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Article: Native-Valve

Caroselli, Claudio / Suardi, Lorenzo Roberto / Besola, Laura / Fiocco, Alessandro / Colli, Andrea / Falcone, Marco

2023 Volume 12, Issue 7

Abstract: ... ...

Abstract	Aspergillus
Language	English
Publishing date	2023-07-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12071190
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Article ; Online: Meropenem/vaborbactam plus aztreonam for the treatment of New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae infections.

Tiseo, Giusy / Suardi, Lorenzo Roberto / Leonildi, Alessandro / Giordano, Cesira / Barnini, Simona / Falcone, Marco

The Journal of antimicrobial chemotherapy

2023 Volume 78, Issue 9, Page(s) 2377–2379

MeSH term(s)	Humans ; Meropenem/therapeutic use ; Aztreonam/pharmacology ; Aztreonam/therapeutic use ; Klebsiella pneumoniae ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; beta-Lactamases ; Drug Combinations ; Microbial Sensitivity Tests ; Klebsiella Infections/drug therapy
Chemical Substances	Meropenem (FV9J3JU8B1) ; Aztreonam (G2B4VE5GH8) ; beta-lactamase NDM-1 (EC 3.5.2.6) ; vaborbactam (1C75676F8V) ; Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6) ; Drug Combinations
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad206
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: Real-world experience with meropenem/vaborbactam for the treatment of infections caused by ESBL-producing Enterobacterales and carbapenem-resistant Klebsiella pneumoniae.

Tiseo, Giusy / Galfo, Valentina / Riccardi, Niccolò / Suardi, Lorenzo Roberto / Pogliaghi, Manuela / Giordano, Cesira / Leonildi, Alessandro / Barnini, Simona / Falcone, Marco

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

2024

Abstract: Purpose: Real-world experience with meropenem/vaborbactam (M/V) is limited. Our aim is to report a clinical experience of M/V in the treatment of resistant Gram-negative bacilli.: Methods: This is a prospective observational study including patients ... ...

Abstract	Purpose: Real-world experience with meropenem/vaborbactam (M/V) is limited. Our aim is to report a clinical experience of M/V in the treatment of resistant Gram-negative bacilli. Methods: This is a prospective observational study including patients hospitalized in the University Hospital of Pisa (March 2021-Jan 2023) with infections by both extended-spectrum β-lactamases (ESBL)-producing Enterobacterales and carbapenem-resistant Klebsiella pneumoniae (Kp) treated with M/V. The primary outcome measure was clinical success, defined as a composite of survival, resolution of signs and symptoms and absence of microbiological failure at day 30 from infection onset. A multivariable regression analysis was performed to identify factors associated with clinical failure. Odds ratio (OR) with 95% confidence intervals (CI) was calculated. Results: A total of 104 patients who received M/V were included: 24/104 (23.1%) infections were caused by ESBL non-hypervirulent Enterobacterales, 17/104 (16.3%) by ESBL-producing hypervirulent Klebsiella pneumoniae (hvKp) and 63/104 (60.6%) by CRE. The most common infections were bloodstream infections, followed by urinary tract infections, hospital-acquired pneumonia, intra-abdominal infections and others. Septic shock occurred in 16/104 (15.4%) patients. Clinical success was achieved in 77% of patients, and 30-day mortality rate was 15.4%. In patients with KPC-producing Kp infections, clinical success and 30-day mortality rates were 82% and 11.5%, respectively. On multivariable analysis, SOFA score (OR 1.32, 95% CI 1.02-1.7, p=0.032) was independently associated with clinical failure, while source control (OR 0.16, 95% CI 0.03-0.89, p=0.036) was protective. Conclusions: M/V is a promising therapeutic option against infections caused by difficult-to-treat ESBL-producing Enterobacterales and CR-Kp.
Language	English
Publishing date	2024-02-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	603155-9
ISSN	1435-4373 ; 0934-9723 ; 0722-2211
ISSN (online)	1435-4373
ISSN	0934-9723 ; 0722-2211
DOI	10.1007/s10096-024-04758-2
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Article ; Online: Clinical features and outcomes of infections caused by metallo-β-lactamases producing Enterobacterales: a 3-year prospective study from an endemic area.

Falcone, Marco / Giordano, Cesira / Leonildi, Alessandro / Galfo, Valentina / Lepore, Aurelio / Suardi, Lorenzo Roberto / Riccardi, Niccolò / Barnini, Simona / Tiseo, Giusy

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2023

Abstract: Background: Metallo-β-lactamases (MBL)-producing Enterobacterales are increasing worldwide. Our aim was to describe clinical features, treatments and outcomes of infections by MBL-Enterobacterales.: Methods: Prospective observational study conducted ... ...

Abstract	Background: Metallo-β-lactamases (MBL)-producing Enterobacterales are increasing worldwide. Our aim was to describe clinical features, treatments and outcomes of infections by MBL-Enterobacterales. Methods: Prospective observational study conducted in the Pisa University Hospital (Jan 2019-Oct 2022) including patients with MBL-producing Enterobacterales infections. The primary outcome measure was 30-day mortality. A multivariable Cox regression analysis was performed to identify factors associated with 30-day mortality. Adjusted hazard ratio (aHR) (95% confidence intervals, CI) were calculated. Results: 343 patients were included: 15 VIM- and 328 NDM-producing Enterobacterales infections. Overall, 199 (58%) were bloodstream infections, 60 (17.5%) hospital-acquired/ventilator-associated pneumonias, 60 (17.5%) complicated urinary tract infections, 13 (3.8%) intra-abdominal infections, 11 (3.2%) skin and soft tissue infections. Thirty-day mortality was 29.7%. Thirty-two patients did not receive in vitro active antibiotic therapy, 215/343 (62.7%) received ceftazidime-avibactam (CZA) plus aztreonam (ATM), 33/343 (9.6%) cefiderocol-containing regimens, 26/343 (7.6%) colistin-containing regimens and 37 (10.8%) other active antibiotics. On multivariable analysis, septic shock (aHR 3.57, 95% CI 2.05-6.23, p<0.001) and age (aHR 1.05, 95% CI 1.03-1.08, p<0.001) were independently associated with 30-day mortality, while in vitro active antibiotic therapy within 48 hours from infection (aHR 0.48, 95% CI 0.26-0.8, p=0.007) and source control (aHR 0.43, 95% CI 0.26-0.72, p=0.001) were protective factors. Sensitivity analysis showed that CZA plus ATM compared to colistin was independently associated with reduced 30-day mortality (aHR 0.39, 95% CI 0.18-0.86, p=0.019). Propensity score analyses confirmed these findings. Conclusions: MBL-CRE infections are associated with high 30-day mortality rates. Patients with MBL-producing Enterobacterales infections should received early active antibiotic therapy.
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciad725
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

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Article ; Online: Recrudescence of

Forniti, Arianna / Riccardi, Niccolò / Sponga, Pietro / Buono, Chiara / Iapoce, Riccardo / Suardi, Lorenzo Roberto / Tiseo, Giusy / Falcone, Marco / Menichetti, Francesco

Le infezioni in medicina

2022 Volume 30, Issue 2, Page(s) 304–308

Abstract: In the last two decades, several cases of delayed-onset malaria in migrants from endemic areas were reported. The decrease of acquired immunity over time, often enhanced by immune suppression, represents a possible underlying mechanism for recrudescence. ...

Abstract	In the last two decades, several cases of delayed-onset malaria in migrants from endemic areas were reported. The decrease of acquired immunity over time, often enhanced by immune suppression, represents a possible underlying mechanism for recrudescence. Here we describe a case of
Language	English
Publishing date	2022-06-01
Publishing country	Italy
Document type	Case Reports
ZDB-ID	2041081-5
ISSN	2532-8689 ; 1124-9390
ISSN (online)	2532-8689
ISSN	1124-9390
DOI	10.53854/liim-3002-18
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Zs.A 5576: Show issues

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Article ; Online: Procalcitonin for the differential diagnosis of COVID-19 in the emergency department. Prospective monocentric study.

Nazerian, Peiman / Gagliano, Manfredi / Suardi, Lorenzo Roberto / Fanelli, Alessandra / Rossolini, Gian Maria / Grifoni, Stefano

Internal and emergency medicine

2021 Volume 16, Issue 6, Page(s) 1733–1735

MeSH term(s)	Adult ; Aged ; Biomarkers/blood ; Blood Culture/methods ; COVID-19/blood ; COVID-19/diagnosis ; Diagnosis, Differential ; Emergency Medical Services/organization & administration ; Emergency Service, Hospital ; Female ; Humans ; Male ; Middle Aged ; Procalcitonin/blood ; Prospective Studies ; Young Adult
Chemical Substances	Biomarkers ; Procalcitonin
Language	English
Publishing date	2021-02-02
Publishing country	Italy
Document type	Letter
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-021-02641-y
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Zs.A 6673: Show issues

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Article ; Online: Efficacy and Safety of Anti-SARS-CoV-2 Antiviral Agents and Monoclonal Antibodies in Patients with SLE: A Case-Control Study.

Ramirez, Giuseppe A / Gerosa, Maria / Bellocchi, Chiara / Arroyo-Sánchez, Daniel / Asperti, Chiara / Argolini, Lorenza M / Gallina, Gabriele / Cornalba, Martina / Scotti, Isabella / Suardi, Ilaria / Moroni, Luca / Beretta, Lorenzo / Bozzolo, Enrica P / Caporali, Roberto / Dagna, Lorenzo

Biomolecules

2023 Volume 13, Issue 9

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related disease (COVID-19) has spread pandemically with high rates of morbidity and mortality. COVID-19 has also posed unprecedented challenges in terms of rapid development of pharmacological ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related disease (COVID-19) has spread pandemically with high rates of morbidity and mortality. COVID-19 has also posed unprecedented challenges in terms of rapid development of pharmacological countermeasures to prevent or contrast SARS-CoV-2 pathogenicity. Anti-SARS-CoV-2 antiviral agents and monoclonal antibodies have been specifically designed to attenuate COVID-19 morbidity and prevent mortality in vulnerable subjects, such as patients with immune-mediated diseases, but evidence for the safe and effective use of these drugs in this latter population group is scarce. Therefore, we designed a retrospective, multicentre, observational, case-control study to analyse the impact of these treatments in COVID-19 patients with systemic lupus erythematosus (SLE), a paradigmatic, multi-organ autoimmune disease. We identified 21 subjects treated with antivirals and/or monoclonal antibodies who were matched with 42 untreated patients by age, sex, SLE extension and duration. Treated patients had higher baseline SLE disease activity index 2000 scores [SLEDAI-2K median (interquartile range) = 4 (1-5) vs. 0 (0-2);
MeSH term(s)	Humans ; Antibodies, Monoclonal/adverse effects ; Antiviral Agents/adverse effects ; Case-Control Studies ; COVID-19/complications ; Lupus Erythematosus, Systemic/drug therapy ; Retrospective Studies ; SARS-CoV-2
Chemical Substances	Antibodies, Monoclonal ; Antiviral Agents
Language	English
Publishing date	2023-08-22
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13091273
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Article ; Online: Predictors and outcomes of respiratory bacterial coinfections in patients with COVID-19 admitted to hospital: An observational prospective study.

Tiseo, Giusy / Suardi, Lorenzo Roberto / Giusti, Lisa / Forniti, Arianna / Caroselli, Claudio / Galfo, Valentina / Occhineri, Sara / Leonildi, Alessandro / Moscato, Giovanna / Menichetti, Francesco / Falcone, Marco

Respirology (Carlton, Vic.)

2022 Volume 27, Issue 11, Page(s) 987–990

MeSH term(s)	COVID-19/epidemiology ; Coinfection/epidemiology ; Coinfection/microbiology ; Hospitals ; Humans ; Prospective Studies ; SARS-CoV-2
Language	English
Publishing date	2022-09-16
Publishing country	Australia
Document type	Letter ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.14372
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Article ; Online: Remdesivir treatment and transient bradycardia in patients with coronavirus diseases 2019 (COVID-19).

Pallotto, Carlo / Blanc, Pierluigi / Esperti, Sara / Suardi, Lorenzo Roberto / Gabbuti, Andrea / Vichi, Francesca / Mecocci, Lorenzo / Esposti, Anna Degli / Pierotti, Piera / Attala, Letizia / Salomoni, Elena / Baragli, Filippo / Francisci, Daniela / Pietro, Massimo Antonio Di

The Journal of infection

2021 Volume 83, Issue 2, Page(s) 237–279

MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Bradycardia/chemically induced ; COVID-19/drug therapy ; Humans ; SARS-CoV-2
Chemical Substances	remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2021-05-28
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2021.05.025
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Article ; Online: Olfactory and gustatory dysfunctions in 100 patients hospitalized for COVID-19: sex differences and recovery time in real-life.

Meini, Simone / Suardi, Lorenzo Roberto / Busoni, Michele / Roberts, Anna Teresa / Fortini, Alberto

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2020 Volume 277, Issue 12, Page(s) 3519–3523

Abstract: Purpose: COVID-19 displays a variety of clinical manifestations; in pauci-symptomatic patients olfactory (OD) and gustatory dysfunctions (GD) may represent the first or only symptom. This topic is currently arousing great interest, and a growing number ... ...

Abstract	Purpose: COVID-19 displays a variety of clinical manifestations; in pauci-symptomatic patients olfactory (OD) and gustatory dysfunctions (GD) may represent the first or only symptom. This topic is currently arousing great interest, and a growing number of papers are being published. Aim of this study is to investigate the timing of recovery from OD and GD in a real-life population hospitalized for COVID-19. Methods: We followed up by a phone interview the first 100 patients discharged a month earlier from three Italian non-intensive care wards. Results: All 100 patients were Caucasian, mean age was 65 years, 60% were males. Forty-two patients (mean age 63 years) experienced subjective chemosensory dysfunctions (29 OD and 41 GD): the male/female ratio was 2:1; 83% reported a complete or near complete recovery at follow-up. The recovery rate was not significantly different between males and females. The mean duration of OD and GD was 18 and 16 days, respectively. The mean recovery time from OD or GD resulted significantly longer for females than for males (26 vs 14 days, P = 0.009). Among the 42 symptomatic, the mean age of males was significantly higher than that of females (66 vs 57 years, P = 0.04), while the opposite was observed in the 58 asymptomatic patients (60 vs 73 years, P = 0.0018). Conclusions: Recovery from OD or GD was rapid, occurring within 4 weeks in most patients. Chemosensory dysfunctions in women was less frequent, but longer lasting. The value of our study is its focus on a population of hospitalized patients significantly older than those previously described, and the additional data on gender differences.
MeSH term(s)	Aged ; Ageusia/epidemiology ; Ageusia/etiology ; Betacoronavirus ; COVID-19 ; Coronavirus/isolation & purification ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Female ; Follow-Up Studies ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Olfaction Disorders/diagnosis ; Olfaction Disorders/epidemiology ; Olfaction Disorders/etiology ; Olfactory Perception/physiology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Recovery of Function ; SARS-CoV-2 ; Sex Factors ; Smell ; Symptom Assessment/methods ; Taste Disorders/epidemiology ; Taste Disorders/etiology ; Taste Perception/physiology
Keywords	covid19
Language	English
Publishing date	2020-06-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-020-06102-8
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