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  1. Article ; Online: Iohexol-measured glomerular filtration rate in children and adolescents with chronic kidney disease: a pilot study comparing venous and finger stick methods: response to comments from Dr. Luis-Lima.

    Staples, Amy / Wong, Craig / Schwartz, George J

    Pediatric nephrology (Berlin, Germany)

    2019  Volume 34, Issue 9, Page(s) 1631

    MeSH term(s) Adolescent ; Child ; Creatinine ; Glomerular Filtration Rate ; Humans ; Iohexol ; Pilot Projects ; Renal Insufficiency, Chronic
    Chemical Substances Iohexol (4419T9MX03) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2019-06-16
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-019-04286-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Corrigendum: 'Implementation of routine genomic surveillance provided insights into a locally acquired outbreak caused by a rare clade of

    Rathnayake, Irani U / Graham, Rikki M A / Bayliss, Jo / Staples, Megan / Micalizzi, Gino / Ariotti, Lawrence / Cover, Leonie / Heron, Brett / Graham, Trudy / Stafford, Russell / Rubenach, Sally / D'Addona, Andrew / Jennison, Amy V

    Microbial genomics

    2023  Volume 9, Issue 8

    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.001096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Implementation of routine genomic surveillance provided insights into a locally acquired outbreak caused by a rare clade of

    Rathnayake, Irani U / Graham, Rikki M A / Bayliss, Jo / Staples, Megan / Micalizzi, Gino / Ariotti, Lawrence / Cover, Leonie / Heron, Brett / Graham, Trudy / Stafford, Russell / Rubenach, Sally / D'Addona, Andrew / Jennison, Amy V

    Microbial genomics

    2023  Volume 9, Issue 7

    Abstract: Salmonellosis is a significant public health problem globally. In Australia, ...

    Abstract Salmonellosis is a significant public health problem globally. In Australia,
    MeSH term(s) Humans ; Salmonella enteritidis/genetics ; Queensland/epidemiology ; Salmonella Infections/epidemiology ; Salmonella Infections/microbiology ; Salmonella Food Poisoning/epidemiology ; Disease Outbreaks ; Genomics ; Australia
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.001059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Examination of phase-variable haemoglobin-haptoglobin binding proteins in non-typeable Haemophilus influenzae reveals a diverse distribution of multiple variants.

    Phillips, Zachary N / Jennison, Amy V / Whitby, Paul W / Stull, Terrence L / Staples, Megan / Atack, John M

    FEMS microbiology letters

    2022  Volume 369, Issue 1

    Abstract: Non-typeable Haemophilus influenzae (NTHi) is a major human pathogen for which there is no globally licensed vaccine. NTHi has a strict growth requirement for iron and encodes several systems to scavenge elemental iron and heme from the host. An ... ...

    Abstract Non-typeable Haemophilus influenzae (NTHi) is a major human pathogen for which there is no globally licensed vaccine. NTHi has a strict growth requirement for iron and encodes several systems to scavenge elemental iron and heme from the host. An effective NTHi vaccine would target conserved, essential surface factors, such as those involved in iron acquisition. Haemoglobin-haptoglobin binding proteins (Hgps) are iron-uptake proteins localized on the outer-membrane of NTHi. If the Hgps are to be included as components of a rationally designed subunit vaccine against NTHi, it is important to understand their prevalence and diversity. Following analysis of all available Hgp sequences, we propose a standardized grouping method for Hgps, and demonstrate increased diversity of these proteins than previously determined. This analysis demonstrated that genes encoding variants HgpB and HgpC are present in all strains examined, and almost 40% of strains had a duplicate, nonidentical hgpB gene. Hgps are also phase-variably expressed; the encoding genes contain a CCAA(n) simple DNA sequence repeat tract, resulting in biphasic ON-OFF switching of expression. Examination of the ON-OFF state of hgpB and hgpC genes in a collection of invasive NTHi isolates demonstrated that 58% of isolates had at least one of hgpB or hgpC expressed (ON). Varying expression of a diverse repertoire of hgp genes would provide strains a method of evading an immune response while maintaining the ability to acquire iron via heme. Structural analysis of Hgps also revealed high sequence variability at the sites predicted to be surface exposed, demonstrating a further mechanism to evade the immune system-through varying the surface, immune-exposed regions of the membrane anchored protein. This information will direct and inform the choice of candidates to include in a vaccine against NTHi.
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Carrier Proteins/genetics ; Haemophilus influenzae/genetics ; Haptoglobins/metabolism ; Heme/metabolism ; Hemoglobins/metabolism ; Iron/metabolism
    Chemical Substances Bacterial Proteins ; Carrier Proteins ; Haptoglobins ; Hemoglobins ; Heme (42VZT0U6YR) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2022-07-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752343-9
    ISSN 1574-6968 ; 0378-1097
    ISSN (online) 1574-6968
    ISSN 0378-1097
    DOI 10.1093/femsle/fnac064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Iohexol-measured glomerular filtration rate in children and adolescents with chronic kidney disease: a pilot study comparing venous and finger stick methods.

    Staples, Amy / Wong, Craig / Schwartz, George J

    Pediatric nephrology (Berlin, Germany)

    2018  Volume 34, Issue 3, Page(s) 459–464

    Abstract: Background: Measurement of glomerular filtration rate by iohexol disappearance (iGFR) has become a gold standard in the pediatric chronic kidney disease (CKD) population. The need for serial phlebotomy can be difficult and minimizing venipunctures would ...

    Abstract Background: Measurement of glomerular filtration rate by iohexol disappearance (iGFR) has become a gold standard in the pediatric chronic kidney disease (CKD) population. The need for serial phlebotomy can be difficult and minimizing venipunctures would be beneficial. Furthermore, finger stick collection for dried blood spot (DBS) may be more tolerable in the pediatric population, and equivalence between these two methods may further simplify the process.
    Methods: This was a cross-sectional study in children and adolescents 1 to 21 years with stages I-IV CKD. Iohexol was infused and blood drawn 10, 30, 120, and 300 min later. Blood spots on filter paper were collected by finger stick after each of the latter two blood draws. The rate of iohexol plasma disappearance was used to calculate GFR. Pearson's correlation coefficient and bias, Students t test, and Bland-Altman graphical representations were used to compare methods.
    Results: Forty-one patients were recruited. The mean creatinine was 1.13 mg/dL (SD 0.45), the mean 4-point iGFR was 73.2 ml/min/1.73m
    Conclusions: The 2-point iGFR was highly correlated and agreed well with the 4-point iGFR. The same was true for the DBS method and the 2-point venous method. DBS sampling by finger stick sampling at 2 time points after iohexol infusion gave an acceptably accurate measurement of GFR.
    MeSH term(s) Adolescent ; Age Factors ; Blood Specimen Collection/adverse effects ; Blood Specimen Collection/methods ; Child ; Contrast Media/administration & dosage ; Contrast Media/analysis ; Contrast Media/metabolism ; Creatinine/blood ; Cross-Sectional Studies ; Female ; Glomerular Filtration Rate ; Humans ; Injections, Intravenous ; Iohexol/administration & dosage ; Iohexol/analysis ; Iohexol/metabolism ; Male ; Metabolic Clearance Rate ; Pilot Projects ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/physiopathology
    Chemical Substances Contrast Media ; Iohexol (4419T9MX03) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2018-10-12
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-018-4110-4
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    Zs.A 2196: Show issues Location:
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  6. Article: Genomic Evaluation of the Genus

    Hughes, Holly R / Velez, Jason O / Fitzpatrick, Kelly / Davis, Emily H / Russell, Brandy J / Lambert, Amy J / Staples, J Erin / Brault, Aaron C

    Diseases (Basel, Switzerland)

    2021  Volume 9, Issue 4

    Abstract: The type species of the ... ...

    Abstract The type species of the genus
    Language English
    Publishing date 2021-12-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases9040092
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  7. Article: The influence of sociodemographic factors and response style on caregiver report of infant developmental status.

    Connery, Amy K / Raghunathan, Radhika S / Colbert, Alison M / Erdodi, Laszlo / Warschausky, Seth / Huth-Bocks, Alissa / Gerry Taylor, H / Raghunathan, Trivellore / Berglund, Patricia / Staples, Angela D / Lukomski, Angela / Kirkland, Jazmine / Cano, Jennifer / Lajiness-O'Neill, Renee

    Frontiers in pediatrics

    2023  Volume 10, Page(s) 1080163

    Abstract: Caregiver report is the most feasible way to assess early childhood development but is susceptible to the influences of response style and sociodemographic factors. In a sample of 571 caregiver-infant dyads (47.8% female; 48% White), we compared ... ...

    Abstract Caregiver report is the most feasible way to assess early childhood development but is susceptible to the influences of response style and sociodemographic factors. In a sample of 571 caregiver-infant dyads (47.8% female; 48% White), we compared caregiver reports on the Ages and Stages Questionnaire-Third Edition (ASQ-3) with reports on a novel, web-based assessment, PediaTrac™. Ratings on PediaTrac correlated with ratings on the ASQ-3 at all time points (2, 4, 6, and 9 months). Caregiver age, response style, and sociodemographic factors accounted for significant variance on both measures. Developmental reporting of early childhood skills is influenced by caregiver response style and sociodemographic factors. These influences must be considered in order to ensure the accurate identification of infant developmental status.
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.1080163
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  8. Article ; Online: Phylogeny of Yellow Fever Virus, Uganda, 2016.

    Hughes, Holly R / Kayiwa, John / Mossel, Eric C / Lutwama, Julius / Staples, J Erin / Lambert, Amy J

    Emerging infectious diseases

    2018  Volume 24, Issue 8

    Abstract: In April 2016, a yellow fever outbreak was detected in Uganda. Removal of contaminating ribosomal RNA in a clinical sample improved the sensitivity of next-generation sequencing. Molecular analyses determined the Uganda yellow fever outbreak was distinct ...

    Abstract In April 2016, a yellow fever outbreak was detected in Uganda. Removal of contaminating ribosomal RNA in a clinical sample improved the sensitivity of next-generation sequencing. Molecular analyses determined the Uganda yellow fever outbreak was distinct from the concurrent yellow fever outbreak in Angola, improving our understanding of yellow fever epidemiology.
    MeSH term(s) Humans ; Phylogeny ; RNA, Viral/genetics ; Uganda/epidemiology ; Yellow Fever/epidemiology ; Yellow Fever/virology ; Yellow fever virus/genetics
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2018-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2408.180588
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  9. Article ; Online: Characterization of the Phase-Variable Autotransporter Lav Reveals a Role in Host Cell Adherence and Biofilm Formation in Nontypeable Haemophilus influenzae.

    Phillips, Zachary N / Garai, Preeti / Tram, Greg / Martin, Gael / Van Den Bergh, Annelies / Husna, Asma-Ul / Staples, Megan / Grimwood, Keith / Jennison, Amy V / Guillon, Patrice / von Itzstein, Mark / Jennings, Michael P / Brockman, Kenneth L / Atack, John M

    Infection and immunity

    2022  Volume 90, Issue 4, Page(s) e0056521

    Abstract: Lav is an autotransporter protein found in pathogenic Haemophilus ... ...

    Abstract Lav is an autotransporter protein found in pathogenic Haemophilus and
    MeSH term(s) Biofilms ; Haemophilus Infections ; Haemophilus influenzae/genetics ; Haemophilus influenzae/metabolism ; Humans ; Type V Secretion Systems/genetics ; Type V Secretion Systems/metabolism
    Chemical Substances Type V Secretion Systems
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00565-21
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  10. Article ; Online: Reassortant Cache Valley Virus Associated With Acute Febrile, Nonneurologic Illness, Missouri.

    Baker, Molly / Hughes, Holly R / Naqvi, S Hasan / Yates, Karen / Velez, Jason O / McGuirk, Sophia / Schroder, Barb / Lambert, Amy J / Kosoy, Olga I / Pue, Howard / Turabelidze, George / Staples, J Erin

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 9, Page(s) 1700–1702

    Abstract: An adult male from Missouri sought care for fever, fatigue, and gastrointestinal symptoms. He had leukopenia and thrombocytopenia and was treated for a presumed tickborne illness. His condition deteriorated with respiratory and renal failure, lactic ... ...

    Abstract An adult male from Missouri sought care for fever, fatigue, and gastrointestinal symptoms. He had leukopenia and thrombocytopenia and was treated for a presumed tickborne illness. His condition deteriorated with respiratory and renal failure, lactic acidosis, and hypotension. Next-generation sequencing and phylogenetic analysis identified a reassortant Cache Valley virus.
    MeSH term(s) Adult ; Bunyamwera virus ; Bunyaviridae Infections/diagnosis ; Bunyaviridae Infections/epidemiology ; Fever ; Humans ; Male ; Missouri/epidemiology ; Phylogeny
    Language English
    Publishing date 2021-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab175
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    Zs.MO 480: Show issues

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