Article ; Online: The effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalcoholic fatty liver disease: A systematic review and dose-response meta-analysis of randomized controlled trials.
2019 Volume 34, Issue 3, Page(s) 464–474
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity; its prevalence is elevating due to the rising epidemic of obesity. Several clinical trials have examined the effects of curcumin supplementation on anthropometric ... ...
Abstract | Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity; its prevalence is elevating due to the rising epidemic of obesity. Several clinical trials have examined the effects of curcumin supplementation on anthropometric variables in NAFLD patients with inconclusive results. This dose-response meta-analysis aimed to evaluate the impact of curcumin supplementation on body mass index (BMI), body weight, and waist circumference (WC) in patients with NAFLD. A systematic review of the literature was conducted using PubMed/Medline, ISI Web of Science, Scopus, Cochrane Library, EMBASE, Google Scholar, Sid.ir, and Magiran.com to identify eligible studies up to March 2019. A meta-analysis of eligible studies was performed using the random-effects model to estimate the pooled effect size. Eight randomized controlled trials with 520 participants (curcumin group = 265 and placebo group = 255) were included. Supplementation dose and duration ranged from 70 to 3,000 mg/day and 8 to 12 weeks, respectively. Curcumin supplementation significantly reduced BMI (weighted mean difference [WMD] = -0.34 kg/m |
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MeSH term(s) | Adult ; Anthropometry ; Body Mass Index ; Body Weight/drug effects ; Curcumin/administration & dosage ; Dietary Supplements/analysis ; Female ; Humans ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/drug therapy ; Obesity/drug therapy ; Obesity/epidemiology ; Randomized Controlled Trials as Topic ; Waist Circumference/drug effects ; Weight Loss |
Chemical Substances | Curcumin (IT942ZTH98) |
Language | English |
Publishing date | 2019-12-04 |
Publishing country | England |
Document type | Journal Article ; Meta-Analysis ; Systematic Review |
ZDB-ID | 639136-9 |
ISSN | 1099-1573 ; 0951-418X |
ISSN (online) | 1099-1573 |
ISSN | 0951-418X |
DOI | 10.1002/ptr.6542 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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