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  1. Book ; Online ; E-Book: Clinical management of pediatric COVID-19

    Leung, Char

    an international perspective and practical guide

    2023  

    Author's details edited by Char Leung
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xvi, 188 Seiten), Illustrationen, Diagramme
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021724664
    ISBN 978-0-323-95060-2 ; 9780323950596 ; 0-323-95060-4 ; 0323950590
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Reply to Beken et al.

    Leung, Char

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2021  Volume 32, Issue 5, Page(s) 1131–1132

    Language English
    Publishing date 2021-03-09
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3096: Show issues Location:
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  3. Article: The Incubation Period of COVID-19: Current Understanding and Modeling Technique.

    Leung, Char

    Advances in experimental medicine and biology

    2021  Volume 1318, Page(s) 81–90

    Abstract: This chapter aims to answer the following questions regarding the incubation period of COVID-19. Why is understanding the incubation period of COVID-19 important? How long is the incubation time, and what are the associating factors? How should the ... ...

    Abstract This chapter aims to answer the following questions regarding the incubation period of COVID-19. Why is understanding the incubation period of COVID-19 important? How long is the incubation time, and what are the associating factors? How should the incubation period be modeled given the current pandemic situation? Where should we go from here? As a critical epidemiological metric, the incubation period is of public health and clinical importance. While the incubation time of COVID-19 is generally similar to that of SARS and MERS, recent studies identifying factors that impact the incubation period of COVID-19, travel history, for example, only tell part of the story. Therefore, in addition to reviewing current findings, this chapter also explores the modeling technique and future research directions of the incubation period of COVID-19.
    MeSH term(s) COVID-19 ; Humans ; Infectious Disease Incubation Period ; Pandemics ; Public Health ; SARS-CoV-2 ; Travel
    Language English
    Publishing date 2021-05-11
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-63761-3_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Guillain-Barre syndrome should be monitored upon mass vaccination against SARS-CoV-2.

    Leung, Char

    Human vaccines & immunotherapeutics

    2021  Volume 17, Issue 9, Page(s) 2957–2958

    Abstract: In response to the recent pandemic, vaccines have been developed for large-scale immunization. Despite safety and efficacy verified by health authorities, Guillain-Barre syndrome (GBS) remains a risk of unexpected adverse reactions. Since COVID-19- ... ...

    Abstract In response to the recent pandemic, vaccines have been developed for large-scale immunization. Despite safety and efficacy verified by health authorities, Guillain-Barre syndrome (GBS) remains a risk of unexpected adverse reactions. Since COVID-19-related GBS cases have largely been reported in Europe, vaccines involving viral genetic materials can potentially trigger GBS, as demonstrated in clinical trials in the Americas. Therefore, medical professionals should be aware of GBS as a potential adverse reaction in SARS-CoV-2 vaccination. Consultation with a neurologist may be needed. Nevertheless, this is not to say that the use of vaccines against SARS-CoV-2 should be suspended and that the association between GBS and the vaccine is confirmed or excluded. The benefits of vaccine still outweigh potential adverse effects.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Guillain-Barre Syndrome/chemically induced ; Guillain-Barre Syndrome/epidemiology ; Humans ; Mass Vaccination ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2021.1922061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6967: Show issues Location:
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  5. Book ; Online: Author response for "The younger the milder clinical course of COVID‐19

    Char Leung

    Even in newborns?"

    2020  

    Keywords covid19
    Publisher Wiley
    Publishing country us
    Document type Book ; Online
    DOI 10.1111/pai.13371/v2/response1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  6. Article ; Online: Comment on Li et al: COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis.

    Leung, Char

    Journal of medical virology

    2020  Volume 92, Issue 9, Page(s) 1431–1432

    MeSH term(s) COVID-19/mortality ; Humans ; Pandemics ; Patient Discharge ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1320: Show issues Location:
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  7. Article ; Online: The difference in the incubation period of 2019 novel coronavirus (SARS-CoV-2) infection between travelers to Hubei and nontravelers: The need for a longer quarantine period.

    Leung, Char

    Infection control and hospital epidemiology

    2020  Volume 41, Issue 5, Page(s) 594–596

    Abstract: Data collected from the individual cases reported by the media were used to estimate the distribution of the incubation period of travelers to Hubei versus that of nontravelers. Because a longer and more volatile incubation period has been observed in ... ...

    Abstract Data collected from the individual cases reported by the media were used to estimate the distribution of the incubation period of travelers to Hubei versus that of nontravelers. Because a longer and more volatile incubation period has been observed in travelers, the duration of quarantine should be extended to 3 weeks.
    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Communicable Diseases, Imported/virology ; Coronavirus Infections/physiopathology ; Coronavirus Infections/transmission ; Humans ; Pandemics ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Time Factors ; Virus Latency
    Keywords covid19
    Language English
    Publishing date 2020-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2020.81
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1714: Show issues Location:
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  8. Article ; Online: Clinical features of deaths in the novel coronavirus epidemic in China.

    Leung, Char

    Reviews in medical virology

    2020  Volume 30, Issue 3, Page(s) e2103

    Abstract: In response to the recent novel coronavirus outbreak originating in Wuhan, Hubei province, China, observations concerning novel coronavirus mortality are of urgent public health importance. The present work presents the first review of the fatal novel ... ...

    Abstract In response to the recent novel coronavirus outbreak originating in Wuhan, Hubei province, China, observations concerning novel coronavirus mortality are of urgent public health importance. The present work presents the first review of the fatal novel coronavirus cases in China. Clinical data of fatal cases published by the Chinese Government were studied. As of 2 February 2020, the clinical data of 46 fatal cases were identified. The case fatality rate was significantly higher in Hubei province than the rest of China. While 67% of all deceased patients were male, gender was unlikely to be associated with mortality. Diabetes was likely to be associated with mortality. There is, however, not yet sufficient evidence to support the association between hypertension and mortality as similar prevalence of hypertension was also observed in the Hubei population.
    MeSH term(s) Age Factors ; Aged ; COVID-19 ; China/epidemiology ; Comorbidity ; Coronavirus Infections/mortality ; Coronavirus Infections/physiopathology ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/mortality ; Pneumonia, Viral/physiopathology
    Keywords covid19
    Language English
    Publishing date 2020-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1086043-5
    ISSN 1099-1654 ; 1052-9276
    ISSN (online) 1099-1654
    ISSN 1052-9276
    DOI 10.1002/rmv.2103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3308: Show issues Location:
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  9. Article ; Online: A lesson learnt from the emergence of Zika virus: What flaviviruses can trigger Guillain-Barré syndrome?

    Leung, Char

    Journal of medical virology

    2020  Volume 92, Issue 12, Page(s) 2938–2945

    Abstract: While Zika virus outbreaks raised the concern about rare viral infections in human, attention should also be paid to other Guillain-Barré syndrome (GBS) inducing viruses. This study aims to search for other flaviviruses likely to be associated with GBS. ... ...

    Abstract While Zika virus outbreaks raised the concern about rare viral infections in human, attention should also be paid to other Guillain-Barré syndrome (GBS) inducing viruses. This study aims to search for other flaviviruses likely to be associated with GBS. Amino acid (aa) sequence matching analysis was conducted to identify viruses molecularly similar to the Zika virus and human GBS-related proteins. A systematic review of clinical literature was performed to summarize the clinical findings of the GBS-associated flaviviruses identified in the aa sequence matching analysis. It was found that more than 10 pentapeptides were shared between 9 flaviviruses, Zika virus, and human GBS-related proteins. Twenty-six articles totaling 42 clinical cases were eligible for inclusion in the systematic review concerning the nine flaviviruses identified. While some patients showed signs of encephalitis, 5 out of 42 cases demonstrated typical GBS symptoms. Public health professionals should be aware of other GBS-associated flaviviruses and GBS cases with mild symptoms.
    Language English
    Publishing date 2020-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  10. Article ; Online: Clinical characteristics of COVID-19 in children: Are they similar to those of SARS?

    Leung, Char

    Pediatric pulmonology

    2020  Volume 55, Issue 7, Page(s) 1592–1597

    Abstract: Although the number of SARS-CoV-2 infections has been rising amid the current pandemic of COVID-19, the low infection rate of SARS-CoV-2 in children has been low. By examining the clinical data available in the public domain, the present work clarifies ... ...

    Abstract Although the number of SARS-CoV-2 infections has been rising amid the current pandemic of COVID-19, the low infection rate of SARS-CoV-2 in children has been low. By examining the clinical data available in the public domain, the present work clarifies the clinical presentations in children with COVID-19 in China. Statistical significance tests and adjusted odds ratios estimation were performed on the children (age below 18) and adults (age 18 or above) cohorts in China. SARS-CoV and SARS-CoV-2 shared similar clinical features. Lower respiratory tract infection was less prominent in children as evidenced by the relatively low prevalence in chest pain/discomfort and dyspnea. Similar to SARS, younger children had a less aggressive clinical course, compared with adolescents. While fewer symptoms were observed in children compared to adults, there is not yet sufficient evidence to conclude shorter hospital stay in children.
    MeSH term(s) Adolescent ; Adult ; Betacoronavirus ; COVID-19 ; Child ; China/epidemiology ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Female ; Humans ; Male ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; SARS Virus ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/diagnosis ; Severe Acute Respiratory Syndrome/epidemiology ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.24855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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