor-cell AL. Four of 23 patients died from relapse of primary disease, 8 from progression of SNs, and 4 from TRM. Seven patients remain alive; the 5-year OS after AL/MDS diagnosis was 36%. Solid tumors (ST) were reported in 65 patients in a median of 54 months after UCBT. Most common tumor sites were lung, thyroid, bone, and soft tissue. A total of 33 patients died (26 owing to ST, 6 to relapse of primary disease, and 1 cause missing). At last follow-up, 32 of 65 patients were alive; the 5-year OS after the diagnosis of ST was 51%. In conclusion, despite their poor outcomes, SNs that occur after UCBT are extremely rare. Identification of risk factors and early detection may help to improve OS.
MeSH term(s)	Humans ; Child ; Cord Blood Stem Cell Transplantation/adverse effects ; Retrospective Studies ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Myelodysplastic Syndromes ; Leukemia, Myeloid, Acute/pathology ; Acute Disease ; Recurrence
Language	English
Publishing date	2022-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2022007941
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Article ; Online: Recommendations to address respondent burden associated with patient-reported outcome assessment.

Aiyegbusi, Olalekan Lee / Cruz Rivera, Samantha / Roydhouse, Jessica / Kamudoni, Paul / Alder, Yvonne / Anderson, Nicola / Baldwin, Robert Mitchell / Bhatnagar, Vishal / Black, Jennifer / Bottomley, Andrew / Brundage, Michael / Cella, David / Collis, Philip / Davies, Elin-Haf / Denniston, Alastair K / Efficace, Fabio / Gardner, Adrian / Gnanasakthy, Ari / Golub, Robert M /

Nature medicine

2024 Volume 30, Issue 3, Page(s) 650–659

Abstract: Patient-reported outcomes (PROs) are increasingly used in healthcare research to provide evidence of the benefits and risks of interventions from the patient perspective and to inform regulatory decisions and health policy. The use of PROs in clinical ... ...

Abstract	Patient-reported outcomes (PROs) are increasingly used in healthcare research to provide evidence of the benefits and risks of interventions from the patient perspective and to inform regulatory decisions and health policy. The use of PROs in clinical practice can facilitate symptom monitoring, tailor care to individual needs, aid clinical decision-making and inform value-based healthcare initiatives. Despite their benefits, there are concerns that the potential burden on respondents may reduce their willingness to complete PROs, with potential impact on the completeness and quality of the data for decision-making. We therefore conducted an initial literature review to generate a list of candidate recommendations aimed at reducing respondent burden. This was followed by a two-stage Delphi survey by an international multi-stakeholder group. A consensus meeting was held to finalize the recommendations. The final consensus statement includes 19 recommendations to address PRO respondent burden in healthcare research and clinical practice. If implemented, these recommendations may reduce PRO respondent burden.
MeSH term(s)	Humans ; Patient Outcome Assessment ; Patient Reported Outcome Measures ; Consensus ; Clinical Decision-Making
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-024-02827-9
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