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  1. Article: Editorial: Environmental exposures and thyroid health.

    van Gerwen, Maaike / Cerutti, Janete Maria / Sinclair, Catherine Fiona

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1154547

    MeSH term(s) Thyroid Gland ; Environmental Exposure/adverse effects
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1154547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Authors Respond.

    van Gerwen, Maaike / Alsen, Mathilda / Genden, Eric

    Epidemiology (Cambridge, Mass.)

    2022  Volume 34, Issue 2, Page(s) e6–e7

    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1053263-8
    ISSN 1531-5487 ; 1044-3983
    ISSN (online) 1531-5487
    ISSN 1044-3983
    DOI 10.1097/EDE.0000000000001571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3121: Show issues Location:
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  3. Article ; Online: Per- and Polyfluoroalkyl Substances (PFAS) in Community Water Systems (CWS) and the Risk of Thyroid Cancer: An Ecological Study.

    Alsen, Mathilda / Leung, Angela M / van Gerwen, Maaike

    Toxics

    2023  Volume 11, Issue 9

    Abstract: Thyroid cancer incidence has been steadily increasing over the past decade in the United States (US). A discussion exists regarding the potential contribution of exposure to endocrine-disrupting chemicals, encompassing certain per- and poly-fluoroalkyl ... ...

    Abstract Thyroid cancer incidence has been steadily increasing over the past decade in the United States (US). A discussion exists regarding the potential contribution of exposure to endocrine-disrupting chemicals, encompassing certain per- and poly-fluoroalkyl substances (PFASs). This ecological study evaluated the potential correlation between PFAS levels in drinking water and thyroid cancer incidence in the US. Data on age-adjusted thyroid cancer incidence rate (per 100,000 persons) by county were obtained from the Centers for Disease Control and Prevention (CDC) for US counties with available data in 2015-2019. Data on PFAS concentrations in the drinking water of selected community water systems (CWSs) were obtained from the CDC National Environmental Public Health Tracking Network in 2013-2015. The correlation between PFASs in CWSs and thyroid cancer incidence was calculated using Spearman correlation. A statistically significant correlation was found between perfluorooctanoic acid (PFOA) (r = 0.031;
    Language English
    Publishing date 2023-09-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11090786
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  4. Article ; Online: It May Not All Be Overdiagnosis: The Potential Role of Environmental Exposures in the Thyroid Cancer Incidence Increase.

    van Gerwen, Maaike / Alsen, Mathilda / Genden, Eric

    Epidemiology (Cambridge, Mass.)

    2022  Volume 33, Issue 5, Page(s) 607–610

    MeSH term(s) Early Detection of Cancer ; Environmental Exposure/adverse effects ; Humans ; Incidence ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/epidemiology
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1053263-8
    ISSN 1531-5487 ; 1044-3983
    ISSN (online) 1531-5487
    ISSN 1044-3983
    DOI 10.1097/EDE.0000000000001519
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  5. Article: Anxiety and Depression as Potential Predictors for Shorter Time to Undergo Initial Surgical Treatment for Papillary Thyroid Cancer.

    Vujovic, Dragan / Alsen, Mathilda / Vasan, Vikram / Genden, Eric / van Gerwen, Maaike

    Cancers

    2024  Volume 16, Issue 3

    Abstract: 1) Background: A pre-existing psychiatric condition may impact decision making by patients and/or physicians following a thyroid cancer diagnosis, such as potentially electing surgery over active surveillance, thus shortening the time to cancer removal. ...

    Abstract (1) Background: A pre-existing psychiatric condition may impact decision making by patients and/or physicians following a thyroid cancer diagnosis, such as potentially electing surgery over active surveillance, thus shortening the time to cancer removal. This is the first study to investigate the association between pre-existing anxiety and/or depression and time to receive surgical treatment for thyroid cancer. (2) Methods: Retrospective data were collected from 652 surgical thyroid cancer patients at our institution from 2018 to 2020. We investigated the time between thyroid cancer diagnosis and surgery, comparing patients with pre-existing anxiety and/or depression to those without. (3) Results: Patients with anxiety, depression, and both anxiety and depression had a significantly shorter time between diagnosis and surgery (51.6, 57, and 57.4 days, respectively) compared to patients without (111.9 days) (
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030545
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  6. Article ; Online: Investigating potential disparities by exploring time to surgical thyroid cancer treatment.

    Vujovic, Dragan / Rodriguez, Nina / Alsen, Mathilda / Genden, Eric / van Gerwen, Maaike

    American journal of otolaryngology

    2024  Volume 45, Issue 4, Page(s) 104284

    Abstract: 1) Delays in initial treatment have been a frequently used metric for assessing disparities in medicine; however, there has been sparse literature on treatment delays in thyroid cancer. We therefore aimed to assess disparities by investigating the ... ...

    Abstract (1) Delays in initial treatment have been a frequently used metric for assessing disparities in medicine; however, there has been sparse literature on treatment delays in thyroid cancer. We therefore aimed to assess disparities by investigating the association between race/ethnicity, insurance type, and socioeconomic status and time to surgical treatment of thyroid cancer. (2) A retrospective chart review was conducted to collect demographic and clinical data from 443 surgical thyroid cancer patients at Mount Sinai Hospital in 2018-2019. We investigated the time between thyroid cancer diagnosis and surgery by race/ethnicity, insurance, and income groups. (3) Univariate analysis showed that race/ethnicity, insurance type, and SES alone were not statistically significant predictors of earlier time to treatment (p = 0.766, 0.339, 0.435, respectively). On multivariable linear regression, time between diagnosis and surgical treatment was not significantly different for racial minorities compared to non-Hispanic White patients, patients with Medicare/Medicaid compared to private insurance, and patients with lowest income quartile (<$54,585) compared to those with the highest (≥$116,560). (4) Present study showed no significant delays in treatment for different racial/ethnic, insurance, and income groups.
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2024.104284
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1637: Show issues Location:
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  7. Article ; Online: Human 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure and thyroid cancer risk.

    van Gerwen, Maaike / Vasan, Vikram / Genden, Eric / Saul, Shira R

    Toxicology

    2023  Volume 488, Page(s) 153474

    Abstract: Thyroid cancer incidence has been steadily rising since the 1970s and exposure to environmental pollutants, including persistent organic pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxins, has emerged as a potential ... ...

    Abstract Thyroid cancer incidence has been steadily rising since the 1970s and exposure to environmental pollutants, including persistent organic pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxins, has emerged as a potential explanation for this increase. This study aimed to summarize available human studies on the association between TCDD exposure and thyroid cancer. A systematic review of the literature was performed searching the National Library of Medicine and National Institutes of Health PubMed, Embase, and Scopus databases, through January 2022, using the following keywords: "thyroid", "2,3,7,8-tetrachlorodibenzo-p-dioxin", "TCDD", "dioxin", and "Agent Orange". Six studies were included in this review. Three studies evaluated the acute exposure to the chemical factory accident in Seveso, Italy, and found a non-significant increase in the risk of thyroid cancer. Two studies investigating Agent Orange exposure among United States Vietnam War veterans found a significant risk of thyroid cancer following exposure. No association was found in one study evaluating TCDD exposure through herbicides. The current study highlights the limited information on the potential association between TCDD exposure and thyroid cancer and thus the need for future human studies, especially considering the persistent human exposure to dioxins in the environment.
    MeSH term(s) Humans ; Agent Orange ; Dioxins ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Herbicides ; Polychlorinated Dibenzodioxins/toxicity ; Thyroid Neoplasms/chemically induced ; Thyroid Neoplasms/epidemiology ; United States/epidemiology
    Chemical Substances Agent Orange (39277-47-9) ; Dioxins ; Herbicides ; Polychlorinated Dibenzodioxins
    Language English
    Publishing date 2023-03-02
    Publishing country Ireland
    Document type Journal Article ; Review ; Systematic Review ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 184557-3
    ISSN 1879-3185 ; 0300-483X
    ISSN (online) 1879-3185
    ISSN 0300-483X
    DOI 10.1016/j.tox.2023.153474
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    Zs.A 888: Show issues Location:
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  8. Article ; Online: Association between polychlorinated biphenyl exposure and thyroid hormones: a systematic review and meta-analysis.

    Little, Christine C / Barlow, Joshua / Alsen, Mathilda / van Gerwen, Maaike

    Journal of environmental science and health. Part C, Toxicology and carcinogenesis

    2022  Volume 40, Issue 3-4, Page(s) 248–267

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Polychlorinated Biphenyls/analysis ; Thyroid Hormones ; Hormones ; Thyroid Gland/chemistry
    Chemical Substances Polychlorinated Biphenyls (DFC2HB4I0K) ; Thyroid Hormones ; Hormones
    Language English
    Publishing date 2022-12-14
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ISSN 2689-6591
    ISSN (online) 2689-6591
    DOI 10.1080/26896583.2022.2149213
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  9. Article ; Online: Endosulfan use and the risk of thyroid cancer: an ecological study.

    Vasan, Vikram / Alsen, Mathilda / Vujovic, Dragan / Genden, Eric / Sinclair, Catherine / van Gerwen, Maaike

    Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

    2023  Volume 58, Issue 1, Page(s) 51–57

    Abstract: Endosulfan, an organochlorine pesticide, has been understudied in the literature on thyroid cancer. The aim of this ecological study was to assess the correlation between endosulfan exposure and thyroid cancer incidence rates (IRs) in the United States ( ... ...

    Abstract Endosulfan, an organochlorine pesticide, has been understudied in the literature on thyroid cancer. The aim of this ecological study was to assess the correlation between endosulfan exposure and thyroid cancer incidence rates (IRs) in the United States (US). Age-adjusted thyroid cancer IRs per 100,000 people per state for the years 1999 to 2019 were obtained from the Center for Disease Control and Prevention (CDC). To assess the state-level use of endosulfan, data were obtained from the US Geological Survey (USGS). Endosulfan usage estimates (kilograms/acres cropland; quintiles) and thyroid cancer IRs were mapped together. The correlation between age-adjusted thyroid cancer IRs and statewide endosulfan use was calculated using the Spearman correlation. Overall endosulfan usage in the US trended downwards between 1992 and 2007 (
    MeSH term(s) Humans ; Endosulfan ; Pesticides ; Hydrocarbons, Chlorinated ; Thyroid Neoplasms
    Chemical Substances Endosulfan (OKA6A6ZD4K) ; Pesticides ; Hydrocarbons, Chlorinated
    Language English
    Publishing date 2023-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 197072-0
    ISSN 1532-4109 ; 0360-1234
    ISSN (online) 1532-4109
    ISSN 0360-1234
    DOI 10.1080/03601234.2023.2169099
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  10. Article: Epidemiology of mesothelioma in the 21

    Alpert, Naomi / van Gerwen, Maaike / Taioli, Emanuela

    Translational lung cancer research

    2020  Volume 9, Issue Suppl 1, Page(s) S28–S38

    Abstract: Research has established a strong association between asbestos exposure and malignant mesothelioma, a deadly form of cancer. Since the early 1980's many countries have restricted or banned the production of asbestos, leading to a decline of occupational ... ...

    Abstract Research has established a strong association between asbestos exposure and malignant mesothelioma, a deadly form of cancer. Since the early 1980's many countries have restricted or banned the production of asbestos, leading to a decline of occupational asbestos exposure in many industrialized countries. However, some countries continue to use asbestos, and worldwide rates of mesothelioma are still increasing. Because of the long latency between exposure and mesothelioma occurrence and the persistence of environmental exposure, incidence rates (IR) may decrease very slowly for several years ahead. In this review, we examine estimates of asbestos consumption before widespread asbestos regulations and the trends in incidence and mortality rates, as well as changes over time for the United States and Europe. In some countries with earlier asbestos restrictions, mesothelioma incidence has been in a modest decline over time. However, asbestos exposure is still a burden worldwide and legislative action is needed to obtain a full ban. The pattern of mesothelioma is shifting from a mostly male disease to a disease that affects females as well in substantial numbers. Studies on unknown sources of asbestos exposure, of other sources of natural exposure to asbestos and asbestos-like fibers, as well as of individual genetic susceptibility to asbestos fibers are needed.
    Language English
    Publishing date 2020-02-13
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr.2019.11.11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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