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Article: A Fisetin Delivery System for Neuroprotection: A Co-Amorphous Dispersion Prepared in Supercritical Carbon Dioxide.

Sip, Szymon / Rosiak, Natalia / Sip, Anna / Żarowski, Marcin / Hojan, Katarzyna / Cielecka-Piontek, Judyta

2023 Volume 13, Issue 1

Abstract: Fisetin (FIS), a senolytic flavonoid, mitigates age-related neuroprotective changes. An amorphous FIS dispersion with a co-carrier was prepared using supercritical fluid extraction with carbon dioxide ( ... ...

Abstract	Fisetin (FIS), a senolytic flavonoid, mitigates age-related neuroprotective changes. An amorphous FIS dispersion with a co-carrier was prepared using supercritical fluid extraction with carbon dioxide (scCO
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13010024
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Article: The Chitosan-Based System with

Chanaj-Kaczmarek, Justyna / Rosiak, Natalia / Szymanowska, Daria / Rajewski, Marcin / Wender-Ozegowska, Ewa / Cielecka-Piontek, Judyta

Pharmaceutics

2022 Volume 14, Issue 4

Abstract: Scutellarie baicalensis ... ...

Abstract	Scutellarie baicalensis radix
Language	English
Publishing date	2022-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14040740
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Article ; Online: Amorphous Inclusion Complexes: Molecular Interactions of Hesperidin and Hesperetin with HP-Β-CD and Their Biological Effects.

Wdowiak, Kamil / Rosiak, Natalia / Tykarska, Ewa / Żarowski, Marcin / Płazińska, Anita / Płaziński, Wojciech / Cielecka-Piontek, Judyta

International journal of molecular sciences

2022 Volume 23, Issue 7

Abstract: This study aimed at obtaining hesperidin (Hed) and hesperetin (Het) systems with HP-β-CD by means of the solvent evaporation method. The produced systems were identified using infrared spectroscopy (FT-IR), X-ray powder diffraction (XRPD), and ... ...

Abstract	This study aimed at obtaining hesperidin (Hed) and hesperetin (Het) systems with HP-β-CD by means of the solvent evaporation method. The produced systems were identified using infrared spectroscopy (FT-IR), X-ray powder diffraction (XRPD), and differential scanning calorimetry (DSC). Moreover, in silico docking and molecular dynamics studies were performed to assess the most preferable site of interactions between tested compounds and HP-β-CD. The changes of physicochemical properties (solubility, dissolution rate, and permeability) were determined chromatographically. The impact of modification on biological activity was tested in an antioxidant study as well as with regards to inhibition of enzymes important in pathogenesis of neurodegenerative diseases. The results indicated improvement in solubility over 1000 and 2000 times for Hed and Het, respectively. Permeability studies revealed that Hed has difficulties in crossing biological membranes, in contrast with Het, which can be considered to be well absorbed. The improved physicochemical properties influenced the biological activity in a positive manner by the increase in inhibitory activity on the DPPH radical and cholinoesterases. To conclude the use of HP-β-CD as a carrier in the formation of an amorphous inclusion complex seems to be a promising approach to improve the biological activity and bioavailability of Hed and Het.
MeSH term(s)	2-Hydroxypropyl-beta-cyclodextrin/chemistry ; Biological Availability ; Calorimetry, Differential Scanning ; Hesperidin/pharmacology ; Solubility ; Spectroscopy, Fourier Transform Infrared/methods ; X-Ray Diffraction
Chemical Substances	2-Hydroxypropyl-beta-cyclodextrin (1I96OHX6EK) ; Hesperidin (E750O06Y6O) ; hesperetin (Q9Q3D557F1)
Language	English
Publishing date	2022-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23074000
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Article ; Online: Diagnostic imaging in chronic otitis media: does CT and MRI fusion aid therapeutic decision making? - a pilot study.

Kusak, Artur / Rosiak, Oskar / Durko, Marcin / Grzelak, Piotr / Pietruszewska, Wioletta

Otolaryngologia polska = The Polish otolaryngology

2019 Volume 73, Issue 1, Page(s) 1–5

Abstract: Introduction: Despite the recent advances in otosurgery diagnosis of cholesteatoma and qualification for surgery remains an issue in contemporary laryngology. In cases of cholesteatoma recidivism, it is of utmost importance to properly locate the ... ...

Abstract	Introduction: Despite the recent advances in otosurgery diagnosis of cholesteatoma and qualification for surgery remains an issue in contemporary laryngology. In cases of cholesteatoma recidivism, it is of utmost importance to properly locate the pathology in the middle ear to plan surgical approach. Magnetic Resonance imaging in diffusion-weighted non-echoplanar sequences (non-EPI DWI) enables cholesteatoma detection as small as 2 mm and could potentially prevent unnecessary second-look surgery. Computed Tomography of the temporal bone allows precise visualization of bony structures and topographical landmarks of the middle ear. A fusion of both imaging modalities combines the advantages of these techniques. Material and methods: Five patients treated in the Department of Otolaryngology, the Medical University of Lodz for probable cholesteatoma recidivism were included in this study. A high-resolution CT scan of the temporal bone and an MRI scan including non-EPI sequences was obtained in all patients. A fusion of CT and MRI studies was conducted using OsirixMD software. Fist, CT studies were fused with MRI BFFE sequences, then non-EPI sequences were added. Finally, if the patient qualified for surgical treatment histopathological diagnosis was compared with MRI results. Results: CT scans were analyzed to establish the extent of previous surgical interventions and anatomical landmarks preservation. In all cases, MRI results were suspicious of cholesteatoma recidivism. Four cases were confirmed in postoperative histopathological evaluation, there was one false positive case when intraoperatively scar tissue was identified, which was later confirmed as connective tissue upon histopathological evaluation. Conclusions: CT and MRI fusion provides a helpful diagnostic tool in preparation for surgery in patients with suspected cholesteatoma recidivism.
MeSH term(s)	Adult ; Cholesteatoma, Middle Ear/diagnostic imaging ; Cholesteatoma, Middle Ear/physiopathology ; Cholesteatoma, Middle Ear/surgery ; Chronic Disease/therapy ; Decision Making ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Otitis Media/diagnosis ; Otitis Media/surgery ; Pilot Projects ; Poland ; Prospective Studies ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-08-08
Publishing country	Poland
Document type	Journal Article
ZDB-ID	417458-6
ISSN	2300-8423 ; 0030-6657
ISSN (online)	2300-8423
ISSN	0030-6657
DOI	10.5604/01.3001.0012.5423
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Article ; Online: Male aging as a causative factor of detrimental changes in human conventional semen parameters and sperm DNA integrity.

Gill, Kamil / Jakubik-Uljasz, Joanna / Rosiak-Gill, Aleksandra / Grabowska, Marta / Matuszewski, Marcin / Piasecka, Malgorzata

The aging male : the official journal of the International Society for the Study of the Aging Male

2020 Volume 23, Issue 5, Page(s) 1321–1332

Abstract: The effect of male aging on fertility potential is controversial and difficult to predict. The aim of our study was to determine the associations between age, basic semen parameters, and sperm DNA fragmentation (SDF). Comparison of four age-dependent ... ...

Abstract	The effect of male aging on fertility potential is controversial and difficult to predict. The aim of our study was to determine the associations between age, basic semen parameters, and sperm DNA fragmentation (SDF). Comparison of four age-dependent groups (men ≤29 years, 30-35 years, 36-40 years, and >40 years) revealed a significant fall in the basic semen characteristics and sperm genomic integrity with age. Receiver operating characteristic (ROC) analysis confirmed that men >29 years had lower semen quality. In the group of men >29 years, the prevalence of men with abnormal semen parameters was higher, and these men had over a threefold higher odds ratio (OR) for abnormal semen parameters. Next, ROC analysis revealed that a threshold of 18% SDF was optimal for discriminating between men with normal and abnormal standard semen parameters. The prevalence of men with >18% SDF was higher in the group of men >29 years than in men ≤29 years. Older men had an almost twofold higher risk for >18% SDF than younger men. Our results suggest that age >29 years may be a causative factor of detrimental changes in semen quality, which may raise the risk for disorders of male fertility potential.
MeSH term(s)	Aged ; Aging ; DNA ; Humans ; Male ; Semen ; Semen Analysis ; Spermatozoa
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2020-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2108146-3
ISSN	1473-0790 ; 1368-5538
ISSN (online)	1473-0790
ISSN	1368-5538
DOI	10.1080/13685538.2020.1765330
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Article: Is Caperatic Acid the Only Compound Responsible for Activity of Lichen

Studzińska-Sroka, Elżbieta / Majchrzak-Celińska, Aleksandra / Bańdurska, Monika / Rosiak, Natalia / Szwajgier, Dominik / Baranowska-Wójcik, Ewa / Szymański, Marcin / Gruszka, Wojciech / Cielecka-Piontek, Judyta

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 10

Abstract: Lichens are a source of various biologically active compounds. However, the knowledge about them is still scarce, and their use in medicine is limited. This study aimed to investigate the therapeutic potential of the ... ...

Abstract	Lichens are a source of various biologically active compounds. However, the knowledge about them is still scarce, and their use in medicine is limited. This study aimed to investigate the therapeutic potential of the lichen
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11102069
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Article ; Online: Amorphous Inclusion Complexes

Kamil Wdowiak / Natalia Rosiak / Ewa Tykarska / Marcin Żarowski / Anita Płazińska / Wojciech Płaziński / Judyta Cielecka-Piontek

International Journal of Molecular Sciences, Vol 23, Iss 4000, p

Molecular Interactions of Hesperidin and Hesperetin with HP-Β-CD and Their Biological Effects

2022 Volume 4000

Abstract	This study aimed at obtaining hesperidin (Hed) and hesperetin (Het) systems with HP-β-CD by means of the solvent evaporation method. The produced systems were identified using infrared spectroscopy (FT-IR), X-ray powder diffraction (XRPD), and differential scanning calorimetry (DSC). Moreover, in silico docking and molecular dynamics studies were performed to assess the most preferable site of interactions between tested compounds and HP-β-CD. The changes of physicochemical properties (solubility, dissolution rate, and permeability) were determined chromatographically. The impact of modification on biological activity was tested in an antioxidant study as well as with regards to inhibition of enzymes important in pathogenesis of neurodegenerative diseases. The results indicated improvement in solubility over 1000 and 2000 times for Hed and Het, respectively. Permeability studies revealed that Hed has difficulties in crossing biological membranes, in contrast with Het, which can be considered to be well absorbed. The improved physicochemical properties influenced the biological activity in a positive manner by the increase in inhibitory activity on the DPPH radical and cholinoesterases. To conclude the use of HP-β-CD as a carrier in the formation of an amorphous inclusion complex seems to be a promising approach to improve the biological activity and bioavailability of Hed and Het.
Keywords	hesperidin ; hesperetin ; hydroxypropyl-β-cyclodextrin ; solubility ; amorphous inclusion complex ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ocena skuteczności rehabilitacji przedsionkowej u pacjentów z dysfunkcją błędnika.

Rosiak, Oskar / Szczepanik, Marcin / Woszczak, Marek / Lucas-Grzelczyk, Weronika / Józefowicz-Korczyńska, Magdalena

Medycyna pracy

2019 Volume 70, Issue 5, Page(s) 545–553

Abstract: Background: Vertigo and instability due to vestibular dysfunction have been a frequent cause of work absence, with a clearly upward tendency observed in recent years. Uncompensated vestibular hypofunction requires vestibular rehabilitation, but access ... ...

Title translation	Effectiveness of vestibular rehabilitation in patients with vestibular dysfunction.
Abstract	Background: Vertigo and instability due to vestibular dysfunction have been a frequent cause of work absence, with a clearly upward tendency observed in recent years. Uncompensated vestibular hypofunction requires vestibular rehabilitation, but access to this form of treatment remains limited. Therefore, innovative methods of rehabilitation utilizing new technologies, which could promote this therapy, are searched for. Virtual reality (VR) is becoming a popular method of rehabilitation used, for example, in the treatment of stroke or schizophrenia. The aim of this study was to compare and evaluate 2 methods of vestibular rehabilitation in patients with unilateral vestibular disorders. Material and methods: Forty-three patients with unilateral vestibular disorders diagnosed at the Balance Disorders Unit, 1st Otolaryngology Department of the Medical University of Lodz, were included in this study. The patients, divided into 2 groups, received 10 sessions of rehabilitation. Group 1 (N = 22) was rehabilitated using a VR unit consisting of a forceplate and a motion sensor, while Group 2 (N = 21) performed training on a static posturography platform under physiotherapist supervision. The patients were examined at the baseline, 1 month and 3 months after rehabilitation. During each assessment, posturography was performed which recorded the center of pressure (CoP) displacement. The patients also filled out a questionnaire to quantify vertigo symptoms. Results: The CoP parameters decreased in both groups, with no superiority of either form of training. Analysis of the subjective symptoms reduction revealed a decrease in the Vertigo Syndrome Scale - short form (VSS-sf) score in the second evaluation in both groups, which was slightly greater in the VR group. The improvement remained stable 3 months after rehabilitation. Conclusions: Both forms of rehabilitation are effective in increasing postural stability and reducing subjective symptoms. Virtual reality training achieves a slightly greater subjective improvement. Med Pr. 2019;70(5):545-53.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Middle Aged ; Postural Balance ; Surveys and Questionnaires ; Treatment Outcome ; Vertigo/rehabilitation ; Vestibular Diseases/rehabilitation
Language	Polish
Publishing date	2019-06-27
Publishing country	Poland
Document type	Journal Article
ZDB-ID	128739-4
ISSN	2353-1339 ; 0465-5893
ISSN (online)	2353-1339
ISSN	0465-5893
DOI	10.13075/mp.5893.00853
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Article ; Online: Testosterone levels: key to survival after myocardial infarction?

Wranicz, Jerzy K / Rosiak, Marcin

Cardiology journal

2010 Volume 17, Issue 3, Page(s) 217–218

MeSH term(s)	Biomarkers/blood ; Down-Regulation ; Humans ; Male ; Myocardial Infarction/blood ; Myocardial Infarction/mortality ; Prognosis ; Risk Assessment ; Risk Factors ; Testosterone/blood ; Time Factors
Chemical Substances	Biomarkers ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2010
Publishing country	Poland
Document type	Comment ; Editorial
ZDB-ID	2488680-4
ISSN	1897-5593 ; 1897-5593
ISSN (online)	1897-5593
ISSN	1897-5593
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Article ; Online: Effectiveness of vestibular rehabilitation in patients with vestibular dysfunction

Oskar Rosiak / Marcin Szczepanik / Marek Woszczak / Weronika Lucas-Grzelczyk / Magdalena Józefowicz-Korczyńska

Medycyna Pracy, Vol 70, Iss 5, Pp 545-

2019 Volume 553

Abstract: Background Vertigo and instability due to vestibular dysfunction have been a frequent cause of work absence, with a clearly upward tendency observed in recent years. Uncompensated vestibular hypofunction requires vestibular rehabilitation, but access to ... ...

Abstract	Background Vertigo and instability due to vestibular dysfunction have been a frequent cause of work absence, with a clearly upward tendency observed in recent years. Uncompensated vestibular hypofunction requires vestibular rehabilitation, but access to this form of treatment remains limited. Therefore, innovative methods of rehabilitation utilizing new technologies, which could promote this therapy, are searched for. Virtual reality (VR) is becoming a popular method of rehabilitation used, for example, in the treatment of stroke or schizophrenia. The aim of this study was to compare and evaluate 2 methods of vestibular rehabilitation in patients with unilateral vestibular disorders. Material and Methods Forty-three patients with unilateral vestibular disorders diagnosed at the Balance Disorders Unit, 1st Otolaryngology Department of the Medical University of Lodz, were included in this study. The patients, divided into 2 groups, received 10 sessions of rehabilitation. Group 1 (N = 22) was rehabilitated using a VR unit consisting of a forceplate and a motion sensor, while Group 2 (N = 21) performed training on a static posturography platform under physiotherapist supervision. The patients were examined at the baseline, 1 month and 3 months after rehabilitation. During each assessment, posturography was performed which recorded the center of pressure (CoP) displacement. The patients also filled out a questionnaire to quantify vertigo symptoms. Results The CoP parameters decreased in both groups, with no superiority of either form of training. Analysis of the subjective symptoms reduction revealed a decrease in the Vertigo Syndrome Scale – short form (VSS-sf) score in the second evaluation in both groups, which was slightly greater in the VR group. The improvement remained stable 3 months after rehabilitation. Conclusions Both forms of rehabilitation are effective in increasing postural stability and reducing subjective symptoms. Virtual reality training achieves a slightly greater subjective improvement. Med Pr. ...
Keywords	rehabilitation ; vertigo ; postural stability ; loss of balance ; virtual reality ; center of pressure ; Public aspects of medicine ; RA1-1270
Subject code	150
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	Nofer Institute of Occupational Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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