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  1. Article: Human macrophage-engineered vesicles for utilization in ovarian cancer treatment.

    Schweer, David / Anand, Namrata / Anderson, Abigail / McCorkle, J Robert / Neupane, Khaga / Nail, Alexandra N / Harvey, Brock / Hill, Kristen S / Ueland, Frederick / Richards, Christopher / Kolesar, Jill

    Frontiers in oncology

    2023  Volume 12, Page(s) 1042730

    Abstract: Background: Ovarian cancer is a deadly female malignancy with a high rate of recurrent and chemotherapy-resistant disease. Tumor-associated macrophages (TAMs) are a significant component of the tumor microenvironment and include high levels of M2- ... ...

    Abstract Background: Ovarian cancer is a deadly female malignancy with a high rate of recurrent and chemotherapy-resistant disease. Tumor-associated macrophages (TAMs) are a significant component of the tumor microenvironment and include high levels of M2-protumor macrophages that promote chemoresistance and metastatic spread. M2 macrophages can be converted to M1 anti-tumor macrophages, representing a novel therapeutic approach. Vesicles engineered from M1 macrophages (MEVs) are a novel method for converting M2 macrophages to M1 phenotype-like macrophages.
    Methods: Macrophages were isolated and cultured from human peripheral blood mononuclear cells. Macrophages were stimulated to M1 or M2 phenotypes utilizing LPS/IFN-γ and IL-4/IL-13, respectively. M1 MEVs were generated with nitrogen cavitation and ultracentrifugation. Co-culture of ovarian cancer cells with macrophages and M1 MEVs was followed by cytokine, PCR, and cell viability analysis. Murine macrophage cell line, RAW264.7 cells were cultured and used to generate M1 MEVs for use in ovarian cancer xenograft models.
    Results: M1 MEVs can effectively convert M2 macrophages to an M1-like state both in isolation and when co-cultured with ovarian cancer cells
    Conclusion: Human M1 MEVs can repolarize M2 macrophages to a M1 state and have anti-cancer activity against ovarian cancer cell lines. RAW264.7 M1 MEVs localize to tumor xenografts
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1042730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Prolonged Prophylaxis in Orthopedic Surgery: Insights from the United States

    Anderson, Jr., Frederick A. / White, Kami

    Seminars in Thrombosis and Hemostasis

    (Women's Issues in Thrombophilia)

    2003  Volume 29, Issue 02, Page(s) 235–235

    Series title Women's Issues in Thrombophilia
    Language English
    Publishing date 2003-01-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-2003-38841
    Database Thieme publisher's database

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  3. Article: Prey Size Selection under Simultaneous Choice by the Broad-Headed Skink (Eumeces laticeps)

    Cooper, William E. Jr / Anderson, Roger A / Frederick, William G

    Ethology. 2007 May, v. 113, no. 5

    2007  

    Abstract: Diet selection among several prey types present in a dense aggregation, permitting a predator to become satiated without changing patches, may be important for predators that can eat many small prey items in a single bout. Choice in this scenario differs ...

    Abstract Diet selection among several prey types present in a dense aggregation, permitting a predator to become satiated without changing patches, may be important for predators that can eat many small prey items in a single bout. Choice in this scenario differs from that in optimal foraging models for sequential diet choice model and simultaneous choice models when travel time between patches is needed. Furthermore, satiation and depletion effects may be important in dense prey aggregations. We predicted that in dense prey aggregations, predators should eat the most profitable prey first, switching to smaller prey as larger ones become depleted and predators become satiated, and that prey below some minimum profitability should be rejected. When large numbers of prey of varying sizes were presented simultaneously, broad-headed skinks (Eumeces laticeps) preferentially consumed large crickets, ate some medium-sized crickets late in ingestion sequences, but ate no small crickets. Prey depletion, with selection of the currently most profitable prey type, appears to account for much of observed prey switching, and satiation may contribute. When four crickets of each of four sizes were presented, lizards ate largest first, then medium-sized. Some then ate small crickets, but none ate very small crickets. These observations and exclusion of small crickets from the diet by many lizards when larger ones were unavailable support the predictions. In tests with three sizes of juvenile mice presented singly, the smallest were attacked at shortest latency and eaten, medium-sized mice were attacked at greater latency but could not be subdued, and large mice were not attacked. These data suggest that as prey become too large to subdue and eat readily, profitability declines until they are excluded from the diet. Unsuccessful attacks on medium-sized mice suggest that lizards had to learn their own capabilities with respect to a novel prey type.
    Keywords Orthoptera ; Scincidae ; diet ; foraging ; ingestion ; juveniles ; lizards ; mice ; models ; predators ; prediction ; satiety
    Language English
    Size p. 417-425.
    Publishing place Blackwell Publishing Ltd
    Document type Article
    ZDB-ID 2020221-0
    ISSN 1439-0310 ; 0179-1613
    ISSN (online) 1439-0310
    ISSN 0179-1613
    DOI 10.1111/j.1439-0310.2006.01327.x
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Prolonged Prophylaxis in Orthopedic Surgery: Insights from the United States

    Anderson Jr., Frederick A. / White, Kami

    Seminars in Thrombosis and Hemostasis

    2002  Volume 28, Issue s3, Page(s) 43–46

    Abstract: The U.S. Hip and Knee Registry is a voluntary national registry of outcome data for hip and knee surgery. In total, 469 orthopedic surgeons from 325 hospitals reported data on 7677 patients who underwent total hip arthroplasty (THA) and 11,461 patients ... ...

    Abstract The U.S. Hip and Knee Registry is a voluntary national registry of outcome data for hip and knee surgery. In total, 469 orthopedic surgeons from 325 hospitals reported data on 7677 patients who underwent total hip arthroplasty (THA) and 11,461 patients who underwent total knee arthroplasty (TKA). Data on patients enrolled between 1996 and 2000 indicate that 40% of THA patients and 42% of TKA patients received prophylaxis for a period of 8 to 21 days, including the in-hospital period. Prolonged prophylaxis for more than 21 days was used in 49% of THA patients and 44% of TKA patients. Moreover, year on year, data indicate that the percentage of patients who receive prophylaxis for longer than 21 days is gradually increasing. In 2000, 53% of THA patients and 47% of TKA patients received prophylaxis for longer than 21 days.
    Keywords Orthopedic surgeons ; total hip arthroplasty ; total knee arthroplasty ; thromboprophylaxis ; prolonged prophylaxis
    Language English
    Publishing date 2002-01-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-2002-34075
    Database Thieme publisher's database

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  5. Article ; Online: Diagnostic Methods for Deep Vein Thrombosis

    Wheeler, Brownell / Anderson, Jr., Frederick A.

    Pathophysiology of Haemostasis and Thrombosis

    1995  Volume 25, Issue 1-2, Page(s) 26–26

    Abstract: Clinical diagnosis of deep vein thrombosis (DVT) is unreliable, and treatment should not be undertaken without objective confirmation. The traditional ‘gold standard’ for the diagnosis of DVT has been venography, but ultrasonic imaging has now replaced ... ...

    Abstract Clinical diagnosis of deep vein thrombosis (DVT) is unreliable, and treatment should not be undertaken without objective confirmation. The traditional ‘gold standard’ for the diagnosis of DVT has been venography, but ultrasonic imaging has now replaced venography as the new diagnostic standard in many hospitals. A variety of noninvasive physiologic tests are also useful in selected circumstances. These include plethysmography, Doppler flow studies, radioisotope tests, thermography and peripheral blood tests which reflect activation of coagulation or thrombolysis. We describe the clinical application of these diagnostic procedures, both for symptomatic patients suspected to have DVT and for asymptomatic patients at high risk for DVT. The selection of an appropriate diagnostic modality depends upon institutional capabilities, cost-effectiveness and individual patient circumstances.
    Keywords Deep vein thrombosis ; Diagnosis ; Review ; Venography ; Ultrasonic imaging ; Impedance plethysmography ; Thermography ; Fibrinogen ; Blood tests
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ISSN 1424-8840 ; 1424-8832 ; 1424-8832
    ISSN (online) 1424-8840
    ISSN 1424-8832
    DOI 10.1159/000217140
    Database Karger publisher's database

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  6. Article ; Online: Retrograde type A dissection after thoracic endovascular aortic repair for type B aortic dissection.

    Yammine, Halim / Briggs, Charles S / Stanley, Gregory A / Ballast, Jocelyn K / Anderson, William E / Nussbaum, Tzvi / Madjarov, Jeko / Frederick, John R / Arko, Frank R

    Journal of vascular surgery

    2018  Volume 69, Issue 1, Page(s) 24–33

    Abstract: Background: The purpose of this study was to evaluate clinical, anatomic, and procedural characteristics of patients who developed retrograde type A dissection (RTAD) after thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD).! ...

    Abstract Background: The purpose of this study was to evaluate clinical, anatomic, and procedural characteristics of patients who developed retrograde type A dissection (RTAD) after thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD).
    Methods: Between January 2012 and January 2017, there were 186 patients who underwent TEVAR for TBAD at a multidisciplinary aortic center. Patients who developed RTAD after TEVAR (n = 15) were compared with those who did not (no-RTAD group, n = 171). Primary outcomes were survival and need for reintervention.
    Results: The incidence of RTAD in our sample was 8% (n = 15). Kaplan-Meier estimates found that no-RTAD patients had better survival (P = .04). Survival rates at 30 days, 1 year, and 3 years were 93%, 60%, and 60% for RTAD patients and 94%, 87%, and 80% for no-RTAD patients. One RTAD was diagnosed intraoperatively, 5 were diagnosed within 30 days of the index procedure, 6 were diagnosed within 1 year, and 3 were diagnosed after 1 year. Reintervention for RTAD was undertaken in 10 of 15 patients, with a 50% survival rate after reintervention. Partial or complete false lumen thrombosis was more frequently present in RTAD patients (P = .03). RTAD patients more frequently presented with renal ischemia (P = .04). Most RTAD patients (93%, RTAD patients; 64%, no-RTAD patients; P = .02) had a proximal landing zone in zone 0, 1, or 2. Aortic diameter was more frequently ≥40 mm in the RTAD group (47%, RTAD patients; 21%, no-RTAD patients; P = .05). Patients with RTAD had stent grafts placed in the renovisceral arteries for complicated dissections, and this approached significance (P = .05). Three RTAD patients had a type II arch (20%) compared with 53 no-RTAD patients (31%; P = .6), but a comparison of type II arch with type I or type III found no statistical significance (P = .6). No correlations were found between ratio of descending to ascending diameters, average aortic sizing, graft size, or bare-metal struts at proximal attachment zone and development of RTAD. We found no statistically significant differences in demographics, genetic disease, comorbidities, or previous repairs.
    Conclusions: The development of RTAD after TEVAR for TBAD does not appear to be correlated with any easily identifiable demographic feature but appears to be correlated with proximal landing zones in zone 1 and 2 and an ascending diameter >4 cm. Furthermore, the presence of partial or complete false lumen thrombosis as well as more complicated presentation with renal ischemia was significantly more frequent in patients with RTAD. TBAD patients should be observed long term, as type A dissections in our patients occurred even after 1 year.
    MeSH term(s) Aged ; Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/mortality ; Aneurysm, Dissecting/surgery ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/mortality ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/mortality ; Comorbidity ; Endovascular Procedures/adverse effects ; Endovascular Procedures/mortality ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/etiology ; Postoperative Complications/mortality ; Postoperative Complications/therapy ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2018-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2018.04.047
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  7. Article ; Online: Ethnic disparities in outcomes of patients with complicated type B aortic dissection.

    Yammine, Halim / Ballast, Jocelyn K / Anderson, William E / Frederick, John R / Briggs, Charles S / Roush, Timothy / Madjarov, Jeko M / Nussbaum, Tzvi / Sibille, Joshua A / Arko, Frank R

    Journal of vascular surgery

    2018  Volume 68, Issue 1, Page(s) 36–45

    Abstract: Objective: The objective of this study was to evaluate the difference in outcomes after endovascular intervention in patients with complicated type B aortic dissection (TBAD) based on ethnicity and blood pressure control.: Methods: Between 2012 and ... ...

    Abstract Objective: The objective of this study was to evaluate the difference in outcomes after endovascular intervention in patients with complicated type B aortic dissection (TBAD) based on ethnicity and blood pressure control.
    Methods: Between 2012 and 2016, there were 126 patients who underwent endovascular procedures for complicated TBAD at a single-institution quaternary referral center. Patients self-identified as African American (n = 53), white (n = 70), and Asian (n = 3). African American and white patients were compared on a number of variables, including age, ethnicity, insurance type, blood pressure, comorbidities, number of previous interventions, and number of antihypertension medications they were taking before intervention. Primary outcomes were survival and need for reintervention.
    Results: Kaplan-Meier estimates for survival for African Americans vs whites were 94% vs 89%, 91% vs 83%, 89% vs 79%, and 89% vs 76% at 30 days, 1 year, 3 years, and 5 years, respectively (P = .05). African Americans were younger overall (52.5 ± 11 years) vs whites (63.7 ± 14.7 years; P < .0001). African Americans required a significantly greater number of reinterventions (P = .007). They also had higher rates of chronic kidney disease (P = .01), smoking (P = .03), and cocaine use (P = .02) and were more likely to be on Medicaid (P = .02). Hypertension was poorly controlled in both groups, with the percentage of patients with uncontrolled hypertension (systolic >140 mm Hg) preoperatively, postoperatively, and 30 days after intervention at 32%, 32%, and 39%. There was no significant difference between the cohorts in uncontrolled hypertension preoperatively (P = .39) or postoperatively (P = .63). However, more African Americans had uncontrolled hypertension at 30 days (African Americans, 49%; whites, 31%; odds ratio, 2.1; P = .09). African Americans were taking a greater number of antihypertension medications at presentation than whites (P = .01) and specifically had higher use rates of beta blockers (P = .02), diuretics (P = .02), and angiotensin-converting enzyme inhibitors (P = .04).
    Conclusions: African Americans with TBAD present at a younger age than their white counterparts do and have a survival advantage up to at least 5 years. However, African Americans have a higher rate of reintervention that is probably associated with poor blood pressure control despite taking more antihypertension medications both before and after the repair. It appears that optimal medical therapy is difficult to achieve in all groups. More aggressive medical management is needed, particularly more so in African Americans, which may in turn decrease the number of interventions and potentially improve long-term survival.
    MeSH term(s) Adult ; African Americans ; Age Factors ; Aged ; Aneurysm, Dissecting/complications ; Aneurysm, Dissecting/ethnology ; Aneurysm, Dissecting/mortality ; Aneurysm, Dissecting/surgery ; Antihypertensive Agents/therapeutic use ; Aortic Aneurysm/complications ; Aortic Aneurysm/ethnology ; Aortic Aneurysm/mortality ; Aortic Aneurysm/surgery ; Asian Americans ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/mortality ; Comorbidity ; Databases, Factual ; Endovascular Procedures/adverse effects ; Endovascular Procedures/mortality ; European Continental Ancestry Group ; Female ; Health Status Disparities ; Healthcare Disparities/ethnology ; Humans ; Hypertension/drug therapy ; Hypertension/ethnology ; Kaplan-Meier Estimate ; Life Style/ethnology ; Male ; Middle Aged ; North Carolina ; Postoperative Complications/ethnology ; Postoperative Complications/therapy ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Observational Study
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2017.10.083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Acceptability and feasibility of mHealth and community-based directly observed antiretroviral therapy to prevent mother-to-child HIV transmission in South African pregnant women under Option B+: an exploratory study.

    Nachega, Jean B / Skinner, Donald / Jennings, Larissa / Magidson, Jessica F / Altice, Frederick L / Burke, Jessica G / Lester, Richard T / Uthman, Olalekan A / Knowlton, Amy R / Cotton, Mark F / Anderson, Jean R / Theron, Gerhard B

    Patient preference and adherence

    2016  Volume 10, Page(s) 683–690

    Abstract: Objective: To examine the acceptability and feasibility of mobile health (mHealth)/short message service (SMS) and community-based directly observed antiretroviral therapy (cDOT) as interventions to improve antiretroviral therapy (ART) adherence for ... ...

    Abstract Objective: To examine the acceptability and feasibility of mobile health (mHealth)/short message service (SMS) and community-based directly observed antiretroviral therapy (cDOT) as interventions to improve antiretroviral therapy (ART) adherence for preventing mother-to-child human immunodeficiency virus (HIV) transmission (PMTCT).
    Design and methods: A mixed-method approach was used. Two qualitative focus group discussions with HIV-infected pregnant women (n=20) examined the acceptability and feasibility of two ART adherence interventions for PMTCT: 1) SMS text messaging and 2) patient-nominated cDOT supporters. Additionally, 109 HIV-infected, pregnant South African women (18-30 years old) receiving PMTCT services under single-tablet antiretroviral therapy regimen during pregnancy and breastfeeding and continuing for life ("Option B+") were interviewed about mobile phone access, SMS use, and potential treatment supporters.
    Setting: A community primary care clinic in Cape Town, South Africa.
    Participants: HIV-infected pregnant women.
    Main outcomes: Acceptability and feasibility of mHealth and cDOT interventions.
    Results: Among the 109 women interviewed, individual mobile phone access and SMS use were high (>90%), and 88.1% of women were interested in receiving SMS ART adherence support messages such as reminders, motivation, and medication updates. Nearly all women (95%) identified at least one person close to them to whom they had disclosed their HIV status and would nominate as a cDOT supporter. Focus group discussions revealed that cDOT supporters and adherence text messages were valued, but some concerns regarding supporter time availability and risk of unintended HIV status disclosure were expressed.
    Conclusion: mHealth and/or cDOT supporter as interventions to improve ART adherence are feasible in this setting. However, safe HIV status disclosure to treatment supporters and confidentiality of text messaging content about HIV and ART were deemed crucial.
    Language English
    Publishing date 2016-04-28
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2455848-5
    ISSN 1177-889X
    ISSN 1177-889X
    DOI 10.2147/PPA.S100002
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  9. Article ; Online: Prevention of venous thromboembolism after hip or knee arthroplasty: findings from a 2008 survey of US orthopedic surgeons.

    Anderson, Frederick A / Huang, Wei / Friedman, Richard J / Kwong, Louis M / Lieberman, Jay R / Pellegrini, Vincent D

    The Journal of arthroplasty

    2012  Volume 27, Issue 5, Page(s) 659–66.e5

    Abstract: A survey was mailed to a representative sample of US orthopedic surgeons to assess protocols for the prevention of venous thromboembolism after lower extremity total joint arthroplasty. Practices were examined by type of operation, annual surgical volume, ...

    Abstract A survey was mailed to a representative sample of US orthopedic surgeons to assess protocols for the prevention of venous thromboembolism after lower extremity total joint arthroplasty. Practices were examined by type of operation, annual surgical volume, and opinions of consensus guidelines issued by the American Academy of Orthopaedic Surgeons and the American College of Chest Physicians. Although there was near-unanimous agreement that routine thromboprophylaxis should be the standard practice for patients who undergo hip or knee arthroplasty, surgeons were divided as to the exact management approach.
    MeSH term(s) Anticoagulants/therapeutic use ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Hip/statistics & numerical data ; Arthroplasty, Replacement, Knee/adverse effects ; Arthroplasty, Replacement, Knee/statistics & numerical data ; Aspirin/therapeutic use ; Drug Monitoring/utilization ; Humans ; Orthopedics/education ; Orthopedics/statistics & numerical data ; Population Surveillance ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/statistics & numerical data ; Societies, Medical/statistics & numerical data ; Stockings, Compression/utilization ; United States/epidemiology ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control ; Warfarin/therapeutic use
    Chemical Substances Anticoagulants ; Warfarin (5Q7ZVV76EI) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2012-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2011.09.001
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  10. Article ; Online: The Bee Microbiome: Impact on Bee Health and Model for Evolution and Ecology of Host-Microbe Interactions.

    Engel, Philipp / Kwong, Waldan K / McFrederick, Quinn / Anderson, Kirk E / Barribeau, Seth Michael / Chandler, James Angus / Cornman, R Scott / Dainat, Jacques / de Miranda, Joachim R / Doublet, Vincent / Emery, Olivier / Evans, Jay D / Farinelli, Laurent / Flenniken, Michelle L / Granberg, Fredrik / Grasis, Juris A / Gauthier, Laurent / Hayer, Juliette / Koch, Hauke /
    Kocher, Sarah / Martinson, Vincent G / Moran, Nancy / Munoz-Torres, Monica / Newton, Irene / Paxton, Robert J / Powell, Eli / Sadd, Ben M / Schmid-Hempel, Paul / Schmid-Hempel, Regula / Song, Se Jin / Schwarz, Ryan S / vanEngelsdorp, Dennis / Dainat, Benjamin

    mBio

    2016  Volume 7, Issue 2, Page(s) e02164–15

    Abstract: As pollinators, bees are cornerstones for terrestrial ecosystem stability and key components in agricultural productivity. All animals, including bees, are associated with a diverse community of microbes, commonly referred to as the microbiome. The bee ... ...

    Abstract As pollinators, bees are cornerstones for terrestrial ecosystem stability and key components in agricultural productivity. All animals, including bees, are associated with a diverse community of microbes, commonly referred to as the microbiome. The bee microbiome is likely to be a crucial factor affecting host health. However, with the exception of a few pathogens, the impacts of most members of the bee microbiome on host health are poorly understood. Further, the evolutionary and ecological forces that shape and change the microbiome are unclear. Here, we discuss recent progress in our understanding of the bee microbiome, and we present challenges associated with its investigation. We conclude that global coordination of research efforts is needed to fully understand the complex and highly dynamic nature of the interplay between the bee microbiome, its host, and the environment. High-throughput sequencing technologies are ideal for exploring complex biological systems, including host-microbe interactions. To maximize their value and to improve assessment of the factors affecting bee health, sequence data should be archived, curated, and analyzed in ways that promote the synthesis of different studies. To this end, the BeeBiome consortium aims to develop an online database which would provide reference sequences, archive metadata, and host analytical resources. The goal would be to support applied and fundamental research on bees and their associated microbes and to provide a collaborative framework for sharing primary data from different research programs, thus furthering our understanding of the bee microbiome and its impact on pollinator health.
    MeSH term(s) Animals ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Bees/genetics ; Bees/microbiology ; Bees/physiology ; Biological Evolution ; Microbiota ; Pollination ; Symbiosis
    Language English
    Publishing date 2016-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02164-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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