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Article ; Online: Riempjes (Corrigiola litoralis L.) terug in het rivierengebied

Peters, B.W.E. / Weeda, E.J. / Teunissen, T.H. / van den Berg, L.J.

2004 Volume 30, Issue 6

Abstract: Riempjes lijkt definitief terug in het Nederlandse rivierengebied. Vanaf de eerste waarnemingen in 1996 is zowel het aantal groeiplaatsen als het aantal exemplaren langs de Waal in de omgeving van Nijmegen gestaag toegenomen, met als belangrijkste ... ...

Abstract	Riempjes lijkt definitief terug in het Nederlandse rivierengebied. Vanaf de eerste waarnemingen in 1996 is zowel het aantal groeiplaatsen als het aantal exemplaren langs de Waal in de omgeving van Nijmegen gestaag toegenomen, met als belangrijkste standplaatsen: de Gendtse Polder, de Bizonbaai (Ooijpolder) en de Oosterhoutsche Waard
Keywords	betuwe ; caryophyllaceae ; gelderland ; phytogeography ; river forelands ; rivers ; inventarisaties ; plantengeografie ; uiterwaarden
Language	Dutch
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2858950-6
ISSN	0017-2294
ISSN	0017-2294
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effect of lauryl capping group on protein release and degradation of poly(D,L-lactic-co-glycolic acid) particles.

Samadi, N / Abbadessa, A / Di Stefano, A / van Nostrum, C F / Vermonden, T / Rahimian, S / Teunissen, E A / van Steenbergen, M J / Amidi, M / Hennink, W E

Journal of controlled release : official journal of the Controlled Release Society

2013 Volume 172, Issue 2, Page(s) 436–443

Abstract: The aim of this study was to investigate the effect of a specific and frequently used end group (lauryl alcohol) on the protein release and degradation kinetics of poly(DL-lactic-co-glycolic acid) particles of different sizes. Lauryl-capped PLGA and ... ...

Abstract	The aim of this study was to investigate the effect of a specific and frequently used end group (lauryl alcohol) on the protein release and degradation kinetics of poly(DL-lactic-co-glycolic acid) particles of different sizes. Lauryl-capped PLGA and uncapped PLGA (referred to as PLGA-capped and PLGA-COOH, respectively) particles (0.3, 1 and 20 μm) were prepared by a double emulsion solvent evaporation technique. Bovine serum albumin (BSA) was used as a model protein for release studies. During degradation (PBS buffer, pH7.4 at 37°C), a slower dry mass loss was observed for 0.3 μm particles than for particles of 1 and 20 μm. It was further shown that PLGA-capped particles showed slower mass loss likely due to its more hydrophobic nature. It was found that the ester bond hydrolysis rate was substantially slower for PLGA-capped particles and that the rate increased with particle size. Particles showed enrichment in lactic acid content (and thus a decrease in glycolic acid content) in time, and interestingly PLGA-capped particles showed also an enrichment of the lauryl alcohol content. No difference was observed in degradation kinetics between BSA loaded and blank particles. Independent of size, PLGA-COOH based particles showed, after a small burst, a sustained and nearly complete release of BSA during 60-80 days. On the other hand, particles based on PLGA-capped showed a much slower release and exhibited incomplete release, accompanied by the presence of an insoluble residue remaining even after 180 days. FTIR analysis of this residue showed that it contained both polymer and protein. Considering the polymer enrichment in lauryl alcohol, the incomplete release observed for PLGA-capped is likely attributed to interactions between the protein and the lauryl end group. In conclusion, since PLGA-COOH, in contrast to the capped derivative, shows complete degradation as well as quantitative release of an entrapped protein, this polymer is preferred for the design of protein formulations.
MeSH term(s)	Animals ; Cattle ; Dodecanol/chemistry ; Dodecanol/metabolism ; Drug Carriers/chemistry ; Drug Carriers/metabolism ; Hydrolysis ; Lactic Acid/chemistry ; Lactic Acid/metabolism ; Particle Size ; Polyglycolic Acid/chemistry ; Polyglycolic Acid/metabolism ; Serum Albumin, Bovine/administration & dosage
Chemical Substances	Drug Carriers ; polylactic acid-polyglycolic acid copolymer ; Dodecanol (178A96NLP2) ; Polyglycolic Acid (26009-03-0) ; Serum Albumin, Bovine (27432CM55Q) ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2013-12-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2013.05.034
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Article ; Online: Medicatie tegen ernstige aanhoudende vermoeidheid.

De Wit, Laura E / Vis, Roeland / Teunissen, Laurien L

Nederlands tijdschrift voor geneeskunde

2024 Volume 168

Abstract: About 20% of adults experience excessive daytime sleepiness or severe fatigue. Causes include somatic conditions, psychiatric disorders, and medication or drug use. Treatment depends on the underlying cause. If sleepiness persists despite optimal ... ...

Title translation	Wakefulness-promoting agents for severe fatigue: to use or not to use?
Abstract	About 20% of adults experience excessive daytime sleepiness or severe fatigue. Causes include somatic conditions, psychiatric disorders, and medication or drug use. Treatment depends on the underlying cause. If sleepiness persists despite optimal treatment of the underlying condition, exclusion of other causes, and behavioral interventions, wakefulness-promoting agents may be considered. However, no established pharmacological strategy exists for symptomatic treatment. Modafinil and stimulants like methylphenidate may offer some benefit based on experiences with narcolepsy or idiopathic hypersomnia. Studies in specific patient groups (e.g., multiple sclerosis, Parkinson's disease, traumatic brain injury, cancer-related fatigue) show variable results. The use of wakefulness-promoting agents is discouraged for addressing unexplained fatigue, as seen in the context of chronic fatigue syndrome.
MeSH term(s)	Adult ; Humans ; Wakefulness-Promoting Agents/therapeutic use ; Central Nervous System Stimulants/therapeutic use ; Modafinil/therapeutic use ; Behavior Therapy ; Brain Injuries, Traumatic
Chemical Substances	Wakefulness-Promoting Agents ; Central Nervous System Stimulants ; Modafinil (R3UK8X3U3D)
Language	Dutch
Publishing date	2024-04-16
Publishing country	Netherlands
Document type	English Abstract ; Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article: The effect of lauryl capping group on protein release and degradation of poly(d,l-lactic-co-glycolic acid) particles

Samadi, N / Abbadessa, A / Di Stefano, A / van Nostrum, C.F / Vermonden, T / Rahimian, S / Teunissen, E.A / van Steenbergen, M.J / Amidi, M / Hennink, W.E

Journal of controlled release. 2013 Dec. 10, v. 172, no. 2

2013

Abstract	The aim of this study was to investigate the effect of a specific and frequently used end group (lauryl alcohol) on the protein release and degradation kinetics of poly(DL-lactic-co-glycolic acid) particles of different sizes. Lauryl-capped PLGA and uncapped PLGA (referred to as PLGA-capped and PLGA-COOH, respectively) particles (0.3, 1 and 20μm) were prepared by a double emulsion solvent evaporation technique. Bovine serum albumin (BSA) was used as a model protein for release studies. During degradation (PBS buffer, pH7.4 at 37°C), a slower dry mass loss was observed for 0.3μm particles than for particles of 1 and 20μm. It was further shown that PLGA-capped particles showed slower mass loss likely due to its more hydrophobic nature. It was found that the ester bond hydrolysis rate was substantially slower for PLGA-capped particles and that the rate increased with particle size. Particles showed enrichment in lactic acid content (and thus a decrease in glycolic acid content) in time, and interestingly PLGA-capped particles showed also an enrichment of the lauryl alcohol content. No difference was observed in degradation kinetics between BSA loaded and blank particles. Independent of size, PLGA-COOH based particles showed, after a small burst, a sustained and nearly complete release of BSA during 60–80days. On the other hand, particles based on PLGA-capped showed a much slower release and exhibited incomplete release, accompanied by the presence of an insoluble residue remaining even after 180days. FTIR analysis of this residue showed that it contained both polymer and protein. Considering the polymer enrichment in lauryl alcohol, the incomplete release observed for PLGA-capped is likely attributed to interactions between the protein and the lauryl end group. In conclusion, since PLGA-COOH, in contrast to the capped derivative, shows complete degradation as well as quantitative release of an entrapped protein, this polymer is preferred for the design of protein formulations.
Keywords	Fourier transform infrared spectroscopy ; alcohols ; bovine serum albumin ; emulsions ; evaporation ; glycolic acid ; hydrolysis ; hydrophobicity ; lactic acid ; particle size ; polymers ; solvents
Language	English
Dates of publication	2013-1210
Size	p. 436-443.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2013.05.034
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Adverse effectsof agricultaral intensification and climate change on breeding habitat quality of Blacktailed Godwits Limosa l. limosa in the Netherlands

Kleijn, D. / Schekkerman, H. / Dimmers, W.J. / van Kats, R.J.M. / Melman, T.C.P. / Teunissen, W.A.

Ibis

2010 Volume 152, Issue 3

Abstract: ... climate change on a grassland breeding wader, the Black-tailed Godwit Limosa l. limosa, in the Netherlands ...

Abstract	Agricultural intensification is one of the main drivers of farmland bird declines, but effects on birds may be confounded with those of climate change. Here we examine the effects of intensification and climate change on a grassland breeding wader, the Black-tailed Godwit Limosa l. limosa, in the Netherlands. Population decline has been linked to poor chick survival which, in turn, has been linked to available foraging habitat. Foraging habitat of the nidifugous chicks consists of uncut grasslands that provide cover and arthropod prey. Conservation measures such as agri-environment schemes aim to increase the availability of chick foraging habitat but have not yet been successful in halting the decline. Field observations show that since the early 1980s, farmers advanced their first seasonal mowing or grazing date by 15 days, whereas Godwits did not advance their hatching date. Ringing data indicate that between 1945 and 1975 hatching dates advanced by about 2 weeks in parallel with the advancement of median mowing dates. Surprisingly, temperature sums at median mowing and hatching dates suggest that while the agricultural advancement before 1980 was largely due to agricultural intensification, after 1980 it was largely due to climate change. Examining arthropod abundance in a range of differently managed grasslands revealed that chick food abundance was little affected but that food accessibility in intensively used tall swards may be problematic for chicks. Our results suggest that, compared with 25 years ago, nowadays (1) a much higher proportion of clutches and chicks are exposed to agricultural activities, (2) there is little foraging habitat left when chicks hatch and (3) because of climate change, the vegetation in the remaining foraging habitat is taller and denser and therefore of lower quality. This indicates that for agri-environment schemes to make a difference, they should not only be implemented in a larger percentage of the breeding area than the current maxima of 20–30% but they should also ...
Keywords	agri-environment schemes ; biodiversity ; britain ; chicks ; eggs ; europe ; farmland bird populations ; grassland management ; intensity ; lapwing vanellus-vanellus
Subject code	333
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2071870-6
ISSN	1474-919X ; 0019-1019
ISSN (online)	1474-919X
ISSN	0019-1019
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Adverse effects of agricultural intensification and climate change on breeding habitat quality of Black-tailed Godwits Limosa l. limosa in the Netherlands

KLEIJN, DAVID / SCHEKKERMAN, HANS / DIMMERS, WIM J / VAN KATS, RUUD J.M / MELMAN, DICK / TEUNISSEN, WOLF A

Ibis. 2010 July, v. 152, no. 3

2010

Abstract: ... climate change on a grassland breeding wader, the Black-tailed Godwit Limosa l. limosa, in the Netherlands ...

Abstract	Agricultural intensification is one of the main drivers of farmland bird declines, but effects on birds may be confounded with those of climate change. Here we examine the effects of intensification and climate change on a grassland breeding wader, the Black-tailed Godwit Limosa l. limosa, in the Netherlands. Population decline has been linked to poor chick survival which, in turn, has been linked to available foraging habitat. Foraging habitat of the nidifugous chicks consists of uncut grasslands that provide cover and arthropod prey. Conservation measures such as agri-environment schemes aim to increase the availability of chick foraging habitat but have not yet been successful in halting the decline. Field observations show that since the early 1980s, farmers advanced their first seasonal mowing or grazing date by 15 days, whereas Godwits did not advance their hatching date. Ringing data indicate that between 1945 and 1975 hatching dates advanced by about 2 weeks in parallel with the advancement of median mowing dates. Surprisingly, temperature sums at median mowing and hatching dates suggest that while the agricultural advancement before 1980 was largely due to agricultural intensification, after 1980 it was largely due to climate change. Examining arthropod abundance in a range of differently managed grasslands revealed that chick food abundance was little affected but that food accessibility in intensively used tall swards may be problematic for chicks. Our results suggest that, compared with 25 years ago, nowadays (1) a much higher proportion of clutches and chicks are exposed to agricultural activities, (2) there is little foraging habitat left when chicks hatch and (3) because of climate change, the vegetation in the remaining foraging habitat is taller and denser and therefore of lower quality. This indicates that for agri-environment schemes to make a difference, they should not only be implemented in a larger percentage of the breeding area than the current maxima of 20-30% but they should also include measures that create more open, accessible swards.
Keywords	grasslands
Language	English
Dates of publication	2010-07
Size	p. 475-486.
Publisher	Blackwell Publishing Ltd
Publishing place	Oxford, UK
Document type	Article
ZDB-ID	2071870-6
ISSN	1474-919X ; 0019-1019
ISSN (online)	1474-919X
ISSN	0019-1019
DOI	10.1111/j.1474-919X.2010.01025.x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Followership in interprofessional healthcare teams: a state-of-the-art narrative review.

Barry, Erin S / Teunissen, Pim / Varpio, Lara

BMJ leader

2023

Abstract: Objective: A state-of-the-art (SotA) literature review-a type of narrative review- was conducted to answer: What historical developments led to current conceptualisations of followership in interprofessional healthcare teams (IHTs)?: Design: Working ... ...

Abstract	Objective: A state-of-the-art (SotA) literature review-a type of narrative review- was conducted to answer: What historical developments led to current conceptualisations of followership in interprofessional healthcare teams (IHTs)? Design: Working from a constructivist orientation, SotA literature reviews generate a chronological overview of how knowledge evolved and presents this summary in three parts: (1) this is where we are now, (2) this is how we got here and (3) this is where we should go next. Using the SotA six-stage methodology, a total of 48 articles focused on followership in IHTs were used in this study. Results: Articles about followership within IHTs first appeared in 1993. Until 2011, followership was framed as leader-centric; leaders used their position to influence followers to uphold their dictums. This perspective was challenged when scholars outside of healthcare emphasised the importance of team members for achieving goals, rejecting a myopic focus on physicians as leaders. Today, followership is an important focus of IHT research but two contradictory views are present: (1) followers are described as active team members in IHTs where shared leadership models prevail and (2) conceptually and practically, old ways of thinking about followership (ie, followers are passive team members) still occur. This incongruity has generated a variable set of qualities associated with good followership. Conclusions: Leadership and followership are closely linked concepts. For leaders and followers in today's IHTs to flourish, the focus must be on followers being active members of the team instead of passive members. Since theories are increasingly encouraging distributed leadership, shared leadership and/or situational leadership, then we must understand the followership work that all team members need to harness. We need to be cognizant of team dynamics that work within different contexts and use leadership and followership conceptualisations that are congruent with those contexts.
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article
ISSN	2398-631X
ISSN (online)	2398-631X
DOI	10.1136/leader-2023-000773
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Article ; Online: Abrupt, but not gradual, motor adaptation biases saccadic target selection.

Teunissen, Lonneke / Selen, Luc P J / Medendorp, W Pieter

Journal of neurophysiology

2023 Volume 129, Issue 3, Page(s) 733–748

Abstract: Motor costs influence movement selection. These costs could change when movements are adapted in response to errors. When the motor system attributes the encountered errors to an external cause, appropriate movement selection requires an update of the ... ...

Abstract	Motor costs influence movement selection. These costs could change when movements are adapted in response to errors. When the motor system attributes the encountered errors to an external cause, appropriate movement selection requires an update of the movement goal, which prompts the selection of a different control policy. However, when errors are attributed to an internal cause, the initially selected control policy could remain unchanged, but the internal forward model of the body needs to be updated, resulting in an online correction of the movement. We hypothesized that external attribution of errors leads to the selection of a different control policy, and thus to a change in the expected cost of movements. This should also affect subsequent motor decisions. Conversely, internal attribution of errors may (initially) only evoke online corrections, and thus is expected to leave the motor decision process unchanged. We tested this hypothesis using a saccadic adaptation paradigm, designed to change the relative motor cost of two targets. Motor decisions were measured using a target selection task between the two saccadic targets before and after adaptation. Adaptation was induced by either abrupt or gradual perturbation schedules, which are thought to induce more external or internal attribution of errors, respectively. By taking individual variability into account, our results show that saccadic decisions shift toward the least costly target after adaptation, but only when the perturbation is abruptly, and not gradually, introduced. We suggest that credit assignment of errors not only influences motor adaptation but also subsequent motor decisions.
MeSH term(s)	Psychomotor Performance/physiology ; Adaptation, Physiological/physiology ; Movement/physiology ; Saccades ; Bias
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.00223.2022
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Conference proceedings ; Online: LAMBDA 4.0

Massarweh, L. / Verhagen, S. / Teunissen, P.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

an advanced tool for integer estimation, validation and success rate simulation

2023

Abstract: ... given by the Least-squares AMBiguity Decorrelation Adjustment (LAMBDA) method, described in Teunissen (1995 ...

Abstract	The correct resolution of the carrier-phase integer ambiguity is a key aspect for centimetre-level precise positioning with Global Navigation Satellite Systems (GNSS). This integer ambiguity resolution (IAR) process enables the adoption of phase observations as ultra-precise pseudo-range measurements, thus leveraging their millimetre-level precision. An effective and rigorous approach to IAR problems has been given by the Least-squares AMBiguity Decorrelation Adjustment (LAMBDA) method, described in Teunissen (1995). In addition to integer estimation and validation, implemented in the open source LAMBDA software, an evaluation of IAR success rate for different estimators has been made possible by the release of a Ps-LAMBDA toolbox.In this work, we describe the LAMBDA 4.0 toolbox, which has recently been developed by the GNSS research group at TU Delft. This toolbox merges the LAMBDA 3.0 (2012) and Ps-LAMBDA 1.0 (2013) functionalities into a single framework, where new different estimators are implemented, e.g. Vectorial Integer Bootstrapping (VIB), Integer Aperture Bootstrapping (IAB) and Best Integer Equivariant (BIE) solutions. Moreover, different algorithm modifications are introduced for enhanced performances, e.g. in the integer search process, so targeting high dimensional ambiguity resolution (HDAR) problems, which are foreseen to become more and more important in the future years. This high dimensionality challenge is expected in view of the possible deployment of new satellite mega-constellations in Low Earth Orbit (LEO), with hundreds of satellites being tracked by user receivers. This new LAMBDA 4.0 toolbox will officially be released to the public later this year.
Subject code	000
Language	English
Publishing date	2023-07-11
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Shame at the Gates of Medicine: A Hermeneutic Exploration of Premedical Students' Experiences of Shame.

Bynum, William E / Jackson, Joseph A / Varpio, Lara / Teunissen, Pim W

Academic medicine : journal of the Association of American Medical Colleges

2023 Volume 98, Issue 6, Page(s) 709–716

Abstract: Purpose: Little is known about the nature of shame in students attempting to enter medical school, despite its potential to impact well-being and professional identity formation during training. In this study, the authors used hermeneutic phenomenology ... ...

Abstract	Purpose: Little is known about the nature of shame in students attempting to enter medical school, despite its potential to impact well-being and professional identity formation during training. In this study, the authors used hermeneutic phenomenology to ask: How do premedical students experience shame as they apply to medical school? Method: From September 2020 to March 2021, the authors recruited 12 students from a U.S. Master of Biomedical Sciences program who intended to apply to medical school. Data collection consisted of each participant creating a "rich picture" depicting a shame experience during their premedical training, a semistructured interview that deeply explored this and other shame experiences, and a debriefing session. Data were analyzed using Ajjawi and Higgs's 6 steps of hermeneutic analysis. Results: Self-concept, composed of an individual's identities and contingencies of self-esteem, was central to participants' shame experiences. Through a confluence of past and future self-concepts and under the influence of external factors and the weight of expectations, shame often destabilized participants' present self-concepts. This destabilization occurred because of events related to application processes (repeat Medical College Admission Test attempts), interpersonal interactions (prehealth advisor meetings), and objective performance measures (grades, test scores). Participants' efforts to restabilize their self-concept catalyzed specific identity processes and self-concept formation. Conclusions: Shame provided a window into the emotional experiences, identity processes, and ideologies that shape students' attempts to enter medical school. The authors discuss the central role of contingencies of self-esteem, the potential origins of performance-based self-esteem in trainees, and the identity negotiation and identity work involved in shame reactions. They call for the adoption of contingencies of self-esteem within current conceptualizations of professional identity formation; training for faculty and prehealth advisors about the nature of shame in premedical learners; and consideration of the consequential validity of standardized tests, which may trigger damaging shame.
MeSH term(s)	Humans ; Hermeneutics ; Students, Premedical ; Shame ; Emotions ; Curriculum
Language	English
Publishing date	2023-01-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000005152
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