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Article: Exploring the delivery of end-of-life care by community nurses.

Ferguson, Elizabeth / Wiseman, Leanne / Stratton, Fiona / Evans, Catherine / Linton, Joanna / McLeod, Laura / MacArthur, Juliet

British journal of community nursing

2023 Volume 28, Issue 11, Page(s) 542–548

Abstract: Aims: To understand what aspects of care and support were important to bereaved relatives and to explore the experiences of nurses delivering end of life care.: Methods: Interviews and focus groups were undertaken with 17 family members, 31 community ...

Abstract	Aims: To understand what aspects of care and support were important to bereaved relatives and to explore the experiences of nurses delivering end of life care. Methods: Interviews and focus groups were undertaken with 17 family members, 31 community nurses and 13 community hospital staff. A workshop was held with 6 family members, 13 community nurses and 3 hospital nurses to review findings and make recommendations for improvement. Findings: Four themes were identified: relationships and being treated as a whole person; being able to make choices; getting help when and where it is needed; specialist advice and care, especially at the very end of life. Conclusion: Seeking feedback from relatives was valued both by family members and the staff and has provided an effective model to lead to focussed improvements.
MeSH term(s)	Humans ; Terminal Care ; Hospice Care ; Focus Groups ; Family ; Palliative Care ; Qualitative Research
Language	English
Publishing date	2023-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2146386-4
ISSN	1462-4753
ISSN	1462-4753
DOI	10.12968/bjcn.2023.28.11.542
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Article ; Online: Assessment of Fall-Related Emergency Medical Service Calls and Transports after a Community-Level Fall-Prevention Initiative.

Quatman-Yates, Catherine C / Wisner, David / Weade, Mark / Gabriel, Mindy / Wiseman, Jessica M / Sheridan, Elizabeth / Garvin, Jennifer H / Bridges, John F P / Santry, Heena P / Panchal, Ashish R / Fernandez, Soledad / Quatman, Carmen E

Prehospital emergency care

2021 Volume 26, Issue 3, Page(s) 410–421

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Allied Health Personnel ; Emergency Medical Services ; Emergency Medical Technicians ; Humans ; United States
Language	English
Publishing date	2021-05-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1461751-1
ISSN	1545-0066 ; 1090-3127
ISSN (online)	1545-0066
ISSN	1090-3127
DOI	10.1080/10903127.2021.1922556
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Article ; Online: Risk factors for neoplastic progression in Barrett's esophagus.

Wiseman, Elizabeth F / Ang, Yeng S

World journal of gastroenterology

2011 Volume 17, Issue 32, Page(s) 3672–3683

Abstract: Barrett's esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a "metaplasia-dysplasia-carcinoma" (MDC) sequence. Many of the genetic insults driving ... ...

Abstract	Barrett's esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a "metaplasia-dysplasia-carcinoma" (MDC) sequence. Many of the genetic insults driving this MDC sequence have recently been characterized, providing targets for candidate biomarkers with potential clinical utility to stratify risk in individual patients. Many clinical risk factors have been investigated, and associations with a variety of genetic, specific gastrointestinal and other modifiable factors have been proposed in the literature. This review summarizes the current understanding of the mechanisms involved in neoplastic progression of BE to EAC and critically appraises the relative roles and contributions of these putative risk factors from the published evidence currently available.
MeSH term(s)	Barrett Esophagus/complications ; Barrett Esophagus/etiology ; Barrett Esophagus/genetics ; Barrett Esophagus/pathology ; Disease Progression ; Esophageal Neoplasms/etiology ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Gastroesophageal Reflux/complications ; Humans ; Precancerous Conditions/complications ; Precancerous Conditions/genetics ; Precancerous Conditions/pathology ; Risk Factors
Language	English
Publishing date	2011-09-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v17.i32.3672
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Article ; Online: Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B.

Wu, Yixing / Mumford, Paige / Noy, Suzanna / Cleverley, Karen / Mrzyglod, Alicja / Luo, Dinghao / van Dalen, Floris / Verdoes, Martijn / Fisher, Elizabeth M C / Wiseman, Frances K

Acta neuropathologica communications

2023 Volume 11, Issue 1, Page(s) 132

Abstract: Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer's disease pathogenesis. The endogenous inhibitor of this enzyme, cystatin B (CSTB) is encoded on chromosome 21. Thus, individuals who have Down syndrome, a genetic ... ...

Abstract	Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer's disease pathogenesis. The endogenous inhibitor of this enzyme, cystatin B (CSTB) is encoded on chromosome 21. Thus, individuals who have Down syndrome, a genetic condition caused by having an additional copy of chromosome 21, have an extra copy of an endogenous inhibitor of the enzyme. Individuals who have Down syndrome are also at significantly increased risk of developing early-onset Alzheimer's disease (EOAD). The impact of the additional copy of CSTB on Alzheimer's disease development in people who have Down syndrome is not well understood. Here we compared the biology of cathepsin B and CSTB in individuals who had Down syndrome and Alzheimer's disease, with disomic individuals who had Alzheimer's disease or were ageing healthily. We find that the activity of cathepsin B enzyme is decreased in the brain of people who had Down syndrome and Alzheimer's disease compared with disomic individuals who had Alzheimer's disease. This change occurs independently of an alteration in the abundance of the mature enzyme or the number of cathepsin B
MeSH term(s)	Humans ; Mice ; Animals ; Down Syndrome/pathology ; Alzheimer Disease/pathology ; Cystatin B/genetics ; Cathepsin B ; Microglia/metabolism
Chemical Substances	Cystatin B (88844-95-5) ; Cathepsin B (EC 3.4.22.1)
Language	English
Publishing date	2023-08-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-023-01632-8
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Article: Patients' views on their experience of the delivery of single-sex accommodation within the endoscopy department: is it worth it?

Wiseman, Elizabeth F / Chatten, Kelly / Shah, Sita / Keld, Richard R / Ang, Yeng S

Frontline gastroenterology

2016 Volume 8, Issue 1, Page(s) 13–18

Abstract: Introduction: Provision of single-sex accommodation (SSA) in hospitals is a key National Health Service objective. Department of Health policy to eliminate mixed-sex accommodation (MSA) was implemented in our endoscopy department in 2011. We found no ... ...

Abstract	Introduction: Provision of single-sex accommodation (SSA) in hospitals is a key National Health Service objective. Department of Health policy to eliminate mixed-sex accommodation (MSA) was implemented in our endoscopy department in 2011. We found no published studies of patients' views on MSA in endoscopy units. Aim: We explored patients' views on MSA and their experience of attending our unit at Royal Albert Edward Infirmary (Wigan, UK) since implementation of the SSA policy. Methods: Patients attending the endoscopy unit August-October 2012 and February-April 2015 were invited to participate. Views were surveyed using a 10-point questionnaire. Results: 155 patients were included. A minority were aware of national (36%) or local (39%) policies regarding MSA provision. Only 20.0% and 22.9% reported that they would feel uncomfortable changing behind a curtain or waiting in a gown in a mixed-sex area, respectively. Most of those that felt uncomfortable (81% and 71%) were female, and women ranked importance of SSA significantly higher than men. However, both sexes ranked importance of SSA significantly lower than that of prompt investigation/treatment. Admissions to an alternative recovery area specifically to maintain SSA compliance reduced from 25% (2012) to 8% (2015), following simple measures to improve list efficiency, with corollary reduction in reports of compromised patient experience. Conclusions: SSA is an important healthcare priority for some patients, especially women. However, most consider prompt investigation/treatment a much higher priority. Measures to comply with SSA can negatively affect patient experience. However, we demonstrate that simple measures can result in significant improvements in service delivery and patient experience while remaining compliant with SSA guidance.
Language	English
Publishing date	2016-03-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2521857-8
ISSN	2041-4137
ISSN	2041-4137
DOI	10.1136/flgastro-2016-100683
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Article ; Online: Erratum to: 'Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma'.

Wiseman, Elizabeth F / Chen, Xi / Han, Namshik / Webber, Aaron / Ji, Zongling / Sharrocks, Andrew D / Ang, Yeng S

Molecular cancer

2016 Volume 15, Page(s) 21

Language	English
Publishing date	2016-03-02
Publishing country	England
Document type	Published Erratum
ISSN	1476-4598
ISSN (online)	1476-4598
DOI	10.1186/s12943-016-0506-6
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Article ; Online: Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis.

Osinga, Joris A J / Liu, Yindi / Männistö, Tuija / Vafeiadi, Marina / Tao, Fang-Biao / Vaidya, Bijay / Vrijkotte, Tanja G M / Mosso, Lorena / Bassols, Judit / López-Bermejo, Abel / Boucai, Laura / Aminorroaya, Ashraf / Feldt-Rasmussen, Ulla / Hisada, Aya / Yoshinaga, Jun / Broeren, Maarten A C / Itoh, Sachiko / Kishi, Reiko / Ashoor, Ghalia /

Chen, Liangmiao / Veltri, Flora / Lu, Xuemian / Taylor, Peter N / Brown, Suzanne J / Chatzi, Leda / Popova, Polina V / Grineva, Elena N / Ghafoor, Farkhanda / Pirzada, Amna / Kianpour, Maryam / Oken, Emily / Suvanto, Eila / Hattersley, Andrew / Rebagliato, Marisa / Riaño-Galán, Isolina / Irizar, Amaia / Vrijheid, Martine / Delgado-Saborit, Juana Maria / Fernández-Somoano, Ana / Santa-Marina, Loreto / Boelaert, Kristien / Brenta, Gabriela / Dhillon-Smith, Rima / Dosiou, Chrysoula / Eaton, Jennifer L / Guan, Haixia / Lee, Sun Y / Maraka, Spyridoula / Morris-Wiseman, Lilah F / Nguyen, Caroline T / Shan, Zhongyan / Guxens, Mònica / Pop, Victor J M / Walsh, John P / Nicolaides, Kypros H / D'Alton, Mary E / Visser, W Edward / Carty, David M / Delles, Christian / Nelson, Scott M / Alexander, Erik K / Chaker, Layal / Palomaki, Glenn E / Peeters, Robin P / Bliddal, Sofie / Huang, Kun / Poppe, Kris G / Pearce, Elizabeth N / Derakhshan, Arash / Korevaar, Tim I M

Thyroid : official journal of the American Thyroid Association

2024

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1086044-7
ISSN	1557-9077 ; 1050-7256
ISSN (online)	1557-9077
ISSN	1050-7256
DOI	10.1089/thy.2023.0646
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Article: The Toronto Concussion Study: a prospective investigation of characteristics in a cohort of adults from the general population seeking care following acute concussion, 2016-2020.

Comper, Paul / Foster, Evan / Chandra, Tharshini / Langer, Laura / Wiseman-Hakes, Catherine / Mochizuki, George / Ruttan, Lesley / Lawrence, David W / Inness, Elizabeth L / Gladstone, Jonathan / Saverino, Cristina / Tam, Alan / Kam, Alice / Al-Rawi, Firas / Bayley, Mark Theodore

Frontiers in neurology

2023 Volume 14, Page(s) 1152504

Abstract: Purpose: There is limited research regarding the characteristics of those from the general population who seek care following acute concussion.: Methods: To address this gap, a large cohort of 473 adults diagnosed with an acute concussion (female ... ...

Abstract	Purpose: There is limited research regarding the characteristics of those from the general population who seek care following acute concussion. Methods: To address this gap, a large cohort of 473 adults diagnosed with an acute concussion (female participants = 287; male participants = 186) was followed using objective measures prospectively over 16 weeks beginning at a mean of 5.1 days post-injury. Results: Falls were the most common mechanism of injury (MOI) ( Conclusion: Although premorbid diagnoses of depression and/or anxiety were associated with higher symptom burden at the initial visit, the duration of symptoms was not directly associated with a pre-injury history of psychological/psychiatric disturbance. This cohort of adults, from the general population, seeking care for their acute concussion attained clinical and functional recovery over a period of 4-12 weeks.
Language	English
Publishing date	2023-08-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1152504
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Article ; Online: Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains.

Girdhar, Kiran / Hoffman, Gabriel E / Bendl, Jaroslav / Rahman, Samir / Dong, Pengfei / Liao, Will / Hauberg, Mads E / Sloofman, Laura / Brown, Leanne / Devillers, Olivia / Kassim, Bibi S / Wiseman, Jennifer R / Park, Royce / Zharovsky, Elizabeth / Jacobov, Rivky / Flatow, Elie / Kozlenkov, Alexey / Gilgenast, Thomas / Johnson, Jessica S /

Couto, Lizette / Peters, Mette A / Phillips-Cremins, Jennifer E / Hahn, Chang-Gyu / Gur, Raquel E / Tamminga, Carol A / Lewis, David A / Haroutunian, Vahram / Dracheva, Stella / Lipska, Barbara K / Marenco, Stefano / Kundakovic, Marija / Fullard, John F / Jiang, Yan / Roussos, Panos / Akbarian, Schahram

Nature neuroscience

2022 Volume 25, Issue 4, Page(s) 474–483

Abstract: Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-ranging domains encompassing multiple transcriptional units, including heritability loci for psychiatric traits, remains largely unexplored in the human brain. In this ... ...

Abstract	Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-ranging domains encompassing multiple transcriptional units, including heritability loci for psychiatric traits, remains largely unexplored in the human brain. In this study, we constructed promoter- and enhancer-enriched nucleosomal histone modification landscapes for adult prefrontal cortex from H3-lysine 27 acetylation and H3-lysine 4 trimethylation profiles, generated from 388 controls and 351 individuals diagnosed with schizophrenia (SCZ) or bipolar disorder (BD) (n = 739). We mapped thousands of cis-regulatory domains (CRDs), revealing fine-grained, 10
MeSH term(s)	Adult ; Bipolar Disorder/genetics ; Brain ; Chromatin ; Humans ; Lysine/genetics ; Schizophrenia/genetics
Chemical Substances	Chromatin ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2022-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	1420596-8
ISSN	1546-1726 ; 1097-6256
ISSN (online)	1546-1726
ISSN	1097-6256
DOI	10.1038/s41593-022-01032-6
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Article ; Online: Risk factors for neoplastic progression in Barrett’s esophagus

Elizabeth F Wiseman / Yeng S Ang

World Journal of Gastroenterology, Vol 17, Iss 32, Pp 3672-

2011 Volume 3683

Abstract: Barrett’s esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a “metaplasia-dysplasia-carcinoma” (MDC) sequence. Many of the genetic insults driving ... ...

Abstract	Barrett’s esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a “metaplasia-dysplasia-carcinoma” (MDC) sequence. Many of the genetic insults driving this MDC sequence have recently been characterized, providing targets for candidate biomarkers with potential clinical utility to stratify risk in individual patients. Many clinical risk factors have been investigated, and associations with a variety of genetic, specific gastrointestinal and other modifiable factors have been proposed in the literature. This review summarizes the current understanding of the mechanisms involved in neoplastic progression of BE to EAC and critically appraises the relative roles and contributions of these putative risk factors from the published evidence currently available.
Keywords	Barrett’s esophagus ; Esophageal adenocarcinoma ; Metaplasia-dysplasia-carcinoma ; Neoplastic progression ; Risk factors ; Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2011-01-01T00:00:00Z
Publisher	Baishideng Publishing Group Co., Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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