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Article: Near-Field Control and Imaging of Free Charge Carrier Variations in GaN Nanowires.

Berweger, Samuel / Blanchard, Paul T / Brubaker, Matt D / Coakley, Kevin J / Sanford, Norman A / Wallis, Thomas M / Bertness, Kris A / Kabos, Pavel

Applied physics letters

2024 Volume 108, Issue 7

Abstract: Despite their uniform crystallinity, the shape and faceting of semiconducting nanowires (NWs) can give rise to variations in structure and associated electronic properties. Here we develop a hybrid scanning probe-based methodology to investigate local ... ...

Abstract	Despite their uniform crystallinity, the shape and faceting of semiconducting nanowires (NWs) can give rise to variations in structure and associated electronic properties. Here we develop a hybrid scanning probe-based methodology to investigate local variations in electronic structure across individual n-doped GaN NWs integrated into a transistor device. We perform scanning microwave microscopy (SMM), which we combine with scanning gate microscopy (SGM) to determine the free-carrier SMM signal contribution and image local charge carrier density variations. In particular, we find significant variations in free carriers across NWs, with a higher carrier density at the wire facets. By increasing the local carrier density through tip-gating, we find that the tip injects current into the NW with strongly localized current when positioned over the wire vertices. These results suggest that the strong variations in electronic properties observed within NWs have significant implications for device design and may lead to new paths to optimization.
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1469436-0
ISSN	1077-3118 ; 0003-6951
ISSN (online)	1077-3118
ISSN	0003-6951
DOI	10.1063/1.4942107
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Article ; Online: Days alive and out of hospital for adult female and male cardiac surgery patients: a population-based cohort study.

Jerath, Angela / Wallis, Christopher J D / Fremes, Stephen / Rao, Vivek / Yau, Terrence M / Heybati, Kiyan / Lee, Douglas S / Wijeysundera, Harindra C / Sutherland, Jason / Austin, Peter C / Wijeysundera, Duminda N / Ko, Dennis T

BMC cardiovascular disorders

2024 Volume 24, Issue 1, Page(s) 215

Abstract: Background: Research shows women experience higher mortality than men after cardiac surgery but information on sex-differences during postoperative recovery is limited. Days alive and out of hospital (DAH) combines death, readmission and length of stay, ...

Abstract	Background: Research shows women experience higher mortality than men after cardiac surgery but information on sex-differences during postoperative recovery is limited. Days alive and out of hospital (DAH) combines death, readmission and length of stay, and may better quantify sex-differences during recovery. This main objective is to evaluate (i) how DAH at 30-days varies between sex and surgical procedure, (ii) DAH responsiveness to patient and surgical complexity, and (iii) longer-term prognostic value of DAH. Methods: We evaluated 111,430 patients (26% female) who underwent one of three types of cardiac surgery (isolated coronary artery bypass [CABG], isolated non-CABG, combination procedures) between 2009 - 2019. Primary outcome was DAH at 30 days (DAH Results: DAH Conclusion: DAH is a responsive outcome to differences in patient and surgical risk factors. Further research is needed to identify new care pathways to reduce disparities in outcomes between male and female patients.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Cohort Studies ; Postoperative Complications/etiology ; Coronary Artery Bypass/adverse effects ; Risk Factors ; Hospitals
Language	English
Publishing date	2024-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-024-03862-7
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Article: Evaluation of the stability of aciclovir in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy.

Sime, Fekade Bruck / Wallis, Steven / Jamieson, Conor / Hills, Tim / Gilchrist, Mark / Santillo, Mark / Seaton, R Andrew / Drummond, Felicity / Roberts, Jason

European journal of hospital pharmacy : science and practice

2024

Abstract: Objectives: To investigate the stability of aciclovir solutions in elastomeric devices used for outpatient parenteral antimicrobial therapy (OPAT).: Methods: Triplicates of two elastomeric devices, Accufuser and Easypump II, were filled with a ... ...

Abstract	Objectives: To investigate the stability of aciclovir solutions in elastomeric devices used for outpatient parenteral antimicrobial therapy (OPAT). Methods: Triplicates of two elastomeric devices, Accufuser and Easypump II, were filled with a solution of 200 mg, 2400 mg, and 4500 mg aciclovir in 240 mL 0.9% w/v saline. Devices were stored at room temperature for 14 days, followed by 24 hours storage at 32°C. Assessment using a stability indicating assay, pH and subvisible particle analysis was undertaken at 11 time points throughout the study. Results: Aciclovir solution at 200 mg and 2400 mg in 240 mL was stable for 14 days at room temperature (<20°C) and 24 hours of 32°C 'in-use' temperature exposure, remaining above the 95% limit for NHS stability protocols. The high dose was also stable for 14 days at room temperature, but when stored at 32°C there was precipitation of aciclovir within 4 hours in both devices. The precipitate was confirmed as aciclovir and precipitation was not a sign of chemical degradation. Conclusions: Aciclovir concentrations above 2400 mg/240 mL are liable to precipitation and cannot be recommended for OPAT services because of heightened risks of nephrotoxicity. Aciclovir solution can be given as a continuous 24-hour infusion for OPAT services at a concentration range of 200-2400 mg in 240 mL in Accufuser and Easypump II elastomeric devices following 14 days storage at room temperature, protected from light.
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2650179-X
ISSN	2047-9964 ; 2047-9956
ISSN (online)	2047-9964
ISSN	2047-9956
DOI	10.1136/ejhpharm-2023-003784
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Article ; Online: "Much better than I thought it was going to be": Telehealth delivered group-based education and exercise was perceived as acceptable among people with knee osteoarthritis.

Ezzat, A M / Bell, E / Kemp, J L / O'Halloran, P / Russell, T / Wallis, J / Barton, C J

Osteoarthritis and cartilage open

2022 Volume 4, Issue 3, Page(s) 100271

Abstract: Objective: To understand patient perceived acceptability of participating in a telehealth delivered group-based education and exercise-therapy program for knee osteoarthritis.: Design: This qualitative study involved semi-structured, one-on-one ... ...

Abstract	Objective: To understand patient perceived acceptability of participating in a telehealth delivered group-based education and exercise-therapy program for knee osteoarthritis. Design: This qualitative study involved semi-structured, one-on-one interviews with knee osteoarthritis patients who have completed the Good Living with osteoArthritis from Denmark (GLA:D®) program via telehealth or in-person. Interviews were recorded, transcribed verbatim, coded, and analysed using an inductive content analysis approach, focusing on themes related to telehealth. Results: Nineteen participants [12 (63%) female, mean aged 62 years, range 49-72 years] were included. Eleven (58%) received GLA:D® via telehealth and 8 (42%) attended in-person sessions. Two overarching themes (6 sub-themes) related to telehealth perceived acceptability were identified: 1) Perceptions of telehealth acceptability was highly influenced by exposure. Individuals who had received telehealth considered it easy, convenient, and flexible, whereas telehealth was perceived to be inferior and misunderstood by those without exposure. 2) Telehealth participants reported similar program benefits to in-person participants, including reduced fear of pain and joint damage, changed beliefs in value of exercise, and stated improvements in pain and function. Conclusions: Telehealth delivery of group-based education and exercise-therapy for knee osteoarthritis was acceptable for people who had experienced it and provides similar benefits as in-person care for pain and beliefs about the safety and value of exercise. Wider implementation of telehealth group-based education and exercise-therapy may improve access to high value care for people with knee osteoarthritis.
Language	English
Publishing date	2022-05-12
Publishing country	England
Document type	Journal Article
ISSN	2665-9131
ISSN (online)	2665-9131
DOI	10.1016/j.ocarto.2022.100271
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Article ; Online: Safety of Bioplasma FDP and Hemopure in rhesus macaques after 30% hemorrhage.

Pusateri, Anthony E / Morgan, Clifford G / Neidert, Leslie E / Tiller, Michael M / Glaser, Jacob J / Weiskopf, Richard B / Ebrahim, Ismaeel / Stassen, Willem / Rambharose, Sanjeev / Mahoney, Scott H / Wallis, Lee A / Hollis, Ewell M / Delong, Gerald T / Cardin, Sylvain

Trauma surgery & acute care open

2024 Volume 9, Issue Suppl 1, Page(s) e001147

Abstract: Objectives: Prehospital transfusion can be life-saving when transport is delayed but conventional plasma, red cells, and whole blood are often unavailable out of hospital. Shelf-stable products are needed as a temporary bridge to in-hospital transfusion. ...

Abstract	Objectives: Prehospital transfusion can be life-saving when transport is delayed but conventional plasma, red cells, and whole blood are often unavailable out of hospital. Shelf-stable products are needed as a temporary bridge to in-hospital transfusion. Bioplasma FDP (freeze-dried plasma) and Hemopure (hemoglobin-based oxygen carrier; HBOC) are products with potential for prehospital use. In vivo use of these products together has not been reported. This study assessed the safety of intravenous administration of HBOC+FDP, relative to normal saline (NS), in rhesus macaques (RM). Methods: After 30% blood volume removal and 30 minutes in shock, animals were resuscitated with either NS or two units (RM size adjusted) each of HBOC+FDP during 60 minutes. Sequential blood samples were collected. After neurological assessment, animals were killed at 24 hours and tissues collected for histopathology. Results: Due to a shortage of RM during the COVID-19 pandemic, the study was stopped after nine animals (HBOC+FDP, seven; NS, two). All animals displayed physiologic and tissue changes consistent with hemorrhagic shock and recovered normally. There was no pattern of cardiovascular, blood gas, metabolic, coagulation, histologic, or neurological changes suggestive of risk associated with HBOC+FDP. Conclusion: There was no evidence of harm associated with the combined use of Hemopure and Bioplasma FDP. No differences were noted between groups in safety-related cardiovascular, pulmonary, renal or other organ or metabolic parameters. Hemostasis and thrombosis-related parameters were consistent with expected responses to hemorrhagic shock and did not differ between groups. All animals survived normally with intact neurological function. Level of evidence: Not applicable.
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ISSN	2397-5776
ISSN (online)	2397-5776
DOI	10.1136/tsaco-2023-001147
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Article ; Online: Stapled neoappendicostomy: A novel technique.

Kastenberg, Zachary J / Arkin, Cameron / Wallis, M Chad / Boemers, Thomas / Rollins, Michael D

Journal of pediatric surgery

2022 Volume 57, Issue 12, Page(s) 1029–1030

MeSH term(s)	Humans ; Surgical Stapling/methods ; Fecal Incontinence/surgery ; Anastomosis, Surgical ; Suture Techniques
Language	English
Publishing date	2022-08-22
Publishing country	United States
Document type	Letter
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2022.08.012
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Article: Screening and management of metabolic, cardiac, and bone health in prostate cancer patients on androgen deprivation therapy: A survey of specialized physicians.

Nguyen, David-Dan / Mousa, Ahmad / Klotz, Laurence / Niazi, Tamim / Pouliot, Frédéric / Kokorovic, Andrea / Lavallée, Luke T / Huynh, Melissa / Lapointe, Nathalie / Di Risio, Michelle / Wallis, Christopher J D

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

2024

Language	English
Publishing date	2024-04-02
Publishing country	Canada
Document type	Letter
ZDB-ID	2431403-1
ISSN	1911-6470
ISSN	1911-6470
DOI	10.5489/cuaj.8687
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Article ; Online: Association of baseline physical activity participation with participant characteristics and outcomes following education and exercise-therapy in people with knee osteoarthritis: A GLA:D

Bell, Emily C / Pazzinatto, Marcella F / Wallis, Jason A / Kemp, Joanne L / Skou, Søren T / O'Halloran, Paul / Crossley, Kay M / De Oliveira Silva, Danilo / Semciw, Adam I / Dundules, Karen / Barton, Christian J

Musculoskeletal care

2023 Volume 21, Issue 4, Page(s) 1470–1481

Abstract: Objectives: To investigate whether participants with knee osteoarthritis classified as 'more' or 'less' physically active at baseline differ in characteristics and/or outcomes at baseline and at 3 and 12 months following the commencement of an education ...

Abstract	Objectives: To investigate whether participants with knee osteoarthritis classified as 'more' or 'less' physically active at baseline differ in characteristics and/or outcomes at baseline and at 3 and 12 months following the commencement of an education and exercise-therapy program. Methods: Prospective cohort study using the GLA:D Results: We included 1059 participants (70% female). At baseline, 267 (25%) were classified as 'more' active, increasing to 29% and 30% at 3 and 12 months, respectively. At baseline, compared to the 'less' active group, the 'more' active group had a lower proportion of participants who were obese ('more' = 21% vs. 'less' = 44%), had comorbidities (58% vs. 74%) and consumed medications (71% vs. 85%); lower pain intensity (37 vs. 47); and higher KOOS-12 (59 vs. 50), and health-related QoL (0.738 vs. 0.665) scores. When accounting for age, sex and baseline physical activity, improvements seen in knee-related burden and health-related QoL were not different between groups at 3 or 12 months. Compared to the 'less' active group, the proportion of participants not consuming medication remained higher in the 'more' active group at 3 ('more' 45% vs. 'less' 28%) and 12 months (43% vs. 32%). Conclusion: 'More' active people with knee osteoarthritis were less likely to be obese, had fewer comorbidities, lower medication consumption, knee-related burden and pain intensity, and higher health-related QoL than 'less' active participants at all timepoints.
MeSH term(s)	Humans ; Female ; Infant ; Male ; Osteoarthritis, Knee/therapy ; Quality of Life ; Prospective Studies ; Exercise ; Exercise Therapy ; Obesity
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2171452-6
ISSN	1557-0681 ; 1478-2189
ISSN (online)	1557-0681
ISSN	1478-2189
DOI	10.1002/msc.1828
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Article ; Online: Multisite prospective study of perioperative pain management practices for anterior cruciate ligament reconstruction in adolescents: Society for Pediatric Anesthesia Improvement Network (SPAIN) Project Report.

Sadacharam, Kesavan / Furstein, James S / Staffa, Steven J / Li, Galaxy / Karroum, Rami / Booth, Jocelyn M / Kim, Eugene / McCahan, Suzanne M / Muhly, Wallis T / Chidambaran, Vidya

Regional anesthesia and pain medicine

2024

Abstract: Introduction: Although 200 000 adolescents undergo anterior cruciate ligament reconstruction (ACLR) surgery annually, no benchmarks for pediatric post-ACLR pain management exist. We created a multicenter, prospective, observational registry to describe ... ...

Abstract	Introduction: Although 200 000 adolescents undergo anterior cruciate ligament reconstruction (ACLR) surgery annually, no benchmarks for pediatric post-ACLR pain management exist. We created a multicenter, prospective, observational registry to describe pain practices, pain, and functional recovery after pediatric ACLR. Methods: Participants (n=519; 12-17.5 years) were enrolled from 15 sites over 2 years. Data on perioperative management and surgical factors were collected. Pain/opioid use and Lysholm scores were assessed preoperatively, on postoperative day 1 (POD1), POD3, week 6, and month 6. Descriptive statistics and trends for opioid use, pain, and function are presented. Results: Regional analgesia was performed in 447/519 (86%) subjects; of these, adductor canal single shot was most frequent (54%), nerve catheters placed in 24%, and perineural adjuvants used in 43%. On POD1, POD3, week 6, and month 6, survey response rates were 73%, 71%, 61%, and 45%, respectively. Over these respective time points, pain score >3/10 was reported by 64% (95% CI: 59% to 69%), 46% (95% CI: 41% to 52%), 5% (95% CI: 3% to 8%), and 3% (95% CI: 1% to 6%); the number of daily oxycodone doses used was 2.8 (SD 0.19), 1.8 (SD 0.13), 0, and 0. There was considerable variability in timing and tests for postdischarge functional assessments. Numbness and weakness were reported by 11% and 4% at week 6 (n=315) and 16% and 2% at month 6 (n=233), respectively. Conclusion: We found substantial variability in the use of blocks to manage post-ACLR pain in children, with a small percentage experiencing long-term pain and neurological symptoms. Studies are needed to determine best practices for regional anesthesia and functional assessments in this patient population.
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1425299-5
ISSN	1532-8651 ; 1098-7339 ; 0146-521X
ISSN (online)	1532-8651
ISSN	1098-7339 ; 0146-521X
DOI	10.1136/rapm-2024-105381
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Article ; Online: LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis.

Xu, Zijian / Davies, Elizabeth R / Yao, Liudi / Zhou, Yilu / Li, Juanjuan / Alzetani, Aiman / Marshall, Ben G / Hancock, David / Wallis, Tim / Downward, Julian / Ewing, Rob M / Davies, Donna E / Jones, Mark G / Wang, Yihua

Genes & diseases

2024 Volume 11, Issue 3, Page(s) 101065

Abstract: The factors that determine fibrosis progression or normal tissue repair are largely unknown. We previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition (EMT) in human alveolar epithelial type II (ATII) cells augments ... ...

Abstract	The factors that determine fibrosis progression or normal tissue repair are largely unknown. We previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition (EMT) in human alveolar epithelial type II (ATII) cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine signalling. Here, we report that liver kinase B1 (LKB1) inactivation in ATII cells inhibits autophagy and induces EMT as a consequence. In IPF lungs, this is caused by downregulation of
Language	English
Publishing date	2024-01-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2821806-1
ISSN	2352-3042 ; 2352-3042
ISSN (online)	2352-3042
ISSN	2352-3042
DOI	10.1016/j.gendis.2023.06.034
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