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  1. Article ; Online: The effect of advanced age on peri- and post-operative complications following pelvic floor repair surgeries.

    Goni, Shelef / Matan, Rotchild / Shanny, Sade / Ilana, Shoham Vardi / Adi, Y Weintraub

    Archives of gynecology and obstetrics

    2024  Volume 309, Issue 5, Page(s) 2247–2252

    Abstract: Objectives: To assess whether advanced age is a risk factor for complications following pelvic organ prolapse (POP) repair surgeries using the Clavien-Dindo classification system.: Methods: In this retrospective cohort study, 260 women who had ... ...

    Abstract Objectives: To assess whether advanced age is a risk factor for complications following pelvic organ prolapse (POP) repair surgeries using the Clavien-Dindo classification system.
    Methods: In this retrospective cohort study, 260 women who had undergone POP repair surgery at the Soroka University Medical Center (SUMC) between the years 2014-2019 were included. A univariate analysis was conducted to compare the demographical, clinical, obstetrical and operative characteristics of patients by age group (younger or older than 70 years). We performed a similar analysis to assess for the possible association between several variables and post-operative complications. Variables that were found to be associated with post-operative complications (P < 0.2) were included in a multivariate analysis along with advanced age.
    Results: During the 12 months follow-up period, more than half of the women had experienced at least one post-operative complication. Minor complications (grades 1-2 according to the Clavian-Dindo classification system) were the most common. One woman had died during the follow-up period, and none had experienced organ failure (grade 4). Hysterectomy, as part of POP surgery, was found to be significantly associated with post-operative complications. Additionally, grandmultiparity (> 5 births) showed a tendency towards an increased risk for post-operative complications, however this reached only borderline significance. We found no association between advanced age and post-operative complications.
    Conclusions: POP repair surgeries are safe for women of all ages. Major complications (grades 3-5) are rare in all age groups. Although advanced age was associated with a higher prevalence of comorbidity and a higher grade of prolapse, no significant difference in the post-operative complications was found between age groups. Concomitant hysterectomy at the time of POP repair surgery is a risk factor for post-operative complications.
    MeSH term(s) Humans ; Female ; Aged ; Retrospective Studies ; Pelvic Floor ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Hysterectomy/adverse effects ; Pelvic Organ Prolapse/surgery ; Pelvic Organ Prolapse/complications
    Language English
    Publishing date 2024-03-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-024-07437-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pelvic floor disorders among amateur runners.

    Sade, Shanny / Naor, Inbar / Rotem, Reut / Waichenberg, Lauren / Kravits, Dana Zilberman / Weintraub, Adi Y

    Archives of gynecology and obstetrics

    2024  Volume 309, Issue 5, Page(s) 2223–2228

    Abstract: Background: Sports and physical activity are known risk factors for pelvic floor dysfunction (PFD). The aim of this study is to examine the impact of amateur running on PFD, quality of life (QoL), and sexual function.: Methods: Amateur runners were ... ...

    Abstract Background: Sports and physical activity are known risk factors for pelvic floor dysfunction (PFD). The aim of this study is to examine the impact of amateur running on PFD, quality of life (QoL), and sexual function.
    Methods: Amateur runners were contacted through social media. Their PFD, sexual function, and QoL were evaluated by self-reporting validated questionnaires (PFDI-20, PISQ-12, IIQ-7). They were divided by degree of effort into two categories, 'High effort' and 'Moderate effort'. The differences between the two groups were examined by a Mann-Whitney U Test, T-Test, and Chi-square test.
    Results: 180 women were included. A high incidence of PFD was found among 'High effort' runners in comparison to 'Moderate effort' runners. In addition, women who scored above the median in the PFDI-20 showed significantly greater impairment in QoL and sexual function. Interestingly, the 'High effort' group reported experiencing higher intensity orgasms compared with women in the 'Moderate effort' group. A correlation was also found between the weekly running distance and the intensity of orgasm experienced (P value = 0.004).
    Conclusion: 'High effort' runners present a higher incidence of PFD in comparison to 'Moderate effort' runners. Professional pelvic floor muscle training counselling should be considered even for amateur runners. Future interventional physical therapy studies should be carried out in order to investigate preventative strategies.
    MeSH term(s) Female ; Humans ; Pelvic Floor Disorders/epidemiology ; Pelvic Floor Disorders/etiology ; Quality of Life ; Pelvic Floor ; Surveys and Questionnaires ; Exercise ; Pelvic Organ Prolapse
    Language English
    Publishing date 2024-02-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-023-07351-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Obesity is not an independent risk factor for peri- and post-operative complications following mid-urethral sling (MUS) surgeries for the treatment of stress urinary incontinence (SUI).

    Rotchild, Matan / Shelef, Goni / Sade, Shanny / Shoham-Vardi, Ilana / Weintraub, Adi Yehuda

    Archives of gynecology and obstetrics

    2023  Volume 309, Issue 3, Page(s) 1119–1125

    Abstract: Objective: To inquire whether obesity is a risk factor of peri- and post-operative complications following Mid-urethral sling (MUS) surgeries for SUI repair using the Clavien-Dindo classification system (CDcs).: Methods: This retrospective cohort ... ...

    Abstract Objective: To inquire whether obesity is a risk factor of peri- and post-operative complications following Mid-urethral sling (MUS) surgeries for SUI repair using the Clavien-Dindo classification system (CDcs).
    Methods: This retrospective cohort included 304 women who undergone a MUS in a 1000 beds tertiary University medical center between the years 2012-2018. Univariate analysis was conducted to compare clinical and operative traits by BMI group and to examine associations of obesity and complications rates and severity according to the CDcs. Multivariate analysis was conducted to assess the risk for post-operative complications and adjust to potential confounders.
    Results: The study group included 106 (34.9%) women with BMI 30 or higher and the comparison group included 198 (65.1%) women with BMI lower than 30. In the study group we found a significantly higher prevalence of hypertension (P = 0.019), previous abdominal surgeries (P = 0.012) including cesarean section (P = 0.025), previous pelvic floor surgeries (P = 0.005) and pelvic organ prolapse (P = 0.02). In the control group we found a significantly higher rates of concomitant hysterectomy which performed during the MUS (P = 0.005). Obesity was not associated with increased rates of peri and post-operative complications (P = 0.973).
    Conclusions: In our study, obesity was not associated with peri- and post-operative complications following MUS.
    MeSH term(s) Pregnancy ; Female ; Humans ; Male ; Urinary Incontinence, Stress/surgery ; Urinary Incontinence, Stress/complications ; Suburethral Slings/adverse effects ; Retrospective Studies ; Cesarean Section ; Urologic Surgical Procedures ; Obesity/complications ; Obesity/epidemiology ; Risk Factors ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Treatment Outcome
    Language English
    Publishing date 2023-09-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-023-07210-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis.

    Sade, Shanny / Wainstock, Tamar / Sheiner, Eyal / Pariente, Gali

    Journal of clinical medicine

    2020  Volume 9, Issue 9

    Abstract: Objective: To evaluate the perinatal outcome of women with tuberculosis and to assess a possible association between maternal tuberculosis and long-term infectious morbidity of the offspring.: Study design: Perinatal outcome and long-term infectious ... ...

    Abstract Objective: To evaluate the perinatal outcome of women with tuberculosis and to assess a possible association between maternal tuberculosis and long-term infectious morbidity of the offspring.
    Study design: Perinatal outcome and long-term infectious morbidity of offspring of mothers with and without tuberculosis were assessed. The study groups were followed until 18 years of age tracking infectious-related morbidity and infectious-related hospitalizations and then compared. For perinatal outcome, generalized estimation equation models were used. A Kaplan-Meier survival curve was used to compare cumulative incidence of long-term infectious morbidity. A Cox proportional hazards model was conducted to control for confounders.
    Results: During the study period, 243,682 deliveries were included, of which 46 (0.018%) occurred in women with tuberculosis. Maternal tuberculosis was found to be independently associated with placental abruption, cesarean deliveries, and very low birth weight. However, offspring born to mothers with tuberculosis did not demonstrate higher rates of infectious-related morbidity. Maternal tuberculosis was not noted as an independent risk factor for long-term infectious morbidity of the offspring.
    Conclusion: In our study, maternal tuberculosis was found to be independently associated with adverse perinatal outcomes. However, higher risk for long-term infectious morbidity of the offspring was not demonstrated. Careful surveillance of these women is required.
    Language English
    Publishing date 2020-08-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9092768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A systematic review of stem cell therapy treatment for women suffering from stress urinary incontinence.

    Klapper-Goldstein, Hadar / Tamam, Shai / Sade, Shanny / Weintraub, Adi Y

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2021  Volume 157, Issue 1, Page(s) 19–30

    Abstract: Background: Stem cell therapy (SCT) is used for regeneration of injured tissues. This seems a novel promising strategy for restoring urethral sphincter function in patients with stress urinary incontinence (SUI).: Objective: To summarize the clinical ...

    Abstract Background: Stem cell therapy (SCT) is used for regeneration of injured tissues. This seems a novel promising strategy for restoring urethral sphincter function in patients with stress urinary incontinence (SUI).
    Objective: To summarize the clinical trials available to date on SCT for treatment of SUI in women.
    Search strategy: PubMed, Cochrane Library, Scopus and Embase.
    Selection criteria: Prospective interventional case series, randomized prospective interventional study and prospective cohort study assessing women aged 18 years and over diagnosed with SUI and treated by SCT were included. The quality of studies was finally assessed using the JBI Critical Appraisal Checklists according to the PRISMA guidelines.
    Data collection and analysis: Nineteen studies (n = 773 patients) were selected for final analysis. These were conducted worldwide between the years 2005 and 2016. Although different cell types were used, general processing steps were similar. The follow-up period ranged between 6 weeks and 6 years and included common subjective and objective evaluation tools.
    Results: Overall, the studies imply that SCT for treatment of SUI is a safe and effective treatment.
    Conclusion: In our opinion, the initial results of SCT for the treatment of SUI seem promising. Standardization and validation of this treatment modality is required before it can be recommended for routine use.
    MeSH term(s) Adolescent ; Adult ; Anxiety ; Cell- and Tissue-Based Therapy ; Female ; Humans ; Prospective Studies ; Treatment Outcome ; Urinary Incontinence, Stress/surgery
    Language English
    Publishing date 2021-07-17
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.13769
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  6. Article ; Online: The association between amateur running with varying degrees of effort and sexual function among women.

    Sade, Shanny / Naor, Inbar / Rotem, Reut / Kravits, Dana Zilberman / Weintraub, Adi Y

    International urogynecology journal

    2022  Volume 33, Issue 6, Page(s) 1659–1665

    Abstract: Introduction and hypothesis: Sports and physical activity are known risk factors for altered pelvic floor function, which may affect sexual activity. The aim of this study was to examine the impact of amateur running on sexual function.: Methods: ... ...

    Abstract Introduction and hypothesis: Sports and physical activity are known risk factors for altered pelvic floor function, which may affect sexual activity. The aim of this study was to examine the impact of amateur running on sexual function.
    Methods: Amateur runners were contacted through social media. Their pelvic floor dysfunction (PFD), sexual function and quality of life were evaluated by self-reported validated questionnaires (PFDI-20, PISQ-12, IIQ-7). They were divided by degrees of effort into 'High effort' and 'Moderate effort.' The differences between the two groups were examined by Mann-Whitney U, t and chi-square tests.
    Results: One hundred eighty amateur runners were included. No significant differences in the sexual function were found between the two groups. The 'High effort' group reported experiencing higher intensity orgasms compared with women in the 'Moderate effort' group, and a correlation was found between the weekly running distance and intensity of orgasm that they experienced (p = 0.004).
    Conclusions: High effort physical activity may be associated with improved orgasm, which may be explained by better clitoral circulation and better function of the pelvic floor muscles. Clinicians that treat symptoms related to PFD and sexual dysfunction may raise awareness of the advantages of physical activity and pelvic floor muscle training and rehabilitation, which may improve tone and circulation and hence sexual function.
    MeSH term(s) Female ; Humans ; Pelvic Floor ; Pelvic Floor Disorders/complications ; Quality of Life ; Running ; Sexual Behavior/physiology ; Sexual Dysfunction, Physiological ; Surveys and Questionnaires
    Language English
    Publishing date 2022-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1050631-7
    ISSN 1433-3023 ; 0937-3462
    ISSN (online) 1433-3023
    ISSN 0937-3462
    DOI 10.1007/s00192-022-05197-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Positive pathological margins after loop electrosurgical excision procedure - Management and outcome.

    Davidesko, Sharon / Meirovitz, Mihai / Shaco-Levy, Ruthy / Wainstock, Tamar / Baumfeld, Yael / Erenberg, Miriam / Sade, Shanny / Kessous, Roy

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2023  Volume 49, Issue 5, Page(s) 1031–1036

    Abstract: Objective: Pathological involvement of cervical conization margins is a risk factor for recurrence, although management of these patients is controversial. We aimed to define risk factors for positive margins and compare recurrence following additional ... ...

    Abstract Objective: Pathological involvement of cervical conization margins is a risk factor for recurrence, although management of these patients is controversial. We aimed to define risk factors for positive margins and compare recurrence following additional surgical intervention compared to conservative management.
    Methods: A retrospective study of all conizations at our center between 2010 and 2019. Univariate analysis identified characteristics associated with positive margins. Women were stratified by mode of management comparing three groups (surveillance, repeat conization or hysterectomy) then two groups (surveillance vs. additional surgery). Kaplan Meyer survival curves compared cumulative recurrence stratified by mode of management. Pathological results of subsequent surgical procedures were examined for residual disease.
    Results: Of 448 conizations performed, 131 (29.2%) had positive margins which were associated with menopause, high-grade cytology and endocervical gland involvement. Women who underwent surveillance (n = 45) were more likely to be nulliparous, with low-grade histology and less endocervical gland involvement. Women who underwent hysterectomy (n = 61) were more likely to be postmenopausal and parous. Recurrence did not differ significantly in the three-group (p = 0.073) or two-group model (6.4% vs. 7.1% p = 0.869). Kaplan Meyer survival curves depicting cumulative recurrence did not differ significantly in either model (log rank test p = 0.642 for the three-group model, and p = 0.868 for the two-group model). Residual disease was found in 51.6% of hysterectomy specimens and 52.6% of repeat conizations.
    Conclusion: Surveillance is non-inferior to additional surgery in cases with positive conization margins and constitutes a valid option specifically for younger women at risk of future obstetric complications and those susceptible post-hysterectomy complications.
    MeSH term(s) Pregnancy ; Humans ; Female ; Uterine Cervical Dysplasia/pathology ; Uterine Cervical Neoplasms/surgery ; Uterine Cervical Neoplasms/pathology ; Retrospective Studies ; Electrosurgery ; Conization/methods ; Neoplasm, Residual/pathology ; Margins of Excision ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/surgery
    Language English
    Publishing date 2023-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2023.01.025
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  8. Article ; Online: Trend Changes in the individual contribution of risk factors for postpartum hemorrhage over more than two decades.

    Sade, Shanny / Weintraub, Adi Y / Baumfeld, Yael / Kluwgant, Dvora / Yohay, David / Rotem, Reut / Pariente, Gali

    Maternal and child health journal

    2022  Volume 26, Issue 11, Page(s) 2228–2236

    Abstract: Objective: Postpartum hemorrhage is an obstetric emergency with a rising incidence. The aim of this study was to identify trends in the specific contribution of various risk factors for postpartum hemorrhage by observing their odds ratios throughout ... ...

    Abstract Objective: Postpartum hemorrhage is an obstetric emergency with a rising incidence. The aim of this study was to identify trends in the specific contribution of various risk factors for postpartum hemorrhage by observing their odds ratios throughout different time periods.
    Study design: In this population-based retrospective cohort study trends of change in odds ratios for known risk factors for postpartum hemorrhage occurring in three consecutive eight-year intervals between 1988 and 2014 were compared. Two multivariable logistic regression models were used in order to identify independent risk factors for postpartum hemorrhage in our population. Trends of various risk factors were compared along the time period of the study.
    Results: The incidence of postpartum hemorrhage increased from 0.5% to 1988 to 0.6%. Using logistic regression models, preeclampsia, vacuum extraction delivery, retained placenta, perineal or vaginal tears and delivery of a large for gestational age neonate were recognized as independent risk factors for postpartum hemorrhage. While the odds ratios for perineal or vaginal tears significantly increased, odds ratios for delivery of a large for gestational age neonate significantly decreased. Odds ratios for the other risk factors did not change significantly.
    Conclusion: In our study, not only did the rates of statistically significant risk factors for postpartum hemorrhage change during the study period, the specific contribution of each risk factor changed as well. Having a better understanding of these trends might augment our ability to predict this grave obstetric complication and improve maternal outcomes in the future.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Female ; Humans ; Postpartum Hemorrhage/epidemiology ; Postpartum Hemorrhage/etiology ; Delivery, Obstetric/adverse effects ; Retrospective Studies ; Risk Factors ; Odds Ratio
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339905-6
    ISSN 1573-6628 ; 1092-7875
    ISSN (online) 1573-6628
    ISSN 1092-7875
    DOI 10.1007/s10995-022-03461-y
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  9. Article ; Online: Hyperemesis gravidarum and adverse pregnancy outcomes.

    Agmon, Niv / Sade, Shanny / Pariente, Gali / Rotem, Reut / Weintraub, Adi Y

    Archives of gynecology and obstetrics

    2019  Volume 300, Issue 2, Page(s) 347–353

    Abstract: Purpose: To assess adverse pregnancy outcomes in patients complicated with mild or severe Hyperemesis Gravidarum (HG).: Methods: A retrospective cohort study of women aged 18-45 with a singleton pregnancy that were admitted to the gynecological ward ... ...

    Abstract Purpose: To assess adverse pregnancy outcomes in patients complicated with mild or severe Hyperemesis Gravidarum (HG).
    Methods: A retrospective cohort study of women aged 18-45 with a singleton pregnancy that were admitted to the gynecological ward at the Soroka University Medical Center due to HG between the years 2013-2016 and gave birth at the same hospital was conducted. During the study period 89 patients met the inclusion criteria and comprised the study group. Women without HG who gave birth at the same time period comprised the comparison group (n = 91). Univariate analysis was carried out using Chi square or Fisher's exact test for nominal variables, and T test for numeric variables. Significance was defined as a P value < 0.05.
    Results: Women with HG were more likely to have experienced HG in a previous pregnancy. Rate of amniotic fluid abnormalities was significantly lower in the study group. However, rates of all other pregnancy complications were comparable between the groups. A sub-analysis of the HG group comparing mild and severe cases demonstrated no significant differences in rates of adverse pregnancy outcomes between the groups.
    Conclusions: In this retrospective cohort study no association was demonstrated between HG and adverse pregnancy outcomes regardless of HG severity. Women with severe nausea and vomiting during pregnancy can be reassured that HG is not associated with unfavorable maternal and neonatal outcomes.
    MeSH term(s) Adolescent ; Adult ; Cohort Studies ; Female ; Humans ; Hyperemesis Gravidarum/complications ; Pregnancy ; Pregnancy Outcome/epidemiology ; Retrospective Studies ; Young Adult
    Language English
    Publishing date 2019-05-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-019-05192-y
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  10. Article: Risk for Depressive Symptoms among Hospitalized Women in High-Risk Pregnancy Units during the COVID-19 Pandemic.

    Sade, Shanny / Sheiner, Eyal / Wainstock, Tamar / Hermon, Narkis / Yaniv Salem, Shimrit / Kosef, Tamar / Lanxner Battat, Talya / Oron, Sharon / Pariente, Gali

    Journal of clinical medicine

    2020  Volume 9, Issue 8

    Abstract: Objective: Higher rates of mental disorders, specifically depression, were found among affected people in previous epidemiological studies taken after disasters. The aim of the current study was to assess risk for depression among pregnant women ... ...

    Abstract Objective: Higher rates of mental disorders, specifically depression, were found among affected people in previous epidemiological studies taken after disasters. The aim of the current study was to assess risk for depression among pregnant women hospitalized during the "coronavirus disease 2019" (COVID-19) pandemic, as compared to women hospitalized before the COVID-19 pandemic.
    Study design: A cross-sectional study was performed among women hospitalized in the high-risk pregnancy units of the Soroka University Medical Center (SUMC). All participating women completed the Edinburgh Postnatal Depression Scale (EPDS), and the results were compared between women hospitalized during the COVID-19 strict isolation period (19 March 2020 and 26 May 2020) and women hospitalized before the COVID-19 pandemic. Multivariable logistic regression models were constructed to control for potential confounders.
    Results: Women hospitalized during the COVID-19 strict isolation period (
    Conclusion: Women hospitalized at the high-risk pregnancy unit during the COVID-19 strict isolation period were not at increased risk for depression, as compared to women hospitalized before the COVID-19 pandemic.
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9082449
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