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Article ; Online: Luminescent Au(III)-M(I) (M = Cu, Ag) Aggregates Based on Dicyclometalated Bis(alkynyl) Gold Anions†.

Lara Garnica, Rebeca / Rama, Raquel J / Chambrier, Isabelle / Agonigi, Gabriele / Hughes, David L / Lalinde, Elena / Bochmann, Manfred / Fernandez-Cestau, Julio

Inorganic chemistry

2023 Volume 62, Issue 32, Page(s) 12683–12696

Abstract: The syntheses and structures of a series of complexes based on the ... ...

Abstract	The syntheses and structures of a series of complexes based on the C
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c00870
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Characterization of a monoclonal antibody specific to California serogroup orthobunyaviruses and development as a chimeric immunoglobulin M-positive control in human diagnostics.

Powers, Jordan A / Boroughs, Karen L / Mikula, Sierra / Goodman, Christin H / Davis, Emily H / Thrasher, Elisa M / Hughes, Holly R / Biggerstaff, Brad J / Calvert, Amanda E

Microbiology spectrum

2023 , Page(s) e0196623

Abstract: ... diagnosis of CSGVs relies heavily on serologic techniques for detecting immunoglobulin M (IgM ...

Abstract	California serogroup viruses (CSGVs) of medical importance in the United States include La Crosse virus, Jamestown Canyon virus (JCV), California encephalitis virus, and snowshoe hare virus. Current diagnosis of CSGVs relies heavily on serologic techniques for detecting immunoglobulin M (IgM), an indication of a recent CSGV infection. However, human-positive control sera reactive to viruses in the serogroup are scarce because detection of recent infections is rare. Here, we describe the development of new murine monoclonal antibodies (MAbs) reactive to CSGVs and the engineering of a human-murine chimeric antibody by combining the variable regions of the broadly CSGV cross-reactive murine MAb, 3-3B6/2-3B2 and the constant region of the human IgM. MAb 3-3B6/2-3B2 recognizes a tertiary epitope on the Gn/Gc heterodimer, and epitopes important in JCV neutralization were mapped to the Gc glycoprotein. This engineered human IgM constitutively expressed in a HEK-293 stable cell line can replace human-positive control sera in diagnostic serological techniques such as IgM antibody capture enzyme-linked immunosorbent assay (MAC-ELISA). Compared to the parent murine MAbs, the human-chimeric IgM antibody had identical serological activity to CSGVs in ELISA and demonstrated equivalent reactivity compared to human immune sera in the MAC-ELISA.IMPORTANCEOrthobunyaviruses in the California serogroup cause severe neurological disease in children and adults. While these viruses are known to circulate widely in North America, their occurrence is rare. Serological testing for CSGVs is hindered by the limited availability and volumes of human-positive specimens needed as controls in serologic assays. Here, we described the development of a murine monoclonal antibody cross-reactive to CSGVs engineered to contain the variable regions of the murine antibody on the backbone of human IgM. The chimeric IgM produced from the stably expressing HEK293 cell line was evaluated for use as a surrogate human-positive control in a serologic diagnostic test.
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.01966-23
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Article ; Online: Reply to M. Eriksson et al and Z. Jin et al.

Yala, Adam / Mikhael, Peter G / Hughes, Kevin / Barzilay, Regina

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2022 Volume 40, Issue 20, Page(s) 2281–2282

Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.22.00292
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor overexpression in squamous cell carcinoma.

Kucia-Tran, Justyna A / Tulkki, Valtteri / Scarpini, Cinzia G / Smith, Stephen / Wallberg, Maja / Paez-Ribes, Marta / Araujo, Angela M / Botthoff, Jan / Feeney, Maria / Hughes, Katherine / Caffarel, Maria M / Coleman, Nicholas

The Journal of pathology

2018 Volume 244, Issue 3, Page(s) 283–295

Abstract: The oncostatin M (OSM) receptor (OSMR) shows frequent gene copy number gains and overexpression ...

Abstract	The oncostatin M (OSM) receptor (OSMR) shows frequent gene copy number gains and overexpression in cervical squamous cell carcinomas (SCCs), associated with adverse clinical outcomes. In SCC cells that overexpress OSMR, the major ligand OSM induces multiple pro-malignant effects, including invasion, secretion of angiogenic factors, and metastasis. Here, we demonstrate, for the first time, that OSMR overexpression in SCC cells activates cell-autonomous feed-forward signalling, via further expression of OSMR and OSM and sustained STAT3 activation, despite expression of the negative regulator suppressor of cytokine signalling 3 (SOCS3). The pro-malignant effects associated with OSMR overexpression are critically mediated by JAK-STAT3 activation, which is induced by exogenous OSM and also by autocrine OSM-OSMR interactions. Importantly, specific inhibition of OSM-OSMR interactions by neutralizing antibodies significantly inhibits STAT3 activation and feed-forward signalling, leading to reduced invasion, angiogenesis, and metastasis. Our findings are supported by data from 1254 clinical SCC samples, in which OSMR levels correlated with multiple cognate genes, including OSM, STAT3, and downstream targets. These data strongly support the development of OSM-OSMR-blocking antibodies as biologically targeted therapies against SCCs of the cervix and other anatomical sites. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
MeSH term(s)	Animals ; Antineoplastic Agents, Immunological/pharmacology ; Autocrine Communication ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/immunology ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Humans ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Lung Neoplasms/drug therapy ; Lung Neoplasms/immunology ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice, Inbred NOD ; Mice, SCID ; Oncostatin M/genetics ; Oncostatin M/metabolism ; Oncostatin M Receptor beta Subunit/antagonists & inhibitors ; Oncostatin M Receptor beta Subunit/genetics ; Oncostatin M Receptor beta Subunit/immunology ; Oncostatin M Receptor beta Subunit/metabolism ; Phosphorylation ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/immunology ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Suppressor of Cytokine Signaling 3 Protein/genetics ; Suppressor of Cytokine Signaling 3 Protein/metabolism ; Up-Regulation ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/immunology ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology ; Xenograft Model Antitumor Assays
Chemical Substances	Antineoplastic Agents, Immunological ; OSM protein, human ; OSMR protein, human ; Oncostatin M Receptor beta Subunit ; SOCS3 protein, human ; STAT3 Transcription Factor ; STAT3 protein, human ; Suppressor of Cytokine Signaling 3 Protein ; Oncostatin M (106956-32-5) ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
Language	English
Publishing date	2018-01-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3119-7
ISSN	1096-9896 ; 0022-3417
ISSN (online)	1096-9896
ISSN	0022-3417
DOI	10.1002/path.5010
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Article: "I've Had an Alarm Set for 3:00 a.m. for Decades": The Impact of Type 1 Diabetes on Sleep.

Bispham, Jeoffrey A / Hughes, Allyson S / Fan, Ludi / Perez-Nieves, Magaly / McAuliffe-Fogarty, Alicia H

Clinical diabetes : a publication of the American Diabetes Association

2021 Volume 39, Issue 2, Page(s) 153–159

Abstract: There is a dearth of research characterizing the impact on a caregiver's sleep when caring for a minor with type 1 diabetes. This study used focus groups of people with type 1 diabetes and caregivers of minors with type 1 diabetes to explore the ... ...

Abstract	There is a dearth of research characterizing the impact on a caregiver's sleep when caring for a minor with type 1 diabetes. This study used focus groups of people with type 1 diabetes and caregivers of minors with type 1 diabetes to explore the experience of how diabetes affects sleep. The occurrence of both unanticipated and planned sleep disruptions led to the majority of participants reporting that their sleep was considerably affected by diabetes. Despite the improvement in blood glucose management that diabetes technology devices can provide, people with type 1 diabetes and their caregivers still report sleep disruption and sleep loss resulting from overnight diabetes management.
Language	English
Publishing date	2021-05-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025953-3
ISSN	0891-8929
ISSN	0891-8929
DOI	10.2337/cd20-0026
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Zs.A 2591: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: T.E.A.M.S.Work: Leveraging Technicians to Enhance ABM Med Sync in Community Pharmacies.

Hughes, Tamera D / Minshew, Lana M / Cutrell, Stacey / Ferreri, Stefanie P

Pharmacy (Basel, Switzerland)

2020 Volume 8, Issue 2

Abstract: The expansion of pharmacy technicians' roles in community pharmacies allows pharmacists the opportunity to focus on providing clinical services to patients. This study explores the tasks pharmacy technicians' perform to support Med Sync programs in ... ...

Abstract	The expansion of pharmacy technicians' roles in community pharmacies allows pharmacists the opportunity to focus on providing clinical services to patients. This study explores the tasks pharmacy technicians' perform to support Med Sync programs in community pharmacies. Pharmacy staff members at North Carolina pharmacies with more than fifty percent of their prescription volume being dispensed as part of a Med Sync program were recruited to participate in semi-structured interviews. Inductive coding and summary analysis were used to analyze the interview data. Study participants described pharmacy technicians' roles in identifying patients for marketing and enrollment, reviewing patients' medications list, choosing alignment dates based on patient preference, contacting patients in preparation for dispensing and, lastly, engaging in pickup or delivery of medications. This study highlights technicians' vital role in completing tasks that support Med Sync programs in community pharmacies.
Language	English
Publishing date	2020-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737194-3
ISSN	2226-4787 ; 2226-4787
ISSN (online)	2226-4787
ISSN	2226-4787
DOI	10.3390/pharmacy8020051
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Article ; Online: Comment on "Observation of alkaline earth complexes M(CO)

Landis, Clark R / Hughes, Russell P / Weinhold, Frank

Science (New York, N.Y.)

2019 Volume 365, Issue 6453

Abstract: ... ...

Abstract	Wu
Language	English
Publishing date	2019-08-08
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.aay2355
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

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Article ; Online: Hydride Transfer to Gold: Yes or No? Exploring the Unexpected Versatility of Au⋅⋅⋅H-M Bonding in Heterobimetallic Dihydrides.

Rocchigiani, Luca / Klooster, Wim T / Coles, Simon J / Hughes, David L / Hrobárik, Peter / Bochmann, Manfred

Chemistry (Weinheim an der Bergstrasse, Germany)

2020 Volume 26, Issue 37, Page(s) 8267–8280

Abstract: The potential for coordination and H-transfer from ... ...

Abstract	The potential for coordination and H-transfer from Cp
Language	English
Publishing date	2020-06-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202000016
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Article ; Online: Changing patterns of SARS-CoV-2 infection through Delta and Omicron waves by vaccination status, previous infection and neighbourhood deprivation: a cohort analysis of 2.7 M people.

Green, Mark A / Hungerford, Daniel J / Hughes, David M / Garcia-Fiñana, Marta / Turtle, Lance / Cheyne, Christopher / Ashton, Matthew / Leeming, Gary / Semple, Malcolm G / Singleton, Alex / Buchan, Iain

BMC infectious diseases

2022 Volume 22, Issue 1, Page(s) 889

Abstract: ... for 2.7 M residents in Cheshire and Merseyside, England (3rd June 2021 to 1st March 2022). Our outcome ...

Abstract	Background: Our study examines if SARS-CoV-2 infections varied by vaccination status, if an individual had previously tested positive and by neighbourhood socioeconomic deprivation across the Delta and Omicron epidemic waves of SARS-CoV-2. Methods: Population cohort study using electronic health records for 2.7 M residents in Cheshire and Merseyside, England (3rd June 2021 to 1st March 2022). Our outcome variable was registered positive test for SARS-CoV-2. Explanatory variables were vaccination status, previous registered positive test and neighbourhood socioeconomic deprivation. Cox regression models were used to analyse associations. Results: Originally higher SARS-CoV-2 rates in the most socioeconomically deprived neighbourhoods changed to being higher in the least deprived neighbourhoods from the 1st September 2021, and were inconsistent during the Omicron wave. Individuals who were fully vaccinated (two doses) were associated with fewer registered positive tests (e.g., individuals engaged in testing between 1st September and 27th November 2021-Hazards Ratio (HR) = 0.48, 95% Confidence Intervals (CIs) = 0.47-0.50. Individuals with a previous registered positive test were also less likely to have a registered positive test (e.g., individuals engaged in testing between 1st September and 27th November 2021-HR = 0.16, 95% CIs = 0.15-0.18. However, the Omicron period saw smaller effect sizes for both vaccination status and previous registered positive test. Conclusions: Changing patterns of SARS-CoV-2 infections during the Delta and Omicron waves reveals a dynamic pandemic that continues to affect diverse communities in sometimes unexpected ways.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cohort Studies ; SARS-CoV-2 ; Pandemics ; Vaccination
Language	English
Publishing date	2022-11-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-022-07878-2
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Article ; Online: Verification of the Optical System of the 9.7-m Prototype Schwarzschild-Couder Telescope

Adams, C. / Alfaro, R. / Ambrosi, G. / Ambrosio, M. / Aramo, C. / Benbow, W. / Bertucci, B. / Bissaldi, E. / Bitossi, M. / Boiano, A. / Bonavolonta, C. / Bose, R. / Brill, A. / Buckley, J. H. / Byrum, K. / Cameron, R. A. / Capasso, M. / Caprai, M. / Covault, C. E. /

Venere, L. Di / Fegan, S. / Feng, Q. / Fiandrini, E. / Furniss, A. / Garczarczyk, M. / Garfias, F. / Gent, A. / Giglietto, N. / Giordano, F. / Gonz'alez, M. M. / Halliday, R. / Hervet, O. / Hughes, G. / Humensky, T. B. / Ionica, M. / Iriarte, A. / Jin, W. / Kaarat, P. / Kieda, D. / Kim, B. / Licciulli, F. / Limon, M. / Loporchio, S. / Masone, V. / Meures, T. / Mode, B. A. W. / Mukherjee, R. / Nieto, D. / Okumura, A. / Otte, N. / Palombara, N. La / Pantaleo, F. R. / Paoletti, R. / Pareschi, G. / Petrashyk, A. / Powell, J. / Powell, K. / Ribeiro, D. / Roache, E. / Rousselle, J. / Rugliancich, A. / Ru'iz-D'iaz-Soto, J. / Santander, M. / Schlenstedt, S. / Scuderi, S. / Shang, R. / Sironi, G. / Stevenson, B. / Stiaccini, L. / Taylor, L. P. / Tosti, L. / Tovmassian, G. / Vagelli, V. / Valentino, M. / Vandenbroucke, J. / Vassiliev, V. V. / Wakely, S. P. / Wilcox, P. / Williams, D. A. / Yu, P.

Abstract: ... of the dual mirror, aspheric, aplanatic Schwarzschild-Couder optical system has been demonstrated in a $9.7$-m ...

Abstract	For the first time in the history of ground-based $\gamma$-ray astronomy, the on-axis performance of the dual mirror, aspheric, aplanatic Schwarzschild-Couder optical system has been demonstrated in a $9.7$-m aperture imaging atmospheric Cherenkov telescope. The novel design of the prototype Schwarzschild-Couder Telescope (pSCT) is motivated by the need of the next-generation Cherenkov Telescope Array (CTA) observatory to have the ability to perform wide ($\geq 8^{\circ}$) field-of-view observations simultaneously with superior imaging of atmospheric cascades (resolution of $0.067^{\circ}$ per pixel or better). The pSCT design, if implemented in the CTA installation, has the potential to improve significantly both the $\gamma$-ray angular resolution and the off-axis sensitivity of the observatory, reaching nearly the theoretical limit of the technique and thereby making a major impact on the CTA observatory sky survey programs, follow-up observations of multi-messenger transients with poorly known initial localization, as well as on the spatially resolved spectroscopic studies of extended $\gamma$-ray sources. This contribution reports on the initial alignment procedures and point-spread-function results for the challenging segmented aspheric primary and secondary mirrors of the pSCT.
Keywords	covid19
Publisher	ArXiv
Document type	Article ; Online
DOI	10.1117/12.2568134
Database	COVID19

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